Search Results - "MYKLEBOST, Ola"

Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden by Peneder, Peter, Stütz, Adrian M., Surdez, Didier, Krumbholz, Manuela, Semper, Sabine, Chicard, Mathieu, Sheffield, Nathan C., Pierron, Gaelle, Lapouble, Eve, Tötzl, Marcus, Ergüner, Bekir, Barreca, Daniele, Rendeiro, André F., Agaimy, Abbas, Boztug, Heidrun, Engstler, Gernot, Dworzak, Michael, Bernkopf, Marie, Taschner-Mandl, Sabine, Ambros, Inge M., Myklebost, Ola, Marec-Bérard, Perrine, Burchill, Susan Ann, Brennan, Bernadette, Strauss, Sandra J., Whelan, Jeremy, Schleiermacher, Gudrun, Schaefer, Christiane, Dirksen, Uta, Hutter, Caroline, Boye, Kjetil, Ambros, Peter F., Delattre, Olivier, Metzler, Markus, Bock, Christoph, Tomazou, Eleni M.

“…Sequencing of cell-free DNA in the blood of cancer patients (liquid biopsy) provides attractive opportunities for early diagnosis, assessment of treatment…”
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Monogenic and polygenic determinants of sarcoma risk: an international genetic study by Ballinger, Mandy L, PhD, Goode, David L, PhD, Ray-Coquard, Isabelle, Prof, James, Paul A, MBChB, Mitchell, Gillian, PhD, Niedermayr, Eveline, BSc, Puri, Ajay, Prof, Schiffman, Joshua D, Prof, Dite, Gillian S, PhD, Cipponi, Arcadi, PhD, Maki, Robert G, Prof, Brohl, Andrew S, MD, Myklebost, Ola, Prof, Stratford, Eva W, PhD, Lorenz, Susanne, PhD, Ahn, Sung-Min, MD, Ahn, Jin-Hee, MD, Kim, Jeong Eun, MD, Shanley, Sue, MD, Beshay, Victoria, PhD, Randall, Robert Lor, Prof, Judson, Ian, Prof, Seddon, Beatrice, PhD, Campbell, Ian G, Prof, Young, Mary-Anne, MSc, Sarin, Rajiv, Prof, Blay, Jean-Yves, Prof, O'Donoghue, Seán I, PhD, Thomas, David M, Prof

“…Summary Background Sarcomas are rare, phenotypically heterogeneous cancers that disproportionately affect the young. Outside rare syndromes, the nature,…”
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Cell Fusion of Mesenchymal Stem/Stromal Cells and Breast Cancer Cells Leads to the Formation of Hybrid Cells Exhibiting Diverse and Individual (Stem Cell) Characteristics by Dörnen, Jessica, Myklebost, Ola, Dittmar, Thomas

“…Cancer is one of the most common diseases worldwide, and treatment bears many challenges such as drug and radioresistance and formation of metastases. These…”
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Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies by Berg, Kaja C G, Eide, Peter W, Eilertsen, Ina A, Johannessen, Bjarne, Bruun, Jarle, Danielsen, Stine A, Bjørnslett, Merete, Meza-Zepeda, Leonardo A, Eknæs, Mette, Lind, Guro E, Myklebost, Ola, Skotheim, Rolf I, Sveen, Anita, Lothe, Ragnhild A

“…Colorectal cancer (CRC) cell lines are widely used pre-clinical model systems. Comprehensive insights into their molecular characteristics may improve model…”
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Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone by Behjati, Sam, Tarpey, Patrick S, Presneau, Nadège, Scheipl, Susanne, Pillay, Nischalan, Van Loo, Peter, Wedge, David C, Cooke, Susanna L, Gundem, Gunes, Davies, Helen, Nik-Zainal, Serena, Martin, Sancha, McLaren, Stuart, Goody, Victoria, Robinson, Ben, Butler, Adam, Teague, Jon W, Halai, Dina, Khatri, Bhavisha, Myklebost, Ola, Baumhoer, Daniel, Jundt, Gernot, Hamoudi, Rifat, Tirabosco, Roberto, Amary, M Fernanda, Futreal, P Andrew, Stratton, Michael R, Campbell, Peter J, Flanagan, Adrienne M

“…Adrienne Flanagan and colleagues identify distinct driver mutations in H3F3A and H3F3B in chondroblastoma and giant cell tumor of bone. The mutations occur in…”
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Multifocal Primary Prostate Cancer Exhibits High Degree of Genomic Heterogeneity by Løvf, Marthe, Zhao, Sen, Axcrona, Ulrika, Johannessen, Bjarne, Bakken, Anne Cathrine, Carm, Kristina Totland, Hoff, Andreas M., Myklebost, Ola, Meza-Zepeda, Leonardo A., Lie, A. Kathrine, Axcrona, Karol, Lothe, Ragnhild A., Skotheim, Rolf I.

“…Most primary prostate cancers are multifocal with individual tumors harboring different aggressiveness; however, the genomic heterogeneity among these tumors…”
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Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma by Behjati, Sam, Tarpey, Patrick S., Haase, Kerstin, Ye, Hongtao, Young, Matthew D., Alexandrov, Ludmil B., Farndon, Sarah J., Collord, Grace, Wedge, David C., Martincorena, Inigo, Cooke, Susanna L., Davies, Helen, Mifsud, William, Lidgren, Mathias, Martin, Sancha, Latimer, Calli, Maddison, Mark, Butler, Adam P., Teague, Jon W., Pillay, Nischalan, Shlien, Adam, McDermott, Ultan, Futreal, P. Andrew, Baumhoer, Daniel, Zaikova, Olga, Bjerkehagen, Bodil, Myklebost, Ola, Amary, M. Fernanda, Tirabosco, Roberto, Van Loo, Peter, Stratton, Michael R., Flanagan, Adrienne M., Campbell, Peter J.

“…Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, we present the largest sequencing study of osteosarcoma to date,…”
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Modulation of the osteosarcoma expression phenotype by microRNAs by Namløs, Heidi M, Meza-Zepeda, Leonardo A, Barøy, Tale, Østensen, Ingrid H G, Kresse, Stine H, Kuijjer, Marieke L, Serra, Massimo, Bürger, Horst, Cleton-Jansen, Anne-Marie, Myklebost, Ola

“…Osteosarcomas are the most common primary malignant tumors of bone and show multiple and complex genomic aberrations. miRNAs are non-coding RNAs capable of…”
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Evaluation of commercial DNA and RNA extraction methods for high-throughput sequencing of FFPE samples by Kresse, Stine H, Namløs, Heidi M, Lorenz, Susanne, Berner, Jeanne-Marie, Myklebost, Ola, Bjerkehagen, Bodil, Meza-Zepeda, Leonardo A

“…Nucleic acid material of adequate quality is crucial for successful high-throughput sequencing (HTS) analysis. DNA and RNA isolated from archival FFPE material…”
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The Architecture and Evolution of Cancer Neochromosomes by Garsed, Dale W., Marshall, Owen J., Corbin, Vincent D.A., Hsu, Arthur, Di Stefano, Leon, Schröder, Jan, Li, Jason, Feng, Zhi-Ping, Kim, Bo W., Kowarsky, Mark, Lansdell, Ben, Brookwell, Ross, Myklebost, Ola, Meza-Zepeda, Leonardo, Holloway, Andrew J., Pedeutour, Florence, Choo, K.H. Andy, Damore, Michael A., Deans, Andrew J., Papenfuss, Anthony T., Thomas, David M.

“…We isolated and analyzed, at single-nucleotide resolution, cancer-associated neochromosomes from well- and/or dedifferentiated liposarcomas. Neochromosomes,…”
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The Regulatory Landscape of Osteogenic Differentiation by Håkelien, Anne‐Mari, Bryne, Jan Christian, Harstad, Kristine G., Lorenz, Susanne, Paulsen, Jonas, Sun, Jinchang, Mikkelsen, Tarjei S., Myklebost, Ola, Meza‐Zepeda, Leonardo A.

“…Differentiation of osteoblasts from mesenchymal stem cells (MSCs) is an integral part of bone development and homeostasis, and may when improperly regulated…”
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Deciphering the role of FUS::DDIT3 expression and tumor microenvironment in myxoid liposarcoma development by Ranji, Parmida, Jonasson, Emma, Andersson, Lisa, Filges, Stefan, Luna Santamaría, Manuel, Vannas, Christoffer, Dolatabadi, Soheila, Gustafsson, Anna, Myklebost, Ola, Håkansson, Joakim, Fagman, Henrik, Landberg, Göran, Åman, Pierre, Ståhlberg, Anders

“…Myxoid liposarcoma (MLS) displays a distinctive tumor microenvironment and is characterized by the FUS::DDIT3 fusion oncogene, however, the precise functional…”
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Monitoring multiple myeloma by quantification of recurrent mutations in serum by Rustad, Even Holth, Coward, Eivind, Skytøen, Emilie R, Misund, Kristine, Holien, Toril, Standal, Therese, Børset, Magne, Beisvag, Vidar, Myklebost, Ola, Meza-Zepeda, Leonardo A, Dai, Hong Yan, Sundan, Anders, Waage, Anders

“…Circulating tumor DNA is a promising biomarker to monitor tumor load and genome alterations. We explored the presence of circulating tumor DNA in multiple…”
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Discovery of novel candidates for anti-liposarcoma therapies by medium-scale high-throughput drug screening by Grad, Iwona, Hanes, Robert, Ayuda-Durán, Pilar, Kuijjer, Marieke Lydia, Enserink, Jorrit M, Meza-Zepeda, Leonardo A, Myklebost, Ola

“…Sarcomas are a heterogeneous group of mesenchymal orphan cancers and new treatment alternatives beyond traditional chemotherapeutic regimes are much needed. So…”
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Small-Molecule MDM2 Antagonists Reveal Aberrant P53 Signaling in Cancer: Implications for Therapy by Tovar, Christian, Rosinski, James, Filipovic, Zoran, Higgins, Brian, Kolinsky, Kenneth, Hilton, Holly, Zhao, Xiaolan, Vu, Binh T., Qing, Weiguo, Packman, Kathryn, Myklebost, Ola, Heimbrook, David C., Vassilev, Lyubomir T.

“…The p53 tumor suppressor retains its wild-type conformation and transcriptional activity in half of all human tumors, and its activation may offer a…”
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miR-486-5p expression is regulated by DNA methylation in osteosarcoma by Namløs, Heidi M, Skårn, Magne, Ahmed, Deeqa, Grad, Iwona, Andresen, Kim, Kresse, Stine H, Munthe, Else, Serra, Massimo, Scotlandi, Katia, Llombart-Bosch, Antonio, Myklebost, Ola, Lind, Guro E, Meza-Zepeda, Leonardo A

“…Osteosarcoma is the most common primary malignant tumour of bone occurring in children and young adolescents and is characterised by complex genetic and…”
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Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma by Zhou, Yang, Ray, Partho Sarothi, Zhu, Jianguo, Stein, Frank, Rettel, Mandy, Sekaran, Thileepan, Sahadevan, Sudeep, Perez-Perri, Joel I., Roth, Eva K., Myklebost, Ola, Meza-Zepeda, Leonardo A., von Deimling, Andreas, Fu, Chuli, Brosig, Annika N., Boye, Kjetil, Nathrath, Michaela, Blattmann, Claudia, Lehner, Burkhard, Hentze, Matthias W., Kulozik, Andreas E.

“…Osteosarcoma is the most common primary malignant bone tumor with a strong tendency to metastasize, limiting the prognosis of affected patients. Genomic,…”
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Chromosomal instability and a deregulated cell cycle are intrinsic features of high‐risk gastrointestinal stromal tumours with a metastatic potential by Namløs, Heidi Maria, Khelik, Ksenia, Nakken, Sigve, Vodák, Daniel, Hovig, Eivind, Myklebost, Ola, Boye, Kjetil, Meza‐Zepeda, Leonardo A.

“…Patients with localised, high‐risk gastrointestinal stromal tumours (GIST) benefit from adjuvant imatinib treatment. Still, approximately 40% of patients…”
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Multilevel genomics of colorectal cancers with microsatellite instability-clinical impact of JAK1 mutations and consensus molecular subtype 1 by Sveen, Anita, Johannessen, Bjarne, Tengs, Torstein, Danielsen, Stine A, Eilertsen, Ina A, Lind, Guro E, Berg, Kaja C G, Leithe, Edward, Meza-Zepeda, Leonardo A, Domingo, Enric, Myklebost, Ola, Kerr, David, Tomlinson, Ian, Nesbakken, Arild, Skotheim, Rolf I, Lothe, Ragnhild A

“…Approximately 15% of primary colorectal cancers have DNA mismatch repair deficiency, causing a complex genome with thousands of small mutations-the…”
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Identification of osteosarcoma driver genes by integrative analysis of copy number and gene expression data by Kuijjer, Marieke L., Rydbeck, Halfdan, Kresse, Stine H., Buddingh, Emilie P., Lid, Ana B., Roelofs, Helene, Bürger, Horst, Myklebost, Ola, Hogendoorn, Pancras C. W., Meza-Zepeda, Leonardo A., Cleton-Jansen, Anne-Marie

“…High‐grade osteosarcoma is a tumor with a complex genomic profile, occurring primarily in adolescents with a second peak at middle age. The extensive genomic…”
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