Search Results - "MWANGI, Judy"
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Depression among women with obstetric fistula in Kenya
Published in International journal of gynecology and obstetrics (01-10-2011)“…Abstract Objective To establish the prevalence of depression and describe associated factors among fistula patients attending an obstetric fistula surgical…”
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Effects of stigma on quality of life of cancer survivors: Preliminary evidence from a survivorship programme in Kenya
Published in Heliyon (15-05-2024)“…Globally, cancer is a major public health problem. There is a paucity of information regarding stigma and how it affects the cancer survivors' quality of life…”
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Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection
Published in Journal of medicinal chemistry (13-03-2014)“…Investigation of thiophene-2-carboxylic acid HCV NS5B site II inhibitors, guided by measurement of cell culture medium binding, revealed the structure–activity…”
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Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase
Published in Antimicrobial Agents and Chemotherapy (01-02-2013)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Prediction of bictegravir human pharmacokinetics from protein binding and in vitro-in vivo correlation
Published in Drug metabolism and pharmacokinetics (01-01-2018)Get full text
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Clinical targeting of HIV capsid protein with a long-acting small molecule
Published in Nature (London) (27-08-2020)“…Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis 1…”
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Intestinal Excretion is a Major Disposition Pathway of Lenacapavir in Rat and Dog
Published in The FASEB journal (01-05-2021)“…Lenacapavir (LEN), previously known as GS‐6207 or GS‐CA2, is a first‐in‐class HIV capsid inhibitor in clinical development as a long‐acting agent. LEN displays…”
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Lenacapavir Exhibits Atropisomerism-Mechanistic Pharmacokinetics and Disposition Studies of Lenacapavir Reveal Intestinal Excretion as a Major Clearance Pathway
Published in The Journal of pharmacology and experimental therapeutics (18-09-2024)“…Lenacapavir (LEN), a long-acting injectable, is the first approved human immunodeficiency virus type 1 capsid inhibitor and one of a few Food and Drug…”
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Long-acting capsid inhibitor protects macaques from repeat SHIV challenges
Published in Nature (London) (27-01-2022)“…Because no currently available vaccine can prevent HIV infection, pre-exposure prophylaxis (PrEP) with antiretrovirals (ARVs) is an important tool for…”
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Human pharmacokinetics prediction with an in vitro-in vivo correction factor approach and in vitro drug-drug interaction profile of bictegravir, a potent integrase-strand transfer inhibitor component in approved biktarvy® for the treatment of HIV-1 infection
Published in Xenobiotica (02-12-2022)“…Bictegravir (BIC) is a potent small-molecule integrase strand-transfer inhibitor (INSTI) and a component of Biktarvy ® , a single-tablet combination regimen…”
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Cyst Morphology and Serological Variation in Cystic Echinococcosis Patients from Turkana, Kenya
Published 01-01-2019“…Cystic echinococcosis (CE) is parasitic disease caused by cestode E. granulosus. Turkana in Northern Kenya carries one of the highest CE burdens in the world…”
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Dissertation -
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Transporter Roles in the Pharmacokinetics and Tissue Distribution of Voxilaprevir, a Pan‐genotypic HCV NS3/4A Protease Inhibitor
Published in The FASEB journal (01-04-2018)“…Introduction Voxilaprevir (VOX; GS‐9857) is a pan‐genotypic hepatitis C virus nonstructural (NS) protein 3/4A protease inhibitor (HCV‐PI) with potent antiviral…”
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Psychological effects of the Nairobi US embassy bomb blast on pregnant women and their children
Published in World psychiatry (01-02-2005)“…A descriptive study was carried out in pregnant women who were affected by the 1998 bomb blast in Nairobi, Kenya, and their babies who were in utero at the…”
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Traumatic grief in Kenyan bereaved parents following the Kyanguli School fire tragedy
Published in World psychiatry (01-02-2004)“…Following the death of 67 boys in a fire tragedy at Kyanguli School in rural Kenya, the level of traumatic grief was assessed in a sample of 164 parents and…”
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