Search Results - "MUTH, Doreen"

Hosts and Sources of Endemic Human Coronaviruses by Corman, Victor M, Muth, Doreen, Niemeyer, Daniela, Drosten, Christian

“…The four endemic human coronaviruses HCoV-229E, -NL63, -OC43, and -HKU1 contribute a considerable share of upper and lower respiratory tract infections in…”
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SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection by Gassen, Nils C., Niemeyer, Daniela, Muth, Doreen, Corman, Victor M., Martinelli, Silvia, Gassen, Alwine, Hafner, Kathrin, Papies, Jan, Mösbauer, Kirstin, Zellner, Andreas, Zannas, Anthony S., Herrmann, Alexander, Holsboer, Florian, Brack-Werner, Ruth, Boshart, Michael, Müller-Myhsok, Bertram, Drosten, Christian, Müller, Marcel A., Rein, Theo

“…Autophagy is an essential cellular process affecting virus infections and other diseases and Beclin1 (BECN1) is one of its key regulators. Here, we identified…”
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Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform by Thi Nhu Thao, Tran, Labroussaa, Fabien, Ebert, Nadine, V’kovski, Philip, Stalder, Hanspeter, Portmann, Jasmine, Kelly, Jenna, Steiner, Silvio, Holwerda, Melle, Kratzel, Annika, Gultom, Mitra, Schmied, Kimberly, Laloli, Laura, Hüsser, Linda, Wider, Manon, Pfaender, Stephanie, Hirt, Dagny, Cippà, Valentina, Crespo-Pomar, Silvia, Schröder, Simon, Muth, Doreen, Niemeyer, Daniela, Corman, Victor M., Müller, Marcel A., Drosten, Christian, Dijkman, Ronald, Jores, Joerg, Thiel, Volker

“…Reverse genetics has been an indispensable tool to gain insights into viral pathogenesis and vaccine development. The genomes of large RNA viruses, such as…”
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Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection by Drosten, Christian, Prof, Seilmaier, Michael, MD, Corman, Victor M, MD, Hartmann, Wulf, MD, Scheible, Gregor, MD, Sack, Stefan, Prof, Guggemos, Wolfgang, MD, Kallies, Rene, PhD, Muth, Doreen, PhD, Junglen, Sandra, PhD, Müller, Marcel A, PhD, Haas, Walter, MD, Guberina, Hana, MD, Röhnisch, Tim, MD, Schmid-Wendtner, Monika, Prof, Aldabbagh, Souhaib, DVM, Dittmer, Ulf, Prof, Gold, Hermann, MD, Graf, Petra, MD, Bonin, Frank, MD, Rambaut, Andrew, DPhil, Wendtner, Clemens-Martin, Prof

“…Summary Background The Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus involved in cases and case clusters of severe acute…”
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Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission by Muth, Doreen, Corman, Victor Max, Roth, Hanna, Binger, Tabea, Dijkman, Ronald, Gottula, Lina Theresa, Gloza-Rausch, Florian, Balboni, Andrea, Battilani, Mara, Rihtarič, Danijela, Toplak, Ivan, Ameneiros, Ramón Seage, Pfeifer, Alexander, Thiel, Volker, Drexler, Jan Felix, Müller, Marcel Alexander, Drosten, Christian

“…A 29 nucleotide deletion in open reading frame 8 (ORF8) is the most obvious genetic change in severe acute respiratory syndrome coronavirus (SARS-CoV) during…”
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Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC by Raj, V. Stalin, Mou, Huihui, Smits, Saskia L., Dekkers, Dick H. W., Müller, Marcel A., Dijkman, Ronald, Muth, Doreen, Demmers, Jeroen A. A., Zaki, Ali, Fouchier, Ron A. M., Thiel, Volker, Drosten, Christian, Rottier, Peter J. M., Osterhaus, Albert D. M. E., Bosch, Berend Jan, Haagmans, Bart L.

“…Human coronavirus-EMC (hCoV-EMC) is a new coronavirus that has killed around half of the few humans infected so far; this study now identifies DPP4 as the…”
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Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa by Carroll, Miles W., Matthews, David A., Hiscox, Julian A., Elmore, Michael J., Pollakis, Georgios, Rambaut, Andrew, Hewson, Roger, García-Dorival, Isabel, Koundouno, Raymond, Abdellati, Saïd, Afrough, Babak, Aiyepada, John, Akhilomen, Patience, Atkinson, Barry, Bate, Simon, Baumann, Jan, Becker-Ziaja, Beate, Bocquin, Anne, Borremans, Benny, Boettcher, Jan Peter, Cannas, Angela, Carletti, Fabrizio, Clark, Simon, Colavita, Francesca, Diederich, Sandra, Donatus, Adomeh, Duraffour, Sophie, Ehichioya, Deborah, Ellerbrok, Heinz, Fizet, Alexandra, Fleischmann, Erna, Gryseels, Sophie, Hinzmann, Julia, Hopf-Guevara, Ute, Ighodalo, Yemisi, Jameson, Lisa, Kelterbaum, Anne, Kis, Zoltan, Kloth, Stefan, Kraus, Annette, Kuisma, Eeva, Liedigk, Britta, Logue, Christopher H., Lüdtke, Anja, Maes, Piet, Mély, Stéphane, Mertens, Marc, Meschi, Silvia, Meyer, Benjamin, Molkenthin, Peter, Muñoz-Fontela, César, Ngabo, Didier, Okosun, Jennifer, Olokor, Thomas, Omiunu, Racheal, Omomoh, Emmanuel, Pallasch, Elisa, Pályi, Bernadett, Portmann, Jasmine, Pottage, Thomas, Pratt, Catherine, Priesnitz, Simone, Richter, Martin, Sachse, Andreas, Schmidt, Kristina Maria, Schudt, Gordian, Strecker, Thomas, Thomas, Stephen, Tobin, Ekaete, Trautner, Jochen, Vermoesen, Tine, Vitoriano, Inês, Wolff, Svenja, Yue, Constanze, Capobianchi, Maria Rosaria, Kretschmer, Birte, Hall, Yper, Kenny, John G., Rickett, Natasha Y., Dudas, Gytis, Coltart, Cordelia E. M., Kerber, Romy, Wright, Callum, Senyah, Francis, Drury, Patrick, Van Herp, Michel, Sprecher, Armand, Traore, Alexis, Diakite, Mandiou, Konde, Mandy Kader, Magassouba, N’Faly, Avšič-Županc, Tatjana, Nitsche, Andreas, Strasser, Marc, Ippolito, Giuseppe, Becker, Stephan, Raoul, Hervé, Di Caro, Antonino, Wölfel, Roman, Günther, Stephan

“…Analysis of 179 new Ebola virus sequences from patient samples collected in Guinea between March 2014 and January 2015 shows how different lineages evolved and…”
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Middle East Respiratory Syndrome Coronavirus Accessory Protein 4a Is a Type I Interferon Antagonist by Niemeyer, Daniela, Zillinger, Thomas, Muth, Doreen, Zielecki, Florian, Horvath, Gabor, Suliman, Tasnim, Barchet, Winfried, Weber, Friedemann, Drosten, Christian, Müller, Marcel A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Interferon antagonism by SARS-CoV-2: a functional study using reverse genetics by Schroeder, Simon, Pott, Fabian, Niemeyer, Daniela, Veith, Talitha, Richter, Anja, Muth, Doreen, Goffinet, Christine, Müller, Marcel A, Drosten, Christian

“…The COVID-19 agent, SARS-CoV-2, is conspecific with SARS-CoV, the causal agent of the severe acute respiratory syndrome epidemic in 2002–03. Although the…”
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MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity by Chu, Daniel K. W., Hui, Kenrie P. Y., Perera, Ranawaka A. P. M., Miguel, Eve, Niemeyer, Daniela, Zhao, Jincun, Channappanavar, Rudragouda, Dudas, Gytis, Oladipo, Jamiu O., Traoré, Amadou, Fassi-Fihri, Ouafaa, Ali, Abraham, Demissié, Getnet F., Muth, Doreen, Chan, Michael C. W., Nicholls, John M., Meyerholz, David K., Kuranga, Sulyman A., Mamo, Gezahegne, Zhou, Ziqi, So, Ray T. Y., Hemida, Maged G., Webby, Richard J., Roger, Francois, Rambaut, Andrew, Poon, Leo L. M., Perlman, Stanley, Drosten, Christian, Chevalier, Veronique, Peiris, Malik

“…Middle East respiratory syndrome coronavirus (MERS-CoV) causes a zoonotic respiratory disease of global public health concern, and dromedary camels are the…”
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Genomic Characterization of Severe Acute Respiratory Syndrome-Related Coronavirus in European Bats and Classification of Coronaviruses Based on Partial RNA-Dependent RNA Polymerase Gene Sequences by Drexler, Jan Felix, Gloza-Rausch, Florian, Glende, Jörg, Corman, Victor Max, Muth, Doreen, Goettsche, Matthias, Seebens, Antje, Niedrig, Matthias, Pfefferle, Susanne, Yordanov, Stoian, Zhelyazkov, Lyubomir, Hermanns, Uwe, Vallo, Peter, Lukashev, Alexander, Müller, Marcel Alexander, Deng, Hongkui, Herrler, Georg, Drosten, Christian

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential by Kindler, Eveline, Jónsdóttir, Hulda R, Muth, Doreen, Hamming, Ole J, Hartmann, Rune, Rodriguez, Regulo, Geffers, Robert, Fouchier, Ron A M, Drosten, Christian, Müller, Marcel A, Dijkman, Ronald, Thiel, Volker

“…The recent emergence of a novel human coronavirus (HCoV-EMC) in the Middle East raised considerable concerns, as it is associated with severe acute pneumonia,…”
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Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir by Carbajo-Lozoya, Javier, Ma-Lauer, Yue, Malešević, Miroslav, Theuerkorn, Martin, Kahlert, Viktoria, Prell, Erik, von Brunn, Brigitte, Muth, Doreen, Baumert, Thomas F., Drosten, Christian, Fischer, Gunter, von Brunn, Albrecht

“…•Cyclophilin A (CypA) is a host factor for human coronavirus NL63 replication.•CypA is a target for anti-coronaviral therapy.•Non-immunosuppressive CsA…”
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Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5 by Schroeder, Simon, Mache, Christin, Kleine-Weber, Hannah, Corman, Victor M., Muth, Doreen, Richter, Anja, Fatykhova, Diana, Memish, Ziad A., Stanifer, Megan L., Boulant, Steeve, Gultom, Mitra, Dijkman, Ronald, Eggeling, Stephan, Hocke, Andreas, Hippenstiel, Stefan, Thiel, Volker, Pöhlmann, Stefan, Wolff, Thorsten, Müller, Marcel A., Drosten, Christian

“…Middle East respiratory syndrome coronavirus (MERS-CoV) is enzootic in dromedary camels across the Middle East and Africa. Virus-induced pneumonia in humans…”
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Acute middle East respiratory syndrome coronavirus infection in livestock Dromedaries, Dubai, 2014 by Wernery, Ulrich, Corman, Victor M, Wong, Emily Y M, Tsang, Alan K L, Muth, Doreen, Lau, Susanna K P, Khazanehdari, Kamal, Zirkel, Florian, Ali, Mansoor, Nagy, Peter, Juhasz, Jutka, Wernery, Renate, Joseph, Sunitha, Syriac, Ginu, Elizabeth, Shyna K, Patteril, Nissy Annie Georgy, Woo, Patrick C Y, Drosten, Christian

“…Camels carry Middle East respiratory syndrome coronavirus, but little is known about infection age or prevalence. We studied >800 dromedaries of all ages and…”
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Transgene expression in the genome of Middle East respiratory syndrome coronavirus based on a novel reverse genetics system utilizing Red-mediated recombination cloning by Muth, Doreen, Meyer, Benjamin, Niemeyer, Daniela, Schroeder, Simon, Osterrieder, Nikolaus, Müller, Marcel Alexander, Drosten, Christian

“…Middle East respiratory syndrome coronavirus (MERS-CoV) is a high-priority pathogen in pandemic preparedness research. Reverse genetics systems are a valuable…”
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Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines by Müller, Marcel A, Raj, V Stalin, Muth, Doreen, Meyer, Benjamin, Kallies, Stephan, Smits, Saskia L, Wollny, Robert, Bestebroer, Theo M, Specht, Sabine, Suliman, Tasnim, Zimmermann, Katrin, Binger, Tabea, Eckerle, Isabella, Tschapka, Marco, Zaki, Ali M, Osterhaus, Albert D M E, Fouchier, Ron A M, Haagmans, Bart L, Drosten, Christian

“…A new human coronavirus (hCoV-EMC) has emerged very recently in the Middle East. The clinical presentation resembled that of the severe acute respiratory…”
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One-step selection of Vaccinia virus-binding DNA aptamers by MonoLEX by Nitsche, Andreas, Kurth, Andreas, Dunkhorst, Anna, Pänke, Oliver, Sielaff, Hendrik, Junge, Wolfgang, Muth, Doreen, Scheller, Frieder, Stöcklein, Walter, Dahmen, Claudia, Pauli, Georg, Kage, Andreas

“…As a new class of therapeutic and diagnostic reagents, more than fifteen years ago RNA and DNA aptamers were identified as binding molecules to numerous small…”
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Human parvovirus 4 in nasal and fecal specimens from children, Ghana by Drexler, Jan Felix, Reber, Ulrike, Muth, Doreen, Herzog, Petra, Annan, Augustina, Ebach, Fabian, Sarpong, Nimarko, Acquah, Samuel, Adlkofer, Julia, Adu-Sarkodie, Yaw, Panning, Marcus, Tannich, Egbert, May, Jürgen, Drosten, Christian, Eis-Hübinger, Anna Maria

“…Nonparenteral transmission might contribute to human parvovirus 4 (PARV4) infections in sub-Saharan Africa. PARV4 DNA was detected in 8 (0.83%) of 961 nasal…”
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Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the middle East respiratory syndrome virus by Lundin, Anna, Dijkman, Ronald, Bergström, Tomas, Kann, Nina, Adamiak, Beata, Hannoun, Charles, Kindler, Eveline, Jónsdóttir, Hulda R, Muth, Doreen, Kint, Joeri, Forlenza, Maria, Müller, Marcel A, Drosten, Christian, Thiel, Volker, Trybala, Edward

“…Coronaviruses raise serious concerns as emerging zoonotic viruses without specific antiviral drugs available. Here we screened a collection of 16671 diverse…”
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