Search Results - "MUSSON, Donald G"

Single-dose, subcutaneous recombinant phenylalanine ammonia lyase conjugated with polyethylene glycol in adult patients with phenylketonuria: an open-label, multicentre, phase 1 dose-escalation trial by Longo, Nicola, MD, Harding, Cary O, MD, Burton, Barbara K, MD, Grange, Dorothy K, MD, Vockley, Jerry, MD, Wasserstein, Melissa, MD, Rice, Gregory M, MD, Dorenbaum, Alejandro, MD, Neuenburg, Jutta K, MD, Musson, Donald G, PhD, Gu, Zhonghua, PhD, Sile, Saba, MD

“…Summary Background Phenylketonuria is an inherited disease caused by impaired activity of phenylalanine hydroxylase, the enzyme that converts phenylalanine to…”
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Immunogenicity of Elosulfase Alfa, an Enzyme Replacement Therapy in Patients With Morquio A Syndrome: Results From MOR-004, a Phase III Trial by Schweighardt, Becky, PhD, Tompkins, Troy, BS, Lau, Kelly, MS, Jesaitis, Lynne, PhD, Qi, Yulan, PhD, Musson, Donald G., PhD, Farmer, Pamela, MD, Haller, Christine, MD, Shaywitz, Adam J., MD, PhD, Yang, Ke, PhD, O’Neill, Charles A., PhD

“…Abstract Purpose Morquio A syndrome (mucopolysaccharidosis IVA [MPS IVA]) is a lysosomal storage disorder caused by deficiency of the enzyme N…”
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Nonclinical evaluation of CNS-administered TPP1 enzyme replacement in canine CLN2 neuronal ceroid lipofuscinosis by Vuillemenot, Brian R., Kennedy, Derek, Cooper, Jonathan D., Wong, Andrew M.S., Sri, Sarmi, Doeleman, Thom, Katz, Martin L., Coates, Joan R., Johnson, Gayle C., Reed, Randall P., Adams, Eric L., Butt, Mark T., Musson, Donald G., Henshaw, Joshua, Keve, Steve, Cahayag, Rhea, Tsuruda, Laurie S., O'Neill, Charles A.

“…The CLN2 form of neuronal ceroid lipofuscinosis, a type of Batten disease, is a lysosomal storage disorder caused by a deficiency of the enzyme tripeptidyl…”
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Acetylator Status Impacts Amifampridine Phosphate (Firdapse™) Pharmacokinetics and Exposure to a Greater Extent Than Renal Function by Haroldsen, Peter E., PhD, Sisic, Zlatko, MD, Datt, Joe, MD, Musson, Donald G., PhD, Ingenito, Gary, MD, PhD

“…Abstract Purpose The purpose of this study is to evaluate safety, tolerability, and pharmacokinetic (PK) properties of amifampridine phosphate (Firdapse™) and…”
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Effects of Food Intake on the Relative Bioavailability of Amifampridine Phosphate Salt in Healthy Adults by Haroldsen, Peter E., PhD, Musson, Donald G., PhD, Hanson, Boyd, PhD, Quartel, Adrian, MD, O’Neill, Charles A., PhD

“…Abstract Purpose Amifampridine (3,4-diaminopyridine) has been approved in the European Union for the treatment of Lambert-Eaton myasthenic syndrome…”
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Investigation of high-throughput ultrafiltration for the determination of an unbound compound in human plasma using liquid chromatography and tandem mass spectrometry with electrospray ionization by Zhang, Jin, Musson, Donald G.

“…A high-throughput ultrafiltration method with a direct injection assay has been developed to determine unbound concentrations of a high-protein binding…”
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Reversed-phase chiral liquid chromatography on polysaccharide-based stationary phase coupled with tandem mass spectrometry for simultaneous determination of four stereoisomers of MK-0974 in human plasma by Xu, Yang, Musson, Donald G.

“…MK-0974 ( 1a), N-[(3 R,6 S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifuoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1 H-imidazo-[4,5-B]…”
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Strategies on efficient method development of on-line extraction assays for determination of MK-0974 in human plasma and urine using turbulent-flow chromatography and tandem mass spectrometry by Xu, Yang, Willson, Kenneth J., Musson, Donald G.

“…On-line extraction assays using cohesive high-turbulence liquid chromatography (HTLC) coupled with tandem mass spectrometer (MS/MS) have been developed for the…”
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Application of a novel ultra-low elution volume 96-well solid-phase extraction method to the LC/MS/MS determination of simvastatin and simvastatin acid in human plasma by Yang, Amy Y., Sun, Li, Musson, Donald G., Zhao, Jamie J.

“…A novel extraction method has been utilized in the LC/MS/MS determination of simvastatin and simvastatin acid in human plasma. In this method, 300 μl of plasma…”
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Genetic variation in aryl N‐acetyltransferase results in significant differences in the pharmacokinetic and safety profiles of amifampridine (3,4‐diaminopyridine) phosphate by Haroldsen, Peter E., Garovoy, Marvin R., Musson, Donald G., Zhou, Huiyu, Tsuruda, Laurie, Hanson, Boyd, O'Neill, Charles A.

“…The clinical use of amifampridine phosphate for neuromuscular junction disorders is increasing. The metabolism of amifampridine occurs via polymorphic aryl…”
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Relative bioavailability of sapropterin from intact and dissolved sapropterin dihydrochloride tablets and the effects of food: A randomized, open-label, crossover study in healthy adults by Musson, Donald G., PhD, Kramer, William G., PhD, Foehr, Erik D., PhD, Bieberdorf, Frederick A., MD, Hornfeldt, Carl S., PhD, Kim, Sun Sook, MS, Dorenbaum, Alex, MD

“…Abstract Background: Phenylketonuria (PKU) is an autosomal recessive metabolic disorder characterized by hyperphenylalaninemia in association with…”
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High turbulence liquid chromatography online extraction and tandem mass spectrometry for the simultaneous determination of suberoylanilide hydroxamic acid and its two metabolites in human serum by Du, Lihong, Musson, Donald G., Wang, Amy Qiu

“…A reliable and sensitive method incorporating high turbulence liquid chromatography (HTLC) online extraction with tandem mass spectrometry (MS/MS), for…”
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Elimination of diastereomer interference to determine Telcagepant (MK-0974) in human plasma using on-line turbulent-flow technology and off-line solid-phase extraction coupled with liquid chromatography/tandem mass spectrometry by Xu, Yang, Willson, Kenneth J., Anderson, Melanie D.G., Musson, Donald G., Miller-Stein, Cynthia M., Woolf, Eric J.

“…To eliminate the diastereomer interference on Telcagepant (MK-0974) determination during clinical study support, on-line high turbulent-flow liquid…”
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A new approach for evaluating carryover and its influence on quantitation in high-performance liquid chromatography and tandem mass spectrometry assay by Zeng, Wei, Musson, Donald G., Fisher, Alison L., Wang, Amy Qiu

“…In a high‐performance liquid chromatography (HPLC)‐based analytical method, carryover denotes one type of systematic error that is derived from a preceding…”
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Concerns in the development of an assay for determination of a highly conjugated adsorption-prone compound in human urine by YANG XU, LIHONG DU, ROSE, Mark J, IRONG FU, WOOLF, Eric J, MUSSON, Donald G

“…Concerns in pre-analytical handling of urine samples are discussed using a new KDR kinase inhibitor,…”
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Assay methodology for the quantitation of unbound ertapenem, a new carbapenem antibiotic, in human plasma by Musson, Donald G, Birk, Kimberly L, Kitchen, Chester J, Zhang, Jin, Hsieh, John Y.K, Fang, Wei, Majumdar, Anup K, Rogers, John D

“…Ertapenem is a new once-a-day antibiotic with excellent coverage of common community gram negative and gram positive aerobes and anaerobes. It demonstrates…”
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Pharmacokinetic and Pharmacodynamic Evaluation of Elosulfase Alfa, an Enzyme Replacement Therapy in Patients with Morquio A Syndrome by Qi, Yulan, Musson, Donald G., Schweighardt, Becky, Tompkins, Troy, Jesaitis, Lynne, Shaywitz, Adam J., Yang, Ke, O’Neill, Charles A.

“…Background and Objectives Morquio A syndrome (mucopolysaccharidosis IVA; MPS IVA) is a lysosomal storage disorder caused by deficiency of N…”
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High-throughput liquid chromatography for drug analysis in biological fluids: investigation of extraction column life by Zeng, Wei, Fisher, Alison L, Musson, Donald G, Wang, Amy Qiu

“…A novel method was developed and assessed to extend the lifetime of extraction columns of high-throughput liquid chromatography (HTLC) for bioanalysis of human…”
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A Prospective Population Pharmacokinetic Analysis of Sapropterin Dihydrochloride in Infants and Young Children with Phenylketonuria by Qi, Yulan, Mould, Diane R., Zhou, Huiyu, Merilainen, Markus, Musson, Donald G.

“…Background and Objectives Untreated phenylketonuria (PKU), a hereditary metabolic disorder caused by a genetic mutation in phenylalanine hydroxylase (PAH), is…”
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Maternal phenylketonuria syndrome: studies in mice suggest a potential approach to a continuing problem by Zeile, William L, McCune, Helen C, Musson, Donald G, O'Donnell, Brian, O'Neill, Charles A, Tsuruda, Laurie S, Zori, Roberto T, Laipis, Philip J

“…Background Untreated phenylketonuria (PKU), one of the most common human genetic disorders, usually results in mental retardation. Although a…”
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