Search Results - "MUSHYNSKI, W. E"

Cycling at the interface between neurodevelopment and neurodegeneration by Nguyen, M D, Mushynski, W E, Julien, J-P

“…The discovery of cell cycle regulators has directed cell research into uncharted territory. In dividing cells, cell cycle-associated protein kinases, which are…”
Get full text

Up‐Regulation of Protein Chaperones Preserves Viability of Cells Expressing Toxic Cu/Zn‐Superoxide Dismutase Mutants Associated with Amyotrophic Lateral Sclerosis by Bruening, Wendy, Roy, Josée, Giasson, Benoit, Figlewicz, Denise A, Mushynski, Walter E, Durham, Heather D

“…: Mutations in the Cu/Zn‐superoxidedismutase (SOD‐1) gene underlie some familial cases of amytotrophic lateral sclerosis, a neurodegenerative disorder…”
Get full text

Phosphorylation of translation initiation factor eIF-4E is induced in a ras-dependent manner during nerve growth factor-mediated PC12 cell differentiation by FREDERICKSON, R. M, MUSHYNSKI, W. E, SONENBERG, N

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Multiple phosphorylation sites in mammalian neurofilament polypeptides by Julien, J P, Mushynski, W E

“…The 68,000, 145,000, and 200,000 dalton subunits of neurofilaments from rat spinal cord and brain stem were shown by chemical phosphate analysis to contain…”
Get full text

The distribution of phosphorylation sites among identified proteolytic fragments of mammalian neurofilaments by Julien, J P, Mushynski, W E

“…Neurofilaments were treated with chymotrypsin or with Staphylococcus aureus V8 protease (V8 protease) and the proteolytic fragments in soluble and particulate…”
Get full text

Activation of Stress‐Activated Protein Kinases Correlates with Neurite Outgrowth Induced by Protease Inhibition in PC12 Cells by Giasson, Benoit I, Bruening, Wendy, Durham, Heather D, Mushynski, Walter E

“…: PC12 cells are well characterized for their ability to differentiate into neuronal‐like cells when challenged with nerve growth factor. It has been reported…”
Get full text

Differential vulnerability of microtubule components in cerebral ischemia by YANAGIHARA, T, BRENGMAN, J. M, MUSHYNSKI, W. E

“…Differential vulnerability of the major components of microtubules was examined in ischemic gerbil brains by a light microscopic, immunohistochemical method…”
Get full text

Intermediate Filament Disassembly in Cultured Dorsal Root Ganglion Neurons Is Associated with Amino‐Terminal Head Domain Phosphorylation of Specific Subunits by Giasson, Benoit I., Mushynski, Walter E.

“…: We previously reported that activation of protein kinase A in cultured rat dorsal root ganglion neurons, treated concomitantly with low concentrations of…”
Get full text

Transcriptional and post-transcriptional effects of nerve growth factor on expression of the three neurofilament subunits in PC-12 cells by Lindenbaum, M H, Carbonetto, S, Grosveld, F, Flavell, D, Mushynski, W E

“…Nerve growth factor (NGF) is known to increase the levels of neurofilament proteins in PC-12 pheochromocytoma cells. In this report, we show that the three…”
Get full text

Increased phosphorylation of the amino-terminal domain of the low molecular weight neurofilament subunit in okadaic acid-treated neurons by SACHER, M. G, ATHLAN, E. S, MUSHYNSKI, W. E

“…Treatment of rat dorsal root ganglion cultures with 1 microM okadaic acid leads to a fragmentation of neurofilaments and a reduction in the electrophoretic…”
Get full text

Nerve growth factor enhances the synthesis, phosphorylation, and metabolic stability of neurofilament proteins in PC12 cells by Lindenbaum, M H, Carbonetto, S, Mushynski, W E

“…Rat pheochromocytoma (PC12) cells grown in the presence or absence of nerve growth factor (NGF) were pulse-labeled with [35S]methionine or 32Pi, and…”
Get full text

Associations between intermediate filament proteins expressed in cultured dorsal root ganglion neurons by Athlan, E.S., Sacher, M.G., Mushynski, W.E.

“…The developmental profile of the neurofilament (NF) triplet proteins, α‐internexin and peripherin in cultured dorsal root ganglion neurons from gestation day…”
Get full text

Developmentally regulated stabilization of neuronal intermediate filaments in rat cerebral cortex by Giasson, Benoit I, E. Mushynski, Walter

“…The expression and Triton X-100 (Triton) solubility of neuronal intermediate filament proteins were determined in the developing rat cerebral cortex. The level…”
Get full text

Okadaic acid induces the rapid and reversible disruption of the neurofilament network in rat dorsal root ganglion neurons by Sacher, M G, Athlan, E S, Mushynski, W E

“…Treatment of 15-17 day old dissociated cultures of rat dorsal root ganglia with 1 microM okadaic acid caused a reduction in the mobilities of neurofilament…”
Get more information

A Neurotoxic Peripherin Splice Variant in a Mouse Model of ALS by Robertson, Janice, Doroudchi, Mohammad M., Nguyen, Minh Dang, Durham, Heather D., Strong, Michael J., Shaw, Gerry, Julien, Jean-Pierre, Mushynski, Walter E.

“…Peripherin, a neuronal intermediate filament (nIF) protein found associated with pathological aggregates in motor neurons of patients with amyotrophic lateral…”
Get full text

Apoptotic Death of Neurons Exhibiting Peripherin Aggregates Is Mediated by the Proinflammatory Cytokine Tumor Necrosis Factor-α by Robertson, Janice, Beaulieu, Jean-Martin, Doroudchi, Mohammad M., Durham, Heather D., Julien, Jean-Pierre, Mushynski, Walter E.

“…Peripherin, a neuronal intermediate filament protein associated with axonal spheroids in amyotrophic lateral sclerosis (ALS), induces the selective…”
Get full text

AMPA receptor‐mediated toxicity in oligodendrocyte progenitors involves free radical generation and activation of JNK, calpain and caspase 3 by Liu, Hsueh‐Ning, Giasson, Benoit I., Mushynski, Walter E., Almazan, Guillermina

“…The molecular mechanisms underlying AMPA (α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate) receptor‐mediated excitotoxicity were characterized in rat…”
Get full text

Neurofilaments in health and disease by Julien, J P, Mushynski, W E

“…This article reviews current knowledge of neurofilament structure, phosphorylation, and function and neurofilament involvement in disease. Neurofilaments are…”
Get more information

The Environmental Toxin Arsenite Induces Tau Hyperphosphorylation by Giasson, Benoit I, Sampathu, Deepak M, Wilson, Christina A, Vogelsberg-Ragaglia, Vanessa, Mushynski, Walter E, Lee, Virginia M.-Y

“…Abnormally hyperphosphorylated tau polymers known as paired helical filaments constitute one of the major characteristic lesions that lead to the demise of…”
Get full text

Increased phosphorylation of neurofilament subunits in PC12 cells and rat dorsal root ganglion neurons treated with N-Acetyl-Leu-Leu-norleucinal by Jayaraman, D, Giasson, B I, Mushynski, W E

“…Treatment of PC12 cells or dorsal root ganglion neurons with the protease inhibitor, N-Acetyl-Leu-Leu-norleucinal, stimulated phosphorylation of the mid-sized…”
Get more information