Search Results - "MUSHINSKI, J. Frederic"

The Identification of MicroRNAs in a Genomically Unstable Region of Human Chromosome 8q24 by Huppi, Konrad, Volfovsky, Natalia, Runfola, Timothy, Jones, Tamara L, Mackiewicz, Mark, Martin, Scott E, Mushinski, J Frederic, Stephens, Robert, Caplen, Natasha J

“…The PVT1 locus is identified as a cluster of T(2;8) and T(8;22) “variant” MYC -activating chromosomal translocation breakpoints extending 400 kb downstream of…”
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Central role of paxillin phosphorylation in regulation of LFA-1 integrins activity and lymphocyte migration by Romanova, Larisa Y., Mushinski, J. Frederic

“…Coordinated changes of actin cytoskeleton and cell adhesion accompany maturation of lymphoid cells, their migration through lymphoid organs and to sites of…”
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Inhibition of Tumor Cell Motility by the Interferon-inducible GTPase MxA by Mushinski, J. Frederic, Nguyen, PhuongMai, Stevens, Lisa M., Khanna, Chand, Lee, Sunmin, Chung, Eun Joo, Lee, Min-Jung, Kim, Yeong Sang, Linehan, W. Marston, Horisberger, Michel A., Trepel, Jane B.

“…To identify pathways controlling prostate cancer metastasis we performed differential display analysis of the human prostate carcinoma cell line PC-3 and its…”
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Histological staining methods preparatory to laser capture microdissection significantly affect the integrity of the cellular RNA by Wang, Hongyang, Owens, James D, Shih, Joanna H, Li, Ming-Chung, Bonner, Robert F, Mushinski, J Frederic

“…Gene expression profiling by microarray analysis of cells enriched by laser capture microdissection (LCM) faces several technical challenges. Frozen sections…”
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Global gene expression profiling in mouse plasma cell tumor precursor and bystander cells reveals potential intervention targets for plasma cell neoplasia by LeGrand, Jason, Park, Eun Sung, Wang, Hongyang, Gupta, Shalu, Owens, James D., Nelson, Patrick J., DuBois, Wendy, Bair, Thomas, Janz, Siegfried, Mushinski, J. Frederic

“…Tumor progression usually proceeds through several sequential stages, any of which could be targets for interrupting the progression process if one understood…”
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Heterologous tissue culture expression signature predicts human breast cancer prognosis by Park, Eun Sung, Lee, Ju-Seog, Woo, Hyun Goo, Zhan, Fenghuang, Shih, Joanna H, Shaughnessy, Jr, John D, Frederic Mushinski, J

“…Cancer patients have highly variable clinical outcomes owing to many factors, among which are genes that determine the likelihood of invasion and metastasis…”
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Gene expression profiling reveals different pathways related to Abl and other genes that cooperate with c-Myc in a model of plasma cell neoplasia by Park, Eun Sung, Shaughnessy, Jr, John D, Gupta, Shalu, Wang, Hongyang, Lee, Ju-Seog, Woo, Hyun Goo, Zhan, Fenghuang, Owens, Jr, James D, Potter, Michael, Janz, Siegfried, Mushinski, J Frederic

“…To elucidate the genes involved in the neoplastic transformation of B cells, global gene expression profiles were generated using Affymetrix U74Av2…”
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Induction of apoptosis by protein kinase C delta is independent of its kinase activity by Goerke, Axel, Sakai, Norio, Gutjahr, Elisabeth, Schlapkohl, Walter A, Mushinski, J Frederic, Haller, Hermann, Kolch, Walter, Saito, Naoaki, Mischak, Harald

“…Protein kinase C, a multigene family of phospholipid-dependent and diacylglycerol-activated Ser/Thr protein kinases, is a key component in many signal…”
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Linkage of Caspase-mediated Degradation of Paxillin to Apoptosis in Ba/F3 Murine Pro-B Lymphocytes by Chay, Kee-Oh, Park, Sung Sup, Mushinski, J. Frederic

“…We have cloned the complete cDNA from mouse paxillin, a 68-kDa adapter protein found in focal adhesions. We found that paxillin was degraded by caspases in…”
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Phosphorylation of paxillin tyrosines 31 and 118 controls polarization and motility of lymphoid cells and is PMA-sensitive by Romanova, Larisa Y, Hashimoto, Shigeru, Chay, Kee-Oh, Blagosklonny, Mikhail V, Sabe, Hisataka, Mushinski, J Frederic

“…Tyrosine phosphorylation of paxillin regulates actin cytoskeleton-dependent changes in cell morphology and motility in adherent cells. In this report we…”
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Inducible Expression of a Constitutively Active Mutant of Mitogen-activated Protein Kinase Kinase 7 Specifically Activates c-JUN NH2-terminal Protein Kinase, Alters Expression of at Least Nine Genes, and Inhibits Cell Proliferation by Wolter, Sabine, Mushinski, J. Frederic, Saboori, Ali M., Resch, Klaus, Kracht, Michael

“…MKK7 is a recently discovered mitogen-activated protein kinase (MAPK) kinase that is unique in that it specifically activates only the c-JUN NH2-terminal…”
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The V5 Domain of Protein Kinase C Plays a Critical Role in Determining the Isoform-Specific Localization, Translocation, and Biological Function of Protein Kinase C-δ and -ε by Wang, Qiming Jane, Lu, Ganwei, Schlapkohl, Walter A, Goerke, Axel, Larsson, Christer, Mischak, Harald, Blumberg, Peter M, Mushinski, J Frederic

“…The catalytic domain of overexpressed protein kinase C (PKC)-δ mediates phorbol 12-myristate 13-acetate (PMA)-induced differentiation or apoptosis in…”
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Cyclin D expression in chronic lymphocytic leukemia by Paul, James T, Henson, Elizabeth S, Mai, Sabine, Mushinski, J Frederic, Cheang, Mary, Gibson, Spencer B, Johnston, James B

“…Although the majority of circulating leukemic cells in chronic lymphocytic leukemia (CLL) are in G0/early G1, recent studies have shown that these cells have…”
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Lovastatin induces apoptosis in a primitive neuroectodermal tumor cell line in association with RB down-regulation and loss of the G1 checkpoint by KIM, Jung-Sik, PIRNIA, Farzaneh, MUSHINSKI, J. Frederic, TREPEL, Jane B, YUNG HYUN CHOI, NGUYEN, Phuongmai, KNEPPER, Benjamin, TSOKOS, Maria, SCHULTE, Theodor W, BIRRER, Michael J, BLAGOSKLONNY, Mikhail V, SCHAEFER, Olaf

“…To develop a new approach to the treatment of primitive neuroectodermal tumors we evaluated the effect of the HMG-CoA reductase inhibitor lovastatin on the…”
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Selective involvement of protein kinase C isozymes in differentiation and neoplastic transformation by Goodnight, J, Mischak, H, Mushinski, J F

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Chromosomal and Extrachromosomal Instability of the cyclin D2 Gene is Induced by Myc Overexpression by Mai, Sabine, Hanley-Hyde, Joan, Rainey, G. Jonah, Kuschak, Theodore I., Paul, James T., Littlewood, Trevor D., Mischak, Harald, Stevens, Lisa M., Henderson, Darren W., Mushinski, J. Frederic

“…We examined the expression of cyclins D1, D2, D3, and E in mouse B-lymphocytic tumors. Cyclin D2 mRNA was consistently elevated in plasmacytomas, which…”
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Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice by SUNG SUP PARK, JOONG SU KIM, MCNEIL, Nicole, RIED, Thomas, MUSHINSKI, J. Frederic, MORSE, Herbert C, JANZ, Siegfried, TESSAROLLO, Lino, OWENS, James D, LIANGPING PENG, SEONG SU HAN, SEUNG TAE CHUNG, TORREY, Ted A, CHEUNG, Wan C, POLAKIEWICZ, Roberto D

“…We used gene targeting in mice to insert a His(6)-tagged mouse c-Myc cDNA, Myc(His), head to head into the mouse immunoglobulin heavy-chain locus, Igh, just 5'…”
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c-Myc-induced genomic instability by Mai, Sabine, Mushinski, J Frederic

“…c-myc is one of a small family of proto-oncogenes that do not require mutation to contribute to neoplastic transformation. Instead, the deregulated expression…”
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A Preservation Method That Allows Recovery of Intact RNA from Tissues Dissected by Laser Capture Microdissection by Parlato, Rosanna, Rosica, Annamaria, Cuccurullo, Vincenzo, Mansi, Luigi, Macchia, Paolo, Owens, James D., Mushinski, J.Frederic, De Felice, Mario, Bonner, Robert F., Di Lauro, Roberto

“…We report a novel method for preparing samples for laser capture microdissection. The procedure described here permits extraction of intact RNA while…”
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Both the Catalytic and Regulatory Domains of Protein Kinase C Chimeras Modulate the Proliferative Properties of NIH 3T3 Cells by Ács, Péter, Wang, Qiming J., Bögi, Krisztina, Marquez, Adriana M., Lorenzo, Patricia S., Bı́ró, Tamás, Szállási, Zoltán, Mushinski, J. Frederic, Blumberg, Peter M.

“…Protein kinase C (PKC) isozymes exhibit important differences in terms of their regulation and biological functions. Not only may some PKC isoforms be active…”
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