Search Results - "MUSCH, Tanja"

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis by Tuorto, Francesca, Liebers, Reinhard, Musch, Tanja, Schaefer, Matthias, Hofmann, Sarah, Kellner, Stefanie, Frye, Michaela, Helm, Mark, Stoecklin, Georg, Lyko, Frank

“…Although cytosine-C5 methylation is a prominent modification of tRNAs, its functional significance has been unclear. Mice that lack both the Dnmt2 and NSun2…”
Get full text

Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation by Wiehle, Laura, Raddatz, Günter, Musch, Tanja, Dawlaty, Meelad M., Jaenisch, Rudolf, Lyko, Frank, Breiling, Achim

“…DNA methylation is a dynamic epigenetic modification with an important role in cell fate specification and reprogramming. The Ten eleven translocation (Tet)…”
Get full text

Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis by Bormann, Felix, Rodríguez-Paredes, Manuel, Lasitschka, Felix, Edelmann, Dominic, Musch, Tanja, Benner, Axel, Bergman, Yehudit, Dieter, Sebastian M., Ball, Claudia R., Glimm, Hanno, Linhart, Heinz G., Lyko, Frank

“…Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation…”
Get full text

Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines by STRESEMANN, Carlo, BRUECKNER, Bodo, MUSCH, Tanja, STOPPER, Helga, LYKO, Frank

“…DNA methyltransferase inhibitors represent promising new drugs for cancer therapies. The first of these compounds (5-azacytidine, Vidaza) has recently been…”
Get full text

Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome by Köhler, Florian, Bormann, Felix, Raddatz, Günter, Gutekunst, Julian, Corless, Samuel, Musch, Tanja, Lonsdorf, Anke S, Erhardt, Sylvia, Lyko, Frank, Rodríguez-Paredes, Manuel

“…Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body…”
Get full text

Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases by BRUECKUER, Bodo, GARCIA BOY, Regine, SIEDLECKI, Pawel, MUSCH, Tanja, KLIEM, H. Christian, ZIELENKIEWICZ, Piotr, SUHAI, Sandor, WIESSLER, Manfred, LYKO, Frank

“…DNA methylation regulates gene expression in normal and malignant cells. The possibility to reactivate epigenetically silenced genes has generated considerable…”
Get full text

Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster by Bocker, Michael T., Tuorto, Francesca, Raddatz, Günter, Musch, Tanja, Yang, Feng-Chun, Xu, Mingjiang, Lyko, Frank, Breiling, Achim

“…Differentiation is accompanied by extensive epigenomic reprogramming, leading to the repression of stemness factors and the transcriptional maintenance of…”
Get full text

Nucleoside drugs induce cellular differentiation by caspase-dependent degradation of stem cell factors by Musch, Tanja, Oz, Yuva, Lyko, Frank, Breiling, Achim

“…Stem cell characteristics are an important feature of human cancer cells and play a major role in the therapy resistance of tumours. Strategies to target…”
Get full text

Comparative analysis of DNA methylation patterns in transgenic Drosophila overexpressing mouse DNA methyltransferases by Mund, Cora, Musch, Tanja, Strödicke, Martin, Assmann, Birte, Li, En, Lyko, Frank

“…DNA methyltransferases (Dnmts) mediate the epigenetic modification of eukaryotic genomes. Mammalian DNA methylation patterns are established and maintained by…”
Get full text

DNA Hypermethylation in Drosophila melanogaster Causes Irregular Chromosome Condensation and Dysregulation of Epigenetic Histone Modifications by Weissmann, Frank, Muyrers-Chen, Inhua, Musch, Tanja, Stach, Dirk, Wiessler, Manfred, Paro, Renato, Lyko, Frank

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Chronic inflammation induces a novel epigenetic program that is conserved in intestinal adenomas and in colorectal cancer by Abu-Remaileh, Monther, Bender, Sebastian, Raddatz, Günter, Ansari, Ihab, Cohen, Daphne, Gutekunst, Julian, Musch, Tanja, Linhart, Heinz, Breiling, Achim, Pikarsky, Eli, Bergman, Yehudit, Lyko, Frank

“…Chronic inflammation represents a major risk factor for tumor formation, but the underlying mechanisms have remained largely unknown. Epigenetic mechanisms can…”
Get full text

The human let-7a-3 locus contains an epigenetically regulated MicroRNA gene with oncogenic function by BRUECKNER, Bodo, STRESEMANN, Carlo, KUNER, Ruprecht, MUND, Cora, MUSCH, Tanja, MEISTER, Michael, SFÜLTMANN, Holger, LYKO, Frank

“…MicroRNAs (miRNAs) are small noncoding RNAs that repress their target mRNAs by complementary base pairing and induction of the RNA interference pathway. It has…”
Get full text

Discovery of Two Novel, Small-Molecule Inhibitors of DNA Methylation by Siedlecki, Pawel, Boy, Regine Garcia, Musch, Tanja, Brueckner, Bodo, Suhai, Sandor, Lyko, Frank, Zielenkiewicz, Piotr

“…DNA methyltransferases are promising targets for cancer therapy. In many cancer cells promoters of tumor suppressor genes are hypermethylated, which results in…”
Get full text