Search Results - "MURUA ESCOBAR, Hugo"

The Comparative Oncology of Canine Malignant Melanoma in Targeted Therapy: A Systematic Review of In Vitro Experiments and Animal Model Reports by He, Xiaohui, Gao, Yu, Deng, Yuqing, He, Junying, Nolte, Ingo, Murua Escobar, Hugo, Yu, Feng

“…Canine malignant melanoma (CMM) is highly aggressive and mostly located in the oral cavity. CMM is the predominant type of canine oral malignancy and shows…”
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Transfer learning of clinical outcomes from preclinical molecular data, principles and perspectives by Kowald, Axel, Barrantes, Israel, Möller, Steffen, Palmer, Daniel, Murua Escobar, Hugo, Schwerk, Anne, Fuellen, Georg

“…Abstract Accurate transfer learning of clinical outcomes from one cellular context to another, between cell types, developmental stages, omics modalities or…”
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Genomic heterogeneity in primary colorectal carcinomas and their metastases: born bad or brought up a villain? by Hühns, Maja, Krohn, Saskia, Murua Escobar, Hugo, Prall, Friedrich

“…Progression of solid cancers, colorectal carcinomas among them, from their primaries to metastatic lesions traditionally is thought to proceed by a stepwise…”
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Gold nanoparticle mediated laser transfection for efficient siRNA mediated gene knock down by Heinemann, Dag, Schomaker, Markus, Kalies, Stefan, Schieck, Maximilian, Carlson, Regina, Murua Escobar, Hugo, Ripken, Tammo, Meyer, Heiko, Heisterkamp, Alexander

“…Laser based transfection methods have proven to be an efficient and gentle alternative to established molecule delivery methods like lipofection or…”
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Metformin and sodium dichloroacetate effects on proliferation, apoptosis, and metabolic activity tested alone and in combination in a canine prostate and a bladder cancer cell line by Klose, Katharina, Packeiser, Eva-Maria, Müller, Petra, Granados-Soler, José Luis, Schille, Jan Torben, Goericke-Pesch, Sandra, Kietzmann, Manfred, Murua Escobar, Hugo, Nolte, Ingo

“…An important approach in tumor therapy is combining substances with different action mechanisms aiming to enhance the antineoplastic effect, decrease the…”
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Comparative Analyses of Targeted Myeloid Cancer Next-Generation Sequencing Panel in Fresh Blood, Bone Marrow and FFPE Material by Hobeck, Andrea Daniela, Wendt, Sophia, Krohn, Saskia, Knuebel, Gudrun, Bartels, Stephan, Schipper, Elisa, Junghanss, Christian, Murua Escobar, Hugo

“…Next-generation sequencing is a vital tool for personalized diagnostics and therapies in cancer. Despite numerous advantages, the method depends on multiple…”
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MDR1 Inhibition Reverses Doxorubicin-Resistance in Six Doxorubicin-Resistant Canine Prostate and Bladder Cancer Cell Lines by Packeiser, Eva-Maria, Engels, Leoni, Nolte, Ingo, Goericke-Pesch, Sandra, Murua Escobar, Hugo

“…Acquired chemoresistance during chemotherapy, often accompanied by cross- and multi-resistance, limits therapeutic outcomes and leads to recurrence. In order…”
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Intramolecular Base-Free Catalytic Wittig Reaction: Synthesis of Benzoxepinones by Grandane, Aiga, Longwitz, Lars, Roolf, Catrin, Spannenberg, Anke, Murua Escobar, Hugo, Junghanss, Christian, Suna, Edgars, Werner, Thomas

“…A straightforward two-step synthesis of benzoxepinones was developed via base-free phosphane-catalyzed Wittig reaction. 3-Methyl-1-phenyl-2-phospholene 1-oxide…”
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Multicohort study testing the generalisability of the SASKit-ML stroke and PDAC prognostic model pipeline to other chronic diseases by Palmer, Daniel, Henze, Larissa, Murua Escobar, Hugo, Walter, Uwe, Kowald, Axel, Fuellen, Georg

“…ObjectivesTo validate and test the generalisability of the SASKit-ML pipeline, a prepublished feature selection and machine learning pipeline for the…”
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Combined BCL-2 and PI3K/AKT Pathway Inhibition in KMT2A -Rearranged Acute B-Lymphoblastic Leukemia Cells by Holz, Clemens, Lange, Sandra, Sekora, Anett, Knuebel, Gudrun, Krohn, Saskia, Murua Escobar, Hugo, Junghanss, Christian, Richter, Anna

“…Numerous hematologic neoplasms, including acute B-lymphoblastic leukemia (B-ALL), are characterized by overexpression of anti-apoptotic BCL-2 family proteins…”
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Alterations in Tumor Aggression Following Androgen Receptor Signaling Restoration in Canine Prostate Cancer Cell Lines by Vasilatis, Demitria M, Batra, Neelu, Lucchesi, Christopher A, Abria, Christine J, Packeiser, Eva-Maria, Murua Escobar, Hugo, Ghosh, Paramita M

“…In prostate cancer (PCa), androgens upregulate tumorigenesis, whereas in benign tissue, the revival of androgen receptor (AR) signaling suppresses aggressive…”
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Role of miRNA Let-7 and Its Major Targets in Prostate Cancer by Nolte, Ingo, Murua Escobar, Hugo, Ngezahayo, Anaclet, Wagner, S.

“…Prostate cancer is worldwide the sixth leading cause of cancer related death in men thus early detection and successful treatment are still of major interest…”
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Characterization of six canine prostate adenocarcinoma and three transitional cell carcinoma cell lines derived from primary tumor tissues as well as metastasis by Packeiser, Eva-Maria, Hewicker-Trautwein, Marion, Thiemeyer, Heike, Mohr, Annika, Junginger, Johannes, Schille, Jan Torben, Murua Escobar, Hugo, Nolte, Ingo

“…Canine prostate adenocarcinoma (PAC) and transitional cell carcinoma (TCC) of prostate and urinary bladder are highly invasive and metastatic tumors of closely…”
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Validation of an LC-MS/MS Method for the Quantification of the CK2 Inhibitor Silmitasertib (CX-4945) in Human Plasma by Schwarz, Rico, Richter, Anna, Ito, Elisabeth R D, Murua Escobar, Hugo, Junghanß, Christian, Hinz, Burkhard

“…Silmitasertib (CX-4945) is currently being investigated in clinical trials against various types of cancer. The U.S. Food and Drug Administration (FDA) has…”
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Exploring Thiazolopyridine AV25R: Unraveling of Biological Activities, Selective Anti-Cancer Properties and In Silico Target and Binding Prediction in Hematological Neoplasms by Ladwig, Annika, Gupta, Shailendra, Ehlers, Peter, Sekora, Anett, Alammar, Moosheer, Koczan, Dirk, Wolkenhauer, Olaf, Junghanss, Christian, Langer, Peter, Murua Escobar, Hugo

“…Thiazolopyridines are a highly relevant class of small molecules, which have previously shown a wide range of biological activities. Besides their…”
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Ablation of Red Stable Transfected Claudin Expressing Canine Prostate Adenocarcinoma and Transitional Cell Carcinoma Cell Lines by C-CPE Gold-Nanoparticle-Mediated Laser Intervention by Alnajjar, Suhayla, Nolte, Ingo, Becker, Annegret, Schille, Jan Torben, Trakooljul, Nares, Frank, Marcus, Ngezahayo, Anaclet, Murua Escobar, Hugo

“…Claudin (CLDN) proteins are commonly expressed in cancers and targeted in novel therapeutic approaches. The C-terminal of enterotoxin (C-CPE) efficiently binds…”
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SLM produced porous titanium implant improvements for enhanced vascularization and osteoblast seeding by Matena, Julia, Petersen, Svea, Gieseke, Matthias, Kampmann, Andreas, Teske, Michael, Beyerbach, Martin, Murua Escobar, Hugo, Haferkamp, Heinz, Gellrich, Nils-Claudius, Nolte, Ingo

“…To improve well-known titanium implants, pores can be used for increasing bone formation and close bone-implant interface. Selective Laser Melting (SLM)…”
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Transcription profiling of feline mammary carcinomas and derived cell lines reveals biomarkers and drug targets associated with metabolic and cell cycle pathways by Granados-Soler, José Luis, Taher, Leila, Beck, Julia, Bornemann-Kolatzki, Kirsten, Brenig, Bertram, Nerschbach, Verena, Ferreira, Fernando, Junginger, Johannes, Hewicker-Trautwein, Marion, Murua Escobar, Hugo, Nolte, Ingo

“…The molecular heterogeneity of feline mammary carcinomas (FMCs) represents a prognostic and therapeutic challenge. RNA-Seq-based comparative transcriptomic…”
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Functionalization of gold-nanoparticles by the Clostridium perfringens enterotoxin C-terminus for tumor cell ablation using the gold nanoparticle-mediated laser perforation technique by Becker, Annegret, Leskau, Miriam, Schlingmann-Molina, Barbara L., Hohmeier, Susanne C., Alnajjar, Suhayla, Murua Escobar, Hugo, Ngezahayo, Anaclet

“…A recombinant produced C-terminus of the C. perfringens enterotoxin (C-CPE) was conjugated to gold nanoparticles (AuNPs) to produce a C-CPE-AuNP complex…”
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Sex Matters-Insights from Testing Drug Efficacy in an Animal Model of Pancreatic Cancer by Schulz, Benjamin, Leitner, Emily, Schreiber, Tim, Lindner, Tobias, Schwarz, Rico, Aboutara, Nadine, Ma, Yixuan, Escobar, Hugo Murua, Palme, Rupert, Hinz, Burkhard, Vollmar, Brigitte, Zechner, Dietmar

“…Preclinical studies rarely test the efficacy of therapies in both sexes. The field of oncology is no exception in this regard. In a model of syngeneic,…”
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