Search Results - "MURTHY, Kruthi"

Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma by Clark, Curtis A, Gupta, Harshita B, Sareddy, Gangadhara, Pandeswara, Srilakshmi, Lao, Shunhua, Yuan, Bin, Drerup, Justin M, Padron, Alvaro, Conejo-Garcia, José, Murthy, Kruthi, Liu, Yang, Turk, Mary Jo, Thedieck, Kathrin, Hurez, Vincent, Li, Rong, Vadlamudi, Ratna, Curiel, Tyler J

“…PD-L1 antibodies produce efficacious clinical responses in diverse human cancers, but the basis for their effects remains unclear, leaving a gap in the…”
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Mitigating Age-Related Immune Dysfunction Heightens the Efficacy of Tumor Immunotherapy in Aged Mice by HUREZ, Vincent, DANIEL, Benjamin J, WALL, Shawna, BRUMLIK, Michael J, SHIN, Tahiro, BIN ZHANG, CURIEL, Tyler J, LISHI SUN, LIU, Ai-Jie, LUDWIG, Sara M, KIOUS, Mark J, THIBODEAUX, Suzanne R, PANDESWARA, Srilakshmi, MURTHY, Kruthi, LIVI, Carolina B

“…Although cancer tends to affect the elderly, most preclinical studies are carried out in young subjects. In this study, we developed a melanoma-specific cancer…”
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Immunotherapy for Ovarian Cancer by Drerup, Justin M., Liu, Yang, Padron, Alvaro S., Murthy, Kruthi, Hurez, Vincent, Zhang, Bin, Curiel, Tyler J.

“…Opinion statement All work referenced herein relates to treatment of epithelial ovarian carcinomas, as their treatment differs from ovarian germ cell cancers…”
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Parasite Mitogen-Activated Protein Kinases as Drug Discovery Targets to Treat Human Protozoan Pathogens by Brumlik, Michael J., Pandeswara, Srilakshmi, Ludwig, Sara M., Murthy, Kruthi, Curiel, Tyler J.

“…Protozoan pathogens are a highly diverse group of unicellular organisms, several of which are significant human pathogens. One group of protozoan pathogens…”
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Chronic Granulomatous Disease-Like Presentation of a Child with Autosomal Recessive PKCδ Deficiency by Neehus, Anna-Lena, Tuano, Karen, Le Voyer, Tom, Nandiwada, Sarada L., Murthy, Kruthi, Puel, Anne, Casanova, Jean-Laurent, Chinen, Javier, Bustamante, Jacinta

“…Background Autosomal recessive (AR) PKCδ deficiency is a rare inborn error of immunity (IEI) characterized by autoimmunity and susceptibility to bacterial,…”
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Morphologic Features of Lymphoid Tissue Containing an Expanded Subpopulation of Dual CD8/CD23 Positive T-Lymphocytes Identified by Flow Cytometry by Kneib, Jessica, Murthy, Kruthi, Johnson, Cory, Hammer, Richard

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Morphologic Features of Lymphoid Tissue Containing an Expanded Subpopulation of Dual CD8/CD23 Positive T-Lymphocytes Identified by Flow Cytometry by Kneib, Jessica, Murthy, Kruthi, Johnson, Cory, Hammer, Richard

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Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL‐17 producing T cells by Sun, Lishi, Hurez, Vincent J., Thibodeaux, Suzanne R., Kious, Mark J., Liu, Aijie, Lin, Peiyi, Murthy, Kruthi, Pandeswara, Srilakshmi, Shin, Tahiro, Curiel, Tyler J.

“…Summary Regulatory T cells (Tregs) are specialized CD4+ T lymphocytes helping defend against autoimmunity and inflammation. Although age is associated with…”
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B7-H1/PD-1 signals in carcinoma and lymphoma immunopathogenesis and immunotherapy (VAC12P.1118) by Clark, Curtis, Liu, Yang, Murthy, Kruthi, Sareddy, Gangadhara, Vadlamudi, Ratna, Hurez, Vincent, Curiel, Tyler

“…Abstract αB7-H1 (αPD-L1) reportedly treats cancer by blocking PD-1 signals, but few formal data are reported. We showed B16 melanoma is CD80-PD-1-B7-H1+…”
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eRapa Restores a Normal Life Span in a FAP Mouse Model by HASTY, Paul, LIVI, Carolina B, LISHI SUN, HUREZ, Vincent, CURIEL, Tyler J, ZELTON DAVE SHARP, DODDS, Sherry G, JONES, Diane, STRONG, Randy, JAVORS, Martin, FISCHER, Kathleen E, SLOANE, Lauren, MURTHY, Kruthi, HUBBARD, Gene

“…Mutation of a single copy of the adenomatous polyposis coli (APC) gene results in familial adenomatous polyposis (FAP), which confers an extremely high risk…”
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B7-H1 blockade improves efficacy of regulatory T cell depletion as cancer immunotherapy by reducing Treg regeneration, possibly through tumor B7-H1 effects (VAC3P.950) by Curiel, Tyler, Sareddy, Gangadhara, Hurez, Vincent, Qin, Kunhua, Pandeswara, Sri Lakshmi, Vadlamudi, Ratna, Murthy, Kruthi

“…Abstract Immune co-signaling blockade is effective cancer immunotherapy but is not curative alone. Treg depletion has shown potential human anti-cancer…”
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B7-H1 blockade plus regulatory T cell depletion improves clinical efficacy over either strategy alone in a melanoma model (P4268) by Curiel, Tyler, Murthy, Kruthi, Kious, Mark, Sun, Lishi, Zhang, Bin, Pandaswara, Srilakshmi, Hurez, Vincent

“…Abstract Denileukin diftitox (DD) is an FDA-approved conjugate of human IL-2 + diphtheria toxin. It depletes Tregs and improves clinical and immune outcomes,…”
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Denileukin diftitox depletes regulatory T cells without clinical benefit in advanced stage epithelial ovarian carcinoma (VAC3P.945) by Curiel, Tyler, Thibodeaux, Suzanne, Wall, Shawna, Pandeswara, Sri Lakshmi, Daniel, Benjamin, Drerup, Justin, Murthy, Kruthi, Kryczek, Ilona, Zou, Weiping, Barnett, Brian

“…Abstract Denileukin diftitox (DT) depletes regulatory T cells (Treg) that correlates with immune and clinical benefits in metastatic human melanoma and…”
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Novel cancer immunotherapy using rational combinations of B7-H1 blockade, Treg depletion and estrogen receptor beta signaling (165.17) by Curiel, Tyler, Kious, Mark, Sun, Lishi, Vadlamudi, Ratna, Hurez, Vincent, Murthy, Kruthi

“…Abstract We recently showed that B7-H1 blockade in mouse models for B16 melanoma and ID8 ovarian carcinoma worked better in females versus males through…”
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T cell interleukin-15 surface expression in chimpanzees infected with human immunodeficiency virus by Rodriguez, Annette R., Hodara, Vida, Murthy, Kruthi, Morrow, LaShayla, Sanchez, Melissa, Bienvenu, Amy E., Murthy, Krishna K.

“…•Chimpanzee peripheral blood Tcell/NKT cells expressed surface IL-15.•Recombinant gp120 and IL-15 up-regulated CD3−CD8+ IFN-γ+ TNF-α+ NK cells.•Staphylococcal…”
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TgMAPK1 is a Toxoplasma gondii MAP kinase that hijacks host MKK3 signals to regulate virulence and interferon-γ-mediated nitric oxide production by Brumlik, Michael J., Pandeswara, Srilakshmi, Ludwig, Sara M., Jeansonne, Duane P., Lacey, Michelle R., Murthy, Kruthi, Daniel, Benjamin J., Wang, Rong-Fu, Thibodeaux, Suzanne R., Church, Kristina M., Hurez, Vincent, Kious, Mark J., Zhang, Bin, Alagbala, Adebusola, Xia, Xiaojun, Curiel, Tyler J.

“…•TgMAPK1 is a Toxoplasma gondii mitogen-activated protein kinase (MAPK).•It affects parasite proliferation in an IFN-γ, iNOS and MKK3-dependent…”
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