Search Results - "MURRAY, W. V"

1,3-Diarylcycloalkanopyrazoles and diphenyl hydrazides as selective inhibitors of cyclooxygenase-2 by ZHIHUA SUI, JIHUA GUAN, FERRO, M. P, MCCOY, K, WACHTER, M. P, MURRAY, W. V, SINGER, M, STEBER, M, RITCHIE, D. M, ARGENTIERI, D. C

“…Novel 1,3-diarylcycloalkanopyrazoles 1, and diphenyl hydrazides 2 were identified as selective inhibitors of cyclooxygenase-2. The 1,3-diaryl substitution…”
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Synthesis and erythropoietin receptor binding affinities of N,N-disubstituted amino acids by Connolly, Peter J, Wetter, Steven K, Murray, William V, Johnson, Dana L, McMahon, Frank J, Farrell, Francis X, Tullai, Jennifer, Jolliffe, Linda K

“…N,N-Dicinnamyl, N-benzyl- N-cinnamyl, and N,N-dibenzyl amino acids were prepared and evaluated in an EPO binding assay. Several derivatives of aspartic acid,…”
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Synthesis and Discovery of Pyrazine−Pyridine Biheteroaryl as a Novel Series of Potent Vascular Endothelial Growth Factor Receptor-2 Inhibitors by Kuo, Gee-Hong, Wang, Aihua, Emanuel, Stuart, DeAngelis, Alan, Zhang, Rui, Connolly, Peter J, Murray, William V, Gruninger, Robert H, Sechler, Jan, Fuentes-Pesquera, Angel, Johnson, Dana, Middleton, Steven A, Jolliffe, Linda, Chen, Xin

“…Pathological angiogenesis is associated with disease states such as cancer, diabetic retinopathy, rheumatoid arthritis, endometriosis, and psoriasis. There is…”
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An investigation of the uroselective properties of four novel alpha(1a)-adrenergic receptor subtype-selective antagonists by Pulito, V L, Li, X, Varga, S S, Mulcahy, L S, Clark, K S, Halbert, S A, Reitz, A B, Murray, W V, Jolliffe, L K

“…The development of alpha(1a)-adrenergic receptor (AR) subtype-selective antagonists is likely to result in uroselective agents that effectively treat benign…”
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Design, synthesis, and structure-activity relationships of phthalimide-phenylpiperazines: a novel series of potent and selective alpha(1)(a)-adrenergic receptor antagonists by Kuo, G H, Prouty, C, Murray, W V, Pulito, V, Jolliffe, L, Cheung, P, Varga, S, Evangelisto, M, Wang, J

“…Beginning from the screening hit and literature alpha(1)-adrenergic compounds, a hybridized basic skeleton A was proposed as the pharmacophore for potent and…”
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Steroids. 2. Synthesis of C-18 functionalized steroids via the Smith-Hughes route by Pillai, K. M. R, Murray, W. V, Shooshani, I, Williams, D. L, Gordon, D, Wang, S. Y, Johnson, Francis

“…The total synthesis of a series of racemic C-18 functionalized steroids was carried out in a search for novel estrogen-and/or progestin-receptor agonists or…”
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Efficient synthesis of 5-(4'-methyl[1,1'-biphenyl]-2-yl)-1H-tetrazole by Russell, Ronald K, Murray, William V

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A facile synthesis of tepoxalin, 5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamide by Murray, William V, Hadden, Susan K

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Synthesis and properties of aryl-1,3-dioxo carboxylic acids by Murray, William V, Wachter, Michael P

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A simple regioselective synthesis of ethyl 1,5-diarylpyrazole-3-carboxylates by Murray, William V., Wachter, Michael P.

“…Improved procedures for the regioselective preparation of ethyl 1,5‐diarylpyrazole‐3‐carboxylates are described. The new procedures utilize readily prepared…”
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1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogues as Novel and Potent Anticancer Cyclin-Dependent Kinase Inhibitors:  Synthesis and Evaluation of Biological Activities by Lin, Ronghui, Connolly, Peter J, Huang, Shenlin, Wetter, Steven K, Lu, Yanhua, Murray, William V, Emanuel, Stuart L, Gruninger, Robert H, Fuentes-Pesquera, Angel R, Rugg, Catherine A, Middleton, Steven A, Jolliffe, Linda K

“…A series of 1-acyl-1H-[1,2,4]triazole-3,5-diamine analogues were synthesized as cyclin-dependent kinase (CDK) inhibitors. These compounds showed potent and…”
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Synthesis of 3-(1,5-diphenyl-3-pyrazolyl)aryl propanoates by Murray, William V., Hadden, Susan K., Wachter, Michael P.

“…New procedures for the synthesis of 3‐(1,5‐diphenyl‐3‐pyrazolyl)aryl propanoates and related 2‐(1,5‐diphenyl‐3‐pyrazolyl)aryl propanoates from a common…”
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Cross-Metathesis Assisted by Microwave Irradiation by Bargiggia, Frédéric C, Murray, William V

“…Microwave irradiation effectively accelerates cross-coupling metathesis reactions between deactivated olefins. Reactions have been carried out with the…”
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Efficient Conversion of Biginelli 3,4-Dihydropyrimidin-2(1H)-one to Pyrimidines via PyBroP-Mediated Coupling by Kang, Fu-An, Kodah, Jason, Guan, Qunying, Li, Xiaobing, Murray, William V

“…An efficient two-step procedure is described to convert the Biginelli 3,4-dihydropyrimidin-2(1H)-one to various multifunctionalized pyrimidines via the Kappe…”
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Microwave enabled external carboxymethyl substituents in the ring-closing metathesis by Yang, Cangming, Murray, William V., Wilson, Lawrence J.

“…The ring-closing metathesis of diolefin substrates containing an external carboxymethyl substituent is presented. The reaction is enabled through microwave…”
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Synthesis and Identification of [1,3,5]Triazine-pyridine Biheteroaryl as a Novel Series of Potent Cyclin-Dependent Kinase Inhibitors by Kuo, Gee-Hong, DeAngelis, Alan, Emanuel, Stuart, Wang, Aihua, Zhang, Yan, Connolly, Peter J, Chen, Xin, Gruninger, Robert H, Rugg, Catherine, Fuentes-Pesquera, Angel, Middleton, Steven A, Jolliffe, Linda, Murray, William V

“…On the basis of previous studies, we identified pyrazine-pyridine A as a potent vascular endothelial growth factor inhibitor and pyrimidine-pyridine B as a…”
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Novel arylpiperazines as selective alpha1-adrenergic receptor antagonists by Li, X, Murray, W V, Jolliffe, L, Pulito, V

“…A novel series of arylpiperazines has been synthesized and identified as antagonists of alpha1a adrenergic receptor (alpha1a-AR) implicated in benign prostatic…”
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Synthesis and Discovery of Macrocyclic Polyoxygenated Bis-7-azaindolylmaleimides as a Novel Series of Potent and Highly Selective Glycogen Synthase Kinase-3β Inhibitors by Kuo, Gee-Hong, Prouty, Catherine, DeAngelis, Alan, Shen, Lan, O'Neill, David J, Shah, Chandra, Connolly, Peter J, Murray, William V, Conway, Bruce R, Cheung, Peter, Westover, Lori, Xu, Jun Z, Look, Richard A, Demarest, Keith T, Emanuel, Stuart, Middleton, Steven A, Jolliffe, Linda, Beavers, Mary Pat, Chen, Xin

“…Attempts to design the macrocyclic maleimides as selective protein kinase C γ inhibitors led to the unexpected discovery of a novel series of potent and highly…”
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Facile synthesis of α,α′ disubstituted N-hydroxypyrrolidines and N-hydroxypiperidines via double 1,4-addition of hydroxylamine by Bargiggia, Frédéric C., Murray, William V.

“…A versatile synthesis of α and α′ disubstituted N-hydroxypiperidine and N-hydroxypyrrolidine by consecutive double 1,4-addition of hydroxylamine on the…”
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Novel heterocycles as selective alpha1-adrenergic receptor antagonists by Li, X, McCoy, K A, Murray, W V, Jolliffe, L, Pulito, V

“…A novel series of aryl piperazine substituted heterocycles has been synthesized and identified as antagonists of the alpha1a-adrenergic receptor (alpha1a-AR),…”
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