Search Results - "MURRAY, Bernard P"

Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat by Lepist, Eve-Irene, Zhang, Xuexiang, Hao, Jia, Huang, Jane, Kosaka, Alan, Birkus, Gabriel, Murray, Bernard P, Bannister, Roy, Cihlar, Tomas, Huang, Yong, Ray, Adrian S

“…Many xenobiotics including the pharmacoenhancer cobicistat increase serum creatinine by inhibiting its renal active tubular secretion without affecting the…”
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Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells by Li, Ruidong, Liclican, Albert, Xu, Yili, Pitts, Jared, Niu, Congrong, Zhang, Jingyu, Kim, Cynthia, Zhao, Xiaofeng, Soohoo, Daniel, Babusis, Darius, Yue, Qin, Ma, Bin, Murray, Bernard P, Subramanian, Raju, Xie, Xuping, Zou, Jing, Bilello, John P, Li, Li, Schultz, Brian E, Sakowicz, Roman, Smith, Bill J, Shi, Pei-Yong, Murakami, Eisuke, Feng, Joy Y

“…Remdesivir (RDV; GS-5734, Veklury), the first FDA-approved antiviral to treat COVID-19, is a single-diastereomer monophosphoramidate prodrug of an adenosine…”
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Regional proteomic quantification of clinically relevant non-cytochrome P450 enzymes along the human small intestine by Zhang, Haeyoung, Wolford, Chris, Basit, Abdul, Li, Albert P, Fan, Peter W, Takahashi, Ryan H, Khojasteh, S Cyrus, Smith, Bill J, Murray, Bernard P, Thummel, Kenneth, Prasad, Bhagwat

“…Current challenges in accurately predicting intestinal metabolism arise from the complex nature of the intestine, leading to limited applicability of available…”
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Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer by Xu, Lianhong, Liu, Hongtao, Murray, Bernard P, Callebaut, Christian, Lee, Melody S, Hong, Allen, Strickley, Robert G, Tsai, Luong K, Stray, Kirsten M, Wang, Yujin, Rhodes, Gerry R, Desai, Manoj C

“…Cobicistat (3, GS-9350) is a newly discovered, potent, and selective inhibitor of human cytochrome P450 3A (CYP3A) enzymes. In contrast to ritonavir, 3 is…”
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Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase by FENAUX, Martijn, ENG, Stacey, LAZERWITH, Scott E, LEW, Willard, QI LIU, MERTZMAN, Michael, MORGANELLI, Philip, LIANHONG XU, HONG YE, JENNIFER ZHANG, MATLES, Mike, MURRAY, Bernard P, LEAVITT, Stephanie A, MWANGI, Judy, JINGYU ZHANG, HASHASH, Ahmad, KRAWCZYK, Steve H, BIDGOOD, Alison M, APPLEBY, Todd C, WATKINS, William J, LEE, Yu-Jen, MABERY, Eric M, YANG TIAN, BYUN, Daniel, CANALES, Eda, CLARKE, Michael O, DOERFFLER, Edward

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Characterization of the mechanism of action of lanraplenib, a novel spleen tyrosine kinase inhibitor, in models of lupus nephritis by Pohlmeyer, Christopher W, Shang, Ching, Han, Pei, Cui, Zhi-Hua, Jones, Randall M, Clarke, Astrid S, Murray, Bernard P, Lopez, David A, Newstrom, David W, Inzunza, M David, Matzkies, Franziska G, Currie, Kevin S, Di Paolo, Julie A

“…B cells are critical mediators of systemic lupus erythematosus (SLE) and lupus nephritis (LN), and antinuclear antibodies can be found in the serum of…”
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In Vitro Characterization of GS-8374, a Novel Phosphonate-Containing Inhibitor of HIV-1 Protease with a Favorable Resistance Profile by CALLEBAUT, Christian, STRAY, Kirsten, MULATO, Andrew, HATADA, Marcos, PRISKICH, Tina, PARKIN, Neil, SWAMINATHAN, Swami, LEE, William, HE, Gong-Xin, LIANHONG XU, CIHLAR, Tomas, TSAI, Luong, WILLIAMS, Matt, YANG, Zheng-Yu, CANNIZZARO, Carina, LEAVITT, Stephanie A, XIAOHONG LIU, KELLY WANG, MURRAY, Bernard P

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Structure–activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers, part I: Core region by Liu, Hongtao, Xu, Lianhong, Hui, Hon, Vivian, Randy, Callebaut, Christian, Murray, Bernard P., Hong, Allen, Lee, Melody S., Tsai, Luong K., Chau, Jennifer K., Stray, Kirsten M., Cannizzaro, Carina, Choi, You-Chul, Rhodes, Gerry R., Desai, Manoj C.

“…The synthesis and evaluation of analogs with extensive modifications of the 1,4-diamine core along with the structure activity relationships with respect to…”
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Assessing Pleiotropic Effects of a Mixed-Mode Perpetrator Drug, Rifampicin, by Multiple Endogenous Biomarkers in Dogs by Liu, Renmeng, Ma, Bin, Mok, Marilyn M, Murray, Bernard P, Subramanian, Raju, Lai, Yurong

“…Rifampicin (RIF) is a mixed-mode perpetrator that produces pleiotropic effects on liver cytochrome P450 enzymes and drug transporters. To assess the complex…”
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Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species by Basit, Abdul, Fan, Peter W, Khojasteh, S Cyrus, Murray, Bernard P, Smith, Bill J, Heyward, Scott, Prasad, Bhagwat

“…The use of animal pharmacokinetic models as surrogates for humans relies on the assumption that the drug disposition mechanisms are similar between preclinical…”
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Lenacapavir Exhibits Atropisomerism-Mechanistic Pharmacokinetics and Disposition Studies of Lenacapavir Reveal Intestinal Excretion as a Major Clearance Pathway by Zheng, Jim, Lu, Bing, Carr, Gavin, Mwangi, Judy, Wang, Kelly, Hao, Jia, Staiger, Kelly McLennan, Kozon, Nathan, Murray, Bernard P, Bashir, Mohammad, Gohdes, Mark A, Tse, Winston C, Schroeder, Scott, Graupe, Michael, Link, John O, Yoon, Jungjoo, Chiu, Anna, Rowe, William, Smith, Bill J, Subramanian, Raju

“…Lenacapavir (LEN), a long-acting injectable, is the first approved human immunodeficiency virus type 1 capsid inhibitor and one of a few Food and Drug…”
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Identification and characterization of erlotinib as a potent mechanism-based inactivator of human aldehyde oxidase by Dick, Ryan A., Liang, Xiaomin, Sun, Hailing, Murray, Bernard P., Smith, Bill J.

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Dissecting Parameters Contributing to the Underprediction of Aldehyde Oxidase-Mediated Metabolic Clearance of Drugs by Subash, Sandhya, Singh, Dilip K, Ahire, Deepak S, Khojasteh, S Cyrus, Murray, Bernard P, Zientek, Michael A, Jones, Robert S, Kulkarni, Priyanka, Smith, Bill J, Heyward, Scott, Cronin, Ciarán N, Prasad, Bhagwat

“…We investigated the effect of variability and instability in aldehyde oxidase (AO) content and activity on the scaling of in vitro metabolism data. AO content…”
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Ontogeny of Human Liver Aldehyde Oxidase: Developmental Changes and Implications for Drug Metabolism by Subash, Sandhya, Singh, Dilip K., Ahire, Deepak, Khojasteh, S. Cyrus, Murray, Bernard P., Zientek, Michael A., Jones, Robert S., Kulkarni, Priyanka, Zubair, Faizan, Smith, Bill J., Heyward, Scott, Leeder, J. Steven, Prasad, Bhagwat

“…Despite the increasing importance of aldehyde oxidase (AO) in the drug metabolism of clinical candidates, ontogeny data for AO are limited. The objective of…”
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Pharmacokinetics and Disposition of Momelotinib Revealed a Disproportionate Human Metabolite-Resolution for Clinical Development by Zheng, Jim, Xin, Yan, Zhang, Jingyu, Subramanian, Raju, Murray, Bernard P, Whitney, J Andrew, Warr, Matthew R, Ling, John, Moorehead, Lisa, Kwan, Ellen, Hemenway, Jeffrey, Smith, Bill J, Silverman, Jeffrey A

“…Momelotinib (MMB), a small-molecule inhibitor of Janus kinase (JAK)1/2 and of activin A receptor type 1 (ACVR1), is in clinical development for the treatment…”
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Vacuolar degradation of rat liver CYP2B1 in Saccharomyces cerevisiae: further validation of the yeast model and structural implications for the degradation of mammalian endoplasmic reticulum P450 proteins by Liao, Mingxiang, Zgoda, Victor G, Zgoda, Victor A, Murray, Bernard P, Correia, Maria Almira

“…Mammalian hepatic cytochromes P450 (P450s) are endoplasmic reticulum (ER)-anchored hemoproteins with highly variable half-lives. CYP3A4, the dominant human…”
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Effects of GS-9876, a novel spleen tyrosine kinase inhibitor, on platelet function and systemic hemostasis by Clarke, Astrid S., Rousseau, Emma, Wang, Kelly, Kim, Ji-Yun, Murray, Bernard P., Bannister, Roy, Matzkies, Franziska, Currie, Kevin S., Di Paolo, Julie A.

“…Spleen tyrosine kinase (SYK) mediates signal transduction in multiple hematopoietic cells, including platelets. SYK signals downstream of immunoreceptors and…”
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The Drug–Drug Interaction Profile of Presatovir by Xin, Yan, Weng, Winnie, Murray, Bernard P., Eisenberg, Eugene J., Chien, Jason W., Ling, John, Silverman, Jeffrey A.

“…Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in young children. Presatovir (previously GS‐5806) is a novel, orally…”
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Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection by Lazerwith, Scott E., Lew, Willard, Zhang, Jennifer, Morganelli, Philip, Liu, Qi, Canales, Eda, Clarke, Michael O., Doerffler, Edward, Byun, Daniel, Mertzman, Michael, Ye, Hong, Chong, Lee, Xu, Lianhong, Appleby, Todd, Chen, Xiaowu, Fenaux, Martijn, Hashash, Ahmad, Leavitt, Stephanie A., Mabery, Eric, Matles, Mike, Mwangi, Judy W., Tian, Yang, Lee, Yu-Jen, Zhang, Jingyu, Zhu, Christine, Murray, Bernard P., Watkins, William J.

“…Investigation of thiophene-2-carboxylic acid HCV NS5B site II inhibitors, guided by measurement of cell culture medium binding, revealed the structure–activity…”
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Native CYP2C11: heterologous expression in Saccharomyces cerevisiae reveals a role for vacuolar proteases rather than the proteasome system in the degradation of this endoplasmic reticulum protein by Murray, Bernard P, Zgoda, Victor G, Correia, Maria Almira

“…Cytochromes P450 (P450s) are hemoprotein enzymes committed to the metabolism of chemically diverse endo- and xenobiotics. They are anchored to the endoplasmic…”
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