Search Results - "MURRAY, Bernard"

Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat by Lepist, Eve-Irene, Zhang, Xuexiang, Hao, Jia, Huang, Jane, Kosaka, Alan, Birkus, Gabriel, Murray, Bernard P, Bannister, Roy, Cihlar, Tomas, Huang, Yong, Ray, Adrian S

“…Many xenobiotics including the pharmacoenhancer cobicistat increase serum creatinine by inhibiting its renal active tubular secretion without affecting the…”
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Assessing Pleiotropic Effects of a Mixed-Mode Perpetrator Drug, Rifampicin, by Multiple Endogenous Biomarkers in Dogs by Liu, Renmeng, Ma, Bin, Mok, Marilyn M, Murray, Bernard P, Subramanian, Raju, Lai, Yurong

“…Rifampicin (RIF) is a mixed-mode perpetrator that produces pleiotropic effects on liver cytochrome P450 enzymes and drug transporters. To assess the complex…”
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Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells by Li, Ruidong, Liclican, Albert, Xu, Yili, Pitts, Jared, Niu, Congrong, Zhang, Jingyu, Kim, Cynthia, Zhao, Xiaofeng, Soohoo, Daniel, Babusis, Darius, Yue, Qin, Ma, Bin, Murray, Bernard P, Subramanian, Raju, Xie, Xuping, Zou, Jing, Bilello, John P, Li, Li, Schultz, Brian E, Sakowicz, Roman, Smith, Bill J, Shi, Pei-Yong, Murakami, Eisuke, Feng, Joy Y

“…Remdesivir (RDV; GS-5734, Veklury), the first FDA-approved antiviral to treat COVID-19, is a single-diastereomer monophosphoramidate prodrug of an adenosine…”
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Regional proteomic quantification of clinically relevant non-cytochrome P450 enzymes along the human small intestine by Zhang, Haeyoung, Wolford, Chris, Basit, Abdul, Li, Albert P, Fan, Peter W, Takahashi, Ryan H, Khojasteh, S Cyrus, Smith, Bill J, Murray, Bernard P, Thummel, Kenneth, Prasad, Bhagwat

“…Current challenges in accurately predicting intestinal metabolism arise from the complex nature of the intestine, leading to limited applicability of available…”
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Comparison of Tissue Abundance of Non-Cytochrome P450 Drug-Metabolizing Enzymes by Quantitative Proteomics between Humans and Laboratory Animal Species by Basit, Abdul, Fan, Peter W, Khojasteh, S Cyrus, Murray, Bernard P, Smith, Bill J, Heyward, Scott, Prasad, Bhagwat

“…The use of animal pharmacokinetic models as surrogates for humans relies on the assumption that the drug disposition mechanisms are similar between preclinical…”
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Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human by Basit, Abdul, Neradugomma, Naveen K, Wolford, Christopher, Fan, Peter W, Murray, Bernard, Takahashi, Ryan H, Khojasteh, S. Cyrus, Smith, Bill J, Heyward, Scott, Totah, Rheem A, Kelly, Edward J, Prasad, Bhagwat

“…The availability of assays that predict the contribution of cytochrome P450 (CYP) metabolism allows for the design of new chemical entities (NCEs) with minimal…”
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Lenacapavir Exhibits Atropisomerism-Mechanistic Pharmacokinetics and Disposition Studies of Lenacapavir Reveal Intestinal Excretion as a Major Clearance Pathway by Zheng, Jim, Lu, Bing, Carr, Gavin, Mwangi, Judy, Wang, Kelly, Hao, Jia, Staiger, Kelly McLennan, Kozon, Nathan, Murray, Bernard P, Bashir, Mohammad, Gohdes, Mark A, Tse, Winston C, Schroeder, Scott, Graupe, Michael, Link, John O, Yoon, Jungjoo, Chiu, Anna, Rowe, William, Smith, Bill J, Subramanian, Raju

“…Lenacapavir (LEN), a long-acting injectable, is the first approved human immunodeficiency virus type 1 capsid inhibitor and one of a few Food and Drug…”
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Pleiotropic effects of rifampicin as a mixed-mode perpetrator drug assessed simultaneously using multiple endogenous biomarkers in dogs by Liu, Renmeng, Ma, Bin, Mok, Marilyn, Murray, Bernard, Subramanian, Raju, Lai, Yurong

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Cobicistat Boosts the Intestinal Absorption of Transport Substrates, Including HIV Protease Inhibitors and GS-7340, In Vitro by LEPIST, Eve-Irene, PHAN, Truc K, ROY, Anupma, TONG, Leah, MACLENNAN, Kelly, MURRAY, Bernard, RAY, Adrian S

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Dissecting Parameters Contributing to the Underprediction of Aldehyde Oxidase-Mediated Metabolic Clearance of Drugs by Subash, Sandhya, Singh, Dilip K, Ahire, Deepak S, Khojasteh, S Cyrus, Murray, Bernard P, Zientek, Michael A, Jones, Robert S, Kulkarni, Priyanka, Smith, Bill J, Heyward, Scott, Cronin, Ciarán N, Prasad, Bhagwat

“…We investigated the effect of variability and instability in aldehyde oxidase (AO) content and activity on the scaling of in vitro metabolism data. AO content…”
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Ontogeny of Human Liver Aldehyde Oxidase: Developmental Changes and Implications for Drug Metabolism by Subash, Sandhya, Singh, Dilip K., Ahire, Deepak, Khojasteh, S. Cyrus, Murray, Bernard P., Zientek, Michael A., Jones, Robert S., Kulkarni, Priyanka, Zubair, Faizan, Smith, Bill J., Heyward, Scott, Leeder, J. Steven, Prasad, Bhagwat

“…Despite the increasing importance of aldehyde oxidase (AO) in the drug metabolism of clinical candidates, ontogeny data for AO are limited. The objective of…”
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Pharmacokinetics and Disposition of Momelotinib Revealed a Disproportionate Human Metabolite-Resolution for Clinical Development by Zheng, Jim, Xin, Yan, Zhang, Jingyu, Subramanian, Raju, Murray, Bernard P, Whitney, J Andrew, Warr, Matthew R, Ling, John, Moorehead, Lisa, Kwan, Ellen, Hemenway, Jeffrey, Smith, Bill J, Silverman, Jeffrey A

“…Momelotinib (MMB), a small-molecule inhibitor of Janus kinase (JAK)1/2 and of activin A receptor type 1 (ACVR1), is in clinical development for the treatment…”
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Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer by Xu, Lianhong, Liu, Hongtao, Murray, Bernard P, Callebaut, Christian, Lee, Melody S, Hong, Allen, Strickley, Robert G, Tsai, Luong K, Stray, Kirsten M, Wang, Yujin, Rhodes, Gerry R, Desai, Manoj C

“…Cobicistat (3, GS-9350) is a newly discovered, potent, and selective inhibitor of human cytochrome P450 3A (CYP3A) enzymes. In contrast to ritonavir, 3 is…”
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Effects of GS-9876, a novel spleen tyrosine kinase inhibitor, on platelet function and systemic hemostasis by Clarke, Astrid S., Rousseau, Emma, Wang, Kelly, Kim, Ji-Yun, Murray, Bernard P., Bannister, Roy, Matzkies, Franziska, Currie, Kevin S., Di Paolo, Julie A.

“…Spleen tyrosine kinase (SYK) mediates signal transduction in multiple hematopoietic cells, including platelets. SYK signals downstream of immunoreceptors and…”
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Structure–activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers. Part II: P2/P3 region and discovery of cobicistat (GS-9350) by Xu, Lianhong, Liu, Hongtao, Hong, Allen, Vivian, Randy, Murray, Bernard P., Callebaut, Christian, Choi, You-Chul, Lee, Melody S., Chau, Jennifer, Tsai, Luong K., Stray, Kirsten M., Strickley, Robert G., Wang, Jianhong, Tong, Leah, Swaminathan, Swami, Rhodes, Gerry R., Desai, Manoj C.

“…A series of novel 1,4-diamine-based CYP3A inhibitors were designed and evaluated. A potent and selective inhibitor of CYP3A, cobicistat (35, GS-9350) was…”
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The Drug–Drug Interaction Profile of Presatovir by Xin, Yan, Weng, Winnie, Murray, Bernard P., Eisenberg, Eugene J., Chien, Jason W., Ling, John, Silverman, Jeffrey A.

“…Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in young children. Presatovir (previously GS‐5806) is a novel, orally…”
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Preclinical Characterization of GS-9669, a Thumb Site II Inhibitor of the Hepatitis C Virus NS5B Polymerase by FENAUX, Martijn, ENG, Stacey, LAZERWITH, Scott E, LEW, Willard, QI LIU, MERTZMAN, Michael, MORGANELLI, Philip, LIANHONG XU, HONG YE, JENNIFER ZHANG, MATLES, Mike, MURRAY, Bernard P, LEAVITT, Stephanie A, MWANGI, Judy, JINGYU ZHANG, HASHASH, Ahmad, KRAWCZYK, Steve H, BIDGOOD, Alison M, APPLEBY, Todd C, WATKINS, William J, LEE, Yu-Jen, MABERY, Eric M, YANG TIAN, BYUN, Daniel, CANALES, Eda, CLARKE, Michael O, DOERFFLER, Edward

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Structure–activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers, part I: Core region by Liu, Hongtao, Xu, Lianhong, Hui, Hon, Vivian, Randy, Callebaut, Christian, Murray, Bernard P., Hong, Allen, Lee, Melody S., Tsai, Luong K., Chau, Jennifer K., Stray, Kirsten M., Cannizzaro, Carina, Choi, You-Chul, Rhodes, Gerry R., Desai, Manoj C.

“…The synthesis and evaluation of analogs with extensive modifications of the 1,4-diamine core along with the structure activity relationships with respect to…”
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Discovery of GS-9669, a Thumb Site II Non-Nucleoside Inhibitor of NS5B for the Treatment of Genotype 1 Chronic Hepatitis C Infection by Lazerwith, Scott E., Lew, Willard, Zhang, Jennifer, Morganelli, Philip, Liu, Qi, Canales, Eda, Clarke, Michael O., Doerffler, Edward, Byun, Daniel, Mertzman, Michael, Ye, Hong, Chong, Lee, Xu, Lianhong, Appleby, Todd, Chen, Xiaowu, Fenaux, Martijn, Hashash, Ahmad, Leavitt, Stephanie A., Mabery, Eric, Matles, Mike, Mwangi, Judy W., Tian, Yang, Lee, Yu-Jen, Zhang, Jingyu, Zhu, Christine, Murray, Bernard P., Watkins, William J.

“…Investigation of thiophene-2-carboxylic acid HCV NS5B site II inhibitors, guided by measurement of cell culture medium binding, revealed the structure–activity…”
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Identification and characterization of erlotinib as a potent mechanism-based inactivator of human aldehyde oxidase by Dick, Ryan A., Liang, Xiaomin, Sun, Hailing, Murray, Bernard P., Smith, Bill J.

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