Search Results - "MURPHY, T H"

Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging by Hefendehl, J. K., LeDue, J., Ko, R. W. Y., Mahler, J., Murphy, T. H., MacVicar, B. A.

“…Amyloid-β (Aβ) plaques, a hallmark of Alzheimer’s disease (AD), are surrounded by regions of neuronal and glial hyperactivity. We use in vivo two-photon and…”
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Oxidative stress induces apoptosis in embryonic cortical neurons by Ratan, R R, Murphy, T H, Baraban, J M

“…Glutamate-induced glutathione depletion in immature embryonic cortical neurons has been shown to lead to oxidative stress and cell death. We have used this in…”
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Modular Transport of Postsynaptic Density-95 Clusters and Association with Stable Spine Precursors during Early Development of Cortical Neurons by Prange, Oliver, Murphy, Timothy H

“…The properties of filopodia and spines and their association with the postsynaptic density (PSD) protein PSD-95 were studied during early development of…”
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Preferential expression of antioxidant response element mediated gene expression in astrocytes by Murphy, T. H., Yu, J., Ng, R., Johnson, D. A., Shen, H., Honey, C. R., Johnson, J. A.

“…Transcriptional control of target genes by antioxidant/electrophile response elements has been well described in peripheral tissues. Genes that are regulated…”
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Effective release rates at single rat Schaffer collateral–CA1 synapses during sustained theta‐burst activity revealed by optical imaging by Awatramani, G. B., Boyd, J. D., Delaney, K. R., Murphy, T. H.

“…To understand how information is coded at single hippocampal synapses during high‐frequency activity, we imaged NMDA receptor‐mediated Ca2+ responses in spines…”
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Activation of Endogenous Antioxidant Defenses in Neuronal Cells Prevents Free Radical‐Mediated Damage by Duffy, Steven, So, Austin, Murphy, Timothy H.

“…: Dopamine (DA) is oxidized to the neurotoxic prooxidant species H2O2, OH•, and DA quinones. We tested whether dimethyl fumarate (DMF), an electrophile shown…”
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Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line by Miyamoto, M, Murphy, T H, Schnaar, R L, Coyle, J T

“…The effects of reducing agents and antioxidants on L-Glutamate (Glu)-induced cytotoxicity were examined in the N18-RE-105 neuronal cell line. The cytotoxicity…”
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Activation of p42 mitogen-activated protein kinase by glutamate receptor stimulation in rat primary cortical cultures by Fiore, R S, Murphy, T H, Sanghera, J S, Pelech, S L, Baraban, J M

“…Recent studies have identified at least two homologous mitogen-activated protein (MAP) kinases that are activated by phosphorylation of both tyrosine and…”
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Spontaneous synchronous synaptic calcium transients in cultured cortical neurons by Murphy, TH, Blatter, LA, Wier, WG, Baraban, JM

“…The firing pattern displayed by neuronal aggregates is thought to play a key role in cortical development and physiology. In this study, we have employed…”
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L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genes by Murphy, T H, Worley, P F, Baraban, J M

“…Although L-type voltage-sensitive calcium channels (VSCCs) have been well characterized electrophysiologically, their role in synaptic physiology has remained…”
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Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione by Ratan, RR, Murphy, TH, Baraban, JM

“…Although macromolecular synthesis inhibitors have been demonstrated to prevent neuronal apoptosis in a number of paradigms, their mechanisms of protection…”
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Rapid communication between neurons and astrocytes in primary cortical cultures by Murphy, TH, Blatter, LA, Wier, WG, Baraban, JM

“…The identification of neurotransmitter receptors and voltage-sensitive ion channels on astrocytes (reviewed by Barres, 1991) has renewed interest in how these…”
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In Vivo Calcium Imaging Reveals Functional Rewiring of Single Somatosensory Neurons after Stroke by Winship, Ian R, Murphy, Timothy H

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Activation of Nuclear Calcium Dynamics by Synaptic Stimulation in Cultured Cortical Neurons by Nakazawa, Hiroyuki, Murphy, Timothy H.

“…: L‐type voltage‐sensitive Ca2+ channels (VSCCs) are enriched on the neuronal soma and trigger gene expression during synaptic activity. To understand better…”
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Context and connectivity in plant metapopulations and landscape mosaics: does the matrix matter? by Murphy, Helen T., Lovett-Doust, Jon

“…Recent reviews of evidence for plant metapopulation prevalence in nature have concluded that most species appear not to be arranged as metapopulations - hence…”
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Differential regulation of calcium/calmodulin-dependent protein kinase II and p42 MAP kinase activity by synaptic transmission by Murphy, TH, Blatter, LA, Bhat, RV, Fiore, RS, Wier, WG, Baraban, JM

“…Calcium/calmodulin-dependent protein kinase II (CaMK) and p42 mitogen-activated protein kinase (MAPK) are enriched in neurons and possess the capacity to…”
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Restriction of peroxidase-mediated antibody reactivity to single neurons by local hydrogen peroxide production by Shayan, H., Murphy, T.H.

“…Current electrophysiological and imaging methods have begun to target the subcellular structure and function of single CNS neurons. Although physiological…”
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Synaptic regulation of immediate early gene expression in primary cultures of cortical neurons by Murphy, T H, Worley, P F, Nakabeppu, Y, Christy, B, Gastel, J, Baraban, J M

“…Neuronal stimulation can rapidly activate several immediate early genes that code for transcription factors. We have used primary cortical cultures to study…”
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Recruitment dynamics of invasive species in rainforest habitats following Cyclone Larry by MURPHY, H.T, METCALFE, D.J, BRADFORD, M.G, FORD, A.F, GALWAY, K.E, SYDES, T.A, WESTCOTT, D.J

“…In tropical forests, natural disturbance creates opportunities for species to claim previously utilized space and resources and is considered an important…”
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Vesicle number does not predict postsynaptic measures of miniature synaptic activity frequency in cultured cortical neurons by Mackenzie, P.J, Kenner, G.S, Prange, O, Murphy, T.H

“…We tested the hypothesis that heterogeneity in the frequency of miniature synaptic activity reflects differences in the number of vesicles present in…”
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