Search Results - "MURPHY, Susan K"

A TAZ-ANGPTL4-NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer by Yang, Wen-Hsuan, Huang, Zhiqing, Wu, Jianli, Ding, Chien-Kuang C, Murphy, Susan K, Chi, Jen-Tsan

“…Ovarian cancer is the deadliest gynecologic cancer. Despite recent advances, clinical outcomes remain poor, necessitating novel therapeutic approaches. To…”
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Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues by Murphy, Susan K, Huang, Zhiqing, Hoyo, Cathrine

“…Epigenetic plasticity in relation to in utero exposures may mechanistically explain observed differences in the likelihood of developing common complex…”
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Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG by Cordero, Francisco J, Huang, Zhiqing, Grenier, Carole, He, Xingyao, Hu, Guo, McLendon, Roger E, Murphy, Susan K, Hashizume, Rintaro, Becher, Oren J

“…Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive pediatric brainstem tumor genetically distinguished from adult GBM by the high prevalence of the…”
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Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group by Breton, Carrie V, Marsit, Carmen J, Faustman, Elaine, Nadeau, Kari, Goodrich, Jaclyn M, Dolinoy, Dana C, Herbstman, Julie, Holland, Nina, LaSalle, Janine M, Schmidt, Rebecca, Yousefi, Paul, Perera, Frederica, Joubert, Bonnie R, Wiemels, Joseph, Taylor, Michele, Yang, Ivana V, Chen, Rui, Hew, Kinjal M, Freeland, Deborah M Hussey, Miller, Rachel, Murphy, Susan K

“…Characterization of the epigenome is a primary interest for children's environmental health researchers studying the environmental influences on human…”
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Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes by Su, Dan, Wang, Xuting, Campbell, Michelle R, Porter, Devin K, Pittman, Gary S, Bennett, Brian D, Wan, Ma, Englert, Neal A, Crowl, Christopher L, Gimple, Ryan N, Adamski, Kelly N, Huang, Zhiqing, Murphy, Susan K, Bell, Douglas A

“…Tobacco smoke exposure dramatically alters DNA methylation in blood cells and may mediate smoking-associated complex diseases through effects on immune cell…”
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Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort by Soubry, Adelheid, Schildkraut, Joellen M, Murtha, Amy, Wang, Frances, Huang, Zhiqing, Bernal, Autumn, Kurtzberg, Joanne, Jirtle, Randy L, Murphy, Susan K, Hoyo, Cathrine

“…Data from epidemiological and animal model studies suggest that nutrition during pregnancy may affect the health status of subsequent generations. These…”
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Cannabinoid exposure and altered DNA methylation in rat and human sperm by Murphy, Susan K., Itchon-Ramos, Nilda, Visco, Zachary, Huang, Zhiqing, Grenier, Carole, Schrott, Rose, Acharya, Kelly, Boudreau, Marie-Helene, Price, Thomas M., Raburn, Douglas J., Corcoran, David L., Lucas, Joseph E., Mitchell, John T., McClernon, F. Joseph, Cauley, Marty, Hall, Brandon J., Levin, Edward D., Kollins, Scott H.

“…Little is known about the reproductive effects of paternal cannabis exposure. We evaluated associations between cannabis or tetrahydrocannabinol (THC) exposure…”
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DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination by Korch, Christopher, Spillman, Monique A, Jackson, Twila A, Jacobsen, Britta M, Murphy, Susan K, Lessey, Bruce A, Jordan, V. Craig, Bradford, Andrew P

“…Abstract Objectives Cell lines derived from human ovarian and endometrial cancers, and their immortalized non-malignant counterparts, are critical tools to…”
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Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study by Green, Adrian J., Hoyo, Cathrine, Mattingly, Carolyn J., Luo, Yiwen, Tzeng, Jung-Ying, Murphy, Susan K., Buchwalter, David B., Planchart, Antonio

“…Objective Human obesity is a complex metabolic disorder disproportionately affecting people of lower socioeconomic strata, and ethnic minorities, especially…”
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Cannabis use is associated with potentially heritable widespread changes in autism candidate gene DLGAP2 DNA methylation in sperm by Schrott, Rose, Acharya, Kelly, Itchon-Ramos, Nilda, Hawkey, Andrew B., Pippen, Erica, Mitchell, John T., Kollins, Scott H., Levin, Edward D., Murphy, Susan K.

“…Parental cannabis use has been associated with adverse neurodevelopmental outcomes in offspring, but how such phenotypes are transmitted is largely unknown…”
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Financial stress as a mediator of the association between maternal childhood adversity and infant birth weight, gestational age, and NICU admission by Sosnowski, David W, Ellison-Barnes, Alejandra, Kaufman, Joan, Hoyo, Cathrine, Murphy, Susan K, Hernandez, Raquel G, Marchesoni, Joddy, Klein, Lauren M, Johnson, Sara B

“…To examine whether financial stress during pregnancy mediates the association between maternal exposure to adverse childhood experiences (ACEs) and three birth…”
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Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis by Tang, Xiaohu, Keenan, Melissa M, Wu, Jianli, Lin, Chih-An, Dubois, Laura, Thompson, J Will, Freedland, Stephen J, Murphy, Susan K, Chi, Jen-Tsan

“…Besides being building blocks for protein synthesis, amino acids serve a wide variety of cellular functions, including acting as metabolic intermediates for…”
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Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke by Murphy, Susan K., Adigun, Abayomi, Huang, Zhiqing, Overcash, Francine, Wang, Frances, Jirtle, Randy L., Schildkraut, Joellen M., Murtha, Amy P., Iversen, Edwin S., Hoyo, Cathrine

“…Epigenetic alterations may mechanistically explain the developmental origins of adult disease, namely the hypothesis that many complex adult chronic diseases…”
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Insulin-Like Growth Factor 2/H19 Methylation at Birth and Risk of Overweight and Obesity in Children by Perkins, Ellen, MD, Murphy, Susan K., PhD, Murtha, Amy P., MD, Schildkraut, Joellen, PhD, Jirtle, Randy L., PhD, Demark-Wahnefried, Wendy, PhD, Forman, Michele R., PhD, Kurtzberg, Joanne, MD, Overcash, Francine, MPH, Huang, Zhiqing, MD, PhD, Hoyo, Cathrine, PhD

“…Objective To determine whether aberrant DNA methylation at differentially methylated regions (DMRs) regulating insulin-like growth factor 2 ( IGF2 ) expression…”
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Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight by Luo, Yiwen, McCullough, Lauren E, Tzeng, Jung-Ying, Darrah, Thomas, Vengosh, Avner, Maguire, Rachel L, Maity, Arnab, Samuel-Hodge, Carmen, Murphy, Susan K, Mendez, Michelle A, Hoyo, Cathrine

“…Cadmium (Cd), lead (Pb) and arsenic (As) are common environmental contaminants that have been associated with lower birthweight. Although some essential metals…”
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Periostin facilitates ovarian cancer recurrence by enhancing cancer stemness by Huang, Zhiqing, Byrd, Olivia, Tan, Sarah, Hu, Katrina, Knight, Bailey, Lo, Gaomong, Taylor, Lila, Wu, Yuan, Berchuck, Andrew, Murphy, Susan K.

“…The lethality of epithelial ovarian cancer (OC) is largely due to a high rate of recurrence and development of chemoresistance, which requires synergy between…”
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Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth by Vidal, Adriana C, Sosnowski, David W, Marchesoni, Joddy, Grenier, Carole, Thorp, John, Murphy, Susan K, Johnson, Sara B, Schlief, Billy, Hoyo, Cathrine

“…Adverse childhood experiences (ACEs) contribute to numerous negative health outcomes across the life course and across generations. Here, we extend prior work…”
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Maternal pre-pregnancy obesity, offspring cord blood DNA methylation, and offspring cardiometabolic health in early childhood: an epigenome-wide association study by Martin, Chantel L., Jima, Dereje, Sharp, Gemma C., McCullough, Lauren E., Park, Sarah S., Gowdy, Kymberly M., Skaar, David, Cowley, Michael, Maguire, Rachel L., Fuemmeler, Bernard, Collier, David, Relton, Caroline L., Murphy, Susan K., Hoyo, Cathrine

“…Pre-pregnancy obesity is an established risk factor for adverse sex-specific cardiometabolic health in offspring. Epigenetic alterations, such as in DNA…”
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Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma by Hemachandra, L P Madhubhani P, Shin, Dong-Hui, Dier, Usawadee, Iuliano, James N, Engelberth, Sarah A, Uusitalo, Larissa M, Murphy, Susan K, Hempel, Nadine

“…Epithelial ovarian cancer (EOC) is the fourth leading cause of death due to cancer in women and comprises distinct histologic subtypes, which vary widely in…”
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Epigenome-wide methylation and progression to high-grade cervical intraepithelial neoplasia (CIN2+): a prospective cohort study in the United States by Bukowski, Alexandra, Hoyo, Cathrine, Vielot, Nadja A, Graff, Misa, Kosorok, Michael R, Brewster, Wendy R, Maguire, Rachel L, Murphy, Susan K, Nedjai, Belinda, Ladoukakis, Efthymios, North, Kari E, Smith, Jennifer S

“…Methylation levels may be associated with and serve as markers to predict risk of progression of precancerous cervical lesions. We conducted an epigenome-wide…”
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