Search Results - "MURPHY, P. M"

MitoQ administration prevents endotoxin-induced cardiac dysfunction by Supinski, G S, Murphy, M P, Callahan, L A

“…Sepsis elicits severe alterations in cardiac function, impairing cardiac mitochondrial and pressure-generating capacity. Currently, there are no therapies to…”
Get more information

Age‐related endothelial dysfunction in human skeletal muscle feed arteries: the role of free radicals derived from mitochondria in the vasculature by Park, S.‐Y., Kwon, O. S., Andtbacka, R. H. I., Hyngstrom, J. R., Reese, V., Murphy, M. P., Richardson, R. S.

“…Aim This study sought to determine the role of free radicals derived from mitochondria in the vasculature in the recognized age‐related endothelial dysfunction…”
Get full text

The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling by Saez-Atienzar, S, Bonet-Ponce, L, Blesa, J R, Romero, F J, Murphy, M P, Jordan, J, Galindo, M F

“…Mutations in the leucine-rich repeat kinase 2 ( LRRK2 ) gene have been associated with Parkinson’s disease, and its inhibition opens potential new therapeutic…”
Get full text

Type-2 copper-containing enzymes by MacPherson, I. S, Murphy, M. E. P

“…Type-2 Cu sites are found in all the major branches of life and are often involved in the catalysis of oxygen species. Four type-2 Cu protein families are…”
Get full text

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein by Hutton, Mike, Lewis, Jada, McGowan, Eileen, Rockwood, Julia, Melrose, Heather, Nacharaju, Parimala, Van Slegtenhorst, Marjon, Gwinn-Hardy, Katrina, Murphy, M. P, Baker, Matt, Yu, Xin, Duff, Karen, Hardy, John, Corral, Anthony, Lin, Wen-Lang, Yen, Shu-Hui, Dickson, Dennis W, Davies, Peter

“…Neurofibrillary tangles (NFT) composed of the microtubule-associated protein tau are prominent in Alzheimer disease (AD), Pick disease, progressive…”
Get full text

Anti-neutrophil cytoplasmic antibody-positive vasculitis presenting with periaortitis and muscle vasculitis in a patient with chronic Chagas disease: comment on the letter by Garcia-Bustos et al by Roffe, E, Murphy, PM

Get full text

International Union of Pharmacology. XXX. Update on Chemokine Receptor Nomenclature by Murphy, Philip M

“…An update of the International Union of Pharmacology nomenclature for chemokines is outlined, defining one new receptor type, CXCR6, and disqualifying the…”
Get full text

The Molecular Biology of Leukocyte Chemoattractant Receptors by Murphy, P M

“…Leukocytes migrate from the blood to sites of inflammation in response to locally produced chemoattractants that activate specific cell surface receptors. The…”
Get full text

β-Amyloid deposition and tau phosphorylation in clinically characterized aged cats by Head, E., Moffat, K., Das, P., Sarsoza, F., Poon, W.W., Landsberg, G., Cotman, Carl W., Murphy, M.P.

“…The current study describes both Aβ and tau abnormalities that accumulate in the brains of aged (16–21 years), but not young (<4 years) clinically…”
Get full text

Optimizing the Dose of Intrathecal Morphine in Older Patients Undergoing Hip Arthroplasty by Murphy, P. M., Stack, D., Kinirons, B., Laffey, J. G.

“…Intrathecal (IT) morphine provides excellent postoperative analgesia but may result in many side effects, including postoperative nausea and vomiting,…”
Get full text

Androgens modulate β‐amyloid levels in male rat brain by Ramsden, M., Nyborg, A. C., Murphy, M. P., Chang, L., Stanczyk, F. Z., Golde, T. E., Pike, C. J.

“…As a normal consequence of aging, men experience a significant decline in androgen levels. Although the neural consequences of age‐related androgen depletion…”
Get full text

Chemokines and the Molecular Basis of Cancer Metastasis by Murphy, Philip M

“…Metastasis is the chief cause of morbidity and mortality in most cancers. Appropriately, the words “cancer” (from the Latin for “crab”) and “metastasis” (from…”
Get full text

Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology by Ross, M F, Kelso, G F, Blaikie, F H, James, A M, Cochemé, H M, Filipovska, A, Da Ros, T, Hurd, T R, Smith, R A J, Murphy, M P

“…Lipophilic phosphonium cations were first used to investigate mitochondrial biology by Vladimir Skulachev and colleagues in the late 1960s. Since then, these…”
Get full text

CCR5 deficiency and severe polio infection in the 1984 outbreak in Finland by Rosenberg, A.S., Roivainen, M., Hovi, T., Liu, Q., Murphy, P.M.

“…CCR5, a leukocyte chemoattractant receptor for chemokines CCL3, CCL4, and CCL5, promotes innate and adaptive immune responses by mediating leukocyte…”
Get full text

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis by Lowes, D.A., Webster, N.R., Murphy, M.P., Galley, H.F.

“…Sepsis-induced organ failure is the major cause of death in critical care units, and is characterized by a massive dysregulated inflammatory response and…”
Get full text

Selective targeting of bioactive compounds to mitochondria by Murphy, Michael P.

“…Mitochondrial function can be manipulated selectively by targeting bioactive compounds to mitochondria in living cells. Current targeting mechanisms involve…”
Get full text

Neutrophil receptors for interleukin-8 and related CXC chemokines by Murphy, P M

“…Both the beneficial and harmful roles of neutrophils are critically dependent on the capacity of the cell to undergo directed migration from the blood to local…”
Get more information

Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive by Kohlhauer, M., Pell, V. R., Burger, N., Spiroski, A. M., Gruszczyk, A., Mulvey, J. F., Mottahedin, Amin, Costa, A. S. H., Frezza, C., Ghaleh, B., Murphy, M. P., Tissier, R., Krieg, T.

“…Hypothermia induced at the onset of ischemia is a potent experimental cardioprotective strategy for myocardial infarction. The aim of our study was to…”
Get full text

Chronic Fragmentation of the Daily Sleep-Wake Rhythm Increases Amyloid-beta Levels and Neuroinflammation in the 3xTg-AD Mouse Model of Alzheimer’s Disease by Duncan, M.J., Guerriero, L.E., Kohler, K., Beechem, L.E., Gillis, B.D., Salisbury, F., Wessel, C., Wang, J., Sunderam, S., Bachstetter, A.D., O'Hara, B.F., Murphy, M.P.

“…•Four daily bouts of exposure to novelty and gentle stimulation fragment the daily sleep-wake rhythm in female 3xTg-AD mice.•Chronic fragmentation of the daily…”
Get full text

Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease by Platt, T.L, Beckett, T.L, Kohler, K, Niedowicz, D.M, Murphy, M.P

“…Highlights • Obesity, diabetes, and leptin resistance promote tau phosphorylation in vivo. • Leptin resistance promotes tau phosphorylation in vitro. •…”
Get full text