Search Results - "MURINEDDU, Gabriele"

Tricyclic Pyrazole-Based Compounds as Useful Scaffolds for Cannabinoid CB1/CB2 Receptor Interaction by Asproni, Battistina, Murineddu, Gabriele, Corona, Paola, Pinna, Gérard A.

“…Cannabinoids comprise different classes of compounds, which aroused interest in recent years because of their several pharmacological properties. Such…”
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RNAseq Analysis of Novel 1,3,4-Oxadiazole Chalcogen Analogues Reveals Anti-Tubulin Properties on Cancer Cell Lines by Zoroddu, Stefano, Sanna, Luca, Bordoni, Valentina, Lyu, Weidong, Murineddu, Gabriele, Pinna, Gerard A, Forcales, Sonia Vanina, Sala, Arturo, Kelvin, David J, Bagella, Luigi

“…1,3,4-Oxadiazole derivatives are among the most studied anticancer drugs. Previous studies have analyzed the action of different 1,3,4-oxadiazole derivatives…”
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Biological Effects on μ-Receptors Affinity and Selectivity of Arylpropenyl Chain Structural Modification on Diazatricyclodecane Derivatives by Piras, Sandra, Murineddu, Gabriele, Loriga, Giovanni, Carta, Antonio, Battistello, Enrica, Merighi, Stefania, Gessi, Stefania, Corona, Paola, Asproni, Battistina, Ibba, Roberta, Temml, Veronika, Schuster, Daniela, Pinna, Gérard Aimè

“…Opioid analgesics are clinically used to relieve severe pain in acute postoperative and cancer pain, and also in the long term in chronic pain. The analgesic…”
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5,6-Dichloro-2-phenyl-benzotriazoles: New Potent Inhibitors of Orthohantavirus by Sanna, Giuseppina, Piras, Sandra, Madeddu, Silvia, Busonera, Bernardetta, Klempa, Boris, Corona, Paola, Ibba, Roberta, Murineddu, Gabriele, Carta, Antonio, Loddo, Roberta

“…Orthohantaviruses, previously known as hantaviruses (family Hantaviridae, order Bunyavirales), are emerging zoonoses hosted by different rodent and insectivore…”
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Development of Oxygen-Bridged Pyrazole-Based Structures as Cannabinoid Receptor 1 Ligands by Murineddu, Gabriele, Asproni, Battistina, Corona, Paola, Piras, Sandra, Lazzari, Paolo, Ruiu, Stefania, Legnani, Laura, Toma, Lucio, Pinna, Gérard A

“…In this work, the synthesis of the cannabinoid receptor 1 neutral antagonists 8-chloro-1-(2,4-dichlorophenyl)- -piperidin-1-yl-4,5-dihydrobenzo-1…”
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New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking by Ragusa, Giulio, Gómez-Cañas, María, Morales, Paula, Rodríguez-Cueto, Carmen, Pazos, María R., Asproni, Battistina, Cichero, Elena, Fossa, Paola, Pinna, Gerard A., Jagerovic, Nadine, Fernández-Ruiz, Javier, Murineddu, Gabriele

“…In the last few years, cannabinoid type-2 receptor (CB2R) selective ligands have shown a great potential as novel therapeutic drugs in several diseases. With…”
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Preliminary Anti-Coxsackie Activity of Novel 1-[4-(5,6-dimethyl(H)- 1H(2H)-benzotriazol-1(2)-yl)phenyl]-3-alkyl(aryl)ureas by Piras, Sandra, Corona, Paola, Ibba, Roberta, Riu, Federico, Murineddu, Gabriele, Sanna, Giuseppina, Madeddu, Silvia, Delogu, Ilenia, Loddo, Roberta, Carta, Antonio

“…Coxsackievirus infections are associated with cases of aseptic meningitis, encephalitis, myocarditis, and some chronic disease. A series of…”
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Synthesis and cytotoxicity of novel hexahydrothienocycloheptapyridazinone derivatives by Pau, Amedeo, Murineddu, Gabriele, Asproni, Battistina, Murruzzu, Caterina, Grella, Giuseppe E, Pinna, Gérard A, Curzu, Maria M, Marchesi, Irene, Bagella, Luigi

“…Designed as a new group of tricyclic molecules containing the thienocycloheptapyridazinone ring system, a number of…”
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Synthesis and application in asymmetric copper(I)-catalyzed allylic oxidation of a new chiral 1,10-phenanthroline derived from pinene by Chelucci, Giorgio, Loriga, Giovanni, Murineddu, Gabriele, Pinna, Gerard A

“…A convenient and rapid method for the preparation of chiral C 2-symmetric 1,10-phenanthrolines is reported. As an example of this procedure the synthesis of…”
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Synthesis and Cytotoxic Activities of Pyrrole[2,3-d]pyridazin-4-one Derivatives by Murineddu, Gabriele, Cignarella, Giorgio, Chelucci, Giorgio, Loriga, Giovanni, Pinna, Gérard Aimè

“…1-Methyl-2-phenyl (1) and 1,3-dimethyl-2-phenyl (2)-substituted pyrrole[2,3-d]pyridazinones, as well as their tetracyclic analogues 3—6, were synthesized and…”
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Synthesis and Anti-HIV-1 Activity of New Delavirdine Analogues Carrying Arylpyrrole Moieties by PINNA, Gérard Aimè, LORIGA, Giovanni, MURINEDDU, Gabriele, GRELLA, Giuseppe, MURA, Massimo, VARGIU, Laura, MURGIONI, Chiara, COLLA, Paolo LA

“…In our search for novel anti-human immunodeficiency virus (HIV)-1 agents, 14 delavirdine analogues were synthesized and evaluated as potential anti-HIV-1…”
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Novel 1,3,4-oxadiazole chalcogen analogues: Synthesis and cytotoxic activity by Zoroddu, Stefano, Corona, Paola, Sanna, Luca, Borghi, Federica, Bordoni, Valentina, Asproni, Battistina, Pinna, Gerard A., Bagella, Luigi, Murineddu, Gabriele

“…A small library of novel 1,3,4-oxadiazole bioisosteres was synthesized and their cytotoxic activity evaluated in vitro. Five of the new derivatives (3, 6, 11,…”
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Synthesis and Antineoplastic Evaluation of Novel Unsymmetrical 1,3,4-Oxadiazoles by Nieddu, Valentina, Pinna, Giansalvo, Marchesi, Irene, Sanna, Luca, Asproni, Battistina, Pinna, Gerard A, Bagella, Luigi, Murineddu, Gabriele

“…A series of novel 1,3,4-oxadiazoles was synthesized and evaluated for their cytotoxic activity in in vitro tumor models. Four of the new compounds (2d, 2j, 2k,…”
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Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction by Asproni, Battistina, Catto, Marco, Loriga, Giovanni, Murineddu, Gabriele, Corona, Paola, Purgatorio, Rosa, Cichero, Elena, Fossa, Paola, Scarano, Naomi, Martínez, Antón L., Brea, José, Pinna, Gérard A.

“…[Display omitted] •Synthesis of novel thienocycloalkylpyridazinones.•Biological evaluation: hAChE, hBChE enzyme inhibition; serotonin 5-HT6, 5-HT1A, 5-HT7…”
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Target identification of a novel unsymmetrical 1,3,4‐oxadiazole derivative with antiproliferative properties by Weidong, Lyu, Sanna, Luca, Bordoni, Valentina, Tiansheng, Zeng, Chengxun, Li, Murineddu, Gabriele, Pinna, Gerard A., Kelvin, David J., Bagella, Luigi

“…1,3,4‐Oxadiazole derivatives are widely used in research on antineoplastic drugs. Recently, we discovered a novel unsymmetrical 1,3,4‐oxadiazole compound with…”
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Tricyclic Pyrazole-Based Compounds as Useful Scaffolds for Cannabinoid CB 1 /CB 2 Receptor Interaction by Asproni, Battistina, Murineddu, Gabriele, Corona, Paola, Pinna, Gérard A

“…Cannabinoids comprise different classes of compounds, which aroused interest in recent years because of their several pharmacological properties. Such…”
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Synthesis, molecular modeling and SAR study of novel pyrazolo[5,1-f][1,6]naphthyridines as CB2 receptor antagonists/inverse agonists by Dore, Antonio, Asproni, Battistina, Scampuddu, Alessia, Gessi, Stefania, Murineddu, Gabriele, Cichero, Elena, Fossa, Paola, Merighi, Stefania, Bencivenni, Serena, Pinna, Gérard A.

“…[Display omitted] •Novel pyrazolo[5,1-f][1,6]naphthyridines were synthesized.•Cannabinoid receptor binding at CB1/CB2 and functional assays were…”
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Tricyclic pyrazoles. Part 1: synthesis and biological evaluation of novel 1,4-dihydroindeno[1,2-c]pyrazol-based ligands for CB1and CB2 cannabinoid receptors by Mussinu, Jean Mario, Ruiu, Stefania, Mulè, Antonio C, Pau, Amedeo, Carai, Mauro A M, Loriga, Giovanni, Murineddu, Gabriele, Pinna, Gérard A

“…Cannabinoids receptors, cellular elements of the endocannabinoid system, have been the focus of extensive studies because of their potential functional role in…”
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Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for α4β2 nACh receptors by Deligia, Francesco, Murineddu, Gabriele, Gotti, Cecilia, Ragusa, Giulio, Fasoli, Francesca, Sciaccaluga, Miriam, Plutino, Simona, Fucile, Sergio, Loriga, Giovanni, Asproni, Battistina, Pinna, Gerard A.

“…The cholinergic pathways in the central nervous system (CNS) of animals and humans are important for cognitive and behavioural functions. Until a few years…”
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Novel N-aryl nicotinamide derivatives: Taking stock on 3,6-diazabicyclo[3.1.1]heptanes as ligands for neuronal acetylcholine receptors by Murineddu, Gabriele, Gotti, Cecilia, Asproni, Battistina, Corona, Paola, Martinello, Katiuscia, Plutino, Simona, Fucile, Sergio, Temml, Veronika, Moretti, Milena, Viani, Paola, Schuster, Daniela, Piras, Sandra, Deligia, Francesco, Pinna, Gerard A.

“…We designed the synthesis of a small library of 3-substituted-3,6-diazabicyclo[3.1.1]heptanes whose affinity on neuronal nicotinic receptors (nAChRs) was…”
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