Search Results - "MURILLAS, R"

Risk assessment in skin gene therapy: viral-cellular fusion transcripts generated by proviral transcriptional read-through in keratinocytes transduced with self-inactivating lentiviral vectors by Almarza, D, Bussadori, G, Navarro, M, Mavilio, F, Larcher, F, Murillas, R

“…Cutaneous gene therapy can be envisioned through the use of keratinocyte stem cell clones in which retroviral genotoxic risks can be pre-assessed. While…”
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Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure by Murillas, R., Larcher, F., Conti, C. J., Santos, M., Ullrich, A., Jorcano, J. L.

“…Epidermal growth factor receptor (EGFR) is a key regulator of keratinocyte biology. However, the physiological role of EGFR in vivo has not been well…”
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Expression of Cyclin D1 in Epithelial Tissues of Transgenic Mice Results in Epidermal Hyperproliferation and Severe Thymic Hyperplasia by Robles, Ana I., Larcher, Fernando, Whalin, Robert B., Murillas, Rodolfo, Richie, Ellen, Gimenez-Conti, Irma B., Jorcano, Jose L., Conti, Claudio J.

“…To study the involvement of cyclin D1 in epithelial growth and differentiation and its putative role as an oncogene in skin, transgenic mice were developed…”
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869 Gene editing for ex vivo pachyonychia congenita correction by Diez, M. Garcia, Sot, B., Moreno, M., Morin, M., Soletto, L., Fernandez, S., Prado, D., Murillas, R., Mencia, A.

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LB968 COL7A1 frame restoration by CRISPR/Cas9-facilitated, NHEJ-mediated removal of mutant exons as a reliable broad-range therapeutic strategy for RDEB by Mencia, A., Bonafont, J., Murillas, R., Modamio, S., Nystrom, A., Zambruno, G., Duarte, B., Del Río, M., Llames, S., Larcher, F.

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834 CRISPR/Cas9 based COL7A1 genomic editing in recessive dystrophic epidermolysis bullosa (RDEB) via non-viral polymer delivery system by O'Keeffe Ahern, J., Lara-Saez, I., Cutlar, L., Zhou, D., Murillas, R., Larcher, F., Wang, W.

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LB1544 Highly efficient, permanent ex vivo correction of RDEB via non-viral CRISPR/Cas9 excision of COL7A1 Exon 80 bearing a prevalent mutation by Bonafont, J., Mencia, A., Del Rio, M., Escamez, M., Torres, R., Hauser-Siller, I., Murillas, R., Larcher, F.

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309 Development of a Netherton Syndrome model based on targeted deletion of SPINK5 in human keratinocytes by Gálvez Cortés, V., Aragó, J Bonafont, Mencía, Á., Carretero, M., Solano, E Chacón, Angoiti, R Murillas, Vicente, A., Di, W., Larcher, F.

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A critical role for ras-mediated, epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis by LLANOS CASANOVA, M, LARCHER, Fernando, CASANOVA, Benito, MURILLAS, Rodolfo, FERNANDEZ-ACENERO, M. Jesus, VILLANUEVA, Concepcion, MARTINEZ-PALACIO, Jesus, ULLRICH, Axel, CONTI, Claudio J, JORCANO, Jose Luis

“…Epidermal growth factor receptor (EGFR) plays a critical role in epidermal biology. Abnormal EGFR function has been described in epithelial tumors including…”
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VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development by LARCHER, F, MURILLAS, R, BOLONTRADE, M, CONTI, C. J, JORCANO, J. L

“…Upregulation of keratinocyte-derived VEGF-A expression has recently been established in non-neoplastic processes of skin such as wound healing, blistering…”
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Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways by Cataisson, Christophe, Joseloff, Elizabeth, Murillas, Rodolfo, Wang, Alice, Atwell, Coralyn, Torgerson, Sara, Gerdes, Michael, Subleski, Jeffrey, Gao, Ji-Liang, Murphy, Philip M, Wiltrout, Robert H, Vinson, Charles, Yuspa, Stuart H

“…Skin keratinocytes are major mediators of host immune responses. The skin is also a target for immunologically based inflammation in many pathological states…”
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Identification of Developmentally Expressed Proteins That Functionally Interact with Nedd4 Ubiquitin Ligase by Murillas, Rodolfo, Simms, Kimberly S., Hatakeyama, Shigetsugu, Weissman, Allan M., Kuehn, Michael R.

“…Nedd4 is a HECT domain-containing ubiquitin ligase that mediates ubiquitylation and proteasome degradation of target proteins. The molecular basis for the…”
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Up-regulation of Vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels by LARCHER, F, ROBLES, A. I, DURAN, H, MURILLAS, R, QUINTANILLA, M, CANO, A, CONTI, C. J, JORCANO, J. L

“…Angiogenesis is a crucial process for tumor growth and metastasis regulated by the balance of positive and negative factors. Vascular endothelial growth factor…”
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Activation of Cutaneous Protein Kinase C{alpha} Induces Keratinocyte Apoptosis and Intraepidermal Inflammation by Independent Signaling Pathways by Cataisson, Christophe, Joseloff, Elizabeth, Murillas, Rodolfo, Wang, Alice, Atwell, Coralyn, Torgerson, Sara, Gerdes, Michael, Subleski, Jeffrey, Gao, Ji-Liang, Murphy, Philip M, Wiltrout, Robert H, Vinson, Charles, Yuspa, Stuart H

“…Skin keratinocytes are major mediators of host immune responses. The skin is also a target for immunologically based inflammation in many pathological states…”
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