Search Results - "MURANSKI, P"

Inhibition of TGF-β signaling in genetically engineered tumor antigen-reactive T cells significantly enhances tumor treatment efficacy by Zhang, L, Yu, Z, Muranski, P, Palmer, D C, Restifo, N P, Rosenberg, S A, Morgan, R A

“…Transforming growth factor β (TGF-β) is a cytokine with complex biological functions that may involve tumor promotion or tumor suppression. It has been…”
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High angiopoietin-2 and suppression of tumorigenicity-2 levels correlate with onset of sinusoidal obstructive syndrome—implication for the utility of serial biomarker monitoring by Nunes, A T, Jain, P, Kleiner, D E, Shah, N N, Anandi, P, Chinian, F, Muranski, P, Battiwalla, M, Barrett, A J, Ito, S

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Clinical and biological predictors of outcome following relapse of CML post-allo-SCT by Jain, N A, Ito, S, Tian, X, Kurlander, R, Battiwalla, M, Lu, K, Savani, B N, Malkovska, V, Rezvani, K, Le, R Q, Shenoy, A, Hourigan, C S, Keyvanfar, K, Koklanaris, E, Superata, J, Muranski, P, Barrett, A J, Yong, A S M

“…Although there are now fewer allo-SCTs performed for CML, leukemic relapse post transplant remains a persistent problem. To better define clinical and…”
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Selective depletion of alloreactive donor t cells with adenosine—clinical scale up for allogeneic stem cell transplantation by Battiwalla, M, Zhang, N, Li, Z, Whitehill, G, Wong, S, Jain, P, Ito, S, Muranski, P, Highfill, S.L, Stroncek, D, Barrett, J

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Improved reproducibility and quality of GvHD biomarker assay: application of multiplex microfluidic channel system by Anandi, P, Tian, X, Chinian, F, Cantilena, C R, Dunavin, N, Hensel, N, Draper, D, Koklanaris, E, Maxwell, S, Superata, J, Muranski, P, Battiwalla, M, Paczesny, S, Barrett, A J, Ito, S

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Large granular lymphocyte (LGL)-like clonal expansions in paroxysmal nocturnal hemoglobinuria (PNH) patients by RISITANO, A. M, MACIEJEWSKI, J. P, MURANSKI, P, WLODARSKI, M, O'KEEFE, C, SLOAND, E. M, YOUNG, N. S

“…In paroxysmal nocturnal hemoglobinuria (PNH), clonal expansion of glycosylphosphatidylinositol-anchored proteins (GPI-AP)-deficient cells leads to a syndrome…”
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T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity by Martin-Orozco, Natalia, Muranski, Pawel, Chung, Yeonseok, Yang, Xuexian O., Yamazaki, Tomohide, Lu, Sijie, Hwu, Patrick, Restifo, Nicholas P., Overwijk, Willem W., Dong, Chen

“…Although T helper 17 (Th17) cells have been found in tumor tissues, their function in cancer immunity is unclear. We found that interleukin-17A…”
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Altered Selection of CD4+ T Cells by Class II MHC Bound with Dominant and Low Abundance Self-Peptides by Gaszewska-Mastalarz, Anna, Muranski, Pawel, Chmielowski, Bartosz, Kraj, Piotr, Ignatowicz, Leszek

“…We have investigated the development of CD4(+) T cells in mice expressing low levels of transgenic class II MHC molecules (A(b)) preoccupied with covalent…”
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Increased Intensity Lymphodepletion Enhances Tumor Treatment Efficacy of Adoptively Transferred Tumor-specific T Cells by WRZESINSKI, Claudia, PAULOS, Chrystal M, KAISER, Andrew, MURANSKI, Pawel, PALMER, Douglas C, GATTINONI, Luca, ZHIYA YU, ROSENBERG, Steven A, RESTIFO, Nicholas P

“…Lymphodepletion before adoptive cell transfer (ACT)-based immunotherapies can enhance anti-tumor responses by augmenting innate immunity, by increasing access…”
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Adoptive immunotherapy of cancer using CD4 super(+) T cells by Muranski, P, Restifo, N P

“…CD4 super(+) T cells are central to the function of the immune system but their role in tumor immunity remains underappreciated. It is becoming clear that…”
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Identification of novel microRNA signatures linked to acquired aplastic anemia by Hosokawa, Kohei, Muranski, Pawel, Feng, Xingmin, Keyvanfar, Keyvan, Townsley, Danielle M, Dumitriu, Bogdan, Chen, Jichun, Kajigaya, Sachiko, Taylor, James G, Hourigan, Christopher S, Barrett, A John, Young, Neal S

“…Emerging evidence indicates that microRNA control and modulate immunity. MicroRNA have not been investigated in acquired aplastic anemia, a T-cell-mediated…”
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PPAR  antagonist attenuates mouse immune-mediated bone marrow failure by inhibition of T cell function by Sato, K., Feng, X., Chen, J., Li, J., Muranski, P., Desierto, M. J., Keyvanfar, K., Malide, D., Kajigaya, S., Young, N. S.

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24 - Selective depletion of alloreactive donor t cells with adenosine—clinical scale up for allogeneic stem cell transplantation by Battiwalla, M., Zhang, N., Li, Z., Whitehill, G., Wong, S., Jain, P., Ito, S., Muranski, P., Highfill, S.L., Stroncek, D., Barrett, J.

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Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature by Muranski, Pawel, Borman, Zachary A., Kerkar, Sid P., Klebanoff, Christopher A., Ji, Yun, Sanchez-Perez, Luis, Sukumar, Madhusudhanan, Reger, Robert N., Yu, Zhiya, Kern, Steven J., Roychoudhuri, Rahul, Ferreyra, Gabriela A., Shen, Wei, Durum, Scott K., Feigenbaum, Lionel, Palmer, Douglas C., Antony, Paul A., Chan, Chi-Chao, Laurence, Arian, Danner, Robert L., Gattinoni, Luca, Restifo, Nicholas P.

“…Th17 cells have been described as short lived, but this view is at odds with their capacity to trigger protracted damage to normal and transformed tissues. We…”
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Genetic Engineering of Murine CD8+ and CD4+ T Cells for Preclinical Adoptive Immunotherapy Studies by KERKAR, Sid P, SANCHEZ-PEREZ, Luis, SCOTT, Christopher D, GATTINONI, Luca, MORGAN, Richard A, ROSENBERG, Steven A, RESTIFO, Nicholas P, SHICHENG YANG, BORMAN, Zachary A, MURANSKI, Pawel, YUN JI, CHINNASAMY, Dhanalakshmi, KAISER, Andrew D. M, HINRICHS, Christian S, KLEBANOFF, Christopher A

“…T-cell receptor (TCR) gene therapy enables for the rapid creation of antigen-specific T cells from mice of any strain and represents a valuable tool for…”
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Inhibition of TGF-[beta] signaling in genetically engineered tumor antigen-reactive T cells significantly enhances tumor treatment efficacy by Zhang, L, Yu, Z, Muranski, P, Palmer, D C, Restifo, N P, Rosenberg, S A, Morgan, R A

“…Transforming growth factor [beta] (TGF-[beta]) is a cytokine with complex biological functions that may involve tumor promotion or tumor suppression. It has…”
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Mature CD4+ T Cells Perceive a Positively Selecting Class II MHC/Peptide Complex in the Periphery by Muranski, Pawel, Chmielowski, Bartosz, Ignatowicz, Leszek

“…A repertoire of TCRs is selected in the thymus by interactions with MHC bound to self-derived peptides. Whether self peptides bound to MHC influence the…”
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Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8 super(+) T cells via TLR4 signaling by Paulos, G M, Wrzesinski, C, Kaiser, A, Hinrichs, C S, Chieppa, M, Cassard, L, Palmer, D C, Boni, A, Muranski, P, Yu, Z, Gattinoni, L, Antony, P A, Rosenberg, SA, Restifo, N P

“…Lymphodepletion with total body irradiation (TBI) increases the efficacy of adoptively transferred tumor-specific CD8 super(+) T cells by depleting inhibitory…”
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Large granular lymphocyte patients by Risitano, A M, Maciejewski, J P, Muranski, P, Wlodarski, M, O'Keefe, C, Sloand, E M, Young, N S

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Mature CD4 super(+) T Cells Perceive a Positively Selecting Class II MHC/Peptide Complex in the Periphery by Muranski, P, Chmielowski, B, Ignatowicz, L

“…A repertoire of TCRs is selected in the thymus by interactions with MHC bound to self-derived peptides. Whether self peptides bound to MHC influence the…”
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