Search Results - "MUOIO, D. M"

Revisiting the connection between intramyocellular lipids and insulin resistance: a long and winding road by Muoio, D. M.

“…In the mid-1990s, researchers began to re-examine type 2 diabetes from a more ‘lipocentric’ perspective; giving strong consideration to the idea that systemic…”
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A High-Fat Diet Elicits Differential Responses in Genes Coordinating Oxidative Metabolism in Skeletal Muscle of Lean and Obese Individuals by Boyle, K. E, Canham, J. P, Consitt, L. A, Zheng, D, Koves, T. R, Gavin, T. P, Holbert, D, Neufer, P. D, Ilkayeva, O, Muoio, D. M, Houmard, J. A

“…A 5-day, eucaloric high fat diet up-regulates genes involved in fat metabolism in skeletal muscle of lean, but not obese, individuals. Context: In lean…”
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Carnitine revisited: potential use as adjunctive treatment in diabetes by Power, R. A, Hulver, M. W, Zhang, J. Y, Dubois, J, Marchand, R. M, Ilkayeva, O, Muoio, D. M, Mynatt, R. L

“…Aims/hypothesis This study examined the efficacy of supplemental l-carnitine as an adjunctive diabetes therapy in mouse models of metabolic disease. We…”
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Physiological and nutritional regulation of enzymes of triacylglycerol synthesis by COLEMAN, R. A, LEWIN, T. M, MUOIO, D. M

“…Although triacylglycerol stores play the critical role in an organism's ability to withstand fuel deprivation and are strongly associated with such disorders…”
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Leptin directly alters lipid partitioning in skeletal muscle by D M Muoio, G L Dohm, F T Fiedorek, Jr, E B Tapscott, R A Coleman, G L Dohn

“…Leptin directly alters lipid partitioning in skeletal muscle. D M Muoio , G L Dohm , F T Fiedorek, Jr , E B Tapscott , R A Coleman and G L Dohn Department of…”
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Effect of dietary fat on metabolic adjustments to maximal VO2 and endurance in runners by Muoio, D M, Leddy, J J, Horvath, P J, Awad, A B, Pendergast, D R

“…The present study examined the effects of dietary manipulations on six trained runners. The percent energy contributions from carbohydrate, fat, and protein…”
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Leptin directly alters lipid partitioning in skeletal muscle by MUOIO, D. M, DOHN, G. L, FIEDOREK, F. T, TAPSCOTT, E. B, COLEMAN, R. A

“…Leptin, an adipocyte-derived hormone that directly regulates both adiposity and energy homeostasis, decreases food intake and appears to partition metabolic…”
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Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta by Muoio, Deborah M, MacLean, Paul S, Lang, David B, Li, Shi, Houmard, Joseph A, Way, James M, Winegar, Deborah A, Corton, J Christopher, Dohm, G Lynis, Kraus, William E

“…Ablation of peroxisome proliferator activated receptor (PPAR) alpha, a lipid-activated transcription factor that regulates expression of beta-oxidative genes,…”
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Energy Metabolism in Uncoupling Protein 3 Gene Knockout Mice by Vidal-Puig, Antonio J., Grujic, Danica, Zhang, Chen-Yu, Hagen, Thilo, Boss, Olivier, Ido, Yasuo, Szczepanik, Alicja, Wade, Jennifer, Mootha, Vamsi, Cortright, Ronald, Muoio, Deborah M., Lowell, Bradford B.

“…Uncoupling protein 3 (UCP3) is a member of the mitochondrial anion carrier superfamily. Based upon its high homology with UCP1 and its restricted tissue…”
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AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target by Muoio, D M, Seefeld, K, Witters, L A, Coleman, R A

“…AMP-activated kinase (AMPK) is activated in response to metabolic stresses that deplete cellular ATP, and in both liver and skeletal muscle, activated AMPK…”
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Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice by Muoio, D.M, Dohm, G.L, Tapscott, E.B, Coleman, R.A

“…Because muscle triacylglycerol (TAG) accumulation might contribute to insulin resistance in leptin-deficient ob/ob mice, we studied the acute (60- to 90-min)…”
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Acyl-CoAs are functionally channeled in liver: potential role of acyl-CoA synthetase by Muoio, D M, Lewin, T M, Wiedmer, P, Coleman, R A

“…Acyl-CoA synthetase (ACS) catalyzes the activation of long-chain fatty acids to acyl-CoAs, which can be metabolized to form CO(2), triacylglycerol (TAG),…”
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Glucose uptake in muscle cell cultures from endurance-trained men by BERGGREN, Jason R, TANNER, Charles J, KOVES, Timothy R, MUOIO, Deborah M, HOUMARD, Joseph A

“…To examine noninsulin- (basal) and insulin-mediated glucose uptake in human skeletal muscle cells from endurance-trained and sedentary individuals. Muscle…”
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Skeletal muscle lipid metabolism: A frontier for new insights into fuel homeostasis by Cortright, Ronald N., Muoio, Deborah M., Dohm, G.Lynis

“…Although skeletal muscle is recognized as a primary site of lipid utilization, the study of muscle bioenergetics has focused mainly on carbohydrate, and…”
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The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain by Lien, Lillian F, Haqq, Andrea M, Arlotto, Michelle, Slentz, Cris A, Muehlbauer, Michael J, McMahon, Ross L, Rochon, James, Gallup, Dianne, Bain, James R, Ilkayeva, Olga, Wenner, Brett R, Stevens, Robert D, Millington, David S, Muoio, Deborah M, Butler, Mark D, Newgard, Christopher B, Svetkey, Laura P

“…The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) Project uses comprehensive metabolic profiling to probe biochemical mechanisms of weight…”
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Peroxisome Proliferator-activated Receptor-γ Co-activator 1α-mediated Metabolic Remodeling of Skeletal Myocytes Mimics Exercise Training and Reverses Lipid-induced Mitochondrial Inefficiency by Koves, Timothy R., Li, Ping, An, Jie, Akimoto, Takayuki, Slentz, Dorothy, Ilkayeva, Olga, Dohm, G. Lynis, Yan, Zhen, Newgard, Christopher B., Muoio, Deborah M.

“…Peroxisome proliferator-activated receptor-γ co-activator 1α (PGC1α) is a promiscuous co-activator that plays a key role in regulating mitochondrial biogenesis…”
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Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans by Hulver, Matthew W., Berggren, Jason R., Carper, Michael J., Miyazaki, Makoto, Ntambi, James M., Hoffman, Eric P., Thyfault, John P., Stevens, Robert, Dohm, G. Lynis, Houmard, Joseph A., Muoio, Deborah M.

“…Obesity and type 2 diabetes are strongly associated with abnormal lipid metabolism and accumulation of intramyocellular triacylglycerol, but the underlying…”
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Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance by Newgard, Christopher B, An, Jie, Muoio, Deborah M, Shiota, Masakazu, Fujimoto, Yuka, Cline, Gary W, Shulman, Gerald I, Koves, Timothy R, Stevens, Robert, Millington, David

“…Lipid infusion or ingestion of a high-fat diet results in insulin resistance, but the mechanism underlying this phenomenon remains unclear. Here we show that,…”
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Metabolism A is for adipokine by Muoio, Deborah M, Newgard, Christopher B

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Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism by Koves, Timothy R, Noland, Robert C, Bates, Andrew L, Henes, Sarah T, Muoio, Deborah M, Cortright, Ronald N

“…Skeletal muscle contains two populations of mitochondria that appear to be differentially affected by disease and exercise training. It remains unclear how…”
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