Search Results - "MUNSHI, Nikhil C"

Pathogenesis beyond the cancer clone(s) in multiple myeloma by Bianchi, Giada, Munshi, Nikhil C.

“…Over the past 4 decades, basic research has provided crucial information regarding the cellular and molecular biology of cancer. In particular, the relevance…”
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Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma by Samur, Mehmet Kemal, Fulciniti, Mariateresa, Aktas Samur, Anil, Bazarbachi, Abdul Hamid, Tai, Yu-Tzu, Prabhala, Rao, Alonso, Alejandro, Sperling, Adam S., Campbell, Timothy, Petrocca, Fabio, Hege, Kristen, Kaiser, Shari, Loiseau, Hervé Avet, Anderson, Kenneth C., Munshi, Nikhil C.

“…BCMA targeting chimeric antigen receptor (CAR) T cell therapy has shown deep and durable responses in multiple myeloma. However, relapse following therapy is…”
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Gene Expression Profiles in Myeloma: Ready for the Real World? by Szalat, Raphael, Avet-Loiseau, Herve, Munshi, Nikhil C

“…Multiple myeloma is a plasma cell malignancy characterized by molecular and clinical heterogeneity. The outcome of the disease has been dramatically improved…”
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Drugging the lncRNA MALAT1 via LNA gapmeR ASO inhibits gene expression of proteasome subunits and triggers anti-multiple myeloma activity by Amodio, Nicola, Stamato, Maria Angelica, Juli, Giada, Morelli, Eugenio, Fulciniti, Mariateresa, Manzoni, Martina, Taiana, Elisa, Agnelli, Luca, Cantafio, Maria Eugenia Gallo, Romeo, Enrica, Raimondi, Lavinia, Caracciolo, Daniele, Zuccalà, Valeria, Rossi, Marco, Neri, Antonino, Munshi, Nikhil C., Tagliaferri, Pierosandro, Tassone, Pierfrancesco

“…The biological role and therapeutic potential of long non-coding RNAs (lncRNAs) in multiple myeloma (MM) are still to be investigated. Here, we studied the…”
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New Strategies in the Treatment of Multiple Myeloma by MUNSHI, Nikhil C, ANDERSON, Kenneth C

“…Multiple myeloma is the second most common hematologic malignancy affecting terminally differentiated plasma cells. Although high-dose chemotherapy and…”
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Novel anti–B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma by Tai, Yu-Tzu, Mayes, Patrick A., Acharya, Chirag, Zhong, Mike Y., Cea, Michele, Cagnetta, Antonia, Craigen, Jenny, Yates, John, Gliddon, Louise, Fieles, William, Hoang, Bao, Tunstead, James, Christie, Amanda L., Kung, Andrew L., Richardson, Paul, Munshi, Nikhil C., Anderson, Kenneth C.

“…B-cell maturation antigen (BCMA), highly expressed on malignant plasma cells in human multiple myeloma (MM), has not been effectively targeted with therapeutic…”
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Tumor-promoting immune-suppressive myeloid-derived suppressor cells in the multiple myeloma microenvironment in humans by Görgün, Güllü Topal, Whitehill, Gregory, Anderson, Jennifer L., Hideshima, Teru, Maguire, Craig, Laubach, Jacob, Raje, Noopur, Munshi, Nikhil C., Richardson, Paul G., Anderson, Kenneth C.

“…Myeloid-derived suppressor cells (MDSCs) are a heterogeneous, immature myeloid cell population with the ability to suppress immune responses. MDSCs have been…”
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Widespread intronic polyadenylation diversifies immune cell transcriptomes by Singh, Irtisha, Lee, Shih-Han, Sperling, Adam S., Samur, Mehmet K., Tai, Yu-Tzu, Fulciniti, Mariateresa, Munshi, Nikhil C., Mayr, Christine, Leslie, Christina S.

“…Alternative cleavage and polyadenylation (ApA) is known to alter untranslated region (3ʹUTR) length but can also recognize intronic polyadenylation (IpA)…”
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Chromothripsis identifies a rare and aggressive entity among newly diagnosed multiple myeloma patients by Magrangeas, Florence, Avet-Loiseau, Hervé, Munshi, Nikhil C., Minvielle, Stéphane

“…Multiple myeloma (MM) develops from a premalignant plasma cell proliferative disorder, and with time can progress to a more aggressive disease in…”
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Analysis of the genomic landscape of multiple myeloma highlights novel prognostic markers and disease subgroups by Bolli, Niccolo, Biancon, Giulia, Moarii, Matahi, Gimondi, Silvia, Li, Yilong, de Philippis, Chiara, Maura, Francesco, Sathiaseelan, Vijitha, Tai, Yu-Tzu, Mudie, Laura, O’Meara, Sarah, Raine, Keiran, Teague, Jon W., Butler, Adam P., Carniti, Cristiana, Gerstung, Moritz, Bagratuni, Tina, Kastritis, Efstathios, Dimopoulos, Meletios, Corradini, Paolo, Anderson, Kenneth C., Moreau, Philippe, Minvielle, Stephane, Campbell, Peter J., Papaemmanuil, Elli, Avet-Loiseau, Herve, Munshi, Nikhil C.

“…In multiple myeloma, next-generation sequencing (NGS) has expanded our knowledge of genomic lesions, and highlighted a dynamic and heterogeneous composition of…”
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Lenalidomide Enhances Immune Checkpoint Blockade-Induced Immune Response in Multiple Myeloma by Görgün, Güllü, Samur, Mehmet K, Cowens, Kristen B, Paula, Steven, Bianchi, Giada, Anderson, Julie E, White, Randie E, Singh, Ahaana, Ohguchi, Hiroto, Suzuki, Rikio, Kikuchi, Shohei, Harada, Takeshi, Hideshima, Teru, Tai, Yu-Tzu, Laubach, Jacob P, Raje, Noopur, Magrangeas, Florence, Minvielle, Stephane, Avet-Loiseau, Herve, Munshi, Nikhil C, Dorfman, David M, Richardson, Paul G, Anderson, Kenneth C

“…PD-1/PD-L1 signaling promotes tumor growth while inhibiting effector cell-mediated antitumor immune responses. Here, we assessed the impact of single and dual…”
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Blockade of Deubiquitylating Enzyme USP1 Inhibits DNA Repair and Triggers Apoptosis in Multiple Myeloma Cells by Das, Deepika Sharma, Das, Abhishek, Ray, Arghya, Song, Yan, Samur, Mehmet Kemal, Munshi, Nikhil C, Chauhan, Dharminder, Anderson, Kenneth C

“…The ubiquitin proteasome pathway is a validated therapeutic target in multiple myeloma. Deubiquitylating enzyme USP1 participates in DNA damage response and…”
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MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction by Xu, Lian, Hunter, Zachary R., Yang, Guang, Zhou, Yangsheng, Cao, Yang, Liu, Xia, Morra, Enrica, Trojani, Alessandra, Greco, Antonino, Arcaini, Luca, Varettoni, Marzia, Brown, Jennifer R., Tai, Yu-Tzu, Anderson, Kenneth C., Munshi, Nikhil C., Patterson, Christopher J., Manning, Robert J., Tripsas, Christina K., Lindeman, Neal I., Treon, Steven P.

“…By whole-genome and/or Sanger sequencing, we recently identified a somatic mutation (MYD88 L265P) that stimulates nuclear factor κB activity and is present in…”
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Consensus recommendations for standard investigative workup: report of the International Myeloma Workshop Consensus Panel 3 by Dimopoulos, Meletios, Kyle, Robert, Fermand, Jean-Paul, Rajkumar, S. Vincent, San Miguel, Jesus, Chanan-Khan, Asher, Ludwig, Heinz, Joshua, Douglas, Mehta, Jayesh, Gertz, Morie, Avet-Loiseau, Hervé, Beksaç, Meral, Anderson, Kenneth C., Moreau, Philippe, Singhal, Seema, Goldschmidt, Hartmut, Boccadoro, Mario, Kumar, Shaji, Giralt, Sergio, Munshi, Nikhil C., Jagannath, Sundar

“…A panel of members of the 2009 International Myeloma Workshop developed guidelines for standard investigative workup of patients with suspected multiple…”
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Consensus recommendations for the uniform reporting of clinical trials: report of the International Myeloma Workshop Consensus Panel 1 by Rajkumar, S. Vincent, Harousseau, Jean-Luc, Durie, Brian, Anderson, Kenneth C., Dimopoulos, Meletios, Kyle, Robert, Blade, Joan, Richardson, Paul, Orlowski, Robert, Siegel, David, Jagannath, Sundar, Facon, Thierry, Avet-Loiseau, Hervé, Lonial, Sagar, Palumbo, Antonio, Zonder, Jeffrey, Ludwig, Heinz, Vesole, David, Sezer, Orhan, Munshi, Nikhil C., San Miguel, Jesus

“…It is essential that there be consistency in the conduct, analysis, and reporting of clinical trial results in myeloma. The goal of the International Myeloma…”
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Genome-Wide Somatic Alterations in Multiple Myeloma Reveal a Superior Outcome Group by Samur, Mehmet Kemal, Aktas Samur, Anil, Fulciniti, Mariateresa, Szalat, Raphael, Han, Tessa, Shammas, Masood, Richardson, Paul, Magrangeas, Florence, Minvielle, Stephane, Corre, Jill, Moreau, Philippe, Thakurta, Anjan, Anderson, Kenneth C, Parmigiani, Giovanni, Avet-Loiseau, Hervé, Munshi, Nikhil C

“…Multiple myeloma (MM) is accompanied by heterogeneous somatic alterations. The overall goal of this study was to describe the genomic landscape of myeloma…”
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Genomics in multiple myeloma by Munshi, Nikhil C, Avet-Loiseau, Hervé

“…Multiple myeloma (MM) is a complex disease that is driven by numerous genetic and epigenetic alterations. Comprehensive oncogenomic analysis indicates the…”
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A 13 mer LNA-i-miR-221 Inhibitor Restores Drug Sensitivity in Melphalan-Refractory Multiple Myeloma Cells by Gullà, Annamaria, Di Martino, Maria Teresa, Gallo Cantafio, Maria Eugenia, Morelli, Eugenio, Amodio, Nicola, Botta, Cirino, Pitari, Maria Rita, Lio, Santo Giovanni, Britti, Domenico, Stamato, Maria Angelica, Hideshima, Teru, Munshi, Nikhil C, Anderson, Kenneth C, Tagliaferri, Pierosandro, Tassone, Pierfrancesco

“…The onset of drug resistance is a major cause of treatment failure in multiple myeloma. Although increasing evidence is defining the role of miRNAs in…”
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A phase 2 study of modified lenalidomide, bortezomib and dexamethasone in transplant‐ineligible multiple myeloma by O'Donnell, Elizabeth K., Laubach, Jacob P., Yee, Andrew J., Chen, Tianqi, Huff, Carol Ann, Basile, Frank G., Wade, Philip M., Paba‐Prada, Claudia E., Ghobrial, Irene M., Schlossman, Robert L., Burke, Jill N., Harrington, Cynthia C., Lively, Kathleen J., Lyons, Hannah F., Munshi, Nikhil C., Anderson, Kenneth C., Trippa, Lorenzo, Richardson, Paul G., Raje, Noopur S.

“…We sought a regimen that incorporates optimal novel agents and balances efficacy with toxicity in transplant‐ineligible multiple myeloma (MM) patients. Our…”
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Bone marrow stromal cells induce chromatin remodeling in multiple myeloma cells leading to transcriptional changes by Binder, Moritz, Szalat, Raphael E., Talluri, Srikanth, Fulciniti, Mariateresa, Avet-Loiseau, Hervé, Parmigiani, Giovanni, Samur, Mehmet K., Munshi, Nikhil C.

“…The natural history of multiple myeloma is characterized by its localization to the bone marrow and its interaction with bone marrow stromal cells. The bone…”
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