Search Results - "MUNDY, G. R"

MEPE has the properties of an osteoblastic phosphatonin and minhibin by Rowe, P.S.N, Kumagai, Y, Gutierrez, G, Garrett, I.R, Blacher, R, Rosen, D, Cundy, J, Navvab, S, Chen, D, Drezner, M.K, Quarles, L.D, Mundy, G.R

“…Matrix extracellular phosphoglycoprotein (MEPE) is expressed exclusively in osteoblasts, osteocytes and odontoblasts with markedly elevated expression found in…”
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Transdermal application of lovastatin to rats causes profound increases in bone formation and plasma concentrations by GUTIERREZ, G. E, LALKA, D, GARRETT, I. R, ROSSINI, G, MUNDY, G. R

“…Statins are drugs that inhibit HMG Co-A reductase and have been shown to enhance bone formation in vitro and in vivo in rodents. However, the statins currently…”
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The bisphosphonate ibandronate promotes apoptosis in MDA-MB-231 human breast cancer cells in bone metastases by HIRAGA, Toru, WILLIAMS, Paul J, MUNDY, Gregory R, YONEDA, Toshiyuki

“…Bisphosphonate (BP), a specific inhibitor of osteoclasts, has been widely used as a beneficial agent for the treatment of bone metastases in patients with…”
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Statins and their potential for osteoporosis by Mundy, G.R.

“…The observation made several years ago that statins dramatically increase bone formation rates in rodents has provoked a much interest. Statins are natural…”
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A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates by PARFITT, A. M, MUNDY, G. R, ROODMAN, G. D, HUGHES, D. E, BOYCE, B. F

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Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice by BOYCE, B. F, YONEDA, T, LOWE, C, SORIANO, P, MUNDY, G. R

“…Targeted disruption of the c-src proto-oncogene in mice has shown that src expression is required for normal bone resorption, since the src-deficient mutants…”
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Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis by Guise, T A, Yin, J J, Taylor, S D, Kumagai, Y, Dallas, M, Boyce, B F, Yoneda, T, Mundy, G R

“…Breast cancer almost invariably metastasizes to bone in patients with advanced disease and causes local osteolysis. Much of the morbidity of advanced breast…”
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Establishment of an Osteocyte‐like Cell Line, MLO‐Y4 by Kato, Yoichi, Windle, Jolene J., Koop, Barbara A., Mundy, Gregory R., Bonewald, Lynda F.

“…Although osteocytes are the most abundant cells in bone, their functional role remains unclear. In part, this is due to lack of availability of osteocyte cell…”
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Genetic polymorphisms of EPHX1, Gsk3β, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma by Durie, B G M, Van Ness, B, Ramos, C, Stephens, O, Haznadar, M, Hoering, A, Haessler, J, Katz, M S, Mundy, G R, Kyle, R A, Morgan, G J, Crowley, J, Barlogie, B, Shaughnessy, J

“…Bone disease in myeloma occurs as a result of complex interactions between myeloma cells and the bone marrow microenvironment. A custom-built DNA single…”
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Statins and bone formation by Garrett, I R, Gutierrez, G, Mundy, G R

“…The main therapy needed most in the bone field is an anabolic agent for the treatment of osteoporosis. Current drugs on the market, which included…”
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Systemic Administration of Acidic Fibroblast Growth Factor (FGF‐1) Prevents Bone Loss and Increases New Bone Formation in Ovariectomized Rats by Dunstan, C. R., Boyce, R., Boyce, B. F., Garrett, I. R., Izbicka, E., Burgess, W. H., Mundy, G. R.

“…There are no universally accepted agents that will substantially increase bone mass in osteoporotic patients. A number of peptides important in normal bone…”
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Differential Roles for Bone Morphogenetic Protein (BMP) Receptor Type IB and IA in Differentiation and Specification of Mesenchymal Precursor Cells to Osteoblast and Adipocyte Lineages by Chen, D., Ji, X., Harris, M. A., Feng, J. Q., Karsenty, G., Celeste, A. J., Rosen, V., Mundy, G. R., Harris, S. E.

“…Cumulative evidence indicates that osteoblasts and adipocytes share a common mesenchymal precursor and that bone morphogenetic proteins (BMPs) can induce both…”
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Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo by Hughes, David E., Wright, Kenneth R., Uy, Harry L., Sasaki, Akira, Yoneda, Toshiyuki, Roodman, David G., Mundy, Gregory R., Boyce, Brendan F.

“…Bisphosphonates inhibit bone resorption and are therapeutically effective in diseases of increased bone turnover, such as Paget's disease and hypercalcemia of…”
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Hormonal Control of Calcium Homeostasis by Mundy, Gregory R, Guise, Theresa A

“…Calcium homeostasis in the extracellular fluid is tightly controlled and defended physiologically. Hypercalcemia always represents considerable underlying…”
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Osteopetrosis in Src-Deficient Mice is Due to an Autonomous Defect of Osteoclasts by Lowe, Carolyn, Yoneda, Toshiyuki, Boyce, Brendan F., Chen, Hong, Mundy, Gregory R., Soriano, Philippe

“…Osteopetrosis is a bone modeling disorder resulting in excessive accumulation of bone matrix due to defective function of osteoclasts, the cells that resorb…”
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Cellular and molecular regulation of bone turnover by Mundy, G.R

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Role of transforming growth factor-beta in bone remodeling by Bonewald, L F, Mundy, G R

“…Transforming growth factor-beta (TGF-beta) plays a critical role in bone remodeling. TGF-beta stimulates matrix protein synthesis, has dramatic effects on the…”
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Metastasis to bone: causes, consequences and therapeutic opportunities by Mundy, Gregory R

“…The most common human cancers --lung, breast and prostate -- have a great avidity for bone, leading to painful and untreatable consequences. What makes some…”
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Mechanisms of bone metastasis by Mundy, Gregory R.

“…Solid cancers metastasize to bone by a multistep process that involves interactions between tumor cells and normal host cells. Some tumors, most notably breast…”
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Bisphosphonates as Anticancer Drugs by Mundy, Gregory R, Yoneda, Toshiyuki

“…The clinical use of bisphosphonates has increased dramatically during the past five years. The most common indication for these compounds is osteoporosis, but…”
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