Search Results - "MULLIGAN, Richard C"

"Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells by Ramalho-Santos, Miguel, Yoon, Soonsang, Matsuzaki, Yumi, Mulligan, Richard C., Melton, Douglas A.

“…The transcriptional profiles of mouse embryonic, neural, and hematopoietic stem cells were compared to define a genetic program for stem cells. A total of 216…”
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Failure of Bone Marrow to Reconstitute Lung Epithelium by Kotton, Darrell N, Fabian, Attila J, Mulligan, Richard C

“…A new paradigm of epithelial tissue reconstitution has been suggested whereby circulating cells derived from bone marrow contribute to a variety of epithelial…”
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Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow by Balazs, Alejandro B., Fabian, Attila J., Esmon, Charles T., Mulligan, Richard C.

“…The hematopoietic stem cell (HSC) is a unique cell type found in bone marrow, which has the capacity for both self-renewal and differentiation into all blood…”
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Unexpectedly Efficient Homing Capacity of Purified Murine Hematopoietic Stem Cells by Matsuzaki, Yumi, Kinjo, Kentaro, Mulligan, Richard C, Okano, Hideyuki

“…Single-cell transplantation analysis revealed that the cells that had the strongest dye efflux activity (“Tip”-SP cells) and had the phenotype CD34− c-Kit+…”
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Complete Correction of Murine Artemis Immunodeficiency by Lentiviral Vector-Mediated Gene Transfer by Mostoslavsky, Gustavo, Fabian, Attila J., Rooney, Sean, Alt, Frederick W., Mulligan, Richard C.

“…Artemis gene mutations are responsible for the development of a severe combined immunodeficiency [radiation-sensitive (RS) SCID] characterized by a severe B…”
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Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome by Austin, Karyn M, Gupta, Jr, Mohan L, Coats, Scott A, Tulpule, Asmin, Mostoslavsky, Gustavo, Balazs, Alejandro B, Mulligan, Richard C, Daley, George, Pellman, David, Shimamura, Akiko

“…Deficiencies in the SBDS gene result in Shwachman-Diamond syndrome (SDS), an inherited bone marrow failure syndrome associated with leukemia predisposition…”
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Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages by Wilson, Andrew A, Murphy, George J, Hamakawa, Hiroshi, Kwok, Letty W, Srinivasan, Sreedevi, Hovav, Avi-Hai, Mulligan, Richard C, Amar, Salomon, Suki, Bela, Kotton, Darrell N

“…Directed gene transfer into specific cell lineages in vivo is an attractive approach for both modulating gene expression and correcting inherited mutations…”
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Soluble receptor-mediated selective inhibition of VEGFR and PDGFRβ signaling during physiologic and tumor angiogenesis by Kuhnert, Frank, Tam, Betty Y.Y, Sennino, Barbara, Gray, John T, Yuan, Jenny, Jocson, Angeline, Nayak, Nihar R, Mulligan, Richard C, McDonald, Donald M, Kuo, Calvin J

“…The simultaneous targeting of both endothelial cells and pericytes via inhibition of VEGF receptor (VEGFR) and PDGFβ receptor (PDGFRβ) signaling, respectively,…”
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Dose-Dependent Response of FGF-2 for Lymphangiogenesis by Chang, Lynn K., Garcia-Cardeña, Guillermo, Farnebo, Filip, Fannon, Michael, Chen, Emy J., Butterfield, Catherine, Moses, Marsha A., Mulligan, Richard C., Folkman, Judah, Kaipainen, Arja

“…Spatio-temporal studies on the growth of capillary blood vessels and capillary lymphatic vessels in tissue remodeling have suggested that lymphangiogenesis is…”
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Exogenous control of mammalian gene expression through modulation of RNA self-cleavage by Mulligan, Richard C, Yen, Laising, Svendsen, Jennifer, Lee, Jeng-Shin, Gray, John T, Magnier, Maxime, Baba, Takashi, D'Amato, Robert J

“…Recent studies on the control of specific metabolic pathways in bacteria have documented the existence of entirely RNA-based mechanisms for controlling gene…”
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Long-Lived Antitumor CD8+ Lymphocytes for Adoptive Therapy Generated Using an Artificial Antigen-Presenting Cell by BUTLER, Marcus O, LEE, Jeng-Shin, HIRANO, Naoto, ANSEN, Sascha, NEUBERG, Donna, HODI, F. Stephen, MURRAY, Andrew P, DRURY, Linda, BEREZOVSKAYA, Alla, MULLIGAN, Richard C, NADLER, Lee M

“…Purpose: Antitumor lymphocytes can be generated ex vivo unencumbered by immunoregulation found in vivo . Adoptive transfer of these cells is a promising…”
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The Basic Science of Gene Therapy by Mulligan, Richard C.

“…The development over the past decade of methods for delivering genes to mammalian cells has stimulated great interest in the possibility of treating human…”
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Dystrophin expression in the mdx mouse restored by stem cell transplantation by Kunkel, Louis M, Mulligan, Richard C, Gussoni, Emanuela, Soneoka, Yuko, Strickland, Corinne D, Buzney, Elizabeth A, Khan, Mohamed K, Flint, Alan F

“…The development of cell or gene therapies for diseases involving cells that are widely distributed throughout the body has been severely hampered by the…”
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Neural correlates of inhibitory control in adult attention deficit/hyperactivity disorder: Evidence from the Milwaukee longitudinal sample by Mulligan, Richard C, Knopik, Valerie S, Sweet, Lawrence H, Fischer, Mariellen, Seidenberg, Michael, Rao, Stephen M

“…Abstract Only a few studies have investigated the neural substrate of response inhibition in adult attention deficit hyperactivity disorder (ADHD) using…”
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VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis by Kuo, Calvin J, Tam, Betty Y Y, Wei, Kevin, Rudge, John S, Hoffman, Jana, Holash, Joceyln, Park, Sang-ki, Yuan, Jenny, Hefner, Colleen, Chartier, Cecile, Lee, Jeng-Shin, Jiang, Shelly, Nayak, Nihar R, Kuypers, Frans A, Ma, Lisa, Sundram, Uma, Wu, Grace, Garcia, Joseph A, Schrier, Stanley L, Maher, Jacquelyn J, Johnson, Randall S, Yancopoulos, George D, Mulligan, Richard C

“…Vascular endothelial growth factor (VEGF) exerts crucial functions during pathological angiogenesis and normal physiology. We observed increased hematocrit…”
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Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation by Mostoslavsky, Gustavo, Kotton, Darrell N, Fabian, Attila J, Gray, John T, Lee, Jeng-Shin, Mulligan, Richard C

“…The development of leukemias in several children with severe combined immunodeficiency disease who were transplanted with retroviral vector-transduced bone…”
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The Genetics of Impulsivity: Evidence for the Heritability of Delay Discounting by Anokhin, Andrey P, Grant, Julia D, Mulligan, Richard C, Heath, Andrew C

“…Abstract Background Delay discounting (DD), a decline in the subjective value of reward with increasing delay until its receipt, is an established behavioral…”
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PTH/PTHrP Receptor in Early Development and Indian Hedgehog-Regulated Bone Growth by Lanske, Beate, Karaplis, Andrew C., Lee, Kaechong, Luz, Arne, Vortkamp, Andrea, Pirro, Alison, Karperien, Marcel, Libert H. K. Defize, Ho, Chrystal, Mulligan, Richard C., Abou-Samra, Abdul-Badi, Jüppner, Harald, Segre, Gino V., Kronenberg, Henry M.

“…The PTH/PTHrP receptor binds to two ligands with distinct functions: the calcium-regulating hormone, parathyroid hormone (PTH), and the paracrine factor,…”
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Heterogeneity of the Angiogenic Response Induced in Different Normal Adult Tissues by Vascular Permeability Factor/Vascular Endothelial Growth Factor by Pettersson, Anna, Nagy, Janice A, Brown, Lawrence F, Sundberg, Christian, Morgan, Ellen, Jungles, Steven, Carter, Robert, Krieger, Jose E, Manseau, Eleanor J, Harvey, V Susan, Eckelhoefer, Isabelle A, Feng, Dian, Dvorak, Ann M, Mulligan, Richard C, Dvorak, Harold F

“…Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) is an angiogenic cytokine with potential for the treatment of tissue ischemia. To…”
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Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries by Yen, Laising, Magnier, Maxime, Weissleder, Ralph, Stockwell, Brent R, Mulligan, Richard C

“…We have recently described an RNA-only gene regulation system for mammalian cells in which inhibition of self-cleavage of an mRNA carrying ribozyme sequences…”
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