Search Results - "MULLER, Christo J. F"

Therapeutic effects of an aspalathin-rich green rooibos extract, pioglitazone and atorvastatin combination therapy in diabetic db/db mice by Patel, Oelfah, Muller, Christo J F, Joubert, Elizabeth, Rosenkranz, Bernd, Louw, Johan, Awortwe, Charles

“…Oral therapeutics used to treat type 2 diabetes and cardiovascular disease often fail to prevent the progression of disease and their comorbidities. Rooibos…”
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In vitro comparison of various antioxidants and flavonoids from Rooibos as beta cell protectants against lipotoxicity and oxidative stress-induced cell death by Moens, Céline, Muller, Christo J F, Bouwens, Luc

“…Oxidative stress and lipotoxicity effects on pancreatic β cells play a major role in the pathogenesis of type 2 diabetes (T2D). Flavonoids and antioxidants are…”
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Aspalathin, a natural product with the potential to reverse hepatic insulin resistance by improving energy metabolism and mitochondrial respiration by Mazibuko-Mbeje, Sithandiwe E, Dludla, Phiwayinkosi V, Johnson, Rabia, Joubert, Elizabeth, Louw, Johan, Ziqubu, Khanyisani, Tiano, Luca, Silvestri, Sonia, Orlando, Patrick, Opoku, Andy R, Muller, Christo J F

“…Aspalathin is a rooibos flavonoid with established blood glucose lowering properties, however, its efficacy to moderate complications associated with hepatic…”
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Aspalathus linearis suppresses cell survival and proliferation of enzalutamide-resistant prostate cancer cells via inhibition of c-Myc and stability of androgen receptor by Wang, Bi-Juan, Huang, Shih-Han, Kao, Cheng-Li, Muller, Christo J. F, Wang, Ya-Pei, Chang, Kai-Hsiung, Wen, Hui-Chin, Yeh, Chien-Chih, Shih, Li-Jane, Kao, Yung-Hsi, Huang, Shu-Pin, Li, Chia-Yang, Chuu, Chih-Pin

“…Enzalutamide, a nonsteroidal antiandrogen, significantly prolonged the survival of patients with metastatic castration-resistant prostate cancer (CRPC)…”
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Aspalathin improves glucose and lipid metabolism in 3T3‐L1 adipocytes exposed to palmitate by Mazibuko, Sithandiwe E, Joubert, Elizabeth, Johnson, Rabia, Louw, Johan, Opoku, Andrew R, Muller, Christo J. F

“…SCOPE: Saturated‐free fatty acids, such as palmitate, are associated with insulin resistance. This study aimed to establish if an aspalathin‐enriched green…”
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Beta Cell Mass Restoration in Alloxan-Diabetic Mice Treated with EGF and Gastrin by Song, Imane, Patel, Oelfah, Himpe, Eddy, Muller, Christo J F, Bouwens, Luc

“…One week of treatment with EGF and gastrin (EGF/G) was shown to restore normoglycemia and to induce islet regeneration in mice treated with the diabetogenic…”
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Assessing similarity analysis of chromatographic fingerprints of Cyclopia subternata extracts as potential screening tool for in vitro glucose utilisation by Schulze, Alexandra E., De Beer, Dalene, Mazibuko, Sithandiwe E., Muller, Christo J. F., Roux, Candice, Willenburg, Elize L., Nyunaï, Nyemb, Louw, Johan, Manley, Marena, Joubert, Elizabeth

“…Similarity analysis of the phenolic fingerprints of a large number of aqueous extracts of Cyclopia subternata , obtained by high-performance liquid…”
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The Effect of Phytochemicals and Food Bioactive Compounds on Diabetes by Yagasaki, Kazumi, Muller, Christo J. F.

“…There are three main types of diabetes, namely, type 1 diabetes, type 2 diabetes (T2D), and diabetes in pregnancy (gestational diabetes) [...]…”
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Intestinal Barrier Function and Immune Homeostasis Are Missing Links in Obesity and Type 2 Diabetes Development by Riedel, Sylvia, Pheiffer, Carmen, Johnson, Rabia, Louw, Johan, Muller, Christo J F

“…Noncommunicable diseases, such as type 2 diabetes (T2D), place a burden on healthcare systems worldwide. The rising prevalence of obesity, a major risk factor…”
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Anatomical and pathological considerations in percutaneous vertebroplasty and kyphoplasty: A reappraisal of the vertebral venous system by GROEN, Rob J. M, DU TOIT, Don F, PHILLIPS, Frank M, HOOGLAND, Piet V. J. M, KUIZENGA, Karel, COPPES, Maarten H, MULLER, Christo J. F, GROBBELAAR, Marie, MATTYSSEN, Johannes

“…To focus attention of the clinician on the anatomy and (patho)physiology of the vertebral venous system, so as to offer a tool to better understand and…”
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New Insights into the Efficacy of Aspalathin and Other Related Phytochemicals in Type 2 Diabetes-A Review by Muller, Christo J F, Joubert, Elizabeth, Chellan, Nireshni, Miura, Yutaka, Yagasaki, Kazumi

“…In the pursuit of bioactive phytochemicals as a therapeutic strategy to manage metabolic risk factors for type 2 diabetes (T2D), aspalathin, -glucosyl…”
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Afriplex GRTTM extract attenuates hepatic steatosis in an in vitro model of NAFLD by Gabuza, Kwazi, Mabuda, Thendo I, Patel, Oelfah, Khuboni, Noxolo, van Aarde, Ruzayda, Riedel, Sylvia, Sangweni, Nonhlakanipho F, Windvogel, Shantal, Johnson, Rabia, Muller, Christo J F

“…Currently, it is acknowledged that vitamin E, insulin sensitizers and anti-diabetic drugs are used to manage non-alcoholic fatty liver disease (NAFLD),…”
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Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways by Mazibuko-Mbeje, Sithandiwe E, Dludla, Phiwayinkosi V, Roux, Candice, Johnson, Rabia, Ghoor, Samira, Joubert, Elizabeth, Louw, Johan, Opoku, Andy R, Muller, Christo J F

“…We previously demonstrated that an aspalathin-enriched green rooibos extract (GRE) reversed palmitate-induced insulin resistance in C2C12 skeletal muscle and…”
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Aspalathin Protects the Heart against Hyperglycemia-Induced Oxidative Damage by Up-Regulating Nrf2 Expression by Dludla, Phiwayinkosi V, Muller, Christo J F, Joubert, Elizabeth, Louw, Johan, Essop, M Faadiel, Gabuza, Kwazi B, Ghoor, Samira, Huisamen, Barbara, Johnson, Rabia

“…Aspalathin (ASP) can protect H9c2 cardiomyocytes against high glucose (HG)-induced shifts in myocardial substrate preference, oxidative stress, and apoptosis…”
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Metformin and heart failure–related outcomes in patients with or without diabetes: a systematic review of randomized controlled trials by Dludla, Phiwayinkosi V., Nyambuya, Tawanda M., Johnson, Rabia, Silvestri, Sonia, Orlando, Patrick, Mazibuko-Mbeje, Sithandiwe E., Gabuza, Kwazi B., Mxinwa, Vuyolwethu, Mokgalaboni, Kabelo, Tiano, Luca, Muller, Christo J. F., Louw, Johan, Nkambule, Bongani B.

“…Metformin is considered a safe anti-hyperglycemic drug for patients with type 2 diabetes (T2D); however, information on its impact on heart failure–related…”
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Effect of Human Immunodeficiency Virus on Trace Elements in the Brain by Cilliers, Karen, Muller, Christo J. F.

“…Comorbidities of human immunodeficiency virus (HIV) include HIV-associated neurocognitive disorder (HAND). Changes in the brain due to HIV include atrophy,…”
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Potential regulatory role of PGC-1α within the skeletal muscle during metabolic adaptations in response to high-fat diet feeding in animal models by Mthembu, Sinenhlanhla X. H., Mazibuko-Mbeje, Sithandiwe E., Ziqubu, Khanyisani, Muvhulawa, Ndivhuwo, Marcheggiani, Fabio, Cirilli, Ilenia, Nkambule, Bongani B., Muller, Christo J. F., Basson, Albertus K., Tiano, Luca, Dludla, Phiwayinkosi V.

“…High-fat diet (HFD) feeding in rodents has become an essential tool to critically analyze and study the pathological effects of obesity, including…”
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Coenzyme Q10 Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials by Dludla, Phiwayinkosi V., Orlando, Patrick, Silvestri, Sonia, Marcheggiani, Fabio, Cirilli, Ilenia, Nyambuya, Tawanda M., Mxinwa, Vuyolwethu, Mokgalaboni, Kabelo, Nkambule, Bongani B., Johnson, Rabia, Mazibuko-Mbeje, Sithandiwe E., Muller, Christo J. F., Louw, Johan, Tiano, Luca

“…Evidence from randomized controlled trials (RCTs) suggests that coenzyme Q10 (CoQ10) can regulate adipokine levels to impact inflammation and oxidative stress…”
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Identification of Antidiabetic Compounds from the Aqueous Extract of Sclerocarya birrea Leaves by Maharaj, Vinesh, Ezeofor, Chidinma Christiana, Naidoo Maharaj, Dashnie, Muller, Christo J F, Obonye, Nnini Jennifer

“…Diabetes, a prevalent metabolic condition with a wide range of complications, is fast becoming a global health crisis. Herbal medicine and enhanced extracts…”
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Benzophenone C- and O‑Glucosides from Cyclopia genistoides (Honeybush) Inhibit Mammalian α‑Glucosidase by Beelders, Theresa, Brand, D. Jacobus, de Beer, Dalene, Malherbe, Christiaan J, Mazibuko, Sithandiwe E, Muller, Christo J. F, Joubert, Elizabeth

“…An enriched fraction of an aqueous extract prepared from the aerial parts of Cyclopia genistoides Vent. yielded a new benzophenone di-C,O-glucoside,…”
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