Search Results - "MULLEN, G. P"

Role of the neutrophil in adult respiratory distress syndrome by Windsor, A C, Mullen, P G, Fowler, A A, Sugerman, H J

“…Adult respiratory distress syndrome (ARDS) remains a significant cause of morbidity and mortality in surgical practice. Despite the continued advance of…”
Get more information

Products of the unc-52 gene in Caenorhabditis elegans are homologous to the core protein of the mammalian basement membrane heparan sulfate proteoglycan by ROGALSKI, T. M, WILLIAMS, B. D, MULLEN, G. P, MOERMAN, D. G

“…Mutations in the unc-52 gene of Caenorhabditis elegans affect attachment of the myofilament lattice to the muscle cell membrane. Here, we demonstrate that the…”
Get full text

Solution structure of a viral DNA repair polymerase by Mullen, Gregory P, Maciejewski, Mark W, Shin, Ronald, Pan, Borlan, Marintchev, Assen, Denninger, Adam, Mullen, Mary A, Chen, Kang, Gryk, Michael R

“…DNA polymerase X (Pol X) from the African swine fever virus (ASFV) specifically binds intermediates in the single-nucleotide base-excision repair process, an…”
Get full text

Mutations in the unc-52 Gene Responsible for Body Wall Muscle Defects in Adult Caenorhabditis elegans Are Located in Alternatively Spliced Exons by Rogalski, T. M, Gilchrist, E. J, Mullen, G. P, Moerman, D. G

“…The unc-52 gene in Caenorhabditis elegans produces several large proteins that function in the basement membrane underlying muscle cells. Mutations in this…”
Get full text

Interaction of the bHLH-zip domain of c-Myc with H1-type peptides. Characterization of helicity in the H1 peptides by NMR by DRAEGER, L. J, MULLEN, G. P

“…The carboxyl-terminal 92 residues of c-Myc-92 display site-specific DNA binding specificity for the consensus sequence 5'-CACCACGTGGTG-3' (Blackwell, T. K.,…”
Get full text

Tumor necrosis factor-α blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation by WINDSOR, A. C. J, WALSH, C. J, MULLEN, P. G, COOK, D. J, FISHER, B. J, BLOCHER, C. R, LEEPER-WOODFORD, S. K, SUGERMAN, H. J, FOWLER, A. A

“…Tumor necrosis factor (TNF alpha), both by direct action and by trafficking cells of the immune system, is implicated in cardiopulmonary derangements and…”
Get full text

Substrate and DNA binding to a 50-residue peptide fragment of DNA polymerase I. Comparison with the enzyme by MULLEN, G. P, SHENBAGAMURTHI, P, MILDVAN, A. S

“…The fluorescent nucleotide 2',3'-trinitrophenyl-ATP (TNP-ATP) binds at the triphosphate substrate binding site of the large (Klenow) fragment of DNA polymerase…”
Get full text

Tumor Necrosis Factor-α and Interleukin-6 Selectively Regulate Neutrophil Function in Vitro by Mullen, Patrick G., Windsor, Alastair C.J., Walsh, Ciaran J., Fowler, Alpha A., Sugerman, Harvey J.

“…The neutrophil is an important effector cell of the host response to sepsis. Tumor necrosis factor-α (TNF-α), a cytokine mediator of the septic response, is…”
Get full text

The UNC-112 Gene in Caenorhabditis elegans Encodes a Novel Component of Cell-Matrix Adhesion Structures Required for Integrin Localization in the Muscle Cell Membrane by Rogalski, Teresa M., Mullen, Gregory P., Gilbert, Mary M., Williams, Benjamin D., Moerman, Donald G.

“…Embryos homozygous for mutations in the unc-52, pat-2, pat-3, and unc-112 genes of C. elegans exhibit a similar Pat phenotype. Myosin and actin are not…”
Get full text

Acute lung injury: what have we learned from animal models? by Windsor, A C, Mullen, P G, Fowler, A A

“…In 1950, Carl John Wiggers, philosopher and physiologist, wrote, "Reactions to definite types of stimulation may be observed or recorded, and concealed…”
Get more information

NMR docking of a substrate into the X-ray structure of staphylococcal nuclease by Weber, D J, Gittis, A G, Mullen, G P, Abeygunawardana, C, Lattman, E E, Mildvan, A S

“…The conformation of the staphylococcal nuclease-bound metal-dTdA complex, previously determined by NMR methods [Weber, D.J., Mullen, G.P., Mildvan, A.S. (1991)…”
Get more information

Secondary and tertiary structural changes in gamma delta resolvase: comparison of the wild-type enzyme, the I110R mutant, and the C-terminal DNA binding domain in solution by Pan, B, Deng, Z, Liu, D, Ghosh, S, Mullen, G P

“…gamma delta Resolvase is a site-specific DNA recombinase (M(r) 20.5 kDa) in Escherichia coli that shares homology with a family of bacterial resolvases and…”
Get full text

Metal binding to DNA polymerase I, its large fragment, and two 3',5'-exonuclease mutants of the large fragment by MULLEN, G. P, SERPERSU, E. H, FERRIN, L. J, LOEB, L. A, MILDVAN, A. S

“…DNA polymerase I (Pol I) is an enzyme of DNA replication and repair containing three active sites, each requiring divalent metal ions such as Mg2+ or Mn2+ for…”
Get full text

Domain specific interaction in the XRCC1-DNA polymerase beta complex by Marintchev, A, Robertson, A, Dimitriadis, E K, Prasad, R, Wilson, S H, Mullen, G P

“…XRCC1 (X-ray cross-complementing group 1) is a DNA repair protein that forms complexes with DNA polymerase beta (beta-Pol), DNA ligase III and poly-ADP-ribose…”
Get full text

Critical Residues of the Caenorhabditis elegans unc-2 Voltage-Gated Calcium Channel That Affect Behavioral and Physiological Properties by Mathews, Eleanor A, Garcia, Esperanza, Santi, Celia M, Mullen, Gregory P, Thacker, Colin, Moerman, Donald G, Snutch, Terrance P

“…The Caenorhabditis elegans unc-2 gene encodes a voltage-gated calcium channel alpha1 subunit structurally related to mammalian dihydropyridine-insensitive…”
Get full text

Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5'-deoxyribose phosphate lyase activities by Prasad, R, Beard, W A, Chyan, J Y, Maciejewski, M W, Mullen, G P, Wilson, S H

“…The amino-terminal 8-kDa domain of DNA polymerase beta functions in binding single-stranded DNA (ssDNA), recognition of a 5'-phosphate in gapped DNA…”
Get full text

Determination of the structure of the DNA binding domain of gamma delta resolvase in solution by Liu, T, DeRose, E F, Mullen, G P

“…The DNA binding domain (DBD) of gamma delta resolvase (residues 141-183) is responsible for the interaction of this site-specific DNA recombinase with…”
Get full text

Effect of triiodothyronine on postischemic myocardial function in the isolated heart by Kadletz, Margit, Mullen, Patrick G., Ding, Mai, Wolfe, Luke G., Wechsler, Andrew S.

“…Thyroid dysfunction has been shown to have a significant impact on hemodynamic status and cardiac function. The purpose of this study was to determine the…”
Get full text

Site‐directed mutagenesis analysis of the structural interaction of the single‐strand‐break repair protein, X‐ray cross‐complementing group 1, with DNA polymerase β by Marintchev, Assen, Gryk, Michael R., Mullen, Gregory P.

“…Human X‐ray cross‐complementing group 1 (XRCC1) is a single‐strand DNA break repair protein which forms a base excision repair (BER) complex with DNA…”
Get full text

Solution structure of a dynein motor domain associated light chain by Mullen, Gregory P, King, Stephen M, Wu, Hongwei, Maciejewski, Mark W, Marintchev, Assen, Benashski, Sharon E

“…Dyneins are molecular motors that translocate towards the minus ends of microtubules. In Chlamydomonas flagellar outer arm dynein, light chain 1 (LC1)…”
Get full text