Search Results - "MULICHAK, A. M"

Design of Highly Potent Noncovalent Thrombin Inhibitors That Utilize a Novel Lipophilic Binding Pocket in the Thrombin Active Site by Tucker, Thomas J, Lumma, William C, Mulichak, Anne M, Chen, Zhongguo, Naylor-Olsen, Adel M, Lewis, S. Dale, Lucas, Robert, Freidinger, Roger M, Kuo, Lawrence C

Get full text

Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9-Å resolution by MULICHAK, A. M, TULINSKY, A, RAVICHANDRAN, K. G

“…The crystal structure of human plasminogen kringle 4 (PGK4) has been solved by molecular replacement using the bovine prothrombin kringle 1 (PTK1) structure as…”
Get full text

Crystal Structure of Vancosaminyltransferase GtfD from the Vancomycin Biosynthetic Pathway:  Interactions with Acceptor and Nucleotide Ligands by Mulichak, Anne M, Lu, Wei, Losey, Heather C, Walsh, Christopher T, Garavito, R. Michael

“…The TDP-vancosaminyltransferase GtfD catalyzes the attachment of l-vancosamine to a monoglucosylated heptapeptide intermediate during the final stage of…”
Get full text

The refined structure of the .epsilon.-aminocaproic acid complex of human plasminogen kringle 4 by Wu, Tswei Ping, Padmanabhan, Kaillathe, Tulinsky, A, Mulichak, Anne M

“…The crystallographic structure of the plasminogen kringle 4-epsilon-aminocaproic acid (ACA) complex (K4-ACA) has been solved by molecular replacement…”
Get full text

The crystallographic structure of the protease from human immunodeficiency virus type 2 with two synthetic peptidic transition state analog inhibitors by MULICHAK, A. M, HUI, J. O, TOMASSELLI, A. G, HEINRIKSON, R. L, CURRY, K. A, CHE-SHEN TOMICH, SUVIT THAISRIVONGS, SAWYER, T. K, WATENPAUGH, K. D

“…The crystal structure of human immunodeficiency virus (HIV) type 2 protease has been determined in complexes with peptidic inhibitors Noa-His-Cha psi…”
Get full text

Structure of the UDP-Glucosyltransferase GtfB That Modifies the Heptapeptide Aglycone in the Biosynthesis of Vancomycin Group Antibiotics by Mulichak, Anne M., Losey, Heather C., Walsh, Christopher T., Garavito, R.Michael

“…Background: Members of the vancomycin group of glycopeptide antibiotics have an oxidatively crosslinked heptapeptide scaffold decorated at the hydroxyl groups…”
Get full text

Structure of the TDP-epi-Vancosaminyltransferase GtfA from the Chloroeremomycin Biosynthetic Pathway by Mulichak, Anne M., Losey, Heather C., Lu, Wei, Wawrzak, Zdzislaw, Walsh, Christopher T., Garavito, R. Michael

“…During the biosynthesis of the vancomycin-class antibiotic chloroeremomycin, TDP-epi-vancosaminyltransferase GtfA catalyzes the attachment of 4-epi-vancosamine…”
Get full text

Discovery of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors Incorporating Aminopyridyl Moieties at the P1 Position by Feng, Dong-Mei, Gardell, Stephen J, Lewis, S. Dale, Bock, Mark G, Chen, Zhongguo, Freidinger, Roger M, Naylor-Olsen, Adel M, Ramjit, Harri G, Woltmann, Richard, Baskin, Elizabeth P, Lynch, Joseph J, Lucas, Robert, Shafer, Jules A, Dancheck, Kimberley B, Chen, I-Wu, Mao, Shi-Shan, Krueger, Julie A, Hare, Timothy R, Mulichak, Anne M, Vacca, Joseph P

“…A novel class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position has been discovered. Four of these thrombin inhibitors (13b,c,e and…”
Get full text

Crystal structure of a tetrameric GDP‐d‐mannose 4,6‐dehydratase from a bacterial GDP‐d‐rhamnose biosynthetic pathway by Webb, Nicole A., Mulichak, Anne M., Lam, Joseph S., Rocchetta, Heather L., Garavito, R. Michael

“…d‐Rhamnose is a rare 6‐deoxy monosaccharide primarily found in the lipopolysaccharide of pathogenic bacteria, where it is involved in host–bacterium…”
Get full text

Identification and SAR for a selective, nonpeptidyl thrombin inhibitor by Naylor-Olsen, Adel M., Ponticello, Gerald S., Lewis, S.Dale, Mulichak, Anne M., Chen, Zhonguo, Habecker, Charles N., Phillips, Brian T., Sanders, William M., Tucker, Thomas J., Shafer, Jules A., Vacca, Joseph P.

“…A novel, nonpeptidyl thrombin inhibitor, L-636,619 ( 1), was identified via topological similarity searching over the Merck Corporate Sample Database. X-ray…”
Get full text

The Role of Arginine 120 of Human Prostaglandin Endoperoxide H Synthase-2 in the Interaction with Fatty Acid Substrates and Inhibitors by Rieke, C J, Mulichak, A M, Garavito, R M, Smith, W L

“…Arg-120 is located near the mouth of the hydrophobic channel that forms the cyclooxygenase active site of prostaglandin endoperoxide H synthases (PGHSs)-1 and…”
Get full text

Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors by Thaisrivongs, Suvit, Tomich, Paul K, Watenpaugh, Keith D, Chong, Kong-Teck, Howe, W. Jeffrey, Yang, Chih-Ping, Strohbach, Joseph W, Turner, Steve R, McGrath, James P

Get full text

Crystallization and preliminary diffraction data of Escherichia coli ADP glucose pyrophosphorylase by Mulichak, A M, Skrzypczak-Jankun, E, Rydel, T J, Tulinsky, A, Preiss, J

“…ADP glucose pyrophosphorylase from Escherichia coli has been crystallized from polyethylene glycol 8000 solutions. The crystals are: orthorhombic, a = 155(2),…”
Get full text

Human plasminogen kringle 4. Crystallization and preliminary diffraction data of two different crystal forms by MULICHAK, A. M, PARK, C. H, TULINSKY, A, PETROS, A. M, LLINAS, M

“…Human plasminogen kringle 4 has been crystallized in two different crystal forms: monoclinic, a = 32.78(3), b = 49.17(2), c = 46.27(3) A, beta = 100.67…”
Get full text

Crystal structure of SQD1, an enzyme involved in the biosynthesis of the plant sulfolipid headgroup donor UDP-sulfoquinovose by Mulichak, A.M, Theisen, M.J, Essigmann, B, Benning, C, Garavito, R.M

“…The SQD1 enzyme is believed to be involved in the biosynthesis of the sulfoquinovosyl headgroup of plant sulfolipids, catalyzing the transfer of SO(3)- to…”
Get full text

Use of Medium-Sized Cycloalkyl Rings To Enhance Secondary Binding: Discovery of a New Class of Human Immunodeficiency Virus (HIV) Protease Inhibitors by Romines, Karen R, Watenpaugh, Keith D, Tomich, Paul K, Howe, W. Jeffrey, Morris, Jeanette K, Lovasz, Kristine D, Mulichak, Anne M, Finzel, Barry C, Lynn, Janet C

“…A unique strategy for the enhancement of secondary binding of an inhibitor to an enzyme has been demonstrated in the design of new human immunodeficiency virus…”
Get full text

Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors by Thaisrivongs, Suvit, Watenpaugh, Keith D, Howe, W. Jeffrey, Tomich, Paul K, Dolak, Lester A, Chong, Kong-Teck, Tomich, Che-Shen C, Tomasselli, Alfredo G, Turner, Steve R

“…The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibitors have limited their utility as potential therapeutic agents…”
Get full text

Peroxidase Activity in Prostaglandin Endoperoxide H Synthase-1 Occurs with a Neutral Histidine Proximal Heme Ligand by Seibold, Steve A, Cerda, Jose F, Mulichak, Anne M, Song, Inseok, Garavito, R. Michael, Arakawa, Toshiya, Smith, William L, Babcock, Gerald T

“…Prostaglandin endoperoxide H synthases-1 and -2 (PGHS-1 and -2) convert arachidonic acid to prostaglandin H2 (PGH2), the committed step in prostaglandin and…”
Get full text

Structure of the lysine-fibrin binding subsite of human plasminogen kringle 4 by Mulichak, A M, Tulinsky, A

“…Human plasminogen kringle 4, which crystallizes in the orthorhombic system a = 32.15(2), b = 49.01(2), c = 49.04(3) A, space group P2(1)2(1)2(1), four…”
Get more information

The structure of mammalian hexokinase-1 by Mulichak, Anne M, Garavito, R. Michael, Wilson, John E, Padmanabhan, Kaillathe

“…We have determined the structures of the glucose-6-phosphate (G6P)-inhibitable 100,000 Mr Type I hexokinase from rat and the G6P-sensitive 50,000 Mr hexokinase…”
Get full text