Search Results - "MULHOLLAND, P. J"

Technical and implementation issues in using next-generation sequencing of cancers in clinical practice by Ulahannan, D, Kovac, M B, Mulholland, P J, Cazier, J-B, Tomlinson, I

“…Next-generation sequencing (NGS) of cancer genomes promises to revolutionise oncology, with the ability to design and use targeted drugs, to predict outcome…”
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Inter-biome comparison of factors controlling stream metabolism by Mulholland, P. J., Fellows, C. S., Tank, J. L., Grimm, N. B., Webster, J. R., Hamilton, S. K., Martí, E., Ashkenas, L., Bowden, W. B., Dodds, W. K., Mcdowell, W. H., Paul, M. J., Peterson, B. J.

“…1. We studied whole‐ecosystem metabolism in eight streams from several biomes in North America to identify controls on the rate of stream metabolism over a…”
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Cross-stream comparison of substrate-specific denitrification potential by Findlay, S. E. G., Mulholland, P. J., Hamilton, S. K., Tank, J. L., Bernot, M. J., Burgin, A. J., Crenshaw, C. L., Dodds, W. K., Grimm, N. B., McDowell, W. H., Potter, J. D., Sobota, D. J.

“…Headwater streams have a demonstrated ability to denitrify a portion of their nitrate (NO₃⁻) load but there has not been an extensive consideration of where in…”
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Endogenous And Exogenous Control Of Ecosystem Function: N Cycling In Headwater Streams by Valett, H.M, Thomas, S.A, Mulholland, P.J, Webster, J.R, Dahm, C.N, Fellows, C.S, Crenshaw, C.L, Peterson, C.G

“…Allochthonous inputs act as resource subsidies to many ecosystems, where they exert strong influences on metabolism and material cycling. At the same time,…”
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Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N -methyl- d -asparate-type glutamate receptors by Butler, T.R, Self, R.L, Smith, K.J, Sharrett-Field, L.J, Berry, J.N, Littleton, J.M, Pauly, J.R, Mulholland, P.J, Prendergast, M.A

“…Abstract Excess glutamate release and stimulation of post-synaptic glutamatergic receptors have been implicated in the pathophysiology of many neurological…”
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Control of Nitrogen Export from Watersheds by Headwater Streams by Peterson, Bruce J., Wollheim, Wilfred M., Mulholland, Patrick J., Webster, Jackson R., Meyer, Judy L., Tank, Jennifer L., Marti, Eugènia, Bowden, William B., Valett, H. Maurice, Hershey, Anne E., McDowell, William H., Dodds, Walter K., Hamilton, Stephen K., Gregory, Stanley, Morrall, Donna D.

“…A comparative15N-tracer study of nitrogen dynamics in headwater streams from biomes throughout North America demonstrates that streams exert control over…”
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Etoposide and Cisplatin/Etoposide, Methotrexate, and Actinomycin D (EMA) Chemotherapy for Patients With High-Risk Gestational Trophoblastic Tumors Refractory to EMA/Cyclophosphamide and Vincristine Chemotherapy and Patients Presenting With Metastatic Placental Site Trophoblastic Tumors by NEWLANDS, E. S, MULHOLLAND, P. J, HOLDEN, L, SECKL, M. J, RUSTIN, G. J. S

“…To evaluate the results of etoposide, cisplatin/etoposide, methotrexate, and actinomycin D (EP/EMA) chemotherapy in patients with gestational trophoblastic…”
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Pre-clinical and clinical study of QC12, a water-soluble, pro-drug of quercetin by Mulholland, P. J., Ferry, D. R., Anderson, D., Hussain, S. A., Young, A. M., Cook, J. E., Hodgkin, E., Seymour, L. W., Kerr, D. J.

“…Background: Quercetin is a naturally occurring flavonoid with many biological activities including inhibition of a number of tyrosine kinases. A phase I,…”
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Nutrient Uptake and Mineralization during Leaf Decay in Streams - a Model Simulation by Webster, J. R., Newbold, J. D., Thomas, S. A., Valett, H. M., Mulholland, P. J.

“…We developed a stoichiometrically explicit computer model to examine how heterotrophic uptake of nutrients and microbial mineralization occurring during the…”
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A Cross-System Comparison of Bacterial and Fungal Biomass in Detritus Pools of Headwater Streams by Findlay, S., J. Tank, S. Dye, Valett, H. M., Mulholland, P. J., McDowell, W. H., Johnson, S. L., Hamilton, S. K., J. Edmonds, Dodds, W. K., Bowden, W. B.

“…The absolute amount of microbial biomass and relative contribution of fungi and bacteria are expected to vary among types of organic matter (OM) within a…”
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Decadal Changes in Potassium, Calcium, and Magnesium in a Deciduous Forest Soil by Johnson, D.W, Todd, D.E. Jr, Trettin, C.F, Mulholland, P.J

“…Decadal changes in soil exchangeable K+, Ca2+, and Mg2+ concentrations and contents from 1972 to 2004 in eight intensively monitored plots on Walker Branch…”
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Inhibition of glutamate transporters couples to Kv4.2 dephosphorylation through activation of extrasynaptic NMDA receptors by Mulholland, P.J, Chandler, L.J

“…Abstract Activation of glutamate receptors is known to modulate K+ channel surface trafficking, phosphorylation, and function, and increasing evidence has…”
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Brain-derived neurotrophic factor activation of extracellular signal-regulated kinase is autonomous from the dominant extrasynaptic NMDA receptor extracellular signal-regulated kinase shutoff pathway by Mulholland, P.J, Luong, N.T, Woodward, J.J, Chandler, L.J

“…Abstract NMDA receptors bidirectionally modulate extracellular signal-regulated kinase (ERK) through the coupling of synaptic NMDA receptors to an ERK…”
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The Impact of Vertical Wind Shear on the Outcome of Interactions Between Squall Lines and Cities by Naylor, J., Mulholland, J. P.

“…This study examines how organized lines of deep convective storms can be impacted by a large city with a prominent urban heat island and how low‐level…”
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Coupling Nutrient Uptake and Energy Flow in Headwater Streams by Fellows, C. S, Valett, H. M, Dahm, C. N, Mulholland, P. J, Thomas, S. A

“…Nutrient cycling and energy flow in ecosystems are tightly linked through the metabolic processes of organisms. Greater uptake of inorganic nutrients is…”
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Top-down and bottom-up control of stream periphyton: effects of nutrients and herbivores by Rosemond, Amy D., Mulholland, Patrick J., Elwood, Jerry W.

“…We conducted two experiments to determine the relative effects of herbivory and nutrients on an algal community in Walker Branch, a stream having effectively…”
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Preoperative Mitomycin, Ifosfamide, and Cisplatin Followed by Esophagectomy in Squamous Cell Carcinoma of the Esophagus: Pathologic Complete Response Induced by Chemotherapy Leads to Long-Term Survival by DARNTON, S. J, ARCHER, V. R, STOCKEN, D. D, MULHOLLAND, P. J, CASSON, A. G, FERRY, D. R

“…Squamous cell carcinoma of the esophagus remains an aggressive disease with a poor prognosis, even after curative-intent surgery. This article analyzes the…”
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Influence of Drainage Basin Topography and Elevation on Carbon Dioxide and Methane Supersaturation of Stream Water by Jones, Jeremy B., Mulholland, Patrick J.

“…The partial pressures of CO2 (pCO2) and CH4 (pCH4) in streams are not only governed by instream processes, but also by transformations occurring in soil and…”
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Evidence That Hyporheic Zones Increase Heterotrophic Metabolism and Phosphorus Uptake in Forest Streams by Mulholland, Patrick J., Marzolf, Erich R., Webster, Jackson R., Hart, Deborah R., Hendricks, Susan P.

“…We used nondisruptive, whole-stream methods to measure hydraulic characteristics, ecosytem metabolism, and phosphorus cycling in the west fork of Walker Branch…”
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Thiamine deficiency in the pathogenesis of chronic ethanol-associated cerebellar damage in vitro by Mulholland, P.J., Self, R.L., Stepanyan, T.D., Little, H.J., Littleton, J.M., Prendergast, M.A.

“…Nutritional deficiencies associated with long-term ethanol consumption may cause neuronal damage in ethanol-dependent individuals. Thiamine deficiency, in…”
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