Differential Allelic Distribution of V-ets Erythroblastosis Virus E26 Oncogene Homolog2 (ETS2) Functional Polymorphisms in Different Group of Patients

V-ets erythroblastosis virus E26 oncogene homolog2 (ETS2), located at chromosome 21 and overexpressed in Down's syndrome (DS), has known cancer regulatory functions. Because leukemia is of common occurrence in DS subjects while solid tumors are rare, we have explored the role of ETS2 functional...

Full description

Saved in:

Bibliographic Details
Published in:	Gene expression Vol. 15; no. 2; pp. 61 - 73
Main Authors:	CHATTERJEE, ARPITA, DUTTA, SAMIKSHAN, MUKHERJEE, SANJIT, MUKHERJEE, NUPUR, CHANDRA, SHARMILA, MUKHERJEE, ASHIS, SINHA, SWAGATA, PANDA, CHINMAY KUMAR, CHAUDHURI, KEYA, MUKHOPADYAY, KANCHAN
Format:	Journal Article
Language:	English
Published:	Elmsford, NY Cognizant Communication Corporation 01-02-2011 Xia & He Publishing
Subjects:	Acute Lymphoblastic Leukemia (all) Algorithms Amino acids Apoptosis Asian Continental Ancestry Group - genetics Base Sequence Binding sites Breast Cancer Cancer Cancer research Case-Control Studies Cell cycle Child Chromosome 21 Chromosomes Cohort Studies Computational Biology Down Syndrome - complications Down Syndrome - genetics Down's Syndrome Ets-2 protein European Continental Ancestry Group - genetics Female Gene Frequency Gene polymorphism Genes Genetic testing Genotyping Haplotypes Humans India Leukemia Leukemia - etiology Leukemia - genetics Linkage Disequilibrium Male Malignancy Medical research MicroRNAs Minority & ethnic groups Molecular Sequence Data Oncogenes Oral Cancer Patients Polymorphism, Single Nucleotide - physiology Proteins Proto-Oncogene Protein c-ets-2 - chemistry Proto-Oncogene Protein c-ets-2 - genetics Rs1051420 Rs1051425 Rs457705 Rs461155 Single-nucleotide polymorphism Solid tumors Tumors India Europe
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	V-ets erythroblastosis virus E26 oncogene homolog2 (ETS2), located at chromosome 21 and overexpressed in Down's syndrome (DS), has known cancer regulatory functions. Because leukemia is of common occurrence in DS subjects while solid tumors are rare, we have explored the role of ETS2 functional genetic polymorphisms in this differential oncological development. In silico methods were used for identifying deleterious SNPs, tagged SNPs, and linkage disequilibrium followed by genotyping of 14 SNPs in Indo-Caucasoid individuals (N = 668). Significantly different allelic frequencies for rs457705, rs1051420, and rs1051425 were observed in Indian controls (N = 149) compared to other ethnic groups. A heterozygous "T" insertion, between chromosomal contig positions 40195541 and 40195542, was observed in DS subjects and their parents. rs461155 showed significant allelic and genotypic association in breast and oral cancer patients. Significantly higher occurrence of G-C haplotype (rs461155-rs1051425) was also observed in these patients compared to DS and leukemic patients. This is the first report on this type of allelic discrimination pattern of ETS2 under different disease conditions. From the data obtained it may be proposed that allelic discrimination of deleterious SNPs in ETS2 may play a regulatory role in the differential development of malignancy in DS subjects.
Bibliography:	1052-2166(20110201)15:2L.61;1- ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 Present address: Dongguk University, School of Medicine, Department of Anatomy, Gyeongju, South Korea.
ISSN:	1052-2166 1555-3884
DOI:	10.3727/105221611X12973615737541