Search Results - "MUKHERJI, Bijay"

Immunology of melanoma by Mukherji, Bijay, MD

“…Abstract It can be safely said that human melanomas are immunogenic. Virtually all the major principles of “tumor immunology” have been experimentally…”
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Determinant Spreading Associated with Clinical Response in Dendritic Cell-based Immunotherapy for Malignant Melanoma by BUTTERFIELD, Lisa H, RIBAS, Antoni, COCHRAN, Alistair J, GLASPY, John A, ECONOMOU, James S, DISSETTE, Vivian B, AMARNANI, Saral N, VU, Huong T, OSEGUERA, Denise, WANG, He-Jing, ELASHOFF, Robert M, MCBRIDE, William H, MUKHERJI, Bijay

“…Purpose: The purpose of this study was to determine the toxicity and immunological effects of three different doses and two routes of administration of…”
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Medical Education: The Hot Seat by Pal, Ranabir, Kumar, Raman, Pal, Shrayan, Mukherji, Bijay, Debabrata, Sarbapalli

“…Medical science has eventually metamorphosed from ′Knowledge based′ to ′Skill based′ applied social science. So, the age-old traditional courses and…”
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Inhibition of c-Jun N-terminal kinase rescues influenza epitope-specific human cytolytic T lymphocytes from activation-induced cell death by Mehrotra, Shikhar, Chhabra, Arvind, Hegde, Upendra, Chakraborty, Nitya G., Mukherji, Bijay

“…Cytolytic T lymphocytes (CTL) play an important role in defense against viral infections. Following clonal expansion and effector functions, a vast majority of…”
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Obstacles to and opportunities for more effective peptide-based therapeutic immunization in human melanoma by Ray, Swagatam, PhD, Chhabra, Arvind, PhD, Mehrotra, Shikhar, PhD, Chakraborty, Nitya G., PhD, Ribas, Antoni, MD, Economou, James, MD, PhD, Mukherji, Bijay, MD

“…Abstract Melanoma cells can play a number of tricks to evade the host immune response. They can make themselves invisible to cells of the immune system poised…”
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Cross‐presentation of a human tumor antigen delivered to dendritic cells by HSV VP22‐mediated protein translocation by Chhabra, Arvind, Mehrotra, Shikhar, Chakraborty, Nitya G., Mukherji, Bijay, Dorsky, David I.

“…Dendritic cells (DC) capture antigens from apoptotic and/or necrotic tumor cells and cross‐present them to T cells, and various ways of delivering tumor…”
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Suppression of inducible CD4 regulatory cells by MHC class I-restricted human tumor epitope specific TCR engineered multifunctional CD4 T Cells by Chhabra, Arvind, Mukherji, Bijay

“…Abstract Regulatory T cells (Treg) can interfere with the generation and function of anti-tumor immune effectors. Accordingly, ways that could block Treg…”
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Death receptor-independent activation-induced cell death in human melanoma antigen-specific MHC class I-restricted TCR-engineered CD4 T cells by Chhabra, Arvind, Mukherji, Bijay

“…Engaging CD4 T cells in antitumor immunity has been quite challenging, especially in an Ag-specific manner, because most human solid tumors usually do not…”
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Current status of chimeric antigen receptor engineered T cell-based and immune checkpoint blockade-based cancer immunotherapies by Hegde, Upendra P., Mukherji, Bijay

“…Adoptive cell therapies with chimeric antigen receptor (CAR) engineered T cells (CAR-T) and immune checkpoint inhibition (ICI)-based cancer immunotherapies…”
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Antigen presentation by MART‐1 adenovirus‐transduced interleukin‐10‐polarized human monocyte‐derived dendritic cells by Mehrotra, Shikhar, Chhabra, Arvind, Chakraborty, Abolokita, Chattopadhyay, Subhasis, Slowik, Mark, Stevens, Robert, Zengou, Ryan, Mathias, Clinton, Butterfield, Lisa H., Dorsky, David I., Economou, James S., Mukherji, Bijay, Chakraborty, Nitya G.

“…Summary Dendritic cells (DC) play critical roles in generating an immune response and in inducing tolerance. Diverse microenvironmental factors can ‘polarize’…”
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Activation induced cell death (AICD) of human melanoma antigen-specific TCR engineered CD8 T cells involves JNK, Bim and p53 by Chhabra, Arvind, Mukherji, Bijay, Batra, Deepika

“…Adoptive cancer immunotherapy (ACT) with transgenic T cell receptor (TCR) engineered (TCReng) anti-tumor T cells has produced encouraging results, however,…”
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Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma by CHODON, Thinle, COMIN-ANDUIX, Begoña, MCCANNEL, Tara A, ISHIYAMA, Akira, CZERNIN, Johannes, RADU, Caius G, XIAOYAN WANG, GJERTSON, David W, COCHRAN, Alistair J, CORNETTA, Kenneth, WONG, Deborah J. L, KAPLAN-LEFKO, Paula, CHMIELOWSKI, Bartosz, HAMID, Omid, SAMLOWSKI, Wolfram, COHEN, Peter A, DANIELS, Gregory A, MUKHERJI, Bijay, LILI YANG, ZACK, Jerome A, KOHN, Donald B, HEATH, James R, GLASPY, John A, KOYA, Richard C, WITTE, Owen N, BALTIMORE, David, ECONOMOU, James S, RIBAS, Antoni, ZHONGQI WU, AUERBACH, Martin, NG, Charles, AVRAMIS, Earl, SEJA, Elizabeth, VILLANUEVA, Arturo

“…It has been demonstrated that large numbers of tumor-specific T cells for adoptive cell transfer (ACT) can be manufactured by retroviral genetic engineering of…”
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Knockdown of T‐bet expression in Mart‐1 27–35 ‐specific T ‐cell‐receptor‐engineered human CD 4 +  CD25 − and CD 8 + T cells attenuates effector function by Jha, Sidharth S., Chakraborty, Nitya G., Singh, Prashant, Mukherji, Bijay, Dorsky, David I.

“…Gene transfer to create tumour epitope‐specific cytolytic T cells for adoptive immunotherapy of cancer remains an area of active inquiry. When the Mart‐1 27–35…”
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Abstract 3569: Transcriptional signatures in human melanoma epitope MART-127-35 specific TCR-engineered T cells by Singh, Prashant, Chakraborty, Nitya G., Farooq, Umar, Hegde, Upendra P., Everson, Richard, Dorsky, David I., Mukherji, Bijay

“…Adoptive Cell Therapies (ACT) with T cell receptor-engineered (TCReng) T cells have shown promising results. Unfortunately, for a fuller understanding of their…”
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Abstract 4982: Comparison of T cell responses to a melanoma-related antigen in elderly and young melanoma patients by Chakraborty, Nitya G., Singh, Prashant, Dadras, Soheil S., Mukherji, Bijay, Hegde, Upendra P.

“…It is widely believed that a hypo-and/or dysfunctional state in T cells in the elderly is a negative factor in immune defense against cancer. Accordingly,…”
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Regulatory T cells and tumor immunity by CHATTOPADHYAY, Subhasis, CHAKRABORTY, Nitya G, MUKHERJI, Bijay

“…Central deletion of "self-reactive" T cells has been the textbook paradigm for inducing "self-tolerance" in the periphery and the concept of a role of T…”
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Stimulatory and inhibitory maturation of human macrophage-derived dendritic cells by Chakraborty, A, Li, L, Chakraborty, N G, Mukherji, B

“…Circulating human macrophages are often used to generate dendritic cells (DCs) by culturing them in granulocyte macrophage-colony stimulating factor (GM-CSF)…”
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Silencing of endogenous IL-10 in human dendritic cells leads to the generation of an improved CTL response against human melanoma associated antigenic epitope, MART-127–35 by Chhabra, Arvind, Chakraborty, Nitya G, Mukherji, Bijay

“…Abstract Dendritic cells (DC) present antigenic epitopes to and activate T cells. They also polarize the ensuing T cell response to Th1 or Th2 type response,…”
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Knockdown of T‐bet expression in Mart‐127–35‐specific T‐cell‐receptor‐engineered human CD4+ CD25− and CD8+ T cells attenuates effector function by Jha, Sidharth S., Chakraborty, Nitya G., Singh, Prashant, Mukherji, Bijay, Dorsky, David I.

“…Summary Gene transfer to create tumour epitope‐specific cytolytic T cells for adoptive immunotherapy of cancer remains an area of active inquiry. When the…”
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Analyses of the immunologically relevant gene transcript by qRT-PCR in primary cutaneous melanoma by the young and the elderly by Hegde, Upendra P., Dadras, Soheil Sam, Kerr, Phil, Chakraborty, Nitya, grant-Kels, Jane, Mukherji, Bijay

“…Abstract only e21135 Background: To understand the dynamics of anti tumor immune responses (IR) in the setting of the ageing immune system, we examined…”
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