Search Results - "MUHAMMAD ZAEEM NOMAN"

Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges by Noman, Muhammad Zaeem, Hasmim, Meriem, Lequeux, Audrey, Xiao, Malina, Duhem, Caroline, Chouaib, Salem, Berchem, Guy, Janji, Bassam

“…Initially believed to be a disease of deregulated cellular and genetic expression, cancer is now also considered a disease of the tumor microenvironment. Over…”
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Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis by Kiweler, Nicole, Delbrouck, Catherine, Pozdeev, Vitaly I., Neises, Laura, Soriano-Baguet, Leticia, Eiden, Kim, Xian, Feng, Benzarti, Mohaned, Haase, Lara, Koncina, Eric, Schmoetten, Maryse, Jaeger, Christian, Noman, Muhammad Zaeem, Vazquez, Alexei, Janji, Bassam, Dittmar, Gunnar, Brenner, Dirk, Letellier, Elisabeth, Meiser, Johannes

“…Metastasis is the most common cause of death in cancer patients. Canonical drugs target mainly the proliferative capacity of cancer cells, which leaves…”
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The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment by Reynders, Nathan, Abboud, Dayana, Baragli, Alessandra, Noman, Muhammad Zaeem, Rogister, Bernard, Niclou, Simone P, Heveker, Nikolaus, Janji, Bassam, Hanson, Julien, Szpakowska, Martyna, Chevigné, Andy

“…First thought to orchestrate exclusively leukocyte trafficking, chemokines are now acknowledged for their multiple roles in the regulation of cell…”
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The 'Holy Grail' in Immuno-Oncology: AC BioScience SA is Aiming to Potentiate Anti-PD-1 Therapy Efficacy through Tumor Cell Conditioning Strategy by Schläpfer, Andreas, Auclair, Christian, Janji, Bassam, Karam, Manale, Zaeem Noman, Muhammad

“…AC BioScience is a Swiss biotech company based at the EPFL Innovation Park and Biopôle, dedicated to developing groundbreaking therapies to fight a range of…”
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Gene expression profiling identifies microphthalmia-associated transcription factor (MITF) and Dickkopf-1 (DKK1) as regulators of microenvironment-driven alterations in melanoma phenotype by Hartman, Mariusz L, Talar, Beata, Noman, Muhammad Zaeem, Gajos-Michniewicz, Anna, Chouaib, Salem, Czyz, Malgorzata

“…The diversity of functional phenotypes observed within a tumor does not exclusively result from intratumoral genetic heterogeneity but also from the response…”
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Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia by Noman, Muhammad Zaeem, Hasmim, Meriem, Messai, Yosra, Terry, Stéphane, Kieda, Claudine, Janji, Bassam, Chouaib, Salem

“…The tumor microenvironment is a complex system, playing an important role in tumor development and progression. Besides cellular stromal components,…”
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Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints by Lequeux, Audrey, Noman, Muhammad Zaeem, Xiao, Malina, Sauvage, Delphine, Van Moer, Kris, Viry, Elodie, Bocci, Irene, Hasmim, Meriem, Bosseler, Manon, Berchem, Guy, Janji, Bassam

“…Compared to traditional therapies, such as surgery, radio-chemotherapy, or targeted approaches, immunotherapies based on immune checkpoint blockers (ICBs) have…”
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Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy by Lequeux, Audrey, Noman, Muhammad Zaeem, Xiao, Malina, Van Moer, Kris, Hasmim, Meriem, Benoit, Alice, Bosseler, Manon, Viry, Elodie, Arakelian, Tsolere, Berchem, Guy, Chouaib, Salem, Janji, Bassam

“…Hypoxia is a key factor responsible for the failure of therapeutic response in most solid tumors and promotes the acquisition of tumor resistance to various…”
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Targeting autophagy inhibits melanoma growth by enhancing NK cells infiltration in a CCL5-dependent manner by Mgrditchian, Takouhie, Arakelian, Tsolere, Paggetti, Jérôme, Noman, Muhammad Zaeem, Viry, Elodie, Moussay, Etienne, Van Moer, Kris, Kreis, Stephanie, Guerin, Coralie, Buart, Stephanie, Robert, Caroline, Borg, Christophe, Vielh, Philippe, Chouaib, Salem, Berchem, Guy, Janji, Bassam

“…While blocking tumor growth by targeting autophagy is well established, its role on the infiltration of natural killer (NK) cells into tumors remains unknown…”
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Hypoxia-Inducible miR-210 Regulates the Susceptibility of Tumor Cells to Lysis by Cytotoxic T Cells by ZAEEM NOMAN, Muhammad, BUART, Stéphanie, ROMERO, Pedro, KETARI, Sami, JANJI, Bassam, MARI, Bernard, MAMI-CHOUAIB, Fathia, CHOUAIB, Salem

“…Hypoxia in the tumor microenvironment plays a central role in the evolution of immune escape mechanisms by tumor cells. In this study, we report the definition…”
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Targeting hypoxia at the forefront of anticancer immune responses by Noman, Muhammad Zaeem, Chouaib, Salem

“…Hypoxia influences immune checkpoint receptors and their respective ligands. In support, we recently demonstrated that hypoxia selectively upregulates…”
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The immune checkpoint ligand PD-L1 is upregulated in EMT-activated human breast cancer cells by a mechanism involving ZEB-1 and miR-200 by Noman, Muhammad Zaeem, Janji, Bassam, Abdou, Abderemane, Hasmim, Meriem, Terry, Stéphane, Tan, Tuan Zea, Mami-Chouaib, Fathia, Thiery, Jean Paul, Chouaib, Salem

“…PD-L1 expression and regulation by mesenchymal tumor cells remain largely undefined. Here, we report that among different EMT-activated MCF7 human breast…”
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Blocking Hypoxia-Induced Autophagy in Tumors Restores Cytotoxic T-Cell Activity and Promotes Regression by MUHAMMAD ZAEEM NOMAN, JANJI, Bassam, CHOUAIB, Salem, KAMINSKA, Bozena, MOER, Kris Van, PIERSON, Sandrine, PRZANOWSKI, Piotr, BUART, Stéphanie, BERCHEM, Guy, ROMERO, Pedro, MAMI-CHOUAIB, Fathia

“…The relationship between hypoxic stress, autophagy, and specific cell-mediated cytotoxicity remains unknown. This study shows that hypoxia-induced resistance…”
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Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia by Baginska, Joanna, Viry, Elodie, Berchem, Guy, Poli, Aurélie, Noman, Muhammad Zaeem, van Moer, Kris, Medves, Sandrine, Zimmer, Jacques, Oudin, Anaïs, Niclou, Simone P., Bleackley, R. Chris, Goping, Ing Swie, Chouaib, Salem, Janji, Bassam

“…Recent studies demonstrated that autophagy is an important regulator of innate immune response. However, the mechanism by which autophagy regulates natural…”
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Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transfer by Berchem, Guy, Noman, Muhammad Zaeem, Bosseler, Manon, Paggetti, Jerome, Baconnais, Sonia, Le cam, Eric, Nanbakhsh, Arash, Moussay, Etienne, Mami-Chouaib, Fathia, Janji, Bassam, Chouaib, Salem

“…Tumor-derived microvesicles (TD-MVs) are key mediators which are shed by cancer cells and can sensitize neighboring cells in the tumor microenvironment. TD-MVs…”
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Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell―Mediated Lysis by AKALAY, Intissar, JANJI, Bassam, SABBAH, Michele, TUAN ZEA TAN, HERR KEIRA, Joan, TSANG YING HUNG, Nicole, THIERY, Jean Paul, MAMI-CHOUAIB, Fathia, CHOUAIB, Salem, HASMIM, Meriem, ZAEEM NOMAN, Muhammad, ANDRE, Fabrice, DE CREMOUX, Patricia, BERTHEAU, Philippe, BADOUAL, Cécile, VIELH, Philippe, LARSEN, Annette K

“…Epithelial-to-mesenchymal transition (EMT) mediates cancer cell invasion, metastasis, and drug resistance, but its impact on immune surveillance has not been…”
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Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel–Lindau Gene Mutation Status by Messai, Yosra, Gad, Sophie, Noman, Muhammad Zaeem, Le Teuff, Gwenael, Couve, Sophie, Janji, Bassam, Kammerer, Solenne Florence, Rioux-Leclerc, Nathalie, Hasmim, Meriem, Ferlicot, Sophie, Baud, Véronique, Mejean, Arnaud, Mole, David Robert, Richard, Stéphane, Eggermont, Alexander M.M, Albiges, Laurence, Mami-Chouaib, Fathia, Escudier, Bernard, Chouaib, Salem

“…Abstract Background Clear cell renal cell carcinomas (ccRCC) frequently display a loss of function of the von Hippel–Lindau ( VHL ) gene. Objective To…”
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Hypoxia promotes tumor growth in linking angiogenesis to immune escape by Chouaib, Salem, Messai, Yosra, Couve, Sophie, Escudier, Bernard, Hasmim, Meriem, Noman, Muhammad Zaeem

“…Despite the impressive progress over the past decade, in the field of tumor immunology, such as the identification of tumor antigens and antigenic peptides,…”
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ITPR1 protects renal cancer cells against natural killer cells by inducing autophagy by Messai, Yosra, Noman, Muhammad Zaeem, Hasmim, Meriem, Janji, Bassam, Tittarelli, Andrés, Boutet, Marie, Baud, Véronique, Viry, Elodie, Billot, Katy, Nanbakhsh, Arash, Ben Safta, Thouraya, Richon, Catherine, Ferlicot, Sophie, Donnadieu, Emmanuel, Couve, Sophie, Gardie, Betty, Orlanducci, Florence, Albiges, Laurence, Thiery, Jerome, Olive, Daniel, Escudier, Bernard, Chouaib, Salem

“…Clear cell renal cell carcinomas (RCC) frequently display inactivation of von Hippel-Lindau (VHL) gene leading to increased level of hypoxia-inducible factors…”
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Targeting Cytoprotective Autophagy to Enhance Anticancer Therapies by Xiao, Malina, Benoit, Alice, Hasmim, Meriem, Duhem, Caroline, Vogin, Guillaume, Berchem, Guy, Noman, Muhammad Zaeem, Janji, Bassam

“…Autophagy is a highly regulated multi-step process that occurs at the basal level in almost all cells. Although the deregulation of the autophagy process has…”
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