Search Results - "MUCHHAL, Umesh S"

Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody by Chu, Seung Y., PhD, Horton, Holly M., PhD, Pong, Erik, MS, Leung, Irene W.L., PhD, Chen, Hsing, MS, Nguyen, Duc-Hanh, BS, Bautista, Cristina, BS, Muchhal, Umesh S., PhD, Bernett, Matthew J., PhD, Moore, Gregory L., PhD, Szymkowski, David E., PhD, Desjarlais, John R., PhD

“…Background Sequestration of IgE to prevent its binding to high-affinity IgE receptor FcϵRI on basophils and mast cells is an effective therapy for allergic…”
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A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens by Moore, Gregory L., Bautista, Cristina, Pong, Erik, Nguyen, Duc-Hanh T., Jacinto, Jonathan, Eivazi, Araz, Muchhal, Umesh S., Karki, Sher, Chu, Seung Y., Lazar, Greg A.

“…Bispecific antibodies based on full-length antibody structures are more optimal than fragment-based formats because they benefit from the favorable properties…”
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Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function by Tai, Yu-Tzu, Horton, Holly M., Kong, Sun-Young, Pong, Erik, Chen, Hsing, Cemerski, Saso, Bernett, Matthew J., Nguyen, Duc-Hanh T., Karki, Sher, Chu, Seung Y., Lazar, Greg A., Munshi, Nikhil C., Desjarlais, John R., Anderson, Kenneth C., Muchhal, Umesh S.

“…HM1.24, an immunologic target for multiple myeloma (MM) cells, has not been effectively targeted with therapeutic monoclonal antibodies (mAbs). In this study,…”
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Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell-recruiting Antibody Optimized for Cytotoxicity and Cytokine Release by Zuch de Zafra, Christina L, Fajardo, Flordeliza, Zhong, Wendy, Bernett, Matthew J, Muchhal, Umesh S, Moore, Gregory L, Stevens, Jennitte, Case, Ryan, Pearson, Joshua T, Liu, Siyuan, McElroy, Patricia L, Canon, Jude, Desjarlais, John R, Coxon, Angela, Balazs, Mercedesz, Nolan-Stevaux, Olivier

“…Despite advances in the treatment of multiple myeloma, new therapies are needed to induce more profound clinical responses. T-cell-redirected lysis triggered…”
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Transcriptional Regulation of Plant Phosphate Transporters by Muchhal, Umesh S., Raghothama, K. G.

“…Phosphorus is acquired by plant roots primarily via the high-affinity inorganic phosphate (Pi) transporters. The transcripts for Pi transporters are highly…”
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A robust heterodimeric Fc platform engineered for efficient development of bispecific antibodies of multiple formats by Moore, Gregory L., Bernett, Matthew J., Rashid, Rumana, Pong, Erik W., Nguyen, Duc-Hanh T., Jacinto, Jonathan, Eivazi, Araz, Nisthal, Alex, Diaz, Juan E., Chu, Seung Y., Muchhal, Umesh S., Desjarlais, John R.

“…•A novel heterodimeric Fc platform for creating bispecific antibodies is presented.•Heterodimer yields over 95% are achieved with little change in Fc…”
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Abstract 5549: Potency-reduced IL12 heterodimeric Fc-fusions exhibit strong anti-tumor activity by Varma, Rajat, Liu, Ke, Bonzon, Christine, Rashid, Rumana, Rodriguez, Nicole, Hassanzadeh-Kiabi, Nargess, Ardila, Connie, Chu, Seung Y., Muchhal, Umesh S., Desjarlais, John R., Bernett, Matthew J.

“…Interleukin-12 (IL12) is a proinflammatory cytokine produced by activated antigen-presenting cells that induces differentiation of Th1 cells and increased…”
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Abstract 5000: Immunotherapy with anti-PSMA x anti-CD3 bispecific antibody stimulates potent killing of a human prostate cancer cell line and target-mediated T cell activation in monkeys: A potential therapy for prostate cancer by Chu, Seung Y., Pong, Erik W. K., Rashid, Rumana, Chen, Hsing, Chan, Emily W., Phung, Sheryl, Endo, Nancy A., Ardila, Maria C., Bonzon, Christine, Leung, Irene W. L., Muchhal, Umesh S., Moore, Gregory L., Bernett, Matthew J., Desjarlais, John R., Szymkowski, David E.

“…PSMA (Prostate-Specific Membrane Antigen) is a promising therapeutic target in prostate cancer. Exploiting the high and selective expression of PSMA in the…”
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Engineering Fully Human Monoclonal Antibodies from Murine Variable Regions by Bernett, Matthew J., Karki, Sher, Moore, Gregory L., Leung, Irene W.L., Chen, Hsing, Pong, Erik, Nguyen, Duc-Hanh T., Jacinto, Jonathan, Zalevsky, Jonathan, Muchhal, Umesh S., Desjarlais, John R., Lazar, Greg A.

“…Fully human monoclonal antibodies (mAbs) derived from transgenic mice or human antibody libraries are the current state of the art for reducing the…”
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Suppression of mast cell degranulation through a dual-targeting tandem IgE–IgG Fc domain biologic engineered to bind with high affinity to FcγRIIb by Cemerski, Saso, Chu, Seung Y, Moore, Gregory L, Muchhal, Umesh S, Desjarlais, John R, Szymkowski, David E

“…Highlights ► We generated an Fcε–Fcγ fusion protein (tandem Fc) to suppress mast cell activation. ► Enhanced binding to FcγRIIb via Fc engineering…”
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Immune suppression in cynomolgus monkeys by XPro9523: An improved CTLA4-Ig fusion with enhanced binding to CD80, CD86 and neonatal Fc receptor FcRn by Bernett, Matthew J., Chu, Seung Y., Leung, Irene, Moore, Gregory L., Lee, Sung-Hyung, Pong, Erik, Chen, Hsing, Phung, Sheryl, Muchhal, Umesh S., Horton, Holly M., Lazar, Greg A., Desjarlais, John R, Szymkowski, David E.

“…The CTLA4-Ig fusion proteins abatacept and belatacept are clinically proven immunosuppressants used for rheumatoid arthritis and renal transplant,…”
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Phosphate transporters from the higher plant Arabidopsis thaliana by Muchhal, Umesh S., Pardo, Jose M., Raghothama, K. G.

“…Two cDNAs (AtPT1 and AtPT2) encoding plant phosphate transporters have been isolated from a library prepared with mRNA extracted from phosphate-starved…”
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Tomato phosphate transporter genes are differentially regulated in plant tissues by phosphorus by Liu, C, Muchhal, U.S, Uthappa, M, Kononowicz, A.K, Raghothama, K.G

“…Phosphorus is a major nutrient acquired by roots via high-affinity inorganic phosphate (Pi) transporters. In this paper, we describe the tissue-specific…”
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Inactivation of TNF Signaling by Rationally Designed Dominant-Negative TNF Variants by Steed, Paul M., Tansey, Malú G., Zalevsky, Jonathan, Zhukovsky, Eugene A., Desjarlais, John R., Szymkowski, David E., Abbott, Christina, Carmichael, David, Chan, Cheryl, Cherry, Lisa, Cheung, Peter, Chirino, Arthur J., Chung, Hyo H., Doberstein, Stephen K., Eivazi, Araz, Filikov, Anton V., Gao, Sarah X., Hubert, René S., Hwang, Marian, Hyun, Linus, Kashi, Sandhya, Kim, Alice, Kim, Esther, Kung, James, Martinez, Sabrina P., Muchhal, Umesh S., Nguyen, Duc-Hanh T., O'Brien, Christopher, O'Keefe, Donald, Singer, Karen, Vafa, Omid, Vielmetter, Jost, Yoder, Sean C., Dahiyat, Bassil I.

“…Tumor necrosis factor (TNF) is a key regulator of inflammatory responses and has been implicated in many pathological conditions. We used structure-based…”
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Differential expression of TPS11, a phosphate starvation-induced gene in tomato by Liu, C. (Purdue Univ., West Lafayette, IN (USA). Dept. of Horticulture), Muchhal, U.S, Raghothama, K.G

“…Plants respond to phosphate (Pi) deficiency through adaptive mechanisms involving several morphological, biochemical and molecular changes. In this study, we…”
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Abstract 1831: Affinity tuned XmAb®2+1 GPC3 x CD3 bispecific antibodies demonstrate selective activity in liver cancer models by Nisthal, Alex, Hassanzadeh-Kiabi, Nargess, Avery, Kendra N., Rashid, Rumana, Diaz, Juan E., Muchhal, Umesh S., Chu, Seung Y., Moore, Gregory L., Bykova, Katrina, Desjarlais, John R.

“…Bispecific T cell engagers simultaneously bind CD3 on T cells and tumor-associated antigens to promote T cell-mediated killing of tumor cells. These agents…”
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Abstract 5654: Affinity tuned Xmab®2+1 anti-mesothelin x anti-CD3 bispecific antibody induces selective T cell-dependent cellular cytotoxicity of human ovarian cancer cells by Zeng, Veronica G., Faber, Matthew S., Bernett, Matthew J., Avery, Kendra N., Zeytounian, John L., Rashid, Rumana, Muchhal, Umesh S., Moore, Gregory L., Desjarlais, John R., Hedvat, Michael

“…Mesothelin (MSLN) is a tumor-associated antigen highly expressed in ovarian tumors. Current treatment options for ovarian cancer have only modest efficacy and…”
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Abstract 1743: IL12 heterodimeric Fc-fusions engineered for reduced potency exhibit strong anti-tumor activity and improved therapeutic index compared to native IL12 agents by Bernett, Matthew J., Liu, Ke, Bonzon, Christine, Rashid, Rumana, Rodriguez, Nicole, Hassanzadeh-Kiabi, Nargess, Ardila, Connie, Bykova, Katrina, Hackett, Michael, Barlow, Norm, Leung, Irene, Nguyen, Duc-Hanh, Eivazi, Araz, Chu, Seung Y., Varma, Rajat, Muchhal, Umesh S., Desjarlais, John R.

“…Interleukin-12 (IL12) is a proinflammatory cytokine produced by activated antigen-presenting cells that induces differentiation of Th1 cells and increased…”
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Abstract 1880: PDL1-targeted CD28 costimulatory bispecific antibodies enhance T cell activation in solid tumors by Moore, Gregory L., Zeng, Veronica, Diaz, Juan, Bonzon, Christine, Avery, Kendra N., Love, Ruschelle, Dragovich, Matthew, Rashid, Rumana, Hackett, Michael, Leung, Irene W., Qi, Jing, Bakhit, Charles G., Muchhal, Umesh S., Barlow, Norman J., Desjarlais, John R., Hedvat, Michael

“…T cells in the tumor micro-environment require TCR/MHC engagement and co-stimulatory receptor engagement to achieve complete activation. Tumor cells lack…”
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Abstract 5663: Affinity tuned XmAb®2+1 PSMA x CD3 bispecific antibodies demonstrate selective activity in prostate cancer models by Nisthal, Alex, Dragovich, Matthew, Pong, Erik W., Zeng, Veronica, Hedvat, Michael, Bonzon, Christine, Avery, Kendra, Rashid, Rumana, Ardila, Connie, Muchhal, Umesh S., Moore, Gregory L., Chu, Seung Y., Desjarlais, John R.

“…Bispecific antibodies enable therapeutic modalities inaccessible to traditional mAbs, such as T cell engagers that bind both CD3 on T cells and a target…”
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