Search Results - "MSADEK, Tarek"

Natural transformation allows transfer of SCCmec-mediated methicillin resistance in Staphylococcus aureus biofilms by Maree, Mais, Thi Nguyen, Le Thuy, Ohniwa, Ryosuke L., Higashide, Masato, Msadek, Tarek, Morikawa, Kazuya

“…SCC mec is a large mobile genetic element that includes the mecA gene and confers resistance to β-lactam antibiotics in methicillin-resistant Staphylococcus…”
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SpdC, a novel virulence factor, controls histidine kinase activity in Staphylococcus aureus by Poupel, Olivier, Proux, Caroline, Jagla, Bernd, Msadek, Tarek, Dubrac, Sarah

“…The success of Staphylococcus aureus, as both a human and animal pathogen, stems from its ability to rapidly adapt to a wide spectrum of environmental…”
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Bacitracin and nisin resistance in Staphylococcus aureus: a novel pathway involving the BraS/BraR two‐component system (SA2417/SA2418) and both the BraD/BraE and VraD/VraE ABC transporters by Hiron, Aurélia, Falord, Mélanie, Valle, Jaione, Débarbouillé, Michel, Msadek, Tarek

“…Summary Two‐component systems (TCSs) are key regulatory pathways allowing bacteria to adapt their genetic expression to environmental changes. Bacitracin, a…”
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GraXSR Proteins Interact with the VraFG ABC Transporter To Form a Five-Component System Required for Cationic Antimicrobial Peptide Sensing and Resistance in Staphylococcus aureus by FALORD, Mélanie, KARIMOVA, Gouzel, HIRON, Aurélia, MSADEK, Tarek

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matter of life and death: cell wall homeostasis and the WalKR (YycGF) essential signal transduction pathway by Dubrac, Sarah, Bisicchia, Paola, Devine, Kevin M, Msadek, Tarek

“…The WalK/WalR (aka YycG/YycF) two-component system (TCS), originally identified in Bacillus subtilis, is very highly conserved and specific to low G+C…”
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New Insights into the WalK/WalR (YycG/YycF) Essential Signal Transduction Pathway Reveal a Major Role in Controlling Cell Wall Metabolism and Biofilm Formation in Staphylococcus aureus by DUBRAC, Sarah, GOMPERTS BONECA, Ivo, POUPEL, Olivier, MSADEK, Tarek

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Grasping at shadows: revealing the elusive nature of essential genes by Msadek, Tarek

“…The conundrum of studying a gene that is essential for bacterial viability poses a nontrivial genetic challenge that has been met with mixed success using…”
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Staphylococcus aureus Transcriptome Architecture: From Laboratory to Infection-Mimicking Conditions by Mäder, Ulrike, Nicolas, Pierre, Depke, Maren, Pané-Farré, Jan, Debarbouille, Michel, van der Kooi-Pol, Magdalena M, Guérin, Cyprien, Dérozier, Sandra, Hiron, Aurelia, Jarmer, Hanne, Leduc, Aurélie, Michalik, Stephan, Reilman, Ewoud, Schaffer, Marc, Schmidt, Frank, Bessières, Philippe, Noirot, Philippe, Hecker, Michael, Msadek, Tarek, Völker, Uwe, van Dijl, Jan Maarten

“…Staphylococcus aureus is a major pathogen that colonizes about 20% of the human population. Intriguingly, this Gram-positive bacterium can survive and thrive…”
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Investigation of the Staphylococcus aureus GraSR regulon reveals novel links to virulence, stress response and cell wall signal transduction pathways by Falord, Mélanie, Mäder, Ulrike, Hiron, Aurélia, Débarbouillé, Michel, Msadek, Tarek

“…The GraS/GraR two-component system has been shown to control cationic antimicrobial peptide (CAMP) resistance in the major human pathogen Staphylococcus…”
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Identification of Genes Controlled by the Essential YycG/YycF Two-Component System of Staphylococcus aureus by DUBRAC, Sarah, MSADEK, Tarek

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The WalKR System Controls Major Staphylococcal Virulence Genes and Is Involved in Triggering the Host Inflammatory Response by DELAUNE, Aurélia, DUBRAC, Sarah, ADIB-CONQUY, Minou, MSADEK, Tarek, BLANCHET, Charlène, POUPELY, Olivier, MÄDER, Ulrike, HIRON, Aurélia, LEDUC, Aurélie, FITTING, Catherine, NICOLAS, Pierre, CAVALLION, Jean-Marc

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Expression of a cryptic secondary sigma factor gene unveils natural competence for DNA transformation in Staphylococcus aureus by Morikawa, Kazuya, Takemura, Aya J, Inose, Yumiko, Tsai, Melody, Nguyen Thi, Le Thuy, Ohta, Toshiko, Msadek, Tarek

“…It has long been a question whether Staphylococcus aureus, a major human pathogen, is able to develop natural competence for transformation by DNA. We…”
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CtsR, the Master Regulator of Stress-Response in Oenococcus oeni , Is a Heat Sensor Interacting With ClpL1 by Darsonval, Maud, Julliat, Frédérique, Msadek, Tarek, Alexandre, Hervé, Grandvalet, Cosette

“…is a lactic acid bacterium responsible for malolactic fermentation of wine. While many stress response mechanisms implemented by during wine adaptation have…”
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Peptidoglycan crosslinking relaxation plays an important role in Staphylococcus aureus WalKR-dependent cell viability by Delaune, Aurelia, Poupel, Olivier, Mallet, Adeline, Coic, Yves-Marie, Msadek, Tarek, Dubrac, Sarah

“…The WalKR two-component system is essential for viability of Staphylococcus aureus, a major pathogen. We have shown that WalKR acts as the master controller of…”
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Tearing down the wall: peptidoglycan metabolism and the WalK/WalR (YycG/YycF) essential two-component system by Dubrac, Sarah, Msadek, Tarek

“…In order to survive, bacteria have developed avariety of highly sophisticated and sensitive signal transduction pathways with which they adapt their genetic…”
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Characterization of a Serine/Threonine Kinase Involved in Virulence of Staphylococcus aureus by DEBARBOUILLE, Michel, DRAMSI, Shaynoor, DUSSURGET, Olivier, NAHORI, Marie-Anne, VAGANAY, Elisabeth, JOUVION, Grégory, COZZONE, Alain, MSADEK, Tarek, DUCLOS, Bertrand

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Transcriptional Analysis and Subcellular Protein Localization Reveal Specific Features of the Essential WalKR System in Staphylococcus aureus by Poupel, Olivier, Moyat, Mati, Groizeleau, Julie, Antunes, Luísa C S, Gribaldo, Simonetta, Msadek, Tarek, Dubrac, Sarah

“…The WalKR two-component system, controlling cell wall metabolism, is highly conserved among Bacilli and essential for cell viability. In Staphylococcus aureus,…”
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Clp ATPases are required for stress tolerance, intracellular replication and biofilm formation in Staphylococcus aureus by Frees, Dorte, Chastanet, Arnaud, Qazi, Saara, Sørensen, Karen, Hill, Philip, Msadek, Tarek, Ingmer, Hanne

“…Summary The Hsp100/Clp ATPases constitute a family of closely related proteins of which some members function solely as chaperones whereas others additionally…”
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Inhibition of Rho Activity Increases Expression of SaeRS-Dependent Virulence Factor Genes in Staphylococcus aureus, Showing a Link between Transcription Termination, Antibiotic Action, and Virulence by Nagel, Anna, Michalik, Stephan, Debarbouille, Michel, Hertlein, Tobias, Gesell Salazar, Manuela, Rath, Hermann, Msadek, Tarek, Ohlsen, Knut, van Dijl, Jan Maarten, Völker, Uwe, Mäder, Ulrike

“…causes various diseases ranging from skin and soft tissue infections to life-threatening infections. Adaptation to the different host niches is controlled by a…”
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When the going gets tough: survival strategies and environmental signaling networks in Bacillus subtilis by Msadek, Tarek

“…Regulatory pathways involving two-component histidine kinase/response regulator proteins of Bacillus subtilis are highly interconnected and form a signal…”
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