Search Results - "MOZZARELLI, ANDREA"

The Roles of Water in the Protein Matrix: A Largely Untapped Resource for Drug Discovery by Spyrakis, Francesca, Ahmed, Mostafa H, Bayden, Alexander S, Cozzini, Pietro, Mozzarelli, Andrea, Kellogg, Glen E

“…The value of thoroughly understanding the thermodynamics specific to a drug discovery/design study is well known. Over the past decade, the crucial roles of…”
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Targeted Biologics: The New Frontier for Precision Therapy by Bruno, Stefano, Buehler, Paul W, Mozzarelli, Andrea

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Serine racemase: a key player in neuron activity and in neuropathologies by Campanini, Barbara, Spyrakis, Francesca, Peracchi, Alessio, Mozzarelli, Andrea

“…Serine racemase is the pyridoxal 5'-phosphate-dependent enzyme that catalyzes L-serine racemisation to D-serine, and L- and D-serine beta-elimination in…”
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Taming hemoglobin chemistry—a new hemoglobin-based oxygen carrier engineered with both decreased rates of nitric oxide scavenging and lipid oxidation by Cooper, Chris E., Simons, Michelle, Dyson, Alex, Leiva Eriksson, Nélida, Silkstone, Gary G. A., Syrett, Natalie, Allen-Baume, Victoria, Bülow, Leif, Ronda, Luca, Mozzarelli, Andrea, Singer, Mervyn, Reeder, Brandon J.

“…The clinical utility of hemoglobin-based oxygen carriers (HBOC) is limited by adverse heme oxidative chemistry. A variety of tyrosine residues were inserted on…”
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Drug Discovery Targeting Amino Acid Racemases by Conti, Paola, Tamborini, Lucia, Pinto, Andrea, Blondel, Arnaud, Minoprio, Paola, Mozzarelli, Andrea, De Micheli, Carlo

“…Conti et al examine a process of drug discovery targeting amino acid racemases…”
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Tryptophan synthase: a mine for enzymologists by Raboni, Samanta, Bettati, Stefano, Mozzarelli, Andrea

“…Tryptophan synthase is a pyridoxal 5'-phosphate-dependent α₂β₂ complex catalyzing the last two steps of tryptophan biosynthesis in bacteria, plants and fungi…”
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Proteomics of Parma Dry-Cured Ham: Analysis of Salting Exudates by Paredi, Gianluca, Benoni, Roberto, Pighini, Giovanni, Ronda, Luca, Dowle, Adam, Ashford, David, Thomas, Jerry, Saccani, Giovanna, Virgili, Roberta, Mozzarelli, Andrea

“…The production of Parma dry-cured ham involves the steps of salting, drying, and ripening. Although sea salt is the only preserving agent, there are strategies…”
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Experimental basis for a new allosteric model for multisubunit proteins by Viappiani, Cristiano, Abbruzzetti, Stefania, Ronda, Luca, Bettati, Stefano, Henry, Eric. R., Mozzarelli, Andrea, Eaton, William A.

“…Monod, Wyman, and Changeux (MWC) explained allostery in multisubunit proteins with a widely applied theoretical model in which binding of small molecules,…”
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Human Serine Racemase Weakly Binds the Third PDZ Domain of PSD-95 by Giaccari, Roberta, Marchesani, Francesco, Compari, Carlotta, Fisicaro, Emilia, Mozzarelli, Andrea, Campanini, Barbara, Bettati, Stefano, Bruno, Stefano, Faggiano, Serena

“…Human serine racemase (hSR) is a pyridoxal-5'-phosphate (PLP)-dependent dimer that catalyzes the formation of D-serine from L-serine, as well as the…”
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Inhibitors of the sulfur assimilation pathway in bacterial pathogens as enhancers of antibiotic therapy by Campanini, Barbara, Pieroni, Marco, Raboni, Samanta, Bettati, Stefano, Benoni, Roberto, Pecchini, Chiara, Costantino, Gabriele, Mozzarelli, Andrea

“…The rising emergence of antibiotic resistance urges the search for new strategies to defeat microorganisms that lead to persistent infections of the host…”
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Human serine racemase is allosterically modulated by NADH and reduced nicotinamide derivatives by Bruno, Stefano, Marchesani, Francesco, Dellafiora, Luca, Margiotta, Marilena, Faggiano, Serena, Campanini, Barbara, Mozzarelli, Andrea

“…Serine racemase catalyzes both the synthesis and the degradation of d-serine, an obligatory co-agonist of the glutamatergic NMDA receptors. It is…”
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ATP binding to human serine racemase is cooperative and modulated by glycine by Marchetti, Marialaura, Bruno, Stefano, Campanini, Barbara, Peracchi, Alessio, Mai, Nicole, Mozzarelli, Andrea

“…The N‐methyl d‐aspartate (NMDA) receptors play a key role in excitatory neurotransmission, and control learning, memory and synaptic plasticity. Their activity…”
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Magnesium and calcium ions differentially affect human serine racemase activity and modulate its quaternary equilibrium toward a tetrameric form by Bruno, Stefano, Margiotta, Marilena, Marchesani, Francesco, Paredi, Gianluca, Orlandi, Valentina, Faggiano, Serena, Ronda, Luca, Campanini, Barbara, Mozzarelli, Andrea

“…Serine racemase is the pyridoxal 5′-phosphate dependent enzyme that catalyzes both production and catabolism of d-serine, a co-agonist of the NMDA glutamate…”
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Experiments on Hemoglobin in Single Crystals and Silica Gels Distinguish among Allosteric Models by Henry, Eric R., Mozzarelli, Andrea, Viappiani, Cristiano, Abbruzzetti, Stefania, Bettati, Stefano, Ronda, Luca, Bruno, Stefano, Eaton, William A.

“…Trapping quaternary structures of hemoglobin in single crystals or by encapsulation in silica gels has provided a demanding set of data to test statistical…”
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Discovery of Covalent Inhibitors of Glyceraldehyde-3-phosphate Dehydrogenase, A Target for the Treatment of Malaria by Bruno, Stefano, Pinto, Andrea, Paredi, Gianluca, Tamborini, Lucia, De Micheli, Carlo, La Pietra, Valeria, Marinelli, Luciana, Novellino, Ettore, Conti, Paola, Mozzarelli, Andrea

“…We developed a new class of covalent inhibitors of Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase, a validated target for the treatment of…”
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Higher expression of miR-133b is associated with better efficacy of erlotinib as the second or third line in non-small cell lung cancer patients by Bisagni, Alessandra, Pagano, Maria, Maramotti, Sally, Zanelli, Francesca, Bonacini, Martina, Tagliavini, Elena, Braglia, Luca, Paci, Massimiliano, Mozzarelli, Andrea, Croci, Stefania

“…Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (gefitinib, erlotinib and afatinib) are indicated as first-line therapy in patients with…”
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Rational Design of a User-Friendly Aptamer/Peptide-Based Device for the Detection of Staphylococcus aureus by Ronda, Luca, Tonelli, Alessandro, Sogne, Elisa, Autiero, Ida, Spyrakis, Francesca, Pellegrino, Sara, Abbiati, Giorgio, Maffioli, Elisa, Schulte, Carsten, Piano, Riccardo, Cozzini, Pietro, Mozzarelli, Andrea, Bettati, Stefano, Clerici, Francesca, Milani, Paolo, Lenardi, Cristina, Tedeschi, Gabriella, Gelmi, Maria Luisa

“…The urgent need to develop a detection system for , one of the most common causes of infection, is prompting research towards novel approaches and devices,…”
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HINT, a code for understanding the interaction between biomolecules: a tribute to Donald J. Abraham by Kellogg, Glen E, Marabotti, Anna, Spyrakis, Francesca, Mozzarelli, Andrea

“…A long-lasting goal of computational biochemists, medicinal chemists, and structural biologists has been the development of tools capable of deciphering the…”
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Identification of Xenoestrogens in Food Additives by an Integrated in Silico and in Vitro Approach by Amadasi, Alessio, Mozzarelli, Andrea, Meda, Clara, Maggi, Adriana, Cozzini, Pietro

“…In the search for xenoestrogens within food additives, we have analyzed the Joint FAO-WHO expert committee database, containing 1500 compounds, using an…”
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Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives by Franko, Nina, Grammatoglou, Konstantinos, Campanini, Barbara, Costantino, Gabriele, Jirgensons, Aigars, Mozzarelli, Andrea

“…O-acetylserine sulfhydrylase (OASS) is the pyridoxal 5′-phosphate dependent enzyme that catalyses the formation of L-cysteine in bacteria and plants. Its…”
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