Search Results - "MOYNAHAN, M"

Beyond dissolution: Xerostomia rinses affect composition and structure of biomimetic dental mineral in vitro by Moynahan, Mikayla M, Wong, Stephanie L, Deymier, Alix C

“…Xerostomia, known as dry mouth, is caused by decreased salivary flow. Treatment with lubricating oral rinses provides temporary relief of dry mouth discomfort;…”
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Homology-directed DNA repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation by MOYNAHAN, Mary Ellen, CUI, Tracy Y, JASIN, Maria

“…Chromosomal breaks occur spontaneously as a result of normal DNA metabolism and after exposure to DNA-damaging agents. A major pathway involved in chromosomal…”
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Brain-computer interface devices for patients with paralysis and amputation: a meeting report by Bowsher, K, Civillico, E F, Coburn, J, Collinger, J, Contreras-Vidal, J L, Denison, T, Donoghue, J, French, J, Getzoff, N, Hochberg, L R, Hoffmann, M, Judy, J, Kleitman, N, Knaack, G, Krauthamer, V, Ludwig, K, Moynahan, M, Pancrazio, J J, Peckham, P H, Pena, C, Pinto, V, Ryan, T, Saha, D, Scharen, H, Shermer, S, Skodacek, K, Takmakov, P, Tyler, D, Vasudevan, S, Wachrathit, K, Weber, D, Welle, C G, Ye, M

“…The Food and Drug Administration's (FDA) Center for Devices and Radiological Health (CDRH) believes it is important to help stakeholders (e.g., manufacturers,…”
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Dose-dense therapy with weekly 1-hour paclitaxel infusions in the treatment of metastatic breast cancer by Seidman, A D, Hudis, C A, Albanell, J, Albanel, J, Tong, W, Tepler, I, Currie, V, Moynahan, M E, Theodoulou, M, Gollub, M, Baselga, J, Norton, L

“…To evaluate the efficacy and toxicity of paclitaxel administered as a 1-hour infusion on weekly basis, without interruption, to patients with metastatic breast…”
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Detection of IDH1 mutations in circulating free DNA in patients with cholangiocarcinoma by Lowery, M.A, You, D, Samoila, A, Peerschke, E, Viale, A, Patel, R, Selcuklu, D, Rusek, M, Cercek, A, Kemeny, N, Harding, J, Mellinghoff, I, Tap, W, Abou-Alfa, G.K, Moynahan, M

“…Background: In tumors that harbor activating mutations, tumor-derived cfDNA extracted from patient plasma can be serially quantified by droplet digital PCR…”
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BRCA2 Is Required for Homology-Directed Repair of Chromosomal Breaks by Moynahan, Mary Ellen, Pierce, Andrew J, Jasin, Maria

“…The BRCA2 tumor suppressor has been implicated in the maintenance of chromosomal stability through a function in DNA repair. In this report, we examine human…”
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Brca1 Controls Homology-Directed DNA Repair by Moynahan, Mary Ellen, Chiu, Joanne W, Koller, Beverly H, Jasin, Maria

“…Germline mutations in BRCA1 confer a high risk of breast and ovarian tumors. The role of BRCA1 in tumor suppression is not yet understood, but both…”
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Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations by Richardson, C, Moynahan, M E, Jasin, M

“…To directly determine whether recombinational repair of double-strand breaks (DSBs) can occur between heterologous chromosomes and lead to chromosomal…”
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Double-strand breaks and tumorigenesis by Pierce, A J, Stark, J M, Araujo, F D, Moynahan, M E, Berwick, M, Jasin, M

“…The establishment of connections between biochemical defects and clinical disease is a major goal of modern molecular genetics. In this review, we examine the…”
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Weekly Trastuzumab and Paclitaxel Therapy for Metastatic Breast Cancer With Analysis of Efficacy by HER2 Immunophenotype and Gene Amplification by SEIDMAN, Andrew D, FORNIER, Monica N, GILEWSKI, Teresa, THEODOULOU, Maria, MOYNAHAN, Mary Ellen, MOASSER, Mark, SKLARIN, Nancy, DICKLER, Maura, D'ANDREA, Gabriella, CRISTOFANILLI, Massimo, RIVERA, Edgardo, HORTOBAGYI, Gabriel N, ESTEVA, Francisco J, NORTON, Larry, HUDIS, Clifford A, LEE TAN, KAPTAIN, Stamatina, BACH, Ariadne, PANAGEAS, Katherine S, ARROYO, Crispinita, VALERO, Vicente, CURRIE, Violante

“…This phase II study evaluated weekly trastuzumab and paclitaxel therapy in women with HER2-normal and HER2-overexpressing metastatic breast cancer. Efficacy…”
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Ninety-six-hour paclitaxel infusion after progression during short taxane exposure: a phase II pharmacokinetic and pharmacodynamic study in metastatic breast cancer by Seidman, A D, Hochhauser, D, Gollub, M, Edelman, B, Yao, T J, Hudis, C A, Francis, P, Fennelly, D, Gilewski, T A, Moynahan, M E, Currie, V, Baselga, J, Tong, W, O'Donaghue, M, Salvaggio, R, Auguste, L, Spriggs, D, Norton, L

“…A phase II trial of paclitaxel infused over 96 hours in patients with metastatic breast cancer with demonstrated disease progression (PD) during short-infusion…”
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Sequential Dose-Dense Doxorubicin, Paclitaxel, and Cyclophosphamide for Resectable High-Risk Breast Cancer: Feasibility and Efficacy by HUDIS, C, SEIDMAN, A, SURBONE, A, UHLENHOPP, M, RIEDEL, E, YAO, T. J, NORTON, L, BASELGA, J, RAPTIS, G, LEBWOHL, D, GILEWSKI, T, MOYNAHAN, M, SKLARIN, N, FENNELLY, D, CROWN, J. P. A

“…Dose-dense chemotherapy is predicted to be a superior treatment plan. Therefore, we studied dose-dense doxorubicin, paclitaxel, and cyclophosphamide…”
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Targeted Transgenesis by Jasin, Maria, Moynahan, Mary Ellen, Richardson, Christine

“…The decade of the 1980s witnessed a revolution in mouse molecular genetics. At its start, the first transgenic mouse was created by nuclear injection of cloned…”
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Loss of Heterozygosity Induced by a Chromosomal Double-Strand Break by Moynahan, Mary Ellen, Jasin, Maria

“…The repair of chromosomal double-strand breaks (DSBs) is necessary for genomic integrity in all organisms. Genetic consequences of misrepair include…”
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5-Year Results of Dose-Intensive Sequential Adjuvant Chemotherapy for Women With High-Risk Node-Positive Breast Cancer: A Phase II Study by HUDIS, C, FORNIER, M, MOYNAHAN, M, RAPTIS, G, SKLARIN, N, THEODOULOU, M, WEISELBERG, L, SALVAGGIO, R, PANAGEAS, K. S, YAO, T. J, NORTON, L, RICCIO, L, LEBWOHL, D, CROWN, J, GILEWSKI, T, SURBONE, A, CURRIE, V, SEIDMAN, A, REICHMAN, B

“…We conducted a phase II pilot study of dose-intensive adjuvant chemotherapy with doxorubicin followed sequentially by high-dose cyclophosphamide to determine…”
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A Model for Testing Recombinogenic Sequences in the Mouse Germline by Moynahan, Mary Ellen, Akgün, Ercan, Jasin, Maria

“…Homologous recombination is a conserved process of genetic exchange generated by homologous pairing of nucleotides. Species diversity and gene evolution are…”
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Pacemaker and ICD Generator Malfunctions: Analysis of Food and Drug Administration Annual Reports by Maisel, William H, Moynahan, Megan, Zuckerman, Bram D, Gross, Thomas P, Tovar, Oscar H, Tillman, Donna-Bea, Schultz, Daniel B

“…CONTEXT Pacemakers and implantable cardioverter-defibrillators (ICDs) are complex medical devices proven to reduce mortality in specific high-risk patient…”
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Phase I Study of Escalating Doses of Edatrexate in Combination with Paclitaxel in Patients with Metastatic Breast Cancer by D'ANDREA, G, FENNELLY, D, THEODOULOU, M, TEMPLETON, M. A, YAO, T.-J, SEIDMAN, A. D, NORTON, L, BASELGA, J, GILEWSKI, T, HUDIS, C, MOYNAHAN, M. E, RAPTIS, G, SKLARIN, N, SURBONE, A

“…Motivated by the observation of preclinical synergy, a Phase I dose escalation study of edatrexate in combination with a 3-h paclitaxel infusion was performed…”
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Doxorubicin followed by sequential paclitaxel and cyclophosphamide versus concurrent paclitaxel and cyclophosphamide: 5-year results of a Phase II randomized trial of adjuvant Dose-dense chemotherapy for women with node-positive breast carcinoma by FORNIER, Monica N, SEIDMAN, Andrew D, PANAGEAS, Kathy S, NORTON, Larry, HUDIS, Clifford, THEODOULOU, Maria, MOYNAHAN, Mary Ellen, CURRIE, Violante, MOASSER, Mark, SKLARIN, Nancy, GILEWSKI, Theresa, D'ANDREA, Gabriella, SALVAGGIO, Rori

“…We conducted a randomized Phase II trial to directly compare toxicity, feasibility, and delivered dose intensities of two adjuvant dose-intensive regimens…”
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Sequential adjuvant therapy: the Memorial Sloan-Kettering Cancer Center experience by Hudis, C, Seidman, A, Raptis, G, Fennelly, D, Gilewski, T, Baselga, J, Theodoulou, M, Sklarin, N, Moynahan, M, Surbone, A, Currie, V, Lebwohl, D, Uhlenhopp, M, Crown, J, Norton, L

“…Adjuvant chemotherapy has a real but modest impact on the disease-free and overall survival of patients with breast cancer. Recent attempts to improve its…”
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