Secondary Cervical Cancer in a Patient with Chronic Lymphocytic Leukemia and Recurrent Chronic Lymphocytic Leukemia Mimicking Recurrent Cervical Dysplasia: A Case Report

Patients with chronic lymphocytic leukemia (CLL) have up to a 3-fold risk of site-specific secondary cancers. The only exception is a lower incidence of cervical cancer in this population. A 70-year-old, white woman with stage IV CLL was diagnosed 2 years prior to presentation with stage Ia1 squamou...

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Bibliographic Details
Published in:	Journal of reproductive medicine Vol. 55; no. 3-4; pp. 175 - 178
Main Authors:	MAGLEY, Joseph, MOYERS, Carolyn, BALLARD, Karen S, TEDJARATI, Sean
Format:	Journal Article
Language:	English
Published:	St. Louis, MO Science 01-03-2010
Subjects:	Aged Biological and medical sciences Carcinoma, Squamous Cell - pathology Female Female genital diseases Gynecology. Andrology. Obstetrics Hematologic and hematopoietic diseases Humans Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Neoplasms, Second Primary - pathology Tumors Uterine Cervical Dysplasia - pathology Uterine Cervical Neoplasms - pathology Human cervical diseases Relapse Premalignant lesion Gynecology Malignant hemopathy Malignant tumor Uterine cervix Obstetrics Female genital diseases Case study Chronic lymphocytic leukemia Cervical dysplasia Second cancer Lymphoproliferative syndrome Uterine cervix diseases Cervical cancer Cancer
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Summary:	Patients with chronic lymphocytic leukemia (CLL) have up to a 3-fold risk of site-specific secondary cancers. The only exception is a lower incidence of cervical cancer in this population. A 70-year-old, white woman with stage IV CLL was diagnosed 2 years prior to presentation with stage Ia1 squamous cell carcinoma of the cervix. Following an abnormal Pap smear, a colposcopy and biopsies were performed. Initial pathologic impression of the cervical biopsies was high grade dysplasia. The final review was consistent with CLL without cervical dysplasia. Cervical cancer in patients with CLL is a rare occurrence. The pathologic changes on cervical epithelium caused by CLL can mimic dysplastic cellular changes. Expert pathologic review of cervical biopsies is warranted to distinguish between the diagnoses, thus altering management.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0024-7758 1943-3565