Search Results - "MOY, Franklin J"

The Nuclear Hormone Receptor Farnesoid X Receptor (FXR) Is Activated by Androsterone by Wang, Shuguang, Lai, KehDih, Moy, Franklin J, Bhat, Anitha, Hartman, Helen B, Evans, Mark J

“…Farnesoid X receptor (FXR) uses bile acids as endogenous ligands. Here, we demonstrate that androsterone, a metabolic product of testosterone, is also an FXR…”
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Structure-Based Design of a Novel, Potent, and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design by Chen, James M, Nelson, Frances C, Levin, Jeremy I, Mobilio, Dominick, Moy, Franklin J, Nilakantan, Ramaswamy, Zask, Arie, Powers, Robert

“…The high-resolution NMR solution structure of the catalytic fragment of human collagenase-3 (MMP-13) was used as a starting point for structure-based design of…”
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Impact of Mobility on Structure-Based Drug Design for the MMPs by Moy, Franklin J, Chanda, Pranab K, Chen, James, Cosmi, Scott, Edris, Wade, Levin, Jeremy I, Rush, Thomas S, Wilhelm, James, Powers, Robert

“…Structure-based approaches for drug design generally do not incorporate solvent effects and dynamic information to predict inhibitor-binding affinity because…”
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Properly Oriented Heparin−Decasaccharide-Induced Dimers Are the Biologically Active Form of Basic Fibroblast Growth Factor by Moy, Franklin J, Safran, Michal, Seddon, Andrew P, Kitchen, Doug, Böhlen, Peter, Aviezer, David, Yayon, Avner, Powers, Robert

“…Interaction of basic fibroblast growth factor (FGF-2) with heparin or heparan sulfate proteoglycans (HSPGs) is required for receptor activation and initiation…”
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Chemical Diversity of Metabolites from Fungi, Cyanobacteria, and Plants Relative to FDA-Approved Anticancer Agents by El-Elimat, Tamam, Zhang, Xiaoli, Jarjoura, David, Moy, Franklin J, Orjala, Jimmy, Kinghorn, A. Douglas, Pearce, Cedric J, Oberlies, Nicholas H

“…A collaborative project has been undertaken to explore filamentous fungi, cyanobacteria, and tropical plants for anticancer drug leads. Through principal…”
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qNMR for profiling the production of fungal secondary metabolites by Brooks, Wilson C., Paguigan, Noemi D., Raja, Huzefa A., Moy, Franklin J., Cech, Nadja B., Pearce, Cedric J., Oberlies, Nicholas H.

“…Analysis of complex mixtures is a common challenge in natural products research. Quantitative nuclear magnetic resonance spectroscopy offers analysis of…”
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Assignments, Secondary Structure, Global Fold, and Dynamics of Chemotaxis Y Protein Using Three- and Four-Dimensional Heteronuclear (13C,15N) NMR Spectroscopy by Moy, Franklin J, Lowry, David F, Matsumura, Philip, Dahlquist, Frederick W, Krywko, James E, Domaille, Peter J

“…NMR spectroscopy has been used to study recombinant Escherichia coli CheY, a 128-residue protein involved in regulating bacterial chemotaxis. Heteronuclear…”
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Novel Synthesis and Structural Characterization of a High-Affinity Paramagnetic Kinase Probe for the Identification of Non-ATP Site Binders by Nuclear Magnetic Resonance by Moy, Franklin J, Lee, Arthur, Gavrin, Lori Krim, Xu, Zhang Bao, Sievers, Annette, Kieras, Elizabeth, Stochaj, Wayne, Mosyak, Lidia, McKew, John, Tsao, Désirée H. H

“…To aid in the pursuit of selective kinase inhibitors, we have developed a unique ATP site binder tool for the detection of binders outside the ATP site by…”
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NMR dynamics and antibody recognition of the meningococcal lipidated outer membrane protein LP2086 in micellar solution by Mascioni, Alessandro, Moy, Franklin J., McNeil, Lisa K., Murphy, Ellen, Bentley, Breagh E., Camarda, Rosaria, Dilts, Deborah A., Fink, Pamela S., Gusarova, Viktoria, Hoiseth, Susan K., Malakian, Karl, Mininni, Terri, Novikova, Elena, Lin, Shuo, Sigethy, Scott, Zlotnick, Gary W., Tsao, Désirée H.H.

“…Neisseria meningitidis is a major cause of meningitis. Although protective vaccination is available against some pathogenic serogroups, serogroup B…”
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Solution structure of human IL-13 and implication for receptor binding by Moy, Franklin J, Diblasio, Elizabeth, Wilhelm, James, Powers, Robert

“…Interleukin-13 has been implicated as a key factor in asthma, allergy, atopy and inflammatory response, establishing the protein as a valuable therapeutic…”
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MS/NMR:  A Structure-Based Approach for Discovering Protein Ligands and for Drug Design by Coupling Size Exclusion Chromatography, Mass Spectrometry, and Nuclear Magnetic Resonance Spectroscopy by Moy, Franklin J, Haraki, Kevin, Mobilio, Dominick, Walker, Gary, Powers, Robert, Tabei, Keiko, Tong, Hui, Siegel, Marshall M

“…A protocol is described for rapidly screening small organic molecules for their ability to bind a target protein while obtaining structure-related information…”
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Solution Structure of ZipA, a Crucial Component of Escherichia coli Cell Division by Moy, Franklin J, Glasfeld, Elizabeth, Mosyak, Lidia, Powers, Robert

“…ZipA, an essential component of cell division in Escherichia coli, interacts with the FtsZ protein at the midcell in one of the initial steps of septum…”
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High-resolution solution structure of the catalytic fragment of human collagenase-3 (MMP-13) complexed with a hydroxamic acid inhibitor by Moy, Franklin J, Chanda, Pranab K, Chen, James M, Cosmi, Scott, Edris, Wade, Levin, Jeremy I, Powers, Robert

“…The high-resolution solution structure of the catalytic fragment of human collagenase-3 (MMP-13) complexed with a sulfonamide derivative of a hydroxamic acid…”
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Design and Syntheses of 1,6-Naphthalene Derivatives as Selective HCMV Protease Inhibitors by Gopalsamy, Ariamala, Lim, Kitae, Ellingboe, John W., Mitsner, Boris, Nikitenko, Antonia, Upeslacis, Janis, Mansour, Tarek S., Olson, Matthew W., Bebernitz, Geraldine A., Grinberg, Diane, Feld, Boris, Moy, Franklin J., O'Connell, John

“…Through high throughput screening of various libraries, substituted styryl naphthalene 6 was identified as an HCMV protease inhibitor. Optimization of various…”
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NMR Structure of Free RGS4 Reveals an Induced Conformational Change upon Binding Gα by Moy, Franklin J, Chanda, Pranab K, Cockett, Mark I, Edris, Wade, Jones, Philip G, Mason, Kim, Semus, Simon, Powers, Robert

“…Heterotrimeric guanine nucleotide-binding proteins (G-proteins) are transducers in many cellular transmembrane signaling systems where regulators of G-protein…”
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NMR Solution Structure of the Catalytic Fragment of Human Fibroblast Collagenase Complexed with a Sulfonamide Derivative of a Hydroxamic Acid Compound by Moy, Franklin J, Chanda, Pranab K, Chen, James M, Cosmi, Scott, Edris, Wade, Skotnicki, Jerauld S, Wilhelm, Jim, Powers, Robert

“…The solution structure of the catalytic fragment of human fibroblast collagenase (MMP-1) complexed with a sulfonamide derivative of a hydroxamic acid compound…”
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High-Resolution Solution Structure of Basic Fibroblast Growth Factor Determined by Multidimensional Heteronuclear Magnetic Resonance Spectroscopy by Moy, Franklin J, Seddon, Andrew P, Böhlen, Peter, Powers, Robert

“…The high-resolution solution structure of recombinant human basic fibroblast growth factor (FGF-2), a protein of 17.2 kDa that exhibits a variety of functions…”
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High-Resolution Solution Structure of the Inhibitor-Free Catalytic Fragment of Human Fibroblast Collagenase Determined by Multidimensional NMR by Moy, Franklin J, Chanda, Pranab K, Cosmi, Scott, Pisano, Michael R, Urbano, Charlotte, Wilhelm, Jim, Powers, Robert

“…The high-resolution solution structure of the inhibitor-free catalytic fragment of human fibroblast collagenase (MMP-1), a protein of 18.7 kDa, which is a…”
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Assignments, secondary structure and dynamics of the inhibitor-free catalytic fragment of human fibroblast collagenase by Moy, F J, Pisano, M R, Chanda, P K, Urbano, C, Killar, L M, Sung, M L, Powers, R

“…Fibroblast collagenase (MMP-1), a 169-residue protein with a molecular mass of 18.7 kDa, is a matrix metalloproteinase which has been associated with…”
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Homology Model for Oncostatin M Based on NMR Structural Data by Kitchen, Douglas, Hoffman, Ross C, Moy, Franklin J, Powers, Robert

“…Oncostatin M (OM) is a member of the cytokine family which regulates the proliferation and differentiation of a variety of cell types and includes…”
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