Search Results - "MOWLES, Delores"

A comparison of the transportability, and its role in cytotoxicity, of clofarabine, cladribine, and fludarabine by recombinant human nucleoside transporters produced in three model expression systems by King, Karen M, Damaraju, Vijaya L, Vickers, Mark F, Yao, Sylvia Y, Lang, Thach, Tackaberry, Tracey E, Mowles, Delores A, Ng, Amy M L, Young, James D, Cass, Carol E

“…2-Chloro-9-(2'-deoxy-2'-fluoro-beta-d-arabinofuranosyl)adenine (Cl-F-ara-A, clofarabine), a purine nucleoside analog with structural similarity to…”
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Role of Human Nucleoside Transporters in the Uptake and Cytotoxicity of Azacitidine and Decitabine by Damaraju, Vijaya L., Mowles, Delores, Yao, Sylvia, Ng, Amy, Young, James D., Cass, Carol E., Tong, Zeen

“…The nucleoside analogs 5-azacytidine (azacitidine) and 5-aza-2′-deoxycytidine (decitabine) are active against acute myeloid leukemia and myelodysplastic…”
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Cellular influx, efflux, and anabolism of 3-carboranyl thymidine analogs: potential boron delivery agents for neutron capture therapy by Sjuvarsson, Elena, Damaraju, Vijaya L, Mowles, Delores, Sawyer, Michael B, Tiwari, Rohit, Agarwal, Hitesh K, Khalil, Ahmed, Hasabelnaby, Sherifa, Goudah, Ayman, Nakkula, Robin J, Barth, Rolf F, Cass, Carol E, Eriksson, Staffan, Tjarks, Werner

“…3-[5-{2-(2,3-Dihydroxyprop-1-yl)-o-carboran-1-yl}pentan-1-yl]thymidine (N5-2OH) is a first generation 3-carboranyl thymidine analog (3CTA) that has been…”
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Comparative in vitro evaluation of transportability and toxicity of capecitabine and its metabolites in cells derived from normal human kidney and renal cancers by Damaraju, Vijaya L, Mowles, Delores, Wilson, Marnie, Kuzma, Michelle, Cass, Carol E, Sawyer, Michael B

“…The goal of this study was to understand roles of nucleoside and nucleobase transport processes in capecitabine pharmacology in cells derived from human renal…”
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Transepithelial fluxes of adenosine and 2'-deoxyadenosine across human renal proximal tubule cells: roles of nucleoside transporters hENT1, hENT2, and hCNT3 by Elwi, Adam N, Damaraju, Vijaya L, Kuzma, Michelle L, Mowles, Delores A, Baldwin, Stephen A, Young, James D, Sawyer, Michael B, Cass, Carol E

“…This study examined the roles of human nucleoside transporters (hNTs) in mediating transepithelial fluxes of adenosine, 2'-deoxyadenosine, and three purine…”
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Molecular Identification and Characterization of Novel Human and Mouse Concentrative Na+-Nucleoside Cotransporter Proteins (hCNT3 and mCNT3) Broadly Selective for Purine and Pyrimidine Nucleosides (System cib) by Ritzel, Mabel W.L., Ng, Amy M.L., Yao, Sylvia Y.M., Graham, Kathryn, Loewen, Shaun K., Smith, Kyla M., Ritzel, R. Gary, Mowles, Delores A., Carpenter, Pat, Chen, Xing-Zhen, Karpinski, Edward, Hyde, Ralph J., Baldwin, Stephen A., Cass, Carol E., Young, James D.

“…The human concentrative (Na+-linked) plasma membrane transport proteins hCNT1 and hCNT2 are selective for pyrimidine nucleosides (systemcit) and purine…”
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Role of human nucleoside transporters in the cellular uptake of two inhibitors of IMP dehydrogenase, tiazofurin and benzamide riboside by Damaraju, Vijaya L, Visser, Frank, Zhang, Jing, Mowles, Delores, Ng, Amy M L, Young, James D, Jayaram, Hiremagalur N, Cass, Carol E

“…Benzamide riboside (BR) and tiazofurin (TR) are converted to analogs of NAD that inhibit IMP dehydrogenase (IMPDH), resulting in cellular depletion of GTP and…”
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Differential Transport of Cytosine-Containing Nucleosides by Recombinant Human Concentrative Nucleoside Transporter Protein hCNT1 by Graham, Kathryn A., Leithoff, Jackie, Coe, Imogen R., Mowles, Delores, Mackey, John R., Young, James D., Cass, Carol E.

“…The transportability of cytosine-containing nucleosides by recombinant hCNT1 was investigated in transfected mammalian cells. Apparent K m values for…”
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Erlotinib, Gefitinib, and Vandetanib Inhibit Human Nucleoside Transporters and Protect Cancer Cells from Gemcitabine Cytotoxicity by DAMARAJU, Vijaya L, SCRIVER, Tara, MOWLES, Delores, KUZMA, Michelle, RYAN, Anderson J, CASS, Carol E, SAWYER, Michael B

“…Combinations of tyrosine kinase inhibitors (TKI) with gemcitabine have been attempted with little added benefit to patients. We hypothesized that TKIs designed…”
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Interactions of multitargeted kinase inhibitors and nucleoside drugs: Achilles heel of combination therapy? by Damaraju, Vijaya L, Kuzma, Michelle, Mowles, Delores, Cass, Carol E, Sawyer, Michael B

“…Multitargeted tyrosine kinase inhibitors (TKI) axitinib, pazopanib, and sunitinib are used to treat many solid tumors. Combination trials of TKIs with…”
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Abstract 797: Interaction of multitargeted tyrosine kinase inhibitors with human nucleoside transporters by Damaraju, Vijaya L., Kuzma, Michelle, Mowles, Delores, Cass, Carol E., Sawyer, Michael B.

“…Abstract Several oral multitargeted kinase (MTK) inhibitors are approved for use in the clinic among which, axitinib, pazopanib and sunitinib are used to treat…”
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Two Distinct Molecular Mechanisms Underlying Cytarabine Resistance in Human Leukemic Cells by JIE CAI, DAMARAJU, Vijaya L, GROULX, Normand, MOWLES, Delores, YUNSHAN PENG, ROBINS, Morris J, CASS, Carol E, GROS, Philippe

“…To understand the mechanism of cellular resistance to the nucleoside analogue cytarabine (1-beta-D-arabinofuranosylcytosine, AraC), two resistant derivatives…”
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Effects of gefitinib and vandetanib on human equilibrative nucleoside transporter 1 and on gemcitabine cytotoxicity by Damaraju, Vijaya L., Scriver, Tara, Mowles, Delores, Cass, Carol E, Sawyer, Michael B.

“…Abstract only 2546 Background: Combination chemotherapy with tyrosine kinase inhibitors (TKIs) and gemcitabine has been attempted with little added benefit to…”
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Improved Syntheses of 5′-S-(2-Aminoethyl)-6-N-(4-nitrobenzyl)-5′-thioadenosine (SAENTA), Analogues, and Fluorescent Probe Conjugates: Analysis of Cell-Surface Human Equilibrative Nucleoside Transporter 1 (hENT1) Levels for Prediction of the Antitumor Efficacy of Gemcitabine by Robins, Morris J, Peng, Yunshan, Damaraju, Vijaya L, Mowles, Delores, Barron, Geraldine, Tackaberry, Tracey, Young, James D, Cass, Carol E

“…5′-S-(2-Aminoethyl)-6-N-(4-nitrobenzyl)-5′-thioadenosine (SAENTA), 5′-S-(2-acetamidoethyl)-6-N-[(4-substituted)benzyl]-5′-thioadenosine analogues,…”
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Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines by MACKEY, J. R, MANI, R. S, SELNER, M, MOWLES, D, YOUNG, J. D, BELT, J. A, CRAWFORD, C. R, CASS, C. E

“…Gemcitabine (2',2'-difluorodeoxycytidine) is a novel pyrimidine nucleoside drug with clinical efficacy in several common epithelial cancers. We have proposed…”
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Interaction of fused-pyrimidine nucleoside analogs with human concentrative nucleoside transporters: High-affinity inhibitors of human concentrative nucleoside transporter 1 by Damaraju, Vijaya L., Smith, Kyla M., Mowles, Delores, Nowak, Ireneusz, Karpinski, Edward, Young, James D., Robins, Morris J., Cass, Carol E.

“…Human concentrative nucleoside transporters (hCNTs) mediate electrogenic secondary active transport of physiological nucleosides and nucleoside drugs into…”
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Influence of Sugar Ring Conformation on the Transportability of Nucleosides by Human Nucleoside Transporters by Damaraju, Vijaya L., Mowles, Delores, Smith, Kyla M., Yao, Sylvia Y. M., Young, James D., Marquez, Victor E., Cass, Carol E.

“…The conformational preference of human nucleoside transporters (hNTs) with respect to sugar ring was examined using conformationally fixed purine and…”
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Cytotoxic activity of gemcitabine in cultured cell lines derived from histologically different types of bladder cancer: Role of thymidine kinase 2 by Damaraju, Swathi, Damaraju, Vijaya L., Mowles, Delores, Sawyer, Michael B., Damaraju, Sambasivarao, Cass, Carol E.

“…World wide incidence of bladder cancer is rising with nearly 13,760 deaths attributed to bladder cancer in 2007 in the USA. Tumor types of the urothelium…”
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Nucleoside transporter gene expression in wild-type and mENT1 knockout mice by Graham, Kathryn, Yao, Sylvia, Johnson, Lorelei, Mowles, Delores, Ng, Amy, Wilkinson, Jodi, Young, James D, Cass, Carol E

“…Owing to the overlapping and redundant roles of the seven mammalian nucleoside transporters (NTs), which belong to two protein families (ENTs and CNTs), the…”
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The role of human nucleoside transporters in cellular uptake of 4'-thio-beta-D-arabinofuranosylcytosine and beta-D-arabinosylcytosine by Clarke, Marilyn L, Damaraju, Vijaya L, Zhang, Jing, Mowles, Delores, Tackaberry, Tracey, Lang, Thach, Smith, Kyla M, Young, James D, Tomkinson, Blake, Cass, Carol E

“…4'-Thio-beta-D-arabinofuranosyl cytosine (TaraC) is in phase I development for treatment of cancer. In human equilibrative nucleoside transporter (hENT)…”
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