Search Results - "MOUSSAOUI, SALIHA"

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease by Labbadia, John, Cunliffe, Helen, Weiss, Andreas, Katsyuba, Elena, Sathasivam, Kirupa, Seredenina, Tamara, Woodman, Ben, Moussaoui, Saliha, Frentzel, Stefan, Luthi-Carter, Ruth, Paganetti, Paolo, Bates, Gillian P

“…Huntington disease (HD) is a devastating neurodegenerative disorder for which there are no disease-modifying treatments. Previous studies have proposed that…”
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In Vivo Profiling Reveals a Competent Heat Shock Response in Adult Neurons: Implications for Neurodegenerative Disorders by Carnemolla, Alisia, Lazell, Hayley, Moussaoui, Saliha, Bates, Gillian P

“…The heat shock response (HSR) is the main pathway used by cells to counteract proteotoxicity. The inability of differentiated neurons to induce an HSR has been…”
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A kinase inhibitor which specifically targets the ABL myristate pocket (STAMP), but unlike asciminib crosses the blood–brain barrier by Manley, Paul W., Huth, Felix, Moussaoui, Saliha, Schoepfer, Joseph

“…[Display omitted] The ubiquitously expressed ABL1 and ABL2 protein kinases play many important roles in cell function. Although they have been implicated in…”
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Parkin immunoreactivity in the brain of human and non-human primates: An immunohistochemical analysis in normal conditions and in Parkinsonian syndromes by Zarate-Lagunes, Martin, Gu, Wen-Jie, Blanchard, Véronique, Francois, Chantal, Muriel, Marie-Paule, Mouatt-Prigent, Annick, Bonici, Bruno, Parent, André, Hartmann, Andreas, Yelnik, Jérôme, Boehme, Georg A., Pradier, Laurent, Moussaoui, Saliha, Faucheux, Baptiste, Raisman-Vozari, Rita, Agid, Yves, Brice, Alexis, Hirsch, Etienne C.

“…The etiology of Parkinson's disease is unknown, but the gene involved in an autosomic recessive form of the disease with early onset has recently been…”
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Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington's disease by Bouchard, Jill, Truong, Jennifer, Bouchard, Kristofer, Dunkelberger, Diana, Desrayaud, Sandrine, Moussaoui, Saliha, Tabrizi, Sarah J, Stella, Nephi, Muchowski, Paul J

“…Peripheral immune cells and brain microglia exhibit an activated phenotype in premanifest Huntington's disease (HD) patients that persists chronically and…”
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Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice by Furukawa-Hibi, Yoko, Alkam, Tursun, Nitta, Atsumi, Matsuyama, Akihiro, Mizoguchi, Hiroyuki, Suzuki, Kazuhiko, Moussaoui, Saliha, Yu, Qian-Sheng, Greig, Nigel H., Nagai, Taku, Yamada, Kiyofumi

“…► ChE inhibitors are used for therapy of cognitive decline in Alzheimer's disease. ► The effect of BuChE inhibition on Aβ-induced cognitive dysfunction is not…”
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Contesting the dogma of an age-related heat shock response impairment: implications for cardiac-specific age-related disorders by Carnemolla, Alisia, Labbadia, John P, Lazell, Hayley, Neueder, Andreas, Moussaoui, Saliha, Bates, Gillian P

“…Ageing is associated with the reduced performance of physiological processes and has been proposed as a major risk factor for disease. An age-related decline…”
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Novel Isoforms of Heat Shock Transcription Factor 1, HSF1γα and HSF1γβ, Regulate Chaperone Protein Gene Transcription by Neueder, Andreas, Achilli, Francesca, Moussaoui, Saliha, Bates, Gillian P.

“…The heat shock response, resulting in the production of heat shock proteins or molecular chaperones, is triggered by elevated temperature and a variety of…”
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Novel Isoforms of Heat Shock Transcription Factor 1, HSF1 gamma alpha and HSF1 gamma beta , Regulate Chaperone Protein Gene Transcription by Neueder, Andreas, Achilli, Francesca, Moussaoui, Saliha, Bates, Gillian P

“…Background: HSF1 is the major eukaryotic transcription factor that regulates expression of HSP genes. Results: We identify two novel HSF1 isoforms and show…”
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Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition by Siebzehnrübl, Florian A., Raber, Kerstin A., Urbach, Yvonne K., Schulze-Krebs, Anja, Canneva, Fabio, Moceri, Sandra, Habermeyer, Johanna, Achoui, Dalila, Gupta, Bhavana, Steindler, Dennis A., Stephan, Michael, Nguyen, Huu Phuc, Bonin, Michael, Riess, Olaf, Bauer, Andreas, Aigner, Ludwig, Couillard-Despres, Sebastien, Paucar, Martin Arce, Svenningsson, Per, Osmand, Alexander, Andreew, Alexander, Zabel, Claus, Weiss, Andreas, Kuhn, Rainer, Moussaoui, Saliha, Blockx, Ines, Van der Linden, Annemie, Cheong, Rachel Y., Roybon, Laurent, Petersén, Åsa, von Hörsten, Stephan

“…Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene (HTT). Although mutant HTT is…”
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lncRNAs as a novel source of diagnostic applications for early Alzheimer’s disease and other dementia types by Firat, Hüseyin, Nazi, Sami Ait Abbi, Bier, Jean‐Christophe, Blanc, Frédéric, Boutillier, Stéphanie, Danilin, Sabrina, David, Renaud, Démonet, Jean‐François, Dubois, Bruno, Frisoni, Giovanni B, Gabelle, Audrey, Gurvit, Hakan, Ivanoiu, Adrian, Magnin, Eloi, Marizzoni, Moira, Moussaoui, Saliha, Mutter, Catherine, Pasquier, Florence, Schordan, Eric, Sellal, François

“…Background There is an unmet need for an accurate, non‐invasive biomarker test for the diagnosis of early Alzheimer’s disease (AD). To identify new biomarkers,…”
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lncRNAs as a novel source of diagnostic applications for early Alzheimer’s disease and other dementia types: Biomarkers (non‐neuroimaging) / Novel biomarkers by Firat, Hüseyin, Nazi, Sami Ait Abbi, Bier, Jean‐Christophe, Blanc, Frédéric, Boutillier, Stéphanie, Danilin, Sabrina, David, Renaud, Démonet, Jean‐François, Dubois, Bruno, Frisoni, Giovanni B, Gabelle, Audrey, Gurvit, Hakan, Ivanoiu, Adrian, Magnin, Eloi, Marizzoni, Moira, Moussaoui, Saliha, Mutter, Catherine, Pasquier, Florence, Schordan, Eric, Sellal, François

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Antiviral effect of cationic compounds on bacteriophages by Ly-Chatain, Mai H, Moussaoui, Saliha, Vera, Annabelle, Rigobello, Véronique, Demarigny, Yann

“…The antiviral activity of several cationic compounds - cetyltrimethylammonium bromide (CTAB), chitosan, nisin, and lysozyme - was investigated on the…”
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Modeling and simulation of organophosphate-induced neurotoxicity: Prediction and validation by experimental studies by Greget, Renaud, Dadak, Selma, Barbier, Laure, Lauga, Fabien, Linossier-Pierre, Sandra, Pernot, Fabien, Legendre, Arnaud, Ambert, Nicolas, Bouteiller, Jean-Marie, Dorandeu, Frédéric, Bischoff, Serge, Baudry, Michel, Fagni, Laurent, Moussaoui, Saliha

“…•A novel in silico model of Organophosphorus (OP)-induced neuronal toxicity is set up.•This model enables predicting effect of drugs on OP-induced neuronal…”
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A fully parallel in time and space algorithm for simulating the electrical activity of a neural tissue by Bedez, Mathieu, Belhachmi, Zakaria, Haeberlé, Olivier, Greget, Renaud, Moussaoui, Saliha, Bouteiller, Jean-Marie, Bischoff, Serge

“…•Description of a method coupling parallelization in time and space on the GPU.•Resolution of a model describing the propagation of the electrical signal in a…”
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Time sequence of maturation of dystrophic neurites associated with Aβ deposits in APP/PS1 transgenic mice by Blanchard, Véronique, Moussaoui, Saliha, Czech, Christian, Touchet, Nathalie, Bonici, Bruno, Planche, Michel, Canton, Thierry, Jedidi, Iness, Gohin, Micheline, Wirths, Oliver, Bayer, Thomas A, Langui, Dominique, Duyckaerts, Charles, Tremp, Günter, Pradier, Laurent

“…Several novel transgenic mouse models expressing different mutant APPs in combination with mutant PS1 have been developed. These models have been analyzed to…”
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P2‐271: ADDIA, A MULTICENTER CLINICAL STUDY OF PROOF‐OF‐PERFORMANCE TO VALIDATE BLOOD‐BASED BIOMARKERS FOR THE DIAGNOSIS OF ALZHEIMER'S DISEASE (AD): THE STUDY PROTOCOL by Dubois, Bruno, Bier, Jean-Christophe, Blanc, Frederic, David, Renaud, Démonet, Jean-François, Firat, Hüseyin, Frisoni, Giovanni B., Gabelle, Audrey, Gurvit, Hakan I., Ivanoiu, Adrian, Magnin, Eloi, Marizzoni, Moira, Moussaoui, Saliha, Pasquier, Florence, Sellal, François

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ADDIA, A MULTICENTER CLINICAL STUDY OF PROOF-OF-PERFORMANCE TO VALIDATE BLOOD-BASED BIOMARKERS FOR THE DIAGNOSIS OF ALZHEIMER’S DISEASE (AD): THE STUDY PROTOCOL by Dubois, Bruno, Bier, Jean-Christophe, Blanc, Frederic, David, Renaud, Démonet, Jean-François, Firat, Hüseyin, Frisoni, Giovanni B., Gabelle, Audrey, Gurvit, Hakan I., Ivanoiu, Adrian, Magnin, Eloi, Marizzoni, Moira, Moussaoui, Saliha, Pasquier, Florence, Sellal, François

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Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration by Zwilling, Daniel, Huang, Shao-Yi, Sathyasaikumar, Korrapati V., Notarangelo, Francesca M., Guidetti, Paolo, Wu, Hui-Qiu, Lee, Jason, Truong, Jennifer, Andrews-Zwilling, Yaisa, Hsieh, Eric W., Louie, Jamie Y., Wu, Tiffany, Scearce-Levie, Kimberly, Patrick, Christina, Adame, Anthony, Giorgini, Flaviano, Moussaoui, Saliha, Laue, Grit, Rassoulpour, Arash, Flik, Gunnar, Huang, Yadong, Muchowski, Joseph M., Masliah, Eliezer, Schwarcz, Robert, Muchowski, Paul J.

“…Metabolites in the kynurenine pathway, generated by tryptophan degradation, are thought to play an important role in neurodegenerative disorders, including…”
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Impact of synaptic localization and subunit composition of ionotropic glutamate receptors on synaptic function: modeling and simulation studies by Keller, A, Ambert, Nicolas, Legendre, Arnaud, Bedez, Mathieu, Bouteiller, J-M, Bischoff, Serge, Baudry, Michel, Moussaoui, Saliha

“…Ionotropic NMDA and AMPA glutamate receptors (iGluRs) play important roles in synaptic function under physiological and pathological conditions. iGluRs…”
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