Effects of eurocollins solution as aortic flush for the procurement of human pancreas

Effects of eurocollins solution as aortic flush for the procurement of human pancreas

Belzer solution is considered to be the best preservation media used for pancreas transplantation; however, its high cost accounts for approximately 14.5% of all resources allocated by the Brazilian government toward each pancreatic transplant. The objective of the present study was to test a reduct...

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Published in:Transplantation Vol. 80; no. 9; pp. 1269 - 1274
Main Authors: GONZALEZ, Adriano M, LOPES FILHO, Gaspar J, PESTANA, José O. M, LINHARES, Marcelo M, SILVA, Maria Helena G, MOURA, Rita Maria A. M, MELARAGNO, Claudio, DE SA, Joao Roberto, RANGEL, Erica B, TRIVINO, Tarcisio
Format: Journal Article
Language:English
Published: Hagerstown, MD Lippincott 15-11-2005
Subjects:
Adenosine - economics
Adult
Allopurinol - economics
Aorta
Biological and medical sciences
Cost Control
Drug Costs
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Glutathione - economics
Humans
Hypertonic Solutions - standards
Insulin - economics
Length of Stay
Male
Medical sciences
Organ Preservation Solutions - economics
Organ Preservation Solutions - standards
Pancreas - physiopathology
Pancreas Transplantation - adverse effects
Raffinose - economics
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Survival Analysis
Therapeutic Irrigation
Tissue and Organ Harvesting - economics
Tissue and Organ Harvesting - methods
Tissue Survival
Tissue, organ and graft immunology
Human
Procurement
Organ preservation
Blood vessel
Aorta
Graft
Circulatory system
Pancreas
Artery
Solution
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Summary:Belzer solution is considered to be the best preservation media used for pancreas transplantation; however, its high cost accounts for approximately 14.5% of all resources allocated by the Brazilian government toward each pancreatic transplant. The objective of the present study was to test a reduction of Belzer solution during pancreas harvest, thereby lowering procedural cost. The patients received pancreas-kidney transplantations during the period from January 2003 to August 2004. Patients were divided into two groups. Patients assigned to Group A (n=30) received only Belzer solution (2 L through the aorta artery), whereas patients in Group B (n=16) were perfused first with 1 L of Eurocollins solution followed by 1 L of Belzer solution. The two groups were assessed for differences in the following clinical parameters: the need for insulin replacement or antifungal and anticytomegalovirus treatment, pancreatitis, acute cellular rejection, graft vascular thrombosis, fistulas, intra-abdominal collection, graft loss, deaths, pancreatic ischemia time, and average hospitalization time. No statistically significant differences were observed in any of the parameters analyzed (P<0.05). The use of Eurocollins solution, followed by Belzer solution during pancreas harvesting, did not result in differences in graft survival or functionality, postsurgical complications, or patient survival and hospitalization time, when compared to the use of Belzer solution alone. Perfusion with 1 L of Eurocollins solution followed by 1 L of Belzer solution during pancreas harvesting seems to be a simple and efficient alternative for reducing the costs of the harvesting process.
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ISSN:0041-1337
1534-6080
DOI:10.1097/01.TP.0000177640.53848.3D