Search Results - "MOTTOLESE, Marcella"

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets by Medico, Enzo, Russo, Mariangela, Picco, Gabriele, Cancelliere, Carlotta, Valtorta, Emanuele, Corti, Giorgio, Buscarino, Michela, Isella, Claudio, Lamba, Simona, Martinoglio, Barbara, Veronese, Silvio, Siena, Salvatore, Sartore-Bianchi, Andrea, Beccuti, Marco, Mottolese, Marcella, Linnebacher, Michael, Cordero, Francesca, Di Nicolantonio, Federica, Bardelli, Alberto

“…The development of molecularly targeted anticancer agents relies on large panels of tumour-specific preclinical models closely recapitulating the molecular…”
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miR-155 Drives Telomere Fragility in Human Breast Cancer by Targeting TRF1 by DINAMI, Roberto, ERCOLANI, Cristiana, BENETTI, Roberta, MOTTOLESE, Marcella, SCHNEIDER, Claudio, BLANDINO, Giovanni, SCHOEFTNER, Stefan, PETTI, Eleonora, PIAZZA, Silvano, CIANI, Yari, SESTITO, Rosanna, SACCONI, Andrea, BIAGIONI, Francesca, LE SAGE, Carlos, AGAMI, Reuven

“…Telomeres consist of DNA tandem repeats that recruit the multiprotein complex shelterin to build a chromatin structure that protects chromosome ends. Although…”
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Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation by Di Agostino, Silvia, Strano, Sabrina, Emiliozzi, Velia, Zerbini, Valentina, Mottolese, Marcella, Sacchi, Ada, Blandino, Giovanni, Piaggio, Giulia

“…This article investigates the mechanistic aspects of mutant p53 “gain of function” in response to DNA damage. We show that mutant forms of p53 protein interact…”
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Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma by Fianco, Giulia, Mongiardi, Maria Patrizia, Levi, Andrea, De Luca, Teresa, Desideri, Marianna, Trisciuoglio, Daniela, Del Bufalo, Donatella, Cinà, Irene, Di Benedetto, Anna, Mottolese, Marcella, Gentile, Antonietta, Centonze, Diego, Ferrè, Fabrizio, Barilà, Daniela

“…Caspase-8 is a key player in extrinsic apoptosis and its activity is often downregulated in cancer. However, human Caspase-8 expression is retained in some…”
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CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells by Manic, Gwenola, Signore, Michele, Sistigu, Antonella, Russo, Giorgio, Corradi, Francesca, Siteni, Silvia, Musella, Martina, Vitale, Sara, De Angelis, Maria Laura, Pallocca, Matteo, Amoreo, Carla Azzurra, Sperati, Francesca, Di Franco, Simone, Barresi, Sabina, Policicchio, Eleonora, De Luca, Gabriele, De Nicola, Francesca, Mottolese, Marcella, Zeuner, Ann, Fanciulli, Maurizio, Stassi, Giorgio, Maugeri-Saccà, Marcello, Baiocchi, Marta, Tartaglia, Marco, Vitale, Ilio, De Maria, Ruggero

“…Cancer stem cells (CSCs) are responsible for tumour formation and spreading, and their targeting is required for tumour eradication. There are limited…”
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KRAS gene amplification in colorectal cancer and impact on response to EGFR‐targeted therapy by Valtorta, Emanuele, Misale, Sandra, Sartore‐Bianchi, Andrea, Nagtegaal, Iris D., Paraf, François, Lauricella, Calogero, Dimartino, Valentina, Hobor, Sebastijan, Jacobs, Bart, Ercolani, Cristiana, Lamba, Simona, Scala, Elisa, Veronese, Silvio, Laurent‐Puig, Pierre, Siena, Salvatore, Tejpar, Sabine, Mottolese, Marcella, Punt, Cornelis J.A., Gambacorta, Marcello, Bardelli, Alberto, Nicolantonio, Federica

“…KRAS mutations are the most common oncogenic event in colorectal cancer (CRC) progression and their occurrence is associated with lack of response to anti…”
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Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages by Donzelli, Sara, Milano, Elisa, Pruszko, Magdalena, Sacconi, Andrea, Masciarelli, Silvia, Iosue, Ilaria, Melucci, Elisa, Gallo, Enzo, Terrenato, Irene, Mottolese, Marcella, Zylicz, Maciej, Zylicz, Alicja, Fazi, Francesco, Blandino, Giovanni, Fontemaggi, Giulia

“…As crucial regulators of the immune response against pathogens, macrophages have been extensively shown also to be important players in several diseases,…”
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Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors by Di Modugno, Francesca, Iapicca, Pierluigi, Boudreau, Aaron, Mottolese, Marcella, Terrenato, Irene, Perracchio, Letizia, Carstens, Russ P, Santoni, Angela, Bissell, Mina J, Nisticò, Paola

“…Human mena (hMENA), a member of the actin cytoskeleton regulators Ena/VASP, is overexpressed in high-risk preneoplastic lesions and in primary breast tumors…”
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The Hippo transducers TAZ and YAP in breast cancer: oncogenic activities and clinical implications by Maugeri-Saccà, Marcello, Barba, Maddalena, Pizzuti, Laura, Vici, Patrizia, Di Lauro, Luigi, Dattilo, Rosanna, Vitale, Ilio, Bartucci, Monica, Mottolese, Marcella, De Maria, Ruggero

“…The Hippo signalling is emerging as a tumour suppressor pathway whose function is regulated by an intricate network of intracellular and extracellular cues…”
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PLC-gamma-1 phosphorylation status is prognostic of metastatic risk in patients with early-stage Luminal-A and -B breast cancer subtypes by Lattanzio, Rossano, Iezzi, Manuela, Sala, Gianluca, Tinari, Nicola, Falasca, Marco, Alberti, Saverio, Buglioni, Simonetta, Mottolese, Marcella, Perracchio, Letizia, Natali, Pier Giorgio, Piantelli, Mauro

“…Phospholipase Cγ1 (PLCγ1) is highly expressed in human tumours. Our previous studies reported that both stable and inducible PLCγ1 down-regulation can inhibit…”
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HER2 Protein and Gene Variation between Primary and Metastatic Breast Cancer: Significance and Impact on Patient Care by FABI, Alessandra, DI BENEDETTO, Anna, SPERDUTI, Isabella, PAPALDO, Paola, COGNETTI, Francesco, MOTTOLESE, Marcella, METRO, Giulio, PERRACCHIO, Letizia, NISTICO, Cecilia, DI FILIPPO, Franco, ERCOLANI, Cristiana, FERRETTI, Gianluigi, MELUCCI, Elisa, BUGLIONI, Simonetta

“…To analyze HER2 status in primary breast cancer (PBC) compared with correspondent metachronous metastases and to investigate whether BC phenotype may be…”
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Vitamin D supplementation and breast cancer prevention: a systematic review and meta-analysis of randomized clinical trials by Sperati, Francesca, Vici, Patrizia, Maugeri-Saccà, Marcello, Stranges, Saverio, Santesso, Nancy, Mariani, Luciano, Giordano, Antonio, Sergi, Domenico, Pizzuti, Laura, Di Lauro, Luigi, Montella, Maurizio, Crispo, Anna, Mottolese, Marcella, Barba, Maddalena

“…In recent years, the scientific evidence linking vitamin D status or supplementation to breast cancer has grown notably. To investigate the role of vitamin D…”
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Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect by Salvati, Erica, Leonetti, Carlo, Rizzo, Angela, Scarsella, Marco, Mottolese, Marcella, Galati, Rossella, Sperduti, Isabella, Stevens, Malcolm F G, D'Incalci, Maurizio, Blasco, Maria, Chiorino, Giovanna, Bauwens, Serge, Horard, Béatrice, Gilson, Eric, Stoppacciaro, Antonella, Zupi, Gabriella, Biroccio, Annamaria

“…Functional telomeres are required for the replicability of cancer cells. The G-rich strand of telomeric DNA can fold into a 4-stranded structure known as the…”
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TRF2 and VEGF-A: an unknown relationship with prognostic impact on survival of colorectal cancer patients by Dinami, Roberto, Porru, Manuela, Amoreo, Carla Azzurra, Sperduti, Isabella, Mottolese, Marcella, Buglioni, Simonetta, Marinelli, Daniele, Maugeri-Saccà, Marcello, Sacconi, Andrea, Blandino, Giovanni, Leonetti, Carlo, Di Rocco, Giuliana, Verdina, Alessandra, Spinella, Francesca, Fiorentino, Francesco, Ciliberto, Gennaro, Biroccio, Annamaria, Zizza, Pasquale

“…Colorectal cancer is one of most common tumors in developed countries and, despite improvements in treatment and diagnosis, mortality rate of patients remains…”
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A comparative biomarker study of 514 matched cases of male and female breast cancer reveals gender-specific biological differences by Shaaban, Abeer M., Ball, Graham R., Brannan, Rebecca A., Cserni, Gabor, Benedetto, Anna Di, Dent, Jo, Fulford, Laura, Honarpisheh, Helen, Jordan, Lee, Jones, J. Louise, Kanthan, Rani, Maraqa, Loaie, Litwiniuk, Maria, Mottolese, Marcella, Pollock, Steven, Provenzano, Elena, Quinlan, Philip R., Reall, Georgina, Shousha, Sami, Stephens, Mark, Verghese, Eldo T., Walker, Rosemary A., Hanby, Andrew M., Speirs, Valerie

“…Male breast cancer remains understudied despite evidence of rising incidence. Using a co-ordinated multi-centre approach, we present the first large scale…”
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A cut-off of 2150 cytokeratin 19 mRNA copy number in sentinel lymph node may be a powerful predictor of non-sentinel lymph node status in breast cancer patients by Terrenato, Irene, D'Alicandro, Valerio, Casini, Beatrice, Perracchio, Letizia, Rollo, Francesca, De Salvo, Laura, Di Filippo, Simona, Di Filippo, Franco, Pescarmona, Edoardo, Maugeri-Saccà, Marcello, Mottolese, Marcella, Buglioni, Simonetta

“…Since 2007, one-step nucleic acid amplification (OSNA) has been used as a diagnostic system for sentinel lymph node (SLN) examination in patients with breast…”
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Cdx2 polymorphism affects the activities of vitamin D receptor in human breast cancer cell lines and human breast carcinomas by Pulito, Claudio, Terrenato, Irene, Di Benedetto, Anna, Korita, Etleva, Goeman, Frauke, Sacconi, Andrea, Biagioni, Francesca, Blandino, Giovanni, Strano, Sabrina, Muti, Paola, Mottolese, Marcella, Falvo, Elisabetta

“…Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR). It regulates the action of hormone responsive genes and is involved…”
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miR‐10b, a master inhibitor of the cell cycle, is down‐regulated in human breast tumours by Biagioni, Francesca, Bossel Ben‐Moshe, Noa, Fontemaggi, Giulia, Canu, Valeria, Mori, Federica, Antoniani, Barbara, Di Benedetto, Anna, Santoro, Raffaela, Germoni, Sabrina, De Angelis, Fernanda, Cambria, Anna, Avraham, Roi, Grasso, Giuseppe, Strano, Sabrina, Muti, Paola, Mottolese, Marcella, Yarden, Yosef, Domany, Eytan, Blandino, Giovanni

“…Deregulated proliferation is a hallmark of cancer cells. Here, we show that microRNA‐10b* is a master regulator of breast cancer cell proliferation and is…”
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Outcomes of HER2-positive early breast cancer patients in the pre-trastuzumab and trastuzumab eras: a real-world multicenter observational analysis. The RETROHER study by Vici, Patrizia, Pizzuti, Laura, Natoli, Clara, Moscetti, Luca, Mentuccia, Lucia, Vaccaro, Angela, Sergi, Domenico, Di Lauro, Luigi, Trenta, Patrizia, Seminara, Patrizia, Santini, Daniele, Iezzi, Laura, Tinari, Nicola, Bertolini, Ilaria, Sini, Valentina, Mottolese, Marcella, Giannarelli, Diana, Giotta, Francesco, Maugeri-Saccà, Marcello, Barba, Maddalena, Marchetti, Paolo, Michelotti, Andrea, Sperduti, Isabella, Gamucci, Teresa

“…Addition of trastuzumab to adjuvant chemotherapy has dramatically reduced the risk of recurrence and has become the standard of care for human epidermal growth…”
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Gender effects of single nucleotide polymorphisms and miRNAs targeting clock-genes in metastatic colorectal cancer patients (mCRC) by Garufi, Carlo, Giacomini, Elisa, Torsello, Angela, Sperduti, Isabella, Melucci, Elisa, Mottolese, Marcella, Zeuli, Massimo, Ettorre, Giuseppe Maria, Ricciardi, Teresa, Cognetti, Francesco, Magnani, Mauro, Ruzzo, Annamaria

“…The circadian system is composed of a set of clock-genes including PERIOD, CLOCK, BMAL1 and CRY . Disrupting this system promotes cancer development and…”
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