Search Results - "MOTHES, Walther"

The KT Jeang retrovirology prize 2024: Walther Mothes by Mothes, Walther

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Virus Cell-to-Cell Transmission by Mothes, Walther, Sherer, Nathan M, Jin, Jing, Zhong, Peng

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HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations by Ma, Xiaochu, Lu, Maolin, Gorman, Jason, Terry, Daniel S, Hong, Xinyu, Zhou, Zhou, Zhao, Hong, Altman, Roger B, Arthos, James, Blanchard, Scott C, Kwong, Peter D, Munro, James B, Mothes, Walther

“…HIV-1 entry into cells requires binding of the viral envelope glycoprotein (Env) to receptor CD4 and coreceptor. Imaging of individual Env molecules on native…”
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Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions by Munro, James B., Gorman, Jason, Ma, Xiaochu, Zhou, Zhou, Arthos, James, Burton, Dennis R., Koff, Wayne C., Courter, Joel R., Smith, Amos B., Kwong, Peter D., Blanchard, Scott C., Mothes, Walther

“…The HIV-1 envelope (Env) mediates viral entry into host cells. To enable the direct imaging of conformational dynamics within Env, we introduced fluorophores…”
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HIV cell-to-cell transmission: effects on pathogenesis and antiretroviral therapy by Agosto, Luis M, Uchil, Pradeep D, Mothes, Walther

“…Highlights • Cell-to-cell transmission may contribute to pathogenesis seen in HIV-infected individuals. • Effective antiretroviral therapy suppresses both…”
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Real-Time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles by Lu, Maolin, Uchil, Pradeep D., Li, Wenwei, Zheng, Desheng, Terry, Daniel S., Gorman, Jason, Shi, Wei, Zhang, Baoshan, Zhou, Tongqing, Ding, Shilei, Gasser, Romain, Prévost, Jérémie, Beaudoin-Bussières, Guillaume, Anand, Sai Priya, Laumaea, Annemarie, Grover, Jonathan R., Liu, Lihong, Ho, David D., Mascola, John R., Finzi, Andrés, Kwong, Peter D., Blanchard, Scott C., Mothes, Walther

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) mediates viral entry into cells and is critical for vaccine development against…”
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TRIM Protein-Mediated Regulation of Inflammatory and Innate Immune Signaling and Its Association with Antiretroviral Activity by Uchil, Pradeep D, Hinz, Angelika, Siegel, Steven, Coenen-Stass, Anna, Pertel, Thomas, Luban, Jeremy, Mothes, Walther

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Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements by Henderson, Rory, Lu, Maolin, Zhou, Ye, Mu, Zekun, Parks, Robert, Han, Qifeng, Hsu, Allen L., Carter, Elizabeth, Blanchard, Scott C., Edwards, R J, Wiehe, Kevin, Saunders, Kevin O., Borgnia, Mario J., Bartesaghi, Alberto, Mothes, Walther, Haynes, Barton F., Acharya, Priyamvada, Munir Alam, S.

“…The trimeric HIV-1 Envelope protein (Env) mediates viral-host cell fusion via a network of conformational transitions, with allosteric elements in each…”
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Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles by Li, Ze, Li, Wenwei, Lu, Maolin, Bess, Julian, Chao, Cara W., Gorman, Jason, Terry, Daniel S., Zhang, Baoshan, Zhou, Tongqing, Blanchard, Scott C., Kwong, Peter D., Lifson, Jeffrey D., Mothes, Walther, Liu, Jun

“…The HIV-1 envelope glycoprotein (Env) trimer, composed of gp120 and gp41 subunits, mediates viral entry into cells. Recombinant Env trimers have been studied…”
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Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission by Agosto, Luis M, Zhong, Peng, Munro, James, Mothes, Walther

“…HIV-1 cell-to-cell transmission allows for 2-3 orders of magnitude more efficient viral spread than cell-free dissemination. The high local multiplicity of…”
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SARS-CoV-2 Variants Increase Kinetic Stability of Open Spike Conformations as an Evolutionary Strategy by Yang, Ziwei, Han, Yang, Ding, Shilei, Shi, Wei, Zhou, Tongqing, Finzi, Andrés, Kwong, Peter D, Mothes, Walther, Lu, Maolin

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) harbor mutations in the spike (S) glycoprotein that confer more…”
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Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection by Sewald, Xaver, Ladinsky, Mark S., Uchil, Pradeep D., Beloor, Jagadish, Pi, Ruoxi, Herrmann, Christin, Motamedi, Nasim, Murrooka, Thomas T., Brehm, Michael A., Greiner, Dale L., Shultz, Leonard D., Mempel, Thorsten R., Bjorkman, Pamela J., Kumar, Priti, Mothes, Walther

“…Dendritic cells can capture and transfer retroviruses in vitro across synaptic cell-cell contacts to uninfected cells, a process called trans-infection…”
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The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions by Herschhorn, Alon, Gu, Christopher, Moraca, Francesca, Ma, Xiaochu, Farrell, Mark, Smith, Amos B., Pancera, Marie, Kwong, Peter D., Schön, Arne, Freire, Ernesto, Abrams, Cameron, Blanchard, Scott C., Mothes, Walther, Sodroski, Joseph G.

“…The entry of HIV-1 into target cells is mediated by the viral envelope glycoproteins (Env). Binding to the CD4 receptor triggers a cascade of conformational…”
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Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern by Li, Wenwei, Chen, Yaozong, Prévost, Jérémie, Ullah, Irfan, Lu, Maolin, Gong, Shang Yu, Tauzin, Alexandra, Gasser, Romain, Vézina, Dani, Anand, Sai Priya, Goyette, Guillaume, Chaterjee, Debashree, Ding, Shilei, Tolbert, William D., Grunst, Michael W., Bo, Yuxia, Zhang, Shijian, Richard, Jonathan, Zhou, Fei, Huang, Rick K., Esser, Lothar, Zeher, Allison, Côté, Marceline, Kumar, Priti, Sodroski, Joseph, Xia, Di, Uchil, Pradeep D., Pazgier, Marzena, Finzi, Andrés, Mothes, Walther

“…Emerging variants of concern for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can transmit more efficiently and partially evade protective…”
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Cell-to-cell transmission can overcome multiple donor and target cell barriers imposed on cell-free HIV by Zhong, Peng, Agosto, Luis M, Ilinskaya, Anna, Dorjbal, Batsukh, Truong, Rosaline, Derse, David, Uchil, Pradeep D, Heidecker, Gisela, Mothes, Walther

“…Virus transmission can occur either by a cell-free mode through the extracellular space or by cell-to-cell transmission involving direct cell-to-cell contact…”
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Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins by Herschhorn, Alon, Ma, Xiaochu, Gu, Christopher, Ventura, John D, Castillo-Menendez, Luis, Melillo, Bruno, Terry, Daniel S, Smith, 3rd, Amos B, Blanchard, Scott C, Munro, James B, Mothes, Walther, Finzi, Andrés, Sodroski, Joseph

“…Primary human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimers [(gp120/gp41) ] typically exist in a metastable closed conformation (state 1)…”
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Human TRIM gene expression in response to interferons by Carthagena, Laetitia, Bergamaschi, Anna, Luna, Joseph M, David, Annie, Uchil, Pradeep D, Margottin-Goguet, Florence, Mothes, Walther, Hazan, Uriel, Transy, Catherine, Pancino, Gianfranco, Nisole, Sébastien

“…Tripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity…”
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Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission by Pypaert, Marc, Mothes, Walther, Sherer, Nathan M, Lehmann, Maik J, Jimenez-Soto, Luisa F, Horensavitz, Christina

“…The spread of retroviruses between cells is estimated to be 2-3 orders of magnitude more efficient when cells can physically interact with each other. The…”
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Antibody-Induced Internalization of HIV-1 Env Proteins Limits Surface Expression of the Closed Conformation of Env by Anand, Sai Priya, Grover, Jonathan R, Tolbert, William D, Prévost, Jérémie, Richard, Jonathan, Ding, Shilei, Baril, Sophie, Medjahed, Halima, Evans, David T, Pazgier, Marzena, Mothes, Walther, Finzi, Andrés

“…To minimize immune responses against infected cells, HIV-1 limits the surface expression of its envelope glycoprotein (Env). Here, we demonstrate that this…”
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SV40 Polyomavirus Activates the Ras-MAPK Signaling Pathway for Vacuolization, Cell Death, and Virus Release by Motamedi, Nasim, Sewald, Xaver, Luo, Yong, Mothes, Walther, DiMaio, Daniel

“…Polyomaviruses are a family of small, non-enveloped DNA viruses that can cause severe disease in immunosuppressed individuals. Studies with SV40, a…”
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