Search Results - "MOSURE, K"

Disposition of conjugate-bound and free doxorubicin in tumor-bearing mice following administration of a BR96-doxorubicin immunoconjugate (BMS 182248) by MOSURE, K. W, HENDERSON, A. J, KLUNK, L. J, KNIPE, J. O

“…The chimeric BR96-doxorubicin (DOX) immunoconjugate, BMS 182248, has induced remissions and cures of human lung adenocarcinoma (L2987) implanted in athymic…”
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Cathepsin B-Labile Dipeptide Linkers for Lysosomal Release of Doxorubicin from Internalizing Immunoconjugates:  Model Studies of Enzymatic Drug Release and Antigen-Specific In Vitro Anticancer Activity by Dubowchik, Gene M, Firestone, Raymond A, Padilla, Linda, Willner, David, Hofstead, Sandra J, Mosure, Kathleen, Knipe, Jay O, Lasch, Shirley J, Trail, Pamela A

“…The anticancer drug doxorubicin (DOX) has been linked to chimeric BR96, an internalizing monoclonal antibody that binds to a Lewisy-related, tumor-associated…”
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Phosphocholine conjugation: an unexpected in vivo conjugation pathway associated with hepatitis c ns5b inhibitors featuring a bicyclo[1.1.1]pentane by Zhuo, Xiaoliang, Cantone, Joseph L, Wang, Yingzi, Leet, John E, Drexler, Dieter M, Yeung, Kap-Sun, Huang, Xiaohua Stella, Eastman, Kyle J, Parcella, Kyle E, Mosure, Kathleen W, Soars, Matthew G, Kadow, John F, Johnson, Benjamin M

“…During a medicinal chemistry campaign to identify inhibitors of the hepatitis C virus nonstructural protein 5B (RNA-dependent RNA polymerase), a…”
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Cathepsin B-sensitive dipeptide prodrugs. 2. Models of anticancer drugs paclitaxel (Taxol®), mitomycin C and doxorubicin by Dubowchik, Gene M., Mosure, Kathleen, Knipe, Jay O., Firestone, Raymond A.

“…Substrates containing doxorubicin (DOX), paclitaxel (taxol®), and mitomycin C (MMC) attached to the cathepsin B-sensitive dipeptide Phe-Lys via a…”
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Phosphonooxymethyl prodrugs of the broad spectrum antifungal azole, ravuconazole: Synthesis and biological properties by UEDA, Yasutsugu, MATISKELLA, John D, VARIA, Sailesh, KNIPE, Jay, MING ZHENG, MATHEW, Marina, MOSURE, Kathy, CLARK, Junius, LAMB, Lucinda, MEDIN, Ivette, QI GAO, HUANG, Stella, GOLIK, Jerzy, CHEN, Chung-Pin, BRONSON, Joanne J, CONNOLLY, Timothy P, HUDYMA, Thomas W, VENKATESH, Srini, DALI, Mandar, KANG, Shin-Hong, BARBOUR, Nancy, TEJWANI, Ravi

“…Synthesis of phosphonooxymethyl derivatives of ravuconazole, 2 (BMS-379224) and 3 (BMS-315801) and their biological evaluation as potential water-soluble…”
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Biaryl isoxazolinone antibacterial agents by Quesnelle, Claude A., Gill, Patrice, Roy, Stephan, Dodier, Marco, Marinier, Anne, Martel, Alain, Snyder, Lawrence B., D’Andrea, Stanley V., Bronson, Joanne J., Frosco, MaryBeth, Beaulieu, Danielle, Warr, Glen A., DenBleyker, Ken L., Stickle, Terry M., Yang, Hyekyung, Chaniewski, Susan E., Ferraro, Cheryl A., Taylor, Dennis, Russell, John W., Santone, Kenneth S., Clarke, Junius, Drain, Rebecca L., Knipe, Jay O., Mosure, Kathleen, Barrett, John F.

“…The synthesis and SAR of potent isoxazolinone analogs as antibacterial agents is reported. In an era of increasing resistance to classical antibacterial…”
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Effect of linker variation on the stability, potency, and efficacy of carcinoma-reactive BR64-doxorubicin immunoconjugates by TRAIL, P. A, WILLNER, D, BRASLAWSKY, G. R, BROWN, J, HOFSTEAD, S. J, GREENFIELD, R. S, FIRESTONE, R. A, MOSURE, K, KADOW, K. F, YANG, M. B, HELLSTRÖM, K. E, HELLSTRÖM, I, KNIPE, J, HENDERSON, A. J, LASCH, S. J, ZOECKLER, M. E, TRAILSMITH, M. D, DOYLE, T. W, KING, H. D, CASAZZA, A. M

“…The internalizing anti-Le(y) monoclonal antibody (MAb) BR64 was conjugated to the anticancer drug doxorubicin (DOX) using an acid-labile hydrazone bond to the…”
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