Search Results - "MOSIER, Donald E"

Prevention of Vaginal SHIV Transmission in Rhesus Macaques through Inhibition of CCR5 by Lederman, Michael M., Veazey, Ronald S., Offord, Robin, Mosier, Donald E., Dufour, Jason, Mefford, Megan, Piatak, Michael, Lifson, Jeffrey D., Salkowitz, Janelle R., Rodriguez, Benigno, Blauvelt, Andrew, Hartley, Oliver

“…Topical agents, such as microbicides, that can protect against human immunodeficiency virus (HIV) transmission are urgently needed. Using a chimeric…”
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Resistance to the CCR5 inhibitor 5P12-RANTES requires a difficult evolution from CCR5 to CXCR4 coreceptor use by Nedellec, Rebecca, Coetzer, Mia, Lederman, Michael M, Offord, Robin E, Hartley, Oliver, Mosier, Donald E

“…Viral resistance to small molecule allosteric inhibitors of CCR5 is well documented, and involves either selection of preexisting CXCR4-using HIV-1 variants or…”
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Intrinsic Obstacles to Human Immunodeficiency Virus Type 1 Coreceptor Switching by PASTORE, Cristina, RAMOS, Alejandra, MOSIER, Donald E

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Primary Infection by a Human Immunodeficiency Virus with Atypical Coreceptor Tropism by CHUNLAI JIANG, PARRISH, Nicholas F, PFAFF, Jennifer M, HENNING, Elizabeth A, DECKER, Julie M, ANTHONY MOODY, M, DRINKER, Mark S, SCHUTTE, Robert, FREEL, Stephanie, TOMARAS, Georgia D, NEDELLEC, Rebecca, MOSIER, Donald E, WILEN, Craig B, HAYNES, Barton F, SHAW, George M, HAHN, Beatrice H, DOMS, Robert W, FENG GAO, HUI LI, YUE CHEN, PAVLICEK, Jeffrey W, BERG, Anna, XIAOZHI LU, HONGSHUO SONG, TILTON, John C

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CCR5 Mutations Distinguish N-Terminal Modifications of RANTES (CCL5) with Agonist versus Antagonist Activity by CHOI, Won-Tak, NEDELLEC, Rebecca, COETZER, Mia, COLIN, Philippe, LAGANE, Bernard, OFFORD, Robin E, HARTLEY, Oliver, MOSIER, Donald E

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Evolution of CCR5 Use before and during Coreceptor Switching by COETZER, Mia, NEDELLEC, Rebecca, SALKOWITZ, Janelle, MCLAUGHLIN, Sherry, YI LIU, HEATH, Laura, MULLINS, James I, MOSIER, Donald E

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Fitness epistasis and constraints on adaptation in a human immunodeficiency virus type 1 protein region by da Silva, Jack, Coetzer, Mia, Nedellec, Rebecca, Pastore, Cristina, Mosier, Donald E

“…Fitness epistasis, the interaction among alleles at different loci in their effects on fitness, has potentially important consequences for adaptive evolution…”
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Neutralizing Antibodies Have Limited Effects on the Control of Established HIV-1 Infection In Vivo by Poignard, Pascal, Sabbe, Rebecca, Picchio, Gaston R, Wang, Meng, Gulizia, Richard J, Katinger, Hermann, Parren, Paul W.H.I, Mosier, Donald E, Burton, Dennis R

“…Neutralizing antibodies can protect against challenge with HIV-1 in vivo if present at appropriate concentrations at the time of viral challenge, but any role…”
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Conserved Changes in Envelope Function during Human Immunodeficiency Virus Type 1 Coreceptor Switching by PASTORE, Cristina, NEDELLEC, Rebecca, RAMOS, Alejandra, HARTLEY, Oliver, MIAMIDIAN, John L, REEVES, Jacqueline D, MOSIER, Donald E

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Two Mechanisms for Human Immunodeficiency Virus Type 1 Inhibition by N-Terminal Modifications of RANTES by PASTORE, Cristina, PICCHIO, Gaston R, GALIMI, Francesco, FISH, Richard, HARTLEY, Oliver, OFFORD, Robin E, MOSIER, Donald E

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Evolution of CXCR4-Using Human Immunodeficiency Virus Type 1 SF162 Is Associated with Two Unique Envelope Mutations by KISELYEVA, Yana, NEDELLEC, Rebecca, RAMOS, Alejandra, PASTORE, Cristina, MARGOLIS, Leonid B, MOSIER, Donald E

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Extreme Genetic Divergence Is Required for Coreceptor Switching in HIV-1 Subtype C by Coetzer, Mia, Nedellec, Rebecca, Cilliers, Tonie, Meyers, Tammy, Morris, Lynn, Mosier, Donald E

“…BACKGROUND:Coreceptor switching from CCR5 to CXCR4 is less common in subtype C HIV-1 infection than in subtype B for reasons that are unclear. We have examined…”
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How HIV changes its tropism: evolution and adaptation? by Mosier, Donald E

“…PURPOSE OF REVIEWTo present recent information on the evolution of coreceptor use from CCR5 alone to CCR5 and CXCR4, the impact CCR5 inhibitors have on this…”
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Whither or Wither Microbicides? by Grant, Robert M., Hamer, Dean, Hope, Thomas, Johnston, Rowena, Lange, Joep, Lederman, Michael M., Lieberman, Judy, Miller, Christopher J., Moore, John P., Mosier, Donald E., Richman, Douglas D., Schooley, Robert T., Springer, Marty S., Veazey, Ronald S., Wainberg, Mark A.

“…After disappointing results from all efficacy trials conducted to date, the field of microbicides research now faces substantial challenges. Poor coordination…”
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The Story Behind "A Requirement for Two Cell Types for Antibody Formation in vitro" by Mosier, Donald E

“…Not applicable…”
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Characterization of Human Immunodeficiency Virus Type 1 (HIV-1) Gag- and Gag Peptide-Specific CD4+ T-Cell Clones from an HIV-1-Seronegative Donor following In Vitro Immunization by Venturini, Sara, Mosier, Donald E, Burton, Dennis R, Poignard, Pascal

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HIV-1 subtype A envelope variants from early in infection have variable sensitivity to neutralization and to inhibitors of viral entry by BLISH, Catherine A, NEDELLEC, Rebecca, MANDALIYA, Kishorchandra, MOSIER, Donald E, OVERBAUGH, Julie

“…An effective HIV-1 vaccine or microbicide must block the transmitted virus variants that initially establish a new infection; consequently, it is critical that…”
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Human Immunodeficiency Virus Infection of Human-PBL-SCID Mice by Mosier, Donald E., Gulizia, Richard J., Baird, Stephen M., Wilson, Darcy B., Spector, Deborah H., Spector, Stephen A.

“…Severe combined immunodeficient (SCID) mice reconstituted with human peripheral blood leukocytes (hu-PBL-SCID mice) have inducible human immune function and…”
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High-Sequence Diversity and Rapid Virus Turnover Contribute to Higher Rates of Coreceptor Switching in Treatment-Experienced Subjects with HIV-1 Viremia by Nedellec, Rebecca, Herbeck, Joshua T, Hunt, Peter W, Deeks, Steven G, Mullins, James I, Anton, Elizabeth D, Reeves, Jacqueline D, Mosier, Donald E

“…Coreceptor switching from CCR5 to CXCR4 is common during chronic HIV-1 infection, but is even more common in individuals who have failed antiretroviral therapy…”
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Transduction of Human CD34$^+$ Cells That Mediate Long-Term Engraftment of NOD/SCID Mice by HIV Vectors by Miyoshi, Hiroyuki, Smith, Kent A., Mosier, Donald E., Verma, Inder M., Torbett, Bruce E.

“…Efficient gene transfer into human hematopoietic stem cells (HSCs) is an important goal in the study of the hematopoietic system as well as for gene therapy of…”
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