Search Results - "MOSESSON, M. W."

Fibrinogen and fibrin structure and functions by MOSESSON, M. W.

“…Fibrinogen molecules are comprised of two sets of disulfide‐bridged Aα‐, Bβ‐, and γ‐chains. Each molecule contains two outer D domains connected to a central E…”
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Inhibition of thrombin generation in plasma by fibrin formation (Antithrombin I) by de Bosch, N B, Mosesson, M W, Ruiz-Sáez, A, Echenagucia, M, Rodriguez-Lemoin, A

“…The adsorption of thrombin to fibrin during clotting defines "Antithrombin I" activity. We confirmed that thrombin generation in afibrinogenemic or in…”
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Fibrinogen γ chain functions by Mosesson, M. W.

“…This review covers the functional features of the fibrinogen γ chains including their participation in fibrin polymerization and cross‐linking, their role in…”
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Fibrinogen and fibrin structure and functions by MOSESSON, M.W.

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Protransglutaminase (factor XIII) mediated crosslinking of fibrinogen and fibrin by Siebenlist, K R, Meh, D A, Mosesson, M W

“…Plasma factor XIII (plasma protransglutaminase) circulates as an A2B2 tetramer bound to the gamma' variant chains of fibrinogen "2". During clotting the A…”
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Fibrinogen and fibrin polymerization: appraisal of the binding events that accompany fibrin generation and fibrin clot assembly by Mosesson, M W

“…Fibrinogen is a complex multifunctional protein comprised of three major domains (two outer D and one central E) which contains constitutive binding sites…”
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The amino acid sequence in fibrin responsible for high affinity thrombin binding by Meh, D A, Siebenlist, K R, Brennan, S O, Holyst, T, Mosesson, M W

“…Human fibrin has a low affinity thrombin binding site in its E domain and a high affinity binding site in the carboxy-terminal region of its variant gamma'…”
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Short by one mechanism: a rebuttal by MOSESSON, M. W.

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Dysfibrinogenemia and thrombosis by Mosesson, M W

“…Congenital abnormal fibrinogen molecules (dysfibrinogenemias) are due to structural defects in the molecule. The molecular structure of the fibrinogen molecule…”
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Coexisting dysfibrinogenemia (gammaR275C) and factor V Leiden deficiency associated with thromboembolic disease (fibrinogen Cedar Rapids) by Siebenlist, K R, Mosesson, M W, Meh, D A, DiOrio, J P, Albrecht, R M, Olson, J D

“…Fibrinogen Cedar Rapids is a heterozygous dysfibrinogenemia (gammaR275C) that was associated with thromboembolism during and following pregnancy in three…”
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Disintegration and reorganization of fibrin networks during tissue-type plasminogen activator-induced clot lysis by Meh, D A, Mosesson, M W, DiOrio, J P, Siebenlist, K R, Hernandez, I, Amrani, D L, Stojanovich, L

“…In this study, we investigated tissue-type plasminogen activator (tPA)-induced lysis of glutamic acid (glu)-plasminogen-containing or lysine…”
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Evidence that alpha 2-antiplasmin becomes covalently ligated to plasma fibrinogen in the circulation: a new role for plasma factor XIII in fibrinolysis regulation by Mosesson, M W, Siebenlist, K R, Hernandez, I, Lee, K N, Christiansen, V J, McKee, P A

“…Background:Plasma alpha sub(2)-antiplasmin ( alpha sub(2)AP) is a rapid and effective inhibitor of the fibrinolytic enzyme plasmin. Congenital alpha sub(2)AP…”
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Evidence for covalent linkage between some plasma α2‐antiplasmin molecules and Aα chains of circulating fibrinogen by Mosesson, M. W., Holyst, T., Hernandez, I., Siebenlist, K. R.

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The ultrastructure of fibrinogen-420 and the fibrin-420 clot by Mosesson, M.W., DiOrio, J.P., Hernandez, I., Hainfeld, J.F., Wall, J.S., Grieninger, G.

“…Fibrinogen-420 is a minor subclass of human fibrinogen that is so named because of its higher molecular weight compared to fibrinogen-340, the predominant form…”
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The Structure and Biological Features of Fibrinogen and Fibrin by MOSESSON, MICHAEL W., SIEBENLIST, KEVIN R., MEH, DAVID A.

“…: Fibrinogen and fibrin play important, overlapping roles in blood clotting, fibrinolysis, cellular and matrix interactions, inflammation, wound healing, and…”
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Evidence for new endothelial cell binding sites on fibrinogen by Smith, R A, Rooney, M M, Lord, S T, Mosesson, M W, Gartner, T K

“…In vitro assays were used to characterize adhesion of human aortic, microvascular and umbilical vein endothelial cells to various forms of immobilized…”
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Fibrinogen and fibrin polymerization and functions by Mosesson, M W

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Evidence that catalytically-inactivated thrombin forms non-covalently linked dimers that bridge between fibrin/fibrinogen fibers and enhance fibrin polymerization by Mosesson, M.W, Hernandez, I, Siebenlist, K.R

“…Phe-pro-arg-chloromethyl ketone-inhibited α-thrombin [FPRα-thr] retains its fibrinogen recognition site (exosite 1), augments fibrin/fibrinogen [fibrin(ogen)]…”
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Thrombosis risk modification in transgenic mice containing the human fibrinogen thrombin‐binding γ′ chain sequence by MOSESSON, M. W., COOLEY, B. C., HERNANDEZ, I., DIORIO, J. P., WEILER, H.

“…Background and objectives: Thrombin binding activity in murine fibrin (Antithrombin I) is restricted to its E domains inasmuch as murine γ′ chains (mu‐γ′) do…”
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Progressive cross-linking of fibrin gamma chains increases resistance to fibrinolysis by Siebenlist, K R, Mosesson, M W

“…In the presence of plasma transglutaminase (factor XIIIa) fibrin first undergoes intermolecular covalent cross-linking between its gamma chains to create gamma…”
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