Search Results - "MORRISSEY, Colm M"
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Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy
Published in Nature communications (11-04-2023)“…Six transmembrane epithelial antigen of the prostate 1 (STEAP1) is a cell surface antigen for therapeutic targeting in prostate cancer. Here, we report broad…”
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ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis
Published in Nature medicine (01-12-2018)“…Treatment of prostate cancer (PC) by androgen suppression promotes the emergence of aggressive variants that are androgen receptor (AR) independent. Here we…”
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Comparative Analyses of Chromosome Alterations in Soft-Tissue Metastases within and across Patients with Castration-Resistant Prostate Cancer
Published in Cancer research (Chicago, Ill.) (01-10-2009)“…Androgen deprivation is the mainstay of therapy for progressive prostate cancer. Despite initial and dramatic tumor inhibition, most men eventually fail…”
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Abstract 5249: LuCaP prostate cancer xenografts: Models that allow clinically relevant investigation of prostate cancer in a preclinical setting
Published in Cancer research (Chicago, Ill.) (15-04-2012)“…Abstract PCa is an extremely heterogeneous disease and generating relevant data invariably requires the use of multiple models. A paucity of pre-clinical…”
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Abstract 3302: Profiling prostate cancer metastases
Published in Cancer research (Chicago, Ill.) (15-04-2010)“…Abstract Introduction: Prostate cancer (PCa) metastasizes to a number of sites, however, it has a propensity to metastasize to bone. There is considerable…”
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