Search Results - "MORRISON, K. E."

ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B) by PARKINSON, N, INCE, P. G, SHAW, P. J, FISHER, E. M. C, SMITH, M. O, HIGHLEY, R, SKIBINSKI, G, ANDERSEN, P. M, MORRISON, K. E, PALL, H. S, HARDIMAN, O, COLLINGE, J

“…Mutation in the CHMP2B gene has been implicated in frontotemporal dementia. The authors screened CHMP2B in patients with ALS and several cohorts of control…”
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On the Spatial Response of Electromagnetic Flowmeters by Fox, Colin, Morrison, Malcolm E. K.

“…This paper investigates the spatial response of electromagnetic flowmeters, which are commonly used to measure bulk flow in various industrial applications…”
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Social status alters defeat-induced neural activation in Syrian hamsters by Morrison, K.E, Curry, D.W, Cooper, M.A

“…Abstract Although exposure to social stress leads to increased depression-like and anxiety-like behavior, some individuals are more vulnerable than others to…”
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Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: increased susceptibility in male carriers of the -2578AA genotype by Lambrechts, D, Poesen, K, Fernández-Santiago, R, Al-Chalabi, A, Del Bo, R, Van Vught, P W J, Khan, S, Marklund, S L, Brockington, A, van Marion, I, Anneser, J, Shaw, C, Ludolph, A C, Leigh, N P, Comi, G P, Gasser, T, Shaw, P J, Morrison, K E, Andersen, P M, Van den Berg, L H, Thijs, V, Siddique, T, Robberecht, W, Carmeliet, P

“…Targeted delivery of the angiogenic factor, vascular endothelial growth factor (VEGF), to motor neurons prolongs survival in rodent models of amyotrophic…”
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Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS by GOODALL, E. F, GREENWAY, M. J, VAN MARION, I, CARROLL, C. B, HARDIMAN, O, MORRISON, K. E

“…Iron misregulation promotes oxidative stress and abnormally high iron levels have been found in the spinal cords of patients with ALS. The authors investigated…”
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Neurobiological mechanisms supporting experience-dependent resistance to social stress by Cooper, M.A, Clinard, C.T, Morrison, K.E

“…Highlights • Stress resilience is an active process that involves distinct neural circuits. • Experience-dependent neural plasticity in key brain regions…”
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A mechanism for low penetrance in an ALS family with a novel SOD1 deletion by ZINMAN, L, LIU, H. N, ROGAEVA, E, SATO, C, WAKUTANI, Y, MARVELLE, A. F, MORENO, D, MORRISON, K. E, MOHLKE, K. L, BILBAO, J, ROBERTSON, J

“…About 20% of familial amyotrophic lateral sclerosis (ALS) is caused by mutations in SOD1 and is typically transmitted as an autosomal dominant trait. However,…”
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A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS by WILLS, A.-M, CRONIN, S, ROULEAU, G. A, FISHER, E. M. C, SHAW, P. J, MORRISON, K. E, PAMPHLETT, R, VAN DEN BERG, L. H, FIGLEWICZ, D. A, ANDERSEN, P. M, AL-CHALABI, A, HARDIMAN, O, SLOWIK, A, PURCELL, S, LANDERS, J. E, BROWN, Rh, KASPERAVICIUTE, D, VAN ES, M. A, MORAHAN, J. M, VALDMANIS, P. N, MEININGER, V, MELKI, J, SHAW, C. E

“…Six candidate gene studies report a genetic association of DNA variants within the paraoxonase locus with sporadic amyotrophic lateral sclerosis (ALS)…”
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Probable drug–drug interaction leading to serotonin syndrome in a patient treated with concomitant buspirone and linezolid in the setting of therapeutic hypothermia by Morrison, E. K., Rowe, A. S.

“…Summary What is known and objective:  Serotonin syndrome can be a rare but life‐threatening condition that is commonly the result of a drug–drug interaction…”
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Changes in iron-regulatory gene expression occur in human cell culture models of Parkinson’s disease by Carroll, C.B., Zeissler, M.-L., Chadborn, N., Gibson, K., Williams, G., Zajicek, J.P., Morrison, K.E., Hanemann, C.O.

“…► We use differentiated human SH-SY5Y cells exposed to paraquat or MPP + to mimic PD. ► We find increased expression of iron importers TfR1, DMT1+IRE, TfR2 and…”
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Increased serum ferritin levels in amyotrophic lateral sclerosis (ALS) patients by Goodall, E. F., Haque, M. S., Morrison, K. E.

“…Iron misregulation promotes oxidative stress, a proposed pathological mechanism in neurodegenerative disease. The aim of this study was to evaluate serum iron…”
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Epigenetic mechanisms in pubertal brain maturation by Morrison, K.E, Rodgers, A.B, Morgan, C.P, Bale, T.L

“…Highlights • Puberty is a critical period of brain development. • Puberty is a time of greater risk for neuropsychiatric disease. • Epigenectic mechanisms are…”
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Development of 'gastrostomy tube - is it for me?', a web-based patient decision aid for people living with motor neurone disease considering having a gastrostomy tube placed by Wheelwright, S., Maunsell, R., Taylor, S., Drinkwater, N., Erridge, C., Foster, C., Hardcastle, M., Hogden, A., Lawson, I., Lisiecka, D., Mcdermott, C., Morrison, K.E., Muir, C., Recio-Saucedo, A., White, S.

“…Objective: To develop and pilot a web-based patient decision aid (PDA) to support people living with motor neurone disease (plwMND) considering having a…”
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An outbreak of mumps with genetic strain variation in a highly vaccinated student population in Scotland by WILLOCKS, L. J., GUERENDIAIN, D., AUSTIN, H. I., MORRISON, K. E., CAMERON, R. L., TEMPLETON, K. E., DE LIMA, V. R. F., EWING, R., DONOVAN, W., POLLOCK, K. G. J.

“…An outbreak of mumps within a student population in Scotland was investigated to assess the effect of previous vaccination on infection and clinical…”
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Lithium in patients with amyotrophic lateral sclerosis (LiCALS): a phase 3 multicentre, randomised, double-blind, placebo-controlled trial by Morrison, K E, Dhariwal, S, Hornabrook, R, Savage, L, Burn, D J, Khoo, T K, Kelly, J, Murphy, C L, Al-Chalabi, A, Dougherty, A, Leigh, P N, Wijesekera, L, Thornhill, M, Ellis, C M, O'Hanlon, K, Panicker, J, Pate, L, Ray, P, Wyatt, L, Young, C A, Copeland, L, Ealing, J, Hamdalla, H, Leroi, I, Murphy, C, O'Keeffe, F, Oughton, E, Partington, L, Paterson, P, Rog, D, Sathish, A, Sexton, D, Smith, J, Vanek, H, Dodds, S, Williams, T L, Steen, I N, Clarke, J, Eziefula, C, Howard, R, Orrell, R, Sidle, K, Sylvester, R, Barrett, W, Merritt, C, Talbot, K, Turner, M R, Whatley, C, Williams, C, Williams, J, Cosby, C, Hanemann, C O, Iman, I, Philips, C, Timings, L, Crawford, S E, Hewamadduma, C, Hibberd, R, Hollinger, H, McDermott, C, Mils, G, Rafiq, M, Shaw, P J, Taylor, A, Waines, E, Walsh, T, Addison-Jones, R, Birt, J, Hare, M, Majid, T

“…Summary Background Lithium has neuroprotective effects in cell and animal models of amyotrophic lateral sclerosis (ALS), and a small pilot study in patients…”
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Confirmation of psaA in all 90 serotypes of Streptococcus pneumoniae by PCR and potential of this assay for identification and diagnosis by MORRISON, K. E, LAKE, D, CROOK, J, CARLONE, G. M, ADES, E, FACKLAM, R, SAMPSON, J. S

“…The gene encoding the pneumococcal surface adhesin A (PsaA) protein, psaA, was confirmed in all Streptococcus pneumoniae serotypes by a newly developed PCR…”
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Polymorphisms in the glutamate transporter gene EAAT2 in European ALS patients by JACKSON, M, STEERS, G, LEIGH, P. N, MORRISON, K. E

“…Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder characterised by degeneration of upper and lower motor neurons. Whilst the primary…”
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Malignant esophageal obstruction and esophagorespiratory fistula: palliation with a polyethylene-covered Z-stent by Saxon, R R, Morrison, K E, Lakin, P C, Petersen, B D, Barton, R E, Katon, R M, Keller, F S

“…To prospectively evaluate the clinical efficacy of polyethylene-covered metallic Z-stents in treatment of dysphagia secondary to malignant esophageal…”
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Copper/zinc superoxide dismutase 1 and sporadic amyotrophic lateral sclerosis: analysis of 155 cases and identification of a novel insertion mutation by Jackson, M, Al-Chalabi, A, Enayat, Z E, Chioza, B, Leigh, P N, Morrison, K E

“…Amyotrophic lateral sclerosis (ALS) is a progressive paralytic disorder resulting from the degeneration of motor neurons in the brain and spinal cord and…”
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Novel GCH1 variant in Dopa-responsive dystonia and Parkinson's disease by Lewthwaite, A.J, Lambert, T.D, Rolfe, E.B, Olgiati, S, Quadri, M, Simons, E.J, Morrison, K.E, Bonifati, V, Nicholl, D.J

“…Abstract Background GTP cyclohydrolase I ( GCH1 ) mutations are the commonest cause of Dopa-responsive dystonia (DRD). Clinical phenotypes can be broad, even…”
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