Search Results - "MORRISON, CHRISTOPHER D."

Blaming the Brain for Obesity: Integration of Hedonic and Homeostatic Mechanisms by Berthoud, Hans-Rudolf, Münzberg, Heike, Morrison, Christopher D

“…The brain plays a key role in the controls of energy intake and expenditure, and many genes associated with obesity are expressed in the central nervous…”
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Leptin signaling in brain: A link between nutrition and cognition? by Morrison, Christopher D.

“…Leptin is a protein hormone that acts within the hypothalamus to suppress food intake and decrease body adiposity, but it is increasingly clear that the…”
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Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework by Solon-Biet, Samantha M., Cogger, Victoria C., Pulpitel, Tamara, Heblinski, Marika, Wahl, Devin, McMahon, Aisling C., Warren, Alessandra, Durrant-Whyte, Jessica, Walters, Kirsty A., Krycer, James R., Ponton, Fleur, Gokarn, Rahul, Wali, Jibran A., Ruohonen, Kari, Conigrave, Arthur D., James, David E., Raubenheimer, David, Morrison, Christopher D., Le Couteur, David G., Simpson, Stephen J.

“…Fibroblast growth factor 21 (FGF21) is the first known endocrine signal activated by protein restriction. Although FGF21 is robustly elevated in low-protein…”
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Learning of food preferences: mechanisms and implications for obesity & metabolic diseases by Berthoud, Hans-Rudolf, Morrison, Christopher D., Ackroff, Karen, Sclafani, Anthony

“…Omnivores, including rodents and humans, compose their diets from a wide variety of potential foods. Beyond the guidance of a few basic orosensory biases such…”
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FGF21 is an endocrine signal of protein restriction by Laeger, Thomas, Henagan, Tara M, Albarado, Diana C, Redman, Leanne M, Bray, George A, Noland, Robert C, Münzberg, Heike, Hutson, Susan M, Gettys, Thomas W, Schwartz, Michael W, Morrison, Christopher D

“…Enhanced fibroblast growth factor 21 (FGF21) production and circulation has been linked to the metabolic adaptation to starvation. Here, we demonstrated that…”
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Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2 by Laeger, Thomas, Albarado, Diana C., Burke, Susan J., Trosclair, Lexus, Hedgepeth, John W., Berthoud, Hans-Rudolf, Gettys, Thomas W., Collier, J. Jason, Münzberg, Heike, Morrison, Christopher D.

“…FGF21 contributes to the metabolic response to dietary protein restriction, and prior data implicate GCN2 as the amino acid sensor linking protein restriction…”
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FGF21 Signals Protein Status to the Brain and Adaptively Regulates Food Choice and Metabolism by Hill, Cristal M, Laeger, Thomas, Dehner, Madeleine, Albarado, Diana C, Clarke, Blaise, Wanders, Desiree, Burke, Susan J, Collier, J Jason, Qualls-Creekmore, Emily, Solon-Biet, Samantha M, Simpson, Stephen J, Berthoud, Hans-Rudolf, Münzberg, Heike, Morrison, Christopher D

“…Reduced dietary protein intake induces adaptive physiological changes in macronutrient preference, energy expenditure, growth, and glucose homeostasis. We…”
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Homeostatic sensing of dietary protein restriction: A case for FGF21 by Hill, Cristal M., Berthoud, Hans-Rudolf, Münzberg, Heike, Morrison, Christopher D.

“…•Dietary protein restriction triggers adaptive changes in metabolism and behavior.•FGF21 is increased by excess carbohydrate and/or insufficient protein…”
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Galanin-Expressing GABA Neurons in the Lateral Hypothalamus Modulate Food Reward and Noncompulsive Locomotion by Qualls-Creekmore, Emily, Yu, Sangho, Francois, Marie, Hoang, John, Huesing, Clara, Bruce-Keller, Annadora, Burk, David, Berthoud, Hans-Rudolf, Morrison, Christopher D, Münzberg, Heike

“…The lateral hypothalamus (LHA) integrates reward and appetitive behavior and is composed of many overlapping neuronal populations. Recent studies associated…”
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FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice by Hill, Cristal M., Albarado, Diana C., Coco, Lucia G., Spann, Redin A., Khan, Md Shahjalal, Qualls-Creekmore, Emily, Burk, David H., Burke, Susan J., Collier, J. Jason, Yu, Sangho, McDougal, David H., Berthoud, Hans-Rudolf, Münzberg, Heike, Bartke, Andrzej, Morrison, Christopher D.

“…Dietary protein restriction is increasingly recognized as a unique approach to improve metabolic health, and there is increasing interest in the mechanisms…”
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Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints by Hill, Cristal M., Laeger, Thomas, Albarado, Diana C., McDougal, David H., Berthoud, Hans-Rudolf, Münzberg, Heike, Morrison, Christopher D.

“…Dietary protein restriction increases adipose tissue uncoupling protein 1 (UCP1), energy expenditure and food intake, and these effects require the metabolic…”
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Maternal obesity is necessary for programming effect of high-fat diet on offspring by White, Christy L, Purpera, Megan N, Morrison, Christopher D

“…We tested the hypothesis that maternal consumption of dietary fat, independent from obesity, increases serum leptin in neonatal pups and predisposes them to…”
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Regulation of body weight: Lessons learned from bariatric surgery by Albaugh, Vance L., He, Yanlin, Münzberg, Heike, Morrison, Christopher D., Yu, Sangho, Berthoud, Hans-Rudolf

“…Bariatric or weight loss surgery is currently the most effective treatment for obesity and metabolic disease. Unlike dieting and pharmacology, its beneficial…”
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The Nuanced Metabolic Functions of Endogenous FGF21 Depend on the Nature of the Stimulus, Tissue Source, and Experimental Model by Spann, Redin A, Morrison, Christopher D, den Hartigh, Laura J

“…Fibroblast growth factor 21 (FGF21) is a hormone that is involved in the regulation of lipid, glucose, and energy metabolism. Pharmacological FGF21…”
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Homeostatic regulation of protein intake: in search of a mechanism by Morrison, Christopher D, Reed, Scott D, Henagan, Tara M

“…Free-living organisms must procure adequate nutrition by negotiating an environment in which both the quality and quantity of food vary markedly. Recent…”
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High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling by Morrison, Christopher D, Pistell, Paul J, Ingram, Donald K, Johnson, William D, Liu, Ying, Fernandez-Kim, Sun Ok, White, Christy L, Purpera, Megan N, Uranga, Romina M, Bruce-Keller, Annadora J, Keller, Jeffrey N

“…J. Neurochem. (2010) 114, 1581-1589. Long term consumption of a high fat diet (HFD) contributes to increased morbidity and mortality. Yet the specific effects…”
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Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake by Rezai-Zadeh, Kavon, Yu, Sanghou, Jiang, Yanyan, Laque, Amanda, Schwartzenburg, Candice, Morrison, Christopher D, Derbenev, Andrei V, Zsombok, Andrea, Münzberg, Heike

“…Abstract Objective Leptin responsive neurons play an important role in energy homeostasis, controlling specific autonomic, behavioral, and neuroendocrine…”
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Metabolic syndrome and infertility in men by Morrison, Christopher D., MD, Brannigan, Robert E., MD

“…Metabolic syndrome is a compilation of symptoms including central obesity, insulin resistance, dyslipidemia, and hypertension. Initially used to predict…”
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Reprogramming of defended body weight after Roux‐En‐Y gastric bypass surgery in diet‐induced obese mice by Hao, Zheng, Mumphrey, Michael B., Townsend, R. Leigh, Morrison, Christopher D., Münzberg, Heike, Ye, Jianping, Berthoud, Hans‐Rudolf

“…Objective Roux‐en‐Y gastric bypass surgery (RYGB) results in sustained lowering of body weight in most patients, but the mechanisms involved are poorly…”
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Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: Contributions of maternal diet by White, Christy L, Pistell, Paul J, Purpera, Megan N, Gupta, Sunita, Fernandez-Kim, Sun-Ok, Hise, Taylor L, Keller, Jeffrey N, Ingram, Donald K, Morrison, Christopher D, Bruce-Keller, Annadora J

“…Abstract This study was undertaken to investigate the effects of prenatal and postnatal exposure to high fat diet on the brain. Female rats were divided into…”
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