Search Results - "MORRIS, Stephen A"
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Phase 1 study of PSMA ADC, an antibody‐drug conjugate targeting prostate‐specific membrane antigen, in chemotherapy‐refractory prostate cancer
Published in The Prostate (01-05-2019)“…Background Prostate‐specific membrane antigen (PSMA) is a well‐characterized target that is overexpressed selectively on prostate cancer cells. PSMA…”
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Is Fixation Failure After Plate Fixation of the Symphysis Pubis Clinically Important?
Published in Clinical orthopaedics and related research (01-08-2012)“…Background Plate fixation is a recognized treatment for pelvic ring injuries involving disruption of the pubic symphysis. Although fixation failure is well…”
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3
Phase 2a Study of the CCR5 Monoclonal Antibody PRO 140 Administered Intravenously to HIV-Infected Adults
Published in Antimicrobial Agents and Chemotherapy (01-10-2010)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Anti-HIV-1 Activity of Weekly or Biweekly Treatment with Subcutaneous PRO 140, a CCR5 Monoclonal Antibody
Published in The Journal of infectious diseases (15-05-2010)“…Background. PRO 140 is a humanized CCR5 monoclonal antibody that has demonstrated potent antiviral activity when it is administered intravenously to adults…”
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Antiviral Activity of Single-Dose PRO 140, a CCR5 Monoclonal Antibody, in HIV-Infected Adults
Published in The Journal of infectious diseases (01-11-2008)“…Background. The current goal of human immunodeficiency virus type 1 (HIV-1) therapy is to maximally suppress viral replication. Securing this goal requires new…”
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Applying Unique Molecular Identifiers in Next Generation Sequencing Reveals a Constrained Viral Quasispecies Evolution under Cross-Reactive Antibody Pressure Targeting Long Alpha Helix of Hemagglutinin
Published in Viruses (25-03-2018)“…To overcome yearly efforts and costs for the production of seasonal influenza vaccines, new approaches for the induction of broadly protective and long-lasting…”
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Domain Organization of the Type 1 Inositol 1,4,5-Trisphosphate Receptor as Revealed by Single-Particle Analysis
Published in Proceedings of the National Academy of Sciences - PNAS (01-04-2003)“…The inositol 1,4,5-trisphosphate receptor (IP3R) is a tetrameric intracellular Ca2+ channel, which mediates the release of Ca2+ from the endoplasmic reticulum…”
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Identification of Domains in Gag Important for Prototypic Foamy Virus Egress
Published in Journal of Virology (01-05-2005)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Lipid reduction to improve clarification and filterability during primary recovery of intracellular products in yeast lysates using exogenous lipase
Published in Journal of chemical technology and biotechnology (1986) (01-11-2021)“…BACKGROUND The yeast Pichia pastoris is a popular host organism for production of a range of biological products, several of which are intracellular. The…”
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Effect of recombinant human parathyroid hormone (1-84) on vertebral fracture and bone mineral density in postmenopausal women with osteoporosis: a randomized trial
Published in Annals of internal medicine (06-03-2007)“…Recombinant human parathyroid hormone (1-84) (PTH) increases bone mass and strength and improves bone quality by stimulating new bone formation. To determine…”
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A characterisation of long-term depression induced by metabotropic glutamate receptor activation in the rat hippocampus in vitro
Published in The Journal of physiology (01-12-2001)“…In the CA1 region of hippocampal slices prepared from juvenile (12- to 18-day-old) rats, activation of group I metabotropic l -glutamate (mGlu) receptors by…”
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Holistic process development to mitigate proteolysis of a subunit rotavirus vaccine candidate produced in Pichia pastoris by means of an acid pH pulse during fed‐batch fermentation
Published in Biotechnology progress (01-05-2020)“…To meet the challenges of global health, vaccine design and development must be reconsidered to achieve cost of goods as low as 15¢ per dose. A new recombinant…”
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Rapid Developability Assessments to Formulate Recombinant Protein Antigens as Stable, Low-Cost, Multi-Dose Vaccine Candidates: Case-Study With Non-Replicating Rotavirus (NRRV) Vaccine Antigens
Published in Journal of pharmaceutical sciences (01-03-2021)“…A two-step developability assessment workflow is described to screen variants of recombinant protein antigens under various formulation conditions to rapidly…”
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Ca2+-Independent Inhibition of Inositol Trisphosphate Receptors by Calmodulin: Redistribution of Calmodulin as a Possible Means of Regulating Ca2+Mobilization
Published in Proceedings of the National Academy of Sciences - PNAS (14-10-1997)“…The interactions between calmodulin, inositol 1,4,5-trisphosphate (InsP3), and pure cerebellar InsP3receptors were characterized by using a scintillation…”
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Determinants of adenophostin A binding to inositol trisphosphate receptors
Published in Biochemical journal (01-10-2002)“…Inositol 1,4,5-trisphosphate (IP(3)) receptors from cerebellum and recombinant type 1 IP(3) receptors expressed in Sf9 cells had indistinguishable affinities…”
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Cardioprotective effects of verapamil on myocardial structure and function in a murine model of chronic Trypanosoma cruzi infection (Brazil Strain): an echocardiographic study
Published in International journal for parasitology (01-02-2002)“…Verapamil has been shown to attenuate the extent of myocardial injury in murine models of chronic Trypanosoma cruzi infection. Infected mice treated with…”
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Development of a high‐throughput microscale cell disruption platform for Pichia pastoris in rapid bioprocess design
Published in Biotechnology progress (01-01-2018)“…The time and cost benefits of miniaturized fermentation platforms can only be gained by employing complementary techniques facilitating high‐throughput at…”
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The Subaxial Cervical Spine Injury Classification System: an external agreement validation study
Published in The spine journal (01-09-2013)“…Abstract Background context In 2007, the Subaxial Cervical Spine Injury Classification (SLIC) system was introduced demonstrating moderate reliability in an…”
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Myocardial Expression of Endothelin-1 in Murine Trypanosoma cruzi Infection
Published in Cardiovascular pathology (01-09-2000)“…Chagas' disease, caused by Trypanosoma cruzi, is an important cause of myocarditis and chronic cardiomyopathy and is accompanied by microvascular spasm and…”
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Torsion of left main bronchus during general anesthesia for posterior instrumented spinal fusion
Published in Clinical case reports (01-07-2016)“…Key Clinical Message Pulmonary function tests such as flow‐volume loops and reconstructive radiological imaging may aid the detection of large airway…”
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