Search Results - "MORRIS, James C"

Enolase inhibitors as therapeutic leads for Naegleria fowleri infection by Milanes, Jillian E, Yan, Victoria C, Pham, Cong-Dat, Muller, Florian, Kwain, Samuel, Rees, Kerrick C, Dominy, Brian N, Whitehead, Daniel C, Millward, Steven W, Bolejack, Madison, Shek, Roger, Tillery, Logan, Phan, Isabelle Q, Staker, Bart, Moseman, E Ashley, Zhang, Xiang, Ma, Xipeng, Jebet, Audriy, Yin, Xinmin, Morris, James C

“…Infections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amoebic…”
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The transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design by Phan, Isabelle Q., Rice, Christopher A., Craig, Justin, Noorai, Rooksana E., McDonald, Jacquelyn R., Subramanian, Sandhya, Tillery, Logan, Barrett, Lynn K., Shankar, Vijay, Morris, James C., Van Voorhis, Wesley C., Kyle, Dennis E., Myler, Peter J.

“…Balamuthia mandrillaris , a pathogenic free-living amoeba, causes cutaneous skin lesions as well as granulomatous amoebic encephalitis, a ‘brain-eating’…”
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A multiplexed high throughput screening assay using flow cytometry identifies glycolytic molecular probes in bloodstream form Trypanosoma brucei by Call, Daniel H., Adjei, John Asafo, Pilgrim, Ryan, Jeong, James W., Willis, E. Vance, Zegarra, Ronald A., Tapia, Nicholas L., Osterhaus, Madalyn, Vance, Jacob A., Voyton, Charles M., Call, James A., Pizarro, Sabrina S., Morris, James C., Christensen, Kenneth A.

“…Kinetoplastid organisms, including Trypanosoma brucei, are a significant health burden in many tropical and semitropical countries. Much of their metabolism is…”
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Environmentally Regulated Glycosome Protein Composition in the African Trypanosome by Bauer, Sarah, Morris, James C, Morris, Meredith T

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Plasmodium vivax and human hexokinases share similar active sites but display distinct quaternary architectures by Srivastava, Shanti Swaroop, Darling, Joseph E, Suryadi, Jimmy, Morris, James C, Drew, Mark E, Subramaniam, Sriram

“…Malaria is a devastating disease caused by a protozoan parasite. It affects over 300 million individuals and results in over 400 000 deaths annually, most of…”
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Interrogating a Hexokinase-Selected Small-Molecule Library for Inhibitors of Plasmodium falciparum Hexokinase by HARRIS, Michael T, WALKER, Dawn M, DREW, Mark E, MITCHELL, William G, KEVIN DAO, SCHROEDER, Chad E, FLAHERTY, Daniel P, WEINER, Warren S, GOLDEN, Jennifer E, MORRIS, James C

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A FRET flow cytometry method for monitoring cytosolic and glycosomal glucose in living kinetoplastid parasites by Voyton, Charles M, Qiu, Yijian, Morris, Meredith T, Ackroyd, P Christine, Suryadi, Jimmy, Crowe, Logan, Morris, James C, Christensen, Kenneth A

“…The bloodstream lifecycle stage of the kinetoplastid parasite Trypanosoma brucei relies solely on glucose metabolism for ATP production, which occurs in…”
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Glucose Signaling Is Important for Nutrient Adaptation during Differentiation of Pleomorphic African Trypanosomes by Qiu, Yijian, Milanes, Jillian E, Jones, Jessica A, Noorai, Rooksana E, Shankar, Vijay, Morris, James C

“…The African trypanosome has evolved mechanisms to adapt to changes in nutrient availability that occur during its life cycle. During transition from mammalian…”
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Enolase Inhibitors as Early Lead Therapeutics against Trypanosoma brucei by Roster, Colm P., LaVigne, Danielle, Milanes, Jillian E., Knight, Emily, Anderson, Heidi D., Pizarro, Sabrina, Harding, Elijah M., Morris, Meredith T., Yan, Victoria C., Pham, Cong-Dat, Muller, Florian, Kwain, Samuel, Rees, Kerrick C., Dominy, Brian, Whitehead, Daniel C., Uddin, Md Nasir, Millward, Steven W., Morris, James C.

“…Glucose metabolism is critical for the African trypanosome, Trypanosoma brucei, serving as the lone source of ATP production for the bloodstream form (BSF)…”
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A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity by Sharlow, Elizabeth R, Lyda, Todd A, Dodson, Heidi C, Mustata, Gabriela, Morris, Meredith T, Leimgruber, Stephanie S, Lee, Kuo-Hsiung, Kashiwada, Yoshiki, Close, David, Lazo, John S, Morris, James C

“…The parasitic protozoan Trypanosoma brucei utilizes glycolysis exclusively for ATP production during infection of the mammalian host. The first step in this…”
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Assembly of Heterohexameric Trypanosome Hexokinases Reveals That Hexokinase 2 Is a Regulable Enzyme by Chambers, Jeremy W., Kearns, Margaret T., Morris, Meredith T., Morris, James C.

“…Glycolysis is essential to Trypanosoma brucei, the protozoan parasite that causes African sleeping sickness in humans and nagana in cattle. Hexokinase (HK),…”
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Exploring the mode of action of ebselen in Trypanosoma brucei hexokinase inhibition by Joice, April C., Harris, Michael T., Kahney, Elizabeth W., Dodson, Heidi C., Maselli, Andrew G., Whitehead, Daniel C., Morris, James C.

“…[Display omitted] •Trypanosoma brucei hexokinase 1 is irreversibly inhibited by ebselen.•Mutation of Cys residues did not change hexamer abundance.•Active…”
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Mannich‐Type Condensation and Domino Quinazolinone‐Amidine Rearrangement Affords Ring‐Fused Mackinazolinones with Anti‐Amoebic Activity by Lish, Matthew S., Milanes, Jillian E., Sanders, Kyana M., Guzei, Ilia A., Morris, James C., Golden, Jennifer E.

“…A three‐step synthesis of anti‐amoebic, ring‐fused mackinazolinones has been developed. A Mannich‐type reaction between quinazolin‐4‐ones and N‐Cbz propanal in…”
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Pharmacophore Establishment and Optimization of Saturated 1,6-Naphthyridine-Fused Quinazolinones that Inhibit Meningoencephalitis-Causing Naegleria fowleri by Lish, Matthew S., McKeon, Jillian E. M., Palmentiero, Caroline M., Pomeroy, Julia M., Roster, Colm P., Guzei, Ilia A., Morris, James C., Golden, Jennifer E.

“…Primary amoebic meningoencephalitis (PAM) is a human brain infection caused by Naegleria fowleri with a 97% mortality rate. Quinazolinones resulting from a…”
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The Adenosine Analog Tubercidin Inhibits Glycolysis in Trypanosoma brucei as Revealed by an RNA Interference Library by Drew, Mark E., Morris, James C., Wang, Zefeng, Wells, Lance, Sanchez, Marco, Landfear, Scott M., Englund, Paul T.

“…We used an RNA interference (RNAi) library in a forward genetic selection to study the mechanism of toxicity of tubercidin (7-deazaadenosine) to procyclic…”
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Measuring Dynamic Glycosomal pH Changes in Living Trypanosoma brucei by Call, Daniel, Pizarro, Sabrina S, Tovey, Erica, Knight, Emily, Baumgardner, Carrie, Christensen, Kenneth A, Morris, James C

“…Glucose metabolism is critical for the African trypanosome, Trypanosoma brucei, as an essential metabolic process and regulator of parasite development. Little…”
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Activity of a Second Trypanosoma brucei Hexokinase Is Controlled by an 18-Amino-Acid C-Terminal Tail by Morris, Meredith T, DeBruin, Courtney, Yang, Zhaoqing, Chambers, Jeremy W, Smith, Kerry S, Morris, James C

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Enzymatic and Structural Characterization of the Naegleria fowleri Glucokinase by Milanes, Jillian E, Suryadi, Jimmy, Abendroth, Jan, Van Voorhis, Wesley C, Barrett, Kayleigh F, Dranow, David M, Phan, Isabelle Q, Patrick, Stephen L, Rozema, Soren D, Khalifa, Muhammad M, Golden, Jennifer E, Morris, James C

“…Infection with the free-living amoeba leads to life-threatening primary amoebic meningoencephalitis. Efficacious treatment options for these infections are…”
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Synthesis and Evaluation of Benzylamine Inhibitors of Neuropathogenic Naegleria fowleri “Brain-Eating” Amoeba by Pomeroy, Julia M., Khalifa, Muhammad M., Milanes, Jillian E., Palmentiero, Caroline M., Morris, James C., Golden, Jennifer E.

“…Current therapy for primary amoebic meningoencephalitis (PAM), a highly lethal brain infection in humans caused by Naegleria fowleri amoeba, is restricted to…”
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Characterization of Glucokinases from Pathogenic Free-Living Amoebae by Milanes, Jillian E, Suryadi, Jimmy, Monaghan, Neil P, Harding, Elijah M, Morris, Corbin S, Rozema, Soren D, Khalifa, Muhammad M, Golden, Jennifer E, Phan, Isabelle Q, Zigweid, Rachael, Abendroth, Jan, Rice, Christopher A, McCord, Hayden T, Wilson, Stevin, Fenwick, Michael K, Morris, James C

“…Infection with pathogenic free-living amoebae, including Naegleria fowleri, spp., and Balamuthia mandrillaris, can lead to life-threatening illnesses,…”
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