Search Results - "MORRIS, Andrew P"

Transethnic meta-analysis of genomewide association studies by Morris, Andrew P.

“…The detection of loci contributing effects to complex human traits, and their subsequent fine‐mapping for the location of causal variants, remains a…”
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GWAMA: software for genome-wide association meta-analysis by Mägi, Reedik, Morris, Andrew P

“…Despite the recent success of genome-wide association studies in identifying novel loci contributing effects to complex human traits, such as type 2 diabetes…”
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An evaluation of statistical approaches to rare variant analysis in genetic association studies by Morris, Andrew P., Zeggini, Eleftheria

“…Genome‐wide association (GWA) studies have proved to be extremely successful in identifying novel common polymorphisms contributing effects to the genetic…”
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Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution by Mägi, Reedik, Horikoshi, Momoko, Sofer, Tamar, Mahajan, Anubha, Kitajima, Hidetoshi, Franceschini, Nora, McCarthy, Mark I, Morris, Andrew P

“…Trans-ethnic meta-analysis of genome-wide association studies (GWAS) across diverse populations can increase power to detect complex trait loci when the…”
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Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility by Cook, James P, Morris, Andrew P

“…Genome-wide association studies (GWAS) have traditionally been undertaken in homogeneous populations from the same ancestry group. However, with the increasing…”
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Data quality control in genetic case-control association studies by Anderson, Carl A, Zondervan, Krina T, Pettersson, Fredrik H, Clarke, Geraldine M, Cardon, Lon R, Morris, Andrew P

“…This protocol details the steps for data quality assessment and control that are typically carried out during case-control association studies. The steps…”
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Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework by Cho, Yoonsu, Haycock, Philip C., Sanderson, Eleanor, Gaunt, Tom R., Zheng, Jie, Morris, Andrew P., Davey Smith, George, Hemani, Gibran

“…In Mendelian randomization (MR) analysis, variants that exert horizontal pleiotropy are typically treated as a nuisance. However, they could be valuable in…”
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Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease by Folkersen, Lasse, Fauman, Eric, Sabater-Lleal, Maria, Strawbridge, Rona J, Frånberg, Mattias, Sennblad, Bengt, Baldassarre, Damiano, Veglia, Fabrizio, Humphries, Steve E, Rauramaa, Rainer, de Faire, Ulf, Smit, Andries J, Giral, Philippe, Kurl, Sudhir, Mannarino, Elmo, Enroth, Stefan, Johansson, Åsa, Enroth, Sofia Bosdotter, Gustafsson, Stefan, Lind, Lars, Lindgren, Cecilia, Morris, Andrew P, Giedraitis, Vilmantas, Silveira, Angela, Franco-Cereceda, Anders, Tremoli, Elena, Gyllensten, Ulf, Ingelsson, Erik, Brunak, Søren, Eriksson, Per, Ziemek, Daniel, Hamsten, Anders, Mälarstig, Anders

“…Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds of plasma proteins in large cohort studies. In…”
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Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits by Yang, Jian, Ferreira, Teresa, Morris, Andrew P, Medland, Sarah E, Madden, Pamela A F, Heath, Andrew C, Martin, Nicholas G, Montgomery, Grant W, Weedon, Michael N, Loos, Ruth J, Frayling, Timothy M, McCarthy, Mark I, Hirschhorn, Joel N, Goddard, Michael E, Visscher, Peter M

“…Peter Visscher and colleagues report a new method for approximate conditional and joint association analysis that makes use of summary statistics from…”
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Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel by Mitt, Mario, Kals, Mart, Pärn, Kalle, Gabriel, Stacey B, Lander, Eric S, Palotie, Aarno, Ripatti, Samuli, Morris, Andrew P, Metspalu, Andres, Esko, Tõnu, Mägi, Reedik, Palta, Priit

“…Genetic imputation is a cost-efficient way to improve the power and resolution of genome-wide association (GWA) studies. Current publicly accessible imputation…”
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Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets by Rahmioglu, Nilufer, Nyholt, Dale R, Morris, Andrew P, Missmer, Stacey A, Montgomery, Grant W, Zondervan, Krina T

“…Endometriosis is a heritable common gynaecological condition influenced by multiple genetic and environmental factors. Genome-wide association studies (GWASs)…”
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Basic statistical analysis in genetic case-control studies by Clarke, Geraldine M, Anderson, Carl A, Pettersson, Fredrik H, Cardon, Lon R, Morris, Andrew P, Zondervan, Krina T

“…This protocol describes how to perform basic statistical analysis in a population-based genetic association case-control study. The steps described involve the…”
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Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis by Yang, Jing, McGovern, Amanda, Martin, Paul, Duffus, Kate, Ge, Xiangyu, Zarrineh, Peyman, Morris, Andrew P., Adamson, Antony, Fraser, Peter, Rattray, Magnus, Eyre, Stephen

“…Genome-wide association studies have identified genetic variation contributing to complex disease risk. However, assigning causal genes and mechanisms has been…”
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Leveraging information between multiple population groups and traits improves fine-mapping resolution by Zhou, Feng, Soremekun, Opeyemi, Chikowore, Tinashe, Fatumo, Segun, Barroso, Inês, Morris, Andrew P., Asimit, Jennifer L.

“…Statistical fine-mapping helps to pinpoint likely causal variants underlying genetic association signals. Its resolution can be improved by (i) leveraging…”
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Evaluating the Performance of Fine-Mapping Strategies at Common Variant GWAS Loci by van de Bunt, Martijn, Cortes, Adrian, Brown, Matthew A, Morris, Andrew P, McCarthy, Mark I

“…The growing availability of high-quality genomic annotation has increased the potential for mechanistic insights when the specific variants driving common…”
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Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease by Zheng, Jie, Zhang, Yuemiao, Rasheed, Humaira, Walker, Venexia, Sugawara, Yuka, Li, Jiachen, Leng, Yue, Elsworth, Benjamin, Wootton, Robyn E, Fang, Si, Yang, Qian, Burgess, Stephen, Haycock, Philip C, Borges, Maria Carolina, Cho, Yoonsu, Carnegie, Rebecca, Howell, Amy, Robinson, Jamie, Thomas, Laurent F, Brumpton, Ben Michael, Hveem, Kristian, Hallan, Stein, Franceschini, Nora, Morris, Andrew P, Köttgen, Anna, Pattaro, Cristian, Wuttke, Matthias, Yamamoto, Masayuki, Kashihara, Naoki, Akiyama, Masato, Kanai, Masahiro, Matsuda, Koichi, Kamatani, Yoichiro, Okada, Yukinori, Walters, Robin, Millwood, Iona Y, Chen, Zhengming, Davey Smith, George, Barbour, Sean, Yu, Canqing, Åsvold, Bjørn Olav, Zhang, Hong, Gaunt, Tom R

“…Abstract Background This study was to systematically test whether previously reported risk factors for chronic kidney disease (CKD) are causally related to CKD…”
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Improved Detection of Common Variants Associated with Schizophrenia by Leveraging Pleiotropy with Cardiovascular-Disease Risk Factors by Andreassen, Ole A., Djurovic, Srdjan, Thompson, Wesley K., Schork, Andrew J., Kendler, Kenneth S., O’Donovan, Michael C., Rujescu, Dan, Werge, Thomas, van de Bunt, Martijn, Morris, Andrew P., McCarthy, Mark I., Roddey, J. Cooper, McEvoy, Linda K., Desikan, Rahul S., Dale, Anders M.

“…Several lines of evidence suggest that genome-wide association studies (GWASs) have the potential to explain more of the “missing heritability” of common…”
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A Genome‐wide Association Study of Circulating Levels of Atorvastatin and Its Major Metabolites by Turner, Richard M., Fontana, Vanessa, Zhang, Jieying E., Carr, Daniel, Yin, Peng, FitzGerald, Richard, Morris, Andrew P., Pirmohamed, Munir

“…Atorvastatin (ATV) is frequently prescribed and generally well  tolerated, but can lead to myotoxicity, especially at higher doses. A genome‐wide association…”
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Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability by Ge, Xiangyu, Frank-Bertoncelj, Mojca, Klein, Kerstin, McGovern, Amanda, Kuret, Tadeja, Houtman, Miranda, Burja, Blaž, Micheroli, Raphael, Shi, Chenfu, Marks, Miriam, Filer, Andrew, Buckley, Christopher D, Orozco, Gisela, Distler, Oliver, Morris, Andrew P, Martin, Paul, Eyre, Stephen, Ospelt, Caroline

“…Genome-wide association studies have reported more than 100 risk loci for rheumatoid arthritis (RA). These loci are shown to be enriched in immune…”
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Genome-Wide Gene-Set Analysis Identifies Molecular Mechanisms Associated with ALS by Vasilopoulou, Christina, McDaid-McCloskey, Sarah L, McCluskey, Gavin, Duguez, Stephanie, Morris, Andrew P, Duddy, William

“…Amyotrophic lateral sclerosis (ALS) is a fatal late-onset motor neuron disease characterized by the loss of the upper and lower motor neurons. Our…”
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