Search Results - "MORRIS, ANDREW D."

Metformin in Cancer Treatment and Prevention by Morales, Daniel R, Morris, Andrew D

“…Patients with diabetes mellitus are at increased risk of cancer development. Metformin is a well-established, effective agent for the management of type 2…”
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Serum Thyroid-Stimulating Hormone Concentration and Morbidity from Cardiovascular Disease and Fractures in Patients on Long-Term Thyroxine Therapy by Flynn, Robert W, Bonellie, Sandra R, Jung, Roland T, MacDonald, Thomas M, Morris, Andrew D, Leese, Graham P

“…Context: For patients on T4 replacement, the dose is guided by serum TSH concentrations, but some patients request higher doses due to adverse symptoms…”
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Data capture and sharing in the COVID-19 pandemic: a cause for concern by Dron, Louis, Kalatharan, Vinusha, Gupta, Alind, Haggstrom, Jonas, Zariffa, Nevine, Morris, Andrew D, Arora, Paul, Park, Jay

“…Routine health care and research have been profoundly influenced by digital-health technologies. These technologies range from primary data collection in…”
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Epidemiology and Heritability of Major Depressive Disorder, Stratified by Age of Onset, Sex, and Illness Course in Generation Scotland: Scottish Family Health Study (GS:SFHS) by Fernandez-Pujals, Ana Maria, Adams, Mark James, Thomson, Pippa, McKechanie, Andrew G, Blackwood, Douglas H R, Smith, Blair H, Dominiczak, Anna F, Morris, Andrew D, Matthews, Keith, Campbell, Archie, Linksted, Pamela, Haley, Chris S, Deary, Ian J, Porteous, David J, MacIntyre, Donald J, McIntosh, Andrew M

“…The heritability of Major Depressive Disorder (MDD) has been estimated at 37% based largely on twin studies that rely on contested assumptions. More recently,…”
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Risk of cardiovascular disease and total mortality in adults with type 1 diabetes: Scottish registry linkage study by Livingstone, Shona J, Looker, Helen C, Hothersall, Eleanor J, Wild, Sarah H, Lindsay, Robert S, Chalmers, John, Cleland, Stephen, Leese, Graham P, McKnight, John, Morris, Andrew D, Pearson, Donald W M, Peden, Norman R, Petrie, John R, Philip, Sam, Sattar, Naveed, Sullivan, Frank, Colhoun, Helen M

“…Randomized controlled trials have shown the importance of tight glucose control in type 1 diabetes (T1DM), but few recent studies have evaluated the risk of…”
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Metformin and reduced risk of cancer in diabetic patients by Evans, Josie M M, Donnelly, Louise A, Emslie-Smith, Alistair M, Alessi, Dario R, Morris, Andrew D

“…The strengths of the study were its population based sampling, the objective method used to define metformin exposure, detailed dispensed prescribing histories…”
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Allopurinol Reduces Left Ventricular Mass in Patients With Type 2 Diabetes and Left Ventricular Hypertrophy by Szwejkowski, Benjamin R., MBChB, Gandy, Stephen J., PhD, Rekhraj, Sushma, MBChB, Houston, John G., MD, Lang, Chim C., MD, Morris, Andrew D., MD, George, Jacob, MD, Struthers, Allan D., MD

“…Objectives This study sought to ascertain whether high-dose allopurinol causes regression of left ventricular mass (LVM) in patients with type 2 diabetes…”
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SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout by Wright, Alan F, Vitart, Veronique, Rudan, Igor, Hayward, Caroline, Gray, Nicola K, Floyd, James, Palmer, Colin NA, Knott, Sara A, Kolcic, Ivana, Polasek, Ozren, Graessler, Juergen, Wilson, James F, Marinaki, Anthony, Riches, Philip L, Shu, Xinhua, Janicijevic, Branka, Smolej-Narancic, Nina, Gorgoni, Barbara, Morgan, Joanne, Campbell, Susan, Biloglav, Zrinka, Barac-Lauc, Lovorka, Pericic, Marijana, Klaric, Irena Martinovic, Zgaga, Lina, Skaric-Juric, Tatjana, Wild, Sarah H, Richardson, William A, Hohenstein, Peter, Kimber, Charley H, Tenesa, Albert, Donnelly, Louise A, Fairbanks, Lynette D, Aringer, Martin, McKeigue, Paul M, Ralston, Stuart H, Morris, Andrew D, Rudan, Pavao, Hastie, Nicholas D, Campbell, Harry

“…Uric acid is the end product of purine metabolism in humans and great apes, which have lost hepatic uricase activity, leading to uniquely high serum uric acid…”
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Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk by Lango, Hana, Palmer, Colin N A, Morris, Andrew D, Zeggini, Eleftheria, Hattersley, Andrew T, McCarthy, Mark I, Frayling, Timothy M, Weedon, Michael N

“…Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk Hana Lango 1 2 , the U.K. Type 2 Diabetes Genetics…”
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Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1 (TSP-1) by Kim, Chan Woo, Pokutta-Paskaleva, Anastassia, Kumar, Sandeep, Timmins, Lucas H, Morris, Andrew D, Kang, Dong-Won, Dalal, Sidd, Chadid, Tatiana, Kuo, Katie M, Raykin, Julia, Li, Haiyan, Yanagisawa, Hiromi, Gleason, Rudolph L, Jo, Hanjoong, Brewster, Luke P

“…BACKGROUND—Arterial stiffness and wall shear stress are powerful determinants of cardiovascular health, and arterial stiffness is associated with increased…”
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Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes by Borch-Johnsen, Knut, Ghosh, Shyamali, Tong, Peter C Y, Sigurdsson, Asgeir, Asin, Laura, So, Wing-Yee, Hofker, Marten H, Ober, Carole, Jonsson, Eirikur, Palmer, Colin N A, Saez, Berta, Kimber, Charlotte H, Frigge, Michael L, Barkardottir, Rosa B, Agnarsson, Bjarni A, Suarez, Brian K, Bagger, Yu, Wilensky, Robert L, Stacey, Simon N, Swinkels, Dorine W, Hansen, Torben, Einarsson, Gudmundur V, Benediktsdottir, Kristrun R, Gulcher, Jeffrey R, Gudmundsson, Julius, Wijmenga, Cisca, Sigurdsson, Gunnar, Morris, Andrew D, Thorsteinsdottir, Unnur, Tres, Alejandro, Olafsdottir, Adalheidur, Baker, Adam, Magnusdottir, Dana, Chen, Yuanxiu, Thorleifsson, Gudmar, Adeyemo, Adebowale, Fuertes, Fernando, Kong, Augustine, Jakobsdottir, Margret, Kiemeney, Lambertus A, Ng, Maggie C Y, Kristinsson, Kari T, Stefansson, Kari, Klaver, Siem, van Vierssen Trip, Onco, Chan, Juliana C N, Aben, Katja K, Benediktsson, Rafn, Birgisdottir, Birgitta, Blondal, Thorarinn, Jorgensen, Torben, Thorlacius, Steinunn, Stefansdottir, Gerdur, Gudbjartsson, Daniel, Zhou, Jie, Rotimi, Charles, Ruiz-Echarri, Manuel, Mayordomo, Jose I, Helgason, Agnar, Rader, Daniel J, Pedersen, Oluf, Gunnarsdottir, Steinunn, Reilly, Muredach P, van Boven, Erica, Rafnar, Thorunn, Bergthorsson, Jon T, Kristjansson, Kristleifur, Cashy, John, Catalona, William J, Sulem, Patrick, Steinthorsdottir, Valgerdur, Andersen, Gitte, Manolescu, Andrei, Christiansen, Claus, Graif, Theresa

“…We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer…”
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The Common p.R114W HNF4A Mutation Causes a Distinct Clinical Subtype of Monogenic Diabetes by Laver, Thomas W, Colclough, Kevin, Shepherd, Maggie, Patel, Kashyap, Houghton, Jayne A L, Dusatkova, Petra, Pruhova, Stepanka, Morris, Andrew D, Palmer, Colin N, McCarthy, Mark I, Ellard, Sian, Hattersley, Andrew T, Weedon, Michael N

“…HNF4A mutations cause increased birth weight, transient neonatal hypoglycemia, and maturity onset diabetes of the young (MODY). The most frequently reported…”
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Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI by FREATHY, Rachel M, TIMPSON, Nicholas J, LINDGREN, Cecilia M, LANGO, Hana, MELZER, David, FERRUCCI, Luigi, PAOLISSO, Giuseppe, NEVILLE, Matthew J, KARPE, Fredrik, PALMER, Colin N. A, MORRIS, Andrew D, ELLIOTT, Paul, LAWLOR, Debbie A, JARVELIN, Marjo-Riitta, DAVEY SMITH, George, MCCARTHY, Mark I, HATTERSLEY, Andrew T, FRAYLING, Timothy M, POUTA, Anneli, BEN-SHLOMO, Yoav, RUOKONEN, Aimo, EBRAHIM, Shah, SHIELDS, Beverley, ZEGGINI, Eleftheria, WEEDON, Michael N

“…Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI Rachel M. Freathy 1 , Nicholas J…”
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Receipt of Adjuvant Chemotherapy in Stage II Colon Cancer and Overall Survival: A National Cancer Database Study by Enofe, Nosayaba, Morris, Andrew D., Liu, Yuan, Liang, Wendi, Wu, Christina S., Sullivan, Patrick S., Balch, Glen G., Staley, Charles A., Gillespie, Theresa W., Shaffer, Virginia O.

“…There are variations in the use of adjuvant chemotherapy (AC) in stage II colon cancer (CRC). We sought to determine which patients received chemotherapy, what…”
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Retraction Note: Development and evaluation of rapid data-enabled access to routine clinical information to enhance early recruitment to the national clinical platform trial of COVID-19 community treatments by Cake, Caroline, Ogburn, Emma, Pinches, Heather, Coleman, Garry, Seymour, David, Woodard, Fran, Manohar, Sinduja, Monsur, Marjia, Landray, Martin, Dalton, Gaynor, Morris, Andrew D, Chinnery, Patrick F, Hobbs, F D Richard, Butler, Christopher

“…This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13063-021-05965-4…”
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Reduced-Function SLC22A1 Polymorphisms Encoding Organic Cation Transporter 1 and Glycemic Response to Metformin: A GoDARTS Study by Zhou, Kaixin, Donnelly, Louise A, Kimber, Charlotte H, Donnan, Peter T, Doney, Alex S F, Leese, Graham, Hattersley, Andrew T, McCarthy, Mark I, Morris, Andrew D, Palmer, Colin N A, Pearson, Ewan R

“…Reduced-Function SLC22A1 Polymorphisms Encoding Organic Cation Transporter 1 and Glycemic Response to Metformin: A GoDARTS Study Kaixin Zhou 1 , Louise A…”
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Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis by Zhou, Kaixin, Dr, Donnelly, Louise, PhD, Yang, Jian, PhD, Li, Miaoxin, PhD, Deshmukh, Harshal, PhD, Van Zuydam, Natalie, PhD, Ahlqvist, Emma, PhD, Spencer, Chris C, PhD, Groop, Leif, Prof, Morris, Andrew D, Prof, Colhoun, Helen M, Prof, Sham, Pak C, Prof, McCarthy, Mark I, Prof, Palmer, Colin N A, Prof, Pearson, Ewan R, Prof

“…Summary Background Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable…”
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Common variants in WFS1 confer risk of type 2 diabetes by Sandhu, Manjinder S, Barroso, Inês, Weedon, Michael N, Fawcett, Katherine A, Wasson, Jon, Debenham, Sally L, Daly, Allan, Lango, Hana, Frayling, Timothy M, Neumann, Rosalind J, Sherva, Richard, Blech, Ilana, Pharoah, Paul D, Palmer, Colin N A, Kimber, Charlotte, Tavendale, Roger, Morris, Andrew D, McCarthy, Mark I, Walker, Mark, Hitman, Graham, Glaser, Benjamin, Permutt, M Alan, Hattersley, Andrew T, Wareham, Nicholas J

“…We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we…”
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Mosaic structural variation in children with developmental disorders by King, Daniel A, Jones, Wendy D, Crow, Yanick J, Dominiczak, Anna F, Foster, Nicola A, Gaunt, Tom R, Harris, Jade, Hellens, Stephen W, Homfray, Tessa, Innes, Josie, Jones, Elizabeth A, Joss, Shelagh, Kulkarni, Abhijit, Mansour, Sahar, Morris, Andrew D, Parker, Michael J, Porteous, David J, Shihab, Hashem A, Smith, Blair H, Tatton-Brown, Katrina, Tolmie, John L, Trzaskowski, Maciej, Vasudevan, Pradeep C, Wakeling, Emma, Wright, Michael, Plomin, Robert, Timpson, Nicholas J, Hurles, Matthew E

“…Delineating the genetic causes of developmental disorders is an area of active investigation. Mosaic structural abnormalities, defined as copy number or loss…”
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Correction: Development and evaluation of rapid data-enabled access to routine clinical information to enhance early recruitment to the national clinical platform trial of COVID-19 community treatments by Cake, Caroline, Ogburn, Emma, Pinches, Heather, Coleman, Garry, Seymour, David, Woodard, Fran, Manohar, Sinduja, Monsur, Marjia, Landray, Martin, Dalton, Gaynor, Morris, Andrew D, Chinnery, Patrick F, Hobbs, F D Richard, Butler, Christopher

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